Tag: 200-300

On February 28, 2021, Zhu, Feng; Wang, Siqi; Liu, Yujie; Wu, Minghong; Wang, Hongyong; Xu, Gang published an article.Recommanded Product: N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Antibiotics in the surface water of Shanghai, China: screening, distribution, and indicator selecting. And the article contained the following:

The widespread existence of antibiotics has caused inevitable influence on ecol. and humans. In this study, we screened the most commonly used antibiotics, and 64 antibiotics were detected in Shanghai, an international metropolis. Most of the target substances were detected in all 46 water samples including main rivers and districts in Shanghai, with concentrations ranging from 0.02 to 502.43 ng L-1. In particular, sulfadiazine (502.43 ng L-1) had the highest maximum concentration Besides, risk quotients based on fish suggested that sulfonamides had a medium risk (0.12) in Shanghai. Correlation studies had shown that most compounds with frequencies exceeding 60% were significantly pos. correlated with the total concentration Based on further anal., sulfadiazine, sulfamerazine, and sulfapyridine were screened as indicators to reflect the pollution status of antibiotics in Shanghai for a long time. The screening conditions for these indicators include detection rate (> 60%), maximum concentration (> 100 ng L-1), RQ (> 0.01), and correlation (> 0). In addition, population d. may be the main factor for antibiotic pollution through regional comparison. In a word, this work can systematically reflect the overall situation of Shanghai antibiotics and provide support for global data comparison in the future. Meanwhile, we provided the potential indicators that can be applied in the long term and economical monitoring of antibiotics. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Recommanded Product: N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to antibiotics surface water screening distribution sewage treatment plant, antibiotics, distribution, rqs, screening, typical indicators, Water: Analysis and other aspects.Recommanded Product: N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2021, Da Le, Nhu; Hoang, Anh Quoc; Hoang, Thi Thu Ha; Nguyen, Thi Anh Huong; Duong, Thi Thuy; Pham, Thi Mai Huong; Nguyen, Tien Dat; Hoang, Van Chung; Phung, Thi Xuan Binh; Le, Huu Tuyen; Tran, Cao Son; Dang, Thu Hien; Vu, Ngoc Tu; Nguyen, Trong Nghia; Le, Thi Phuong Quynh published an article.Formula: C8H10N2O3S The title of the article was Antibiotic and antiparasitic residues in surface water of urban rivers in the Red River Delta (Hanoi, Vietnam): concentrations, profiles, source estimation, and risk assessment. And the article contained the following:

Antibiotic residues and antimicrobial resistance in surface water are issues of global concern, especially in developing countries. In this study, the occurrence of seven antibiotics and one antiparasitic agent was determined in surface water samples collected from four rivers running through Hanoi urban area in the Red River Delta, northern Vietnam. The pharmaceuticals in water samples were analyzed by solid-phase extraction combined with liquid chromatog.-tandem mass spectrometry method. The concentrations of pharmaceuticals in our samples ranged from 3050 to 16,700 (median 7800) ng/L, which were generally higher than levels found in river water from many other locations in the world. Amoxicillin, oxfendazole, and lincomycin were the most dominant and frequently detected compounds (detection rate 100%), which together accounted for 76 ± 14% of total concentrations Antibiotic concentrations in the water samples were not significantly different between the investigated rivers. Meanwhile, levels of pharmaceuticals in the samples collected in Feb. 2020 were higher than those found in the remaining samples, largely due to the sharp decrease in sulfamethoxazole and azithromycin concentrations of the samples collected in March and Apr. Considerable ecol. risks of antibiotics in surface water were estimated for some compounds such as amoxicillin, ciprofloxacin, and ofloxacin. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Formula: C8H10N2O3S

The Article related to antibiotic antiparasitic residue surface water urban river, antibiotics, hanoi, risk assessment, surface water, urban pollution, Water: Analysis and other aspects.Formula: C8H10N2O3S

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Amide – an overview | ScienceDirect Topics

On September 15, 2021, Lv, Yin-Zhi; Luo, Xiao-Jun; Zhao, Jian-Liang; Wang, Shan-Quan; Mai, Bi-Xian published an article.Safety of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Occurrence and distribution of antibiotics in sediments from black-odor ditches in urban areas from China. And the article contained the following:

Antibiotic levels in black-odor water could reflect the usage amount of antibiotics in population. On the other hand, these antibiotics are the source of antibiotics in the environmental water. Currently, researches on antibiotics in black-odor sediments are still lacking. In this study, 174 black and odor sediment samples from 74 cities in 28 provinces in China were collected for anal. Among 44 targeted antibiotics, 13 antibiotics were detected in more than 30% of sediment samples. Fluoroquinolones and tetracyclines were the predominant antibiotics in these field samples, with average concentrations of up to 2074 and 1902 ng/g dry weight (dw), resp., followed by macrolides (87.9 ng/g dw), lincosamides (8.06 ng/g dw) and sulfonamides (8.38 ng/g dw). High antibiotic contamination levels were almost always detected in black-odor sludges from economically less developed small cities; however, the difference in antibiotic concentrations between well-developed and small cities in China was not statistically significant. In addition, among the seven regions within China, no significant difference in concentrations was observed for the most antibiotics. Variances in antibiotic composition patterns in the 28 provinces of China may be due to differences in bacterial resistance, prescription habits, efficacy, and sediment carbon concentrations among various regions. There were significant pos. correlations among some antibiotics in the same or different classes. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Safety of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to ciprofloxacin enrofloxacin black odor ditch sediment china, antibiotics, black-odor sediments, distribution pattern, occurrence, Water: Analysis and other aspects.Safety of N-((4-Aminophenyl)sulfonyl)acetamide

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2022, Liu, Jing; Deng, Wen-Jing; Ying, Guang-Guo; Tsang, Eric P. K.; Hong, Hua-Chang published an article.HPLC of Formula: 144-80-9 The title of the article was Occurrence and distribution of antibiotics in surface water. And the article contained the following:

The concentrations, distribution, and ecol. risks of 24 typical antibiotics in Hong Kong rivers and seawater were investigated using high-performance liquid chromatog. coupled with electrospray ionization tandem mass spectrometry (UHPLC-EI-MS/MS). The results showed that the select antibiotics were widely distributed in the study area. Among the target antibiotics, the detection rate of tetracyclines (TCs) was 100%, which indicated the widespread use of TCs in Hong Kong. The detection rates of sulfonamides (SAs) (57.1-100%), fluoroquinolones (FQs) (78.6-100%), roxithromycin (RTM) (50%) and novobiocin (NOV) (50%) were all above 50%. Compared with river water (7.9-114.26 ng/L, medium: 27.7 ng/L), concentrations of the most antibiotics in seawater (9.5-32.0 ng/L, medium: 13.3 ng/L) were lower; seawater concentrations were similar to those reported from other coastal cities, such as Guangzhou and Zhuhai in China, which implied that the source of marine antibiotic pollution may be the nearby rivers, and the vastness of the ocean causes environmental dilution of antibiotics. According to the ratio of the measured environmental concentration (MEC) to the predicted no-effect concentration (PNEC), ofloxacin (OFX) (average risk quotient: 1.94E-01) and ciprofloxacin (CFX) (average risk quotient: 3.53E-01) posed medium to high ecol. risk in most places, whereas other antibiotics posed lower risk. In Yuen Long, where there were many livestock farms nearby, the detected concentration of antibiotics was higher, indicating that livestock wastewater may be the major reason for the increase in antibiotic levels in this area. In general, the detected concentration of antibiotics in Hong Kong was lower than that in the United States, Japan, the United Kingdom, and coastal areas of China, but the long-term existence of low concentrations of antibiotics also poses great risks. According to the risk assessment, Hong Kong should pay more attention to the use of FQs (e.g., OFX and CFX) in the future. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).HPLC of Formula: 144-80-9

The Article related to occurrence distribution antibiotics surface water, antibiotics, aquatic environment, ecological risk, uhplc-ms/ms, Water: Analysis and other aspects.HPLC of Formula: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 15, 2021, Zhang, Ruiling; Kang, Yaru; Zhang, Ruijie; Han, Minwei; Zeng, Weibin; Wang, Yinghui; Yu, Kefu; Yang, Ying published an article.Related Products of 144-80-9 The title of the article was Occurrence, source, and the fate of antibiotics in mariculture ponds near the Maowei Sea, South China: Storm caused the increase of antibiotics usage. And the article contained the following:

Antibiotic residues in mariculture environments have been detected globally, while little information is available about their dynamic levels, source, behavior, and fate during the whole culture process. In this study, the dynamic occurrence, bioaccumulation, source, fate, and human dietary risk of 19 antibiotics were investigated in different breeding stages of mariculture ponds near the Maowei Sea, South China. Fourteen antibiotics, including three sulfonamides (SAs), five fluoroquinolones (FQs), three macrolides (MLs), and two chloramphenicols (CAPs), were detected in the mariculture ponds, with FQs being the most abundant antibiotics. Significant variations of antibiotic concentration occurred during the whole culture process. Severe weather, especially typhoons and rainstorms, resulted in the average highest levels of ∑19antibiotics (mean: 567 ng L-1) in mariculture ponds. The source apportionment estimated for the mariculture ponds showed that direct application was the primary source of antibiotics (91.2%). The antibiotics in mariculture ponds were mainly discharged through aquaculture wastewater (65.8%) and settling particles (33.8%). The estimated annual input of antibiotics into the Maowei Sea was 2.24 times higher through the two main rivers (48.0 kg a-1) than through the mariculture wastewater (24.1 kg a-1). The apparent bioaccumulation factors (ABAFs) confirmed that young and adult tilapia accumulated more sulfamethoxazole (SMX) and norfloxacin (NOX), resp. The result from the estimated daily intakes suggested that the antibiotics in the seafood could not pose a risk to human health by dietary exposure assessment. Big variation of antibiotic concentration occurred during the whole culture process in the mariculture farms, and the storm increased antibiotic application. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Related Products of 144-80-9

The Article related to antibiotics mariculture pond seawater, antibiotics, dietary risk, environmental fate, mariculture ponds, source, Water: Analysis and other aspects.Related Products of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Jaydeep, Chauhan; Harshita, Gupta; Komal, Pandey; Viral, Shah; Bhagyashree, Kamble published an article in 2019, the title of the article was Herbosome an approach to deliver Aegle marmelos extract: Formulation, characterization and stability study.Quality Control of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

Aegle marmelos fruit has tremendous potential to treat the various ailments for instance; diabetes, microbial diseases and many more. Despite, having abundant therapeutic activity poor lipid solubility and gastric instability limits the efficacy of Aegle marmelos extract (AME). With an idea to overcome these hurdles, AME was formulated as Herbosome in this study. The concept of Herbosome is gaining popularity, as it provides a sheet of lipid on the outer part of drug or extract, which helps in the bioavailability enhancement. In the present work, AME was prepared by cold extraction method and percentage yield was found to be 20% weight/weight Here, Marmelosin one of the major phytoconstituent in Aegle marmelos, was used as a marker for standardization of the prepared extract Further, preliminary phytochem. screening and thin layer chromatog. (TLC) was carried out. Whereas, quant. estimation of Marmelosin in AME by High-performance thin layer chromatog. (HPTLC) was conducted. In further steps, pre-formulation parameters (effect of several processes and formulation parameters) were studied and Herbosome loaded AME was formulated by conventional technique i.e. thin film method and soyalecithin were used as phospholipids. Several parameters including, percent entrant efficiency (%EE), particle size, polydispersity index (PDI) and zeta-potential were taken into consideration for the evaluation of AME Herbosome. Later on, followed by, In vitro release of optimized formulation was studied and the formulation was able to release up to 92% even after 12 h. After developing successful AME Herbosome, stability study was performed as per the International Conference on Harmonisation (ICH) guidelines up to the period of a month. Herbosome was found to be stable at room temperature, even between 2-4°C. Henceforth, to confirm the efficacy of optimized formulation, In vitro studies (antidiabetic) are going on in the laboratory The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Quality Control of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegle herbosome marmelosin phytoconstituent stability, Pharmaceuticals: General and other aspects.Quality Control of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 15, 2004, Jaiswal, Mona; Khadikar, Padmakar V.; Supuran, Claudiu T. published an article.COA of Formula: C6H5ClN2O4S The title of the article was Topological modeling of lipophilicity, diuretic activity, and carbonic inhibition activity of benzene sulfonamides: a molecular connectivity approach. And the article contained the following:

A large series of distance-based topol. indexes has been used for modeling lipophilicity, diuretic activity, and carbonic anhydrase inhibition activity of a library of simple substituted benzene sulfonamides. The results have shown that the topol. approach used is quite useful for modeling carbonic anhydrase inhibition and the use of mol. connectivity is the best for this purpose. Excellent results are obtained in multiparametric regressions. The results are critically discussed on the basis of statistical parameters. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).COA of Formula: C6H5ClN2O4S

The Article related to qsar benzene sulfonamide diuretic carbonic anhydrase, Pharmacology: Structure-Activity and other aspects.COA of Formula: C6H5ClN2O4S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 15, 2011, Munigunti, Ranjith; Mulabagal, Vanisree; Calderon, Angela I. published an article.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Screening of natural compounds for ligands to PfTrxR by ultrafiltration and LC-MS based binding assay. And the article contained the following:

In our study, we have screened 133 structurally diverse natural compounds from the MEGx collection of AnalytiCon Discovery and three synthetic hispolone analogs for binding affinity to Plasmodium falciparum thioredoxin reductase (PfTrxR) using an ultrafiltration (UF) and liquid chromatog. (LC/MS) based ligand-binding assay newly developed in our laboratory PfTrxR catalyzes the reduction of thioredoxin (PfTrx) protein. In reduced form, PfTrx is essentially involved in the antioxidative defense and redox regulation of P. falciparum. Nine compounds (yohimbine (1), catharanthine (2), vobasine (3), gnetifolin E (4), quinidine N-oxide (5), 11-hydroxycoronaridine (6), hispolone (7), hispolone Me ether (8), and hernagine (9)) displayed binding affinity for PfTrxR at 1 μM. The ranking order of compound’s binding affinities for PfTrxR is 7 > 6 > 2 > 4 > 5 > 8 > 1 > 9 > 3. On the other hand, compounds 6, 7, 2 and 8 demonstrated specific binding to the active site of PfTrxR, when ligands were tested in an equimolar mixture of 1 μM. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to screening ligand lc ms thioredoxin reductase, Pharmacology: Structure-Activity and other aspects.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cornwell, E. published an article in 2007, the title of the article was Application of the Vc3 topographic QSPR parameter to benzene sulfonamide derivatives.Application of 97-09-6 And the article contains the following content:

A novel QSPR topog. parameter (Vc3) is used for reduction of the number of independent variables to one variable Vc3, consistent with Euclidian distances relations. This procedure was applied to a model of 19 benzene sulfonamide derivatives, using benzenesulfonamide as a reference The derivatives were characterized by physicochems. properties used as independent variables. The variables are: refraction index, surface tension and an extra dummy variable that indicated the presence or absence chlorine atoms in the mol., while pKa was used like dependent variable. The linear regression proposed is of the form. pKa = m* Vc3 + n, that is more coherent than its counterpart multivariable regression. The use of this variable reduction eliminated problems of orthogonal procedure or the use of Principal Component Anal. (PCA) to obtain consistent models. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application of 97-09-6

The Article related to qspr benzene sulfonamide derivative, General Organic Chemistry: Other and other aspects.Application of 97-09-6

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Amide – an overview | ScienceDirect Topics

On November 30, 2016, Guillon, Jean; Moreau, Stephane; Ronga, Luisa; Basmacyian, Louise; Cohen, Anita; Rubio, Sandra; Bentzinger, Guillaume; Savrimoutou, Solene; Azas, Nadine; Mullie, Catherine; Sonnet, Pascal published an article.HPLC of Formula: 5455-98-1 The title of the article was Design, Synthesis and Antimalarial Activity of Some New Aminoalcoholpyrrolo[1,2-a]quinoxaline Derivatives. And the article contained the following:

Following our search for antimalarial compounds, novel series of piperazinylalc. pyrrolo[ 1,2-a]quinoxaline derivatives 1-2 were synthesized from 2-nitroaniline or 2-amino-3- nitrophenol and tested for in vitro activity upon the intraerythrocytic stage of W2 and 3D7 Plasmodium falciparum strains. Biol. results showed good antimalarial activity with IC50 ranging from 0.3 to 21.1 μM. In attempting to investigate the large broad-spectrum antiprotozoal activities of these pyrrolo[1,2-a]quinoxaline derivatives, their properties toward the promastigote form of Leishmania donovani were also investigated and revealed their selective antiplasmodial profile. In parallel, the in vitro cytotoxicity of these mols. was assessed on the human HepG2 cell line. Structure-activity relationships of these new synthetic compounds are here discussed. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).HPLC of Formula: 5455-98-1

The Article related to antimalarial msbar, Pharmacology: Structure-Activity and other aspects.HPLC of Formula: 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics