Tag: 200-300

Pandey, Asutosh Kumar published an article in 2013, the title of the article was On diuretic activity of benzene sulfonamide using 113 C NMR chemical shift as a molecular descriptor: regular vs ridge regression.Application In Synthesis of 3-Nitro-4-chlorobenzenesulfonamide And the article contains the following content:

Diuretic activity p1/C of benzene sulfonamides was modeled using 13 C NMR chem. shift as a mol. descriptor. The regression analyses were carried out using regular as well as Ridge multiple regression analyses. Application of variety of statistics namely statistics, Ridge regression and parameter derived there were used for modeling the diuretic activity. Results have shown that 13 C NMR chem. shift yields an excellent model. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application In Synthesis of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to benzene sulfonamide diuretic nmr chem shift mol descriptor qsar, Pharmacology: Structure-Activity and other aspects.Application In Synthesis of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 15, 2005, Khadikar, Padmakar V.; Sharma, Vimukta; Karmarkar, Sneha; Supuran, Claudiu T. published an article.SDS of cas: 97-09-6 The title of the article was Novel use of chemical shift in NMR as molecular descriptor: a first report on modeling carbonic anhydrase inhibitory activity and related parameters. And the article contained the following:

A novel use of NMR chem. shift of the SO2NH2 protons (in dioxane as solvent) as a mol. descriptor is described for modeling the inhibition constant for benzene sulfonamides against the zinc enzyme carbonic anhydrase (CA, E.C. 4.2.1.1). The methodol. is extended to model diuretic activity and lipophilicity of benzene sulfonamide derivatives The regression anal. of the data has shown that the NMR chem. shift is incapable of modeling lipophilicity. However, it is quite useful for modeling the diuretic activity of these derivatives The results are compared with those obtained using distance-based topol. indexes: Wiener (W)-, Szeged (Sz)-, and PI (Padmakar-Ivan) indexes. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6

The Article related to nmr chem shift carbonic anhydrase inhibitor diuretic qsar, Pharmacology: Structure-Activity and other aspects.SDS of cas: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 1989, Menziani, Maria Cristina; De Benedetti, Pier G.; Gago, Federico; Richards, W. Graham published an article.Related Products of 97-09-6 The title of the article was The binding of benzenesulfonamides to carbonic anhydrase enzyme. A molecular mechanics study and quantitative structure-activity relationships. And the article contained the following:

Mol. mechanics methods were used to study the interaction between a series of 20 deprotonated benzenesulfonamides and the enzyme carbonic anhydrase. The different contributions to the binding energy were evaluated and correlated with exptl. inhibition data and MO indexes of the sulfonamides in their bound conformation. The results suggest that the discrimination shown by the enzyme towards these inhibitors is dominated by the short-range van der Waals forces. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Related Products of 97-09-6

The Article related to benzenesulfonamide binding carbonic anhydrase structure, Pharmacology: Structure-Activity and other aspects.Related Products of 97-09-6

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Khadikar, Padmakar V.; Jatiwala, Yusuf Ali; Lakhwani, Meenakshi; Thakur, Poornima; Joshi, Shobha; Joshi, Ashok published an article in 2006, the title of the article was QSAR studies on inhibitory properties of benzenesulfonamides towards CAI. Dominating role of Vander Waals repulsion energy.SDS of cas: 97-09-6 And the article contains the following content:

The structure-activity correlations as well as quant. structure activity relation (QSAR) study for benzene-sulfonamides possessing carbonic anhydrase (CA) inhibitory property towards CAI have been discussed using a series of distance-based topol. indexes together with binding energy of the sulfonamide to CA, Van der Waals repulsion energy and indicator parameters. Excellent results were obtained though multiple regression anal. The results are discussed with a variety of statistics. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6

The Article related to qsar carbonic anhydrase inhibitor benzenesulfonamide, Pharmacology: Structure-Activity and other aspects.SDS of cas: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 1, 2022, Semail, Nadhiratul-Farihin; Abdul Keyon, Aemi Syazwani; Saad, Bahruddin; Kamaruzaman, Sazlinda; Mohamad Zain, Nur Nadhirah; Lim, Vuanghao; Miskam, Mazidatulakmam; Wan Abdullah, Wan Nazwanie; Yahaya, Noorfatimah; Chen, David D. Y. published an article.SDS of cas: 144-80-9 The title of the article was Simultaneous preconcentration and determination of sulfonamide antibiotics in milk and yoghurt by dynamic pH junction focusing coupled with capillary electrophoresis. And the article contained the following:

A dynamic pH junction was used in capillary electrophoresis (CE-DAD) to online preconc., sep., and determine trace amounts of sulfonamide antibiotics (SAs) in milk and yoghurt samples in this study. A sample matrix with 0.15% acetic acid and 10% methanol (MeOH) at a pH of 4.0, and a background electrolyte (BGE) that contained 35 mM sodium citrate with 10% MeOH at a pH of 8.5, and an acidic barrage of 0.4% acetic acid with 10% MeOH at a pH of 2.5 were utilized to achieve a stacking effect for SAs through a dynamic pH junction. Under optimized conditions, the proposed preconcentration method showed good linearity (30-500 ng/mL, r2 ≥ 0.9940), low limits of detection (LODs) of 4.1-6.3 ng/mL, and acceptable analytes recovery (81.2-106.9%) with relative standard deviations (RSDs) within 5.3-13.7 (n = 9). The limits of quantification (LOQs) were below the maximum residue limit approved by the European Union (EU) in this type of matrixes. Sensitivity enhancement factors of up to 129 were reached with the optimized dynamic pH junction using CE with a diode array detector (DAD). The method was used to determine SAs in fresh milk, low-fat milk, full-cream milk, and yoghurt samples. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).SDS of cas: 144-80-9

The Article related to capillary electrophoresis sulfonamide milk yoghurt, capillary electrophoresis, dynamic ph junction, milk, online preconcentration, sulfonamide antibiotics, yoghurt, Food and Feed Chemistry: Analysis and other aspects.SDS of cas: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 16, 2021, Jia, Wei; Zhang, Min; Du, An; Zhang, Rong; Xu, Mudan; Shi, Lin published an article.Formula: C8H10N2O3S The title of the article was Accurate Quantification of Sulfonamide Metabolites in Goat Meat: A New Strategy for Minimizing Interaction between Sheep Serum Albumin and Sulfonamide Metabolites. And the article contained the following:

To date, the determination of sulfonamide metabolites in animal-derived food has universal disadvantages of low throughput and no integrated metabolites involved. In this study, a powerful and reliable strategy for high-throughput screening of sulfonamide metabolites in goat meat was proposed based on an aqueous two-phase separation procedure (ATPS) combined with ultrahigh-performance liquid chromatog. quadrupole-Orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap). Noncovalent interactions including van der Waals force, hydrogen bonding, and hydrophobic effect were determined to be staple interactions between the sulfonamide metabolites and sheep serum albumin by fluorescence spectroscopy and mol. docking technol., and an 80% acetonitrile-water solution/(NH4)2SO4 was used as ATPS in order to release combined sulfonamide metabolites and minimize the influence of sheep serum albumin. Sulfonamide metabolites in the matrix were screened based on a mechanism of mass natural loss and core structure followed by identification combined with the pharmacokinetic. The developed strategy was validated according to EU standard 2002/657/EC with CCα ranging from 0.07 to 0.98μg kg-1, accuracy recovery with 84-107%, and RSDs lower than 8.9%. Eighty seven goat meat samples were used for determination of 26 sulfonamides and 8 potential metabolites. On the basis of the established innovative process, this study has successfully implemented the comprehensive detection of sulfonamide metabolites, including N4-acetylated substitution, N4-hydroxylation, 4-nitroso, azo dimers, oxidized nitro, N4 monoglucose conjugation, β-D-glucuronide, and N-4-aminobenzenesulfonyl metabolites, which were shown to undergo oxidation, hydrogenation, sulfation, glucuronidation, glucosylation, and O-aminomethylation. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Formula: C8H10N2O3S

The Article related to sulfonamide metabolite goat meat albumin uhplc, uhplc-q-orbitrap, goat meat, interaction, noncovalent bonds, quantification, sulfonamide metabolites, Food and Feed Chemistry: Analysis and other aspects.Formula: C8H10N2O3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 1, 2022, Xu, Xu; Zhao, Wenhao; Ji, Baocheng; Han, Yu; Xu, Gaigai; Jie, Mingsha; Wu, Nan; Wu, Yongmei; Li, Junguang; Li, Ke; Zhao, Dianbo; Bai, Yanhong published an article.COA of Formula: C8H10N2O3S The title of the article was Application of silanized melamine sponges in matrix purification for rapid multi-residue analysis of veterinary drugs in eggs by UPLC-MS/MS. And the article contained the following:

Fast and convenient matrix purification is an important prerequisite for high-throughput anal. of drug multiresidues in food. In this study, a silanized melamine sponge was prepared and first applied in the rapid determination of multiclass veterinary drugs in eggs by ultrahigh-performance liquid chromatog.-tandem mass spectrometry. Within five seconds, fast, convenient and efficient matrix separation could be achieved through simple soaking and squeezing. Compared to other matrix adsorbents, the developed material demonstrated equivalent or better purification performance. Good validation results were obtained in terms of drug recoveries (61.5%∼97.0%, relative standard deviation (RSD) ≤ 10.8%), and linearities (R2 ≥ 0.999), as well as low limits of quantitation (0.3 ∼ 10.9μg·kg-1) and detection (0.1 ∼ 3.8μg·kg-1). By analyzing 52 egg samples, high concentrations of ofloxacin, trimethoprim, metronidazole, and dimetridazole were found at 542.9, 121.2, 66.1 and 58.0μg·kg-1, resp. The silanized melamine sponge has shown its great potential for rapid anal. of multiclass residues in food safety. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).COA of Formula: C8H10N2O3S

The Article related to silanized melamine sponges matrix purification drug residue uplc ms, egg, mass spectrometry, matrix purification, melamine sponge, veterinary drug, Food and Feed Chemistry: Analysis and other aspects.COA of Formula: C8H10N2O3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 30, 2020, Sutcharitchan, Chayanis; Miao, Shui; Li, Wenting; Liu, Jiaming; Zhou, Heng; Ma, Yingxian; Ji, Shen; Cui, Yajun published an article.Name: 1,3-Diphenylurea The title of the article was High performance liquid chromatography-tandem mass spectrometry method for residue determination of 39 plant growth regulators in root and rhizome Chinese herbs. And the article contained the following:

A simple, rapid, and effective method based on salting-out extraction and LC-MS/MS techniques was developed for the determination of 39 plant growth regulator (PGR) residues in two of the most common root and rhizome Chinese herbs, Codonopsis Radix (Dangshen) and Notoginseng Radix et Rhizoma (Sanqi). The extraction process was performed with acetonitrile-water (5:1) and citrate buffer extraction salt. The performance of the method was validated in accordance with the anal. quality control criteria of SANTE/11813/2017 guidelines. Analyte recoveries of 79.49-109.41% (Dangshen) and 80.17-102.81% (Sanqi) were achieved. The limit of quantifications (LOQs) were determined with the consideration of accuracy and precision. LOQs were lower than the lowest residue limits in EU pesticide regulation (10μg/kg) for most PGRs. Moreover, the method was successfully applied in the anal. of 35 batches of Dangshen, and 60 batches of Sanqi products. The concentration of eleven PGRs were determined in analyzed samples. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Name: 1,3-Diphenylurea

The Article related to rhizome root hplc dangshen sanqi, chinese medicine, dangshen, determination method, hplc-ms/ms, pesticide residue, plant growth regulator, sanqi, Food and Feed Chemistry: Analysis and other aspects.Name: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 16, 2021, Ji, Baocheng; Zhao, Wenhao; Xu, Xu; Han, Yu; Jie, Mingsha; Xu, Gaigai; Bai, Yanhong published an article.Reference of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Development of a modified quick, easy, cheap, effective, rugged, and safe method based on melamine sponge for multi-residue analysis of veterinary drugs in milks by ultra-performance liquid chromatography tandem mass spectrometry. And the article contained the following:

The purpose of this study was to develop a modified QuEChERS method based on melamine sponge for rapid determination of multi-class veterinary drugs in milks by UPLC-MS/MS. Through simple infiltration and extrusion, fast and convenient matrix purification could be achieved within several seconds, and there was no need of extra phase separation operations. Good linearity with correlation coefficient (R2) ≥0.999 was obtained for all drugs in the range of 2∼500μg·kg-1. The obtained matrix effects were within ±20% for all monitored drugs. The recoveries of all monitored drugs ranged from 60.7% to 116.0% at three spiked levels (50, 100, and 200μg·kg-1), with relative standard deviations less than 7.4%. Comparatively low LODs and LOQs were obtained in the ranges of 0.1∼3.8μg·kg-1 and 0.2∼6.3μg·kg-1, resp. Compared with conventional purification adsorbents, melamine sponge yielded an equal or higher purification performance with matrix removal rate as high as 52.5% and acceptable recoveries in range of 60%-120% for all monitored drugs. The satisfactory results have demonstrated the good potential of melamine sponge in matrix purification for rapid determination of multiclass residues in food safety. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Reference of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to milk veterinary drug melamine sponge uplc ms, matrix purification, melamine sponge, milk, quechers, veterinary drug, Food and Feed Chemistry: Analysis and other aspects.Reference of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2021, Wang, Chun; Chen, Meng; Hu, Qi; Bai, Hua; Wang, Changhai; Ma, Qiang published an article.SDS of cas: 144-80-9 The title of the article was Non-lethal microsampling and rapid identification of multi-residue veterinary drugs in aquacultured fish by direct analysis in real time coupled with quadrupole-Orbitrap high-resolution mass spectrometry. And the article contained the following:

An anal. protocol for the identification of 52 multi-class veterinary drug residues in aquacultured fish has been developed based on direct anal. in real time (DART) coupled with quadrupole-Orbitrap high-resolution mass spectrometry (Q-Orbitrap HRMS). A “sample-and-release” strategy was adopted where live fishes are captured for non-lethal blood microsampling and then released back into the original farming water. A simple micro liquid-liquid extraction (micro-LLE) was incorporated for the extraction and clean-up of veterinary drug analytes from fish blood samples. The main parameters affecting micro-LLE, DART ionization, and Q-Orbitrap HRMS anal. were systematically studied. Data acquisition was carried out using a synchronous full-scan MS/data-dependent MS/MS (full-scan MS1/dd-MS2) workflow. Suspect screening was conducted by comparing the exptl. measured exact mass of precursor and fragment ions with the custom accurate-mass database and by matching the acquired mass spectra against the mass spectral library. The anal. performance of the developed methodol. was assessed in terms of sensitivity, linearity, repeatability, and recovery. The limits of detection (LODs) and quantitation (LOQs) of the 52 analytes were in the range of 0.5-20μg/L and 2-50μg/L, resp. The matrix effect ratios ranged from -23.5% to 25.9%. The developed approach demonstrated promising potential for rapid, real-time monitoring of veterinary drug residues to ensure food safety and consumer health. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).SDS of cas: 144-80-9

The Article related to nonlethal microsampling multiresidue veterinary drug aquacultured fish qorbitrap hrms, Food and Feed Chemistry: Analysis and other aspects.SDS of cas: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics