Tag: 200-300

N,N’-Dicyclohexyl-N-(phthaloylglycyl)urea was written by Bernes, Sylvain;Hernandez-Linares, Maria Guadalupe. And the article was included in IUCrData in 2021.Computed Properties of C13H24N2O This article mentions the following:

The mol. structure of the title compound {systematic name: 1,3-dicyclohexyl-1-[2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)acetyl]urea}, C23H29N3O4, derived from N,N’-dicyclohexylurea, shows that the tertiary N atom substituted by a cyclohexyl and phthaloylglycyl groups adopts a perfectly planar geometry (bond-angle sum = 360.0°). In the same way as for N,N’-dicyclohexylurea, the extended structure of the title compound features N-H···O hydrogen bonds, which generate chains of mols. running in the [001] direction. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Computed Properties of C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Computed Properties of C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis and Investigation of the Antidepressant Properties of Arginine-Vasopressin was written by Borodina, K. V.;Savanets, O. N.;Pustyulga, E. S.;Martinovich, V. P.;Kravchenko, E. V.;Olgomets, L. M.;Golubovich, V. P.. And the article was included in Russian Journal of Bioorganic Chemistry in 2022.Formula: C13H24N2O This article mentions the following:

A search for novel antidepressant analogs of arginine-vasopressin (AVP) by a computer modeling revealed the following peptide analogs of the C-terminal part of AVP: N-Ac-D-Ser-Pro-D-Arg-Gly-NH2, N-Ac-Phe-Pro-Arg-Gly-NH2, and N-Ac-Trp-Pro-Arg-Gly-NH2. Syntheses of the modeled compounds were described in this article. The compounds that could potentially exhibit the antidepressant activity were examined in the forced swimming test. N-Ac-Trp-Pro-Arg-Gly-NH2 (0.1, 1.0, and 10.0 μg/kg) and N-Ac-D-Ser-Pro-D-Arg-Gly-NH2 (1.0 μg/kg) were shown to have the highest similarity to the fluoxetine reference antidepressant according to a number of parameters after the intranasal administration to the Wistar male rats. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Formula: C13H24N2O).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Formula: C13H24N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

New methods for the synthesis of 2-arylpyrroles was written by Kruse, Chris G.;Bouw, Jan P.;Van Hes, Roelof;Van de Kuilen, Aalt;Den Hartog, Jack A. J.. And the article was included in Heterocycles in 1987.COA of Formula: C10H10F3NO2 This article mentions the following:

Two short and efficient synthetic approaches for 2-arylpyrroles I (R = Ph, 4-FC₆H₄, 2,6-F₂C₆H₃, 4-F₃CC₆H₄ etc.) are presented. The key intermediates RCOCH₂CH₂CHO are conveniently obtained from com. available RCOMe or benzoic acid derivatives RCOCl, RCONMeOMe. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7COA of Formula: C10H10F3NO2).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.COA of Formula: C10H10F3NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Composition and application of maleate sulfonate compound neutral deinking agent was written by Ma, Xiaoyu;Li, Xiaorui;Fei, Guiqiang;Mou, Jing. And the article was included in Zhonghua Zhiye in 2010.Recommanded Product: 10543-57-4 This article mentions the following:

Neutral deinking agents were obtained by compounding maleate sulfonate ionic surfactants with two nonionic surfactants, fatty alc. polyoxyethylene ether AEO-9, AEO-3. The maleate sulfonate ionic surfactants were prepared by using maleic anhydride, polyoxyethylene alkyphenol (TX-10) and sodium sulfite. The structure of maleate sulfonate anionic surfactant and the deinking effect were investigated by FTIR and SEM. The results show that when the ratio of maleate sulfonate anionic surfactant:AEO-9:AEO-3 is at 2:1:1, the effect of neutral deinking is ideal, the whiteness of the deinking pulp can be increased above 14% ISO and the residual ink concentration can be decreased above 170 mm²/m². In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Recommanded Product: 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Development of suspect and non-target screening methods for detection of organic contaminants in highway runoff and fish tissue with high-resolution time-of-flight mass spectrometry was written by Du, Bowen;Lofton, Jonathan M.;Peter, Katherine T.;Gipe, Alexander D.;James, C. Andrew;McIntyre, Jenifer K.;Scholz, Nathaniel L.;Baker, Joel E.;Kolodziej, Edward P.. And the article was included in Environmental Science: Processes & Impacts in 2017.SDS of cas: 2387-23-7 This article mentions the following:

Untreated urban stormwater runoff contributes to poor water quality in receiving waters. The ability to identify toxicants and other bioactive mols. responsible for observed adverse effects in a complex mixture of contaminants is critical to effective protection of ecosystem and human health, yet this is a challenging anal. task. The objective of this study was to develop anal. methods using liquid chromatog. coupled to high-resolution quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) to detect organic contaminants in highway runoff and in runoff-exposed fish (adult coho salmon, Oncorhynchus kisutch). Processing of paired water and tissue samples facilitated contaminant prioritization and aided investigation of chem. bioavailability and uptake processes. Simple, minimal processing effort solid phase extraction (SPE) and elution procedures were optimized for water samples, and selective pressurized liquid extraction (SPLE) procedures were optimized for fish tissues. Extraction methods were compared by detection of non-target features and target compounds (e.g., quantity and peak area), while minimizing matrix interferences. Suspect screening techniques utilized inhouse and com. databases to prioritize high-risk detections for subsequent MS/MS characterization and identification efforts. Presumptive annotations were also screened with an inhouse linear regression (log K_owvs. retention time) to exclude isobaric compounds Examples of confirmed identifications (via reference standard comparison) in highway runoff include ethoprophos, prometon, DEET, caffeine, cotinine, 4(or 5)-methyl-1H-methylbenzotriazole, and acetanilide. Acetanilide was also detected in runoff-exposed fish gill and liver samples. Further characterization of highway runoff and fish tissues (14 and 19 compounds, resp. with tentative identification by MS/MS data) suggests that many novel or poorly characterized organic contaminants exist in urban stormwater runoff and exposed biota. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7SDS of cas: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.SDS of cas: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthesis of medicinally relevant phenyl sulphonylamino alkanamides and N-aryl P-toluenesulphonamides was written by Izuchi, Attah S.;Onoabedje, Efeturi A.;Ekoh, Ogechi C.;Okafor, Sunday;Okoro, Uchechukwu C.. And the article was included in Journal of Medicinal and Chemical Sciences in 2019.Application of 1146-43-6 This article mentions the following:

Synthesis of new medicinally important phenylsulfonyl aminoalkanamides and N-aryl p-toluene sulfonamides was reported. The reaction between benzenesulfonylchloride and valine gave 3-methyl-2-[(phenylsulfonyl)amino]butanoic acid which was converted into 2- [acetyl(phenylsulfonyl)amino]-3-Me butanoic acid by reacting with acetic anhydride in acetic acid. The reaction of the latter with SOCl₂ and the former with NH₃ afforded 2-[N-acetyl(phenylsulfonyl)amino]-3-Me butanamide intermediate. The palladium-catalyzed reaction of the intermediate with readily available aryl chlorides and bromides afforded a variety of Ph sulfonylaminoalkanamides I [R = 4-aminophenyl, 4-hydroxyphenyl, 4-methoxyphenyl, pyridin-2-yl, 5-nitropyridin-2-yl, 2,6-diaminopyrimidin-4-yl] was obtained in good yields. In another synthesis, p-toluenesulfonylchloride reacted with aqueous ammonia to give 4-Me benzenesulfonamide which was converted into N-(aryl)-p-toluenesulfonamide, II [R = 4-hydroxyphenyl, 4-formylphenyl, 4-aminophenyl, 2-methylphenyl, 2-methoxyphenyl] in good yields, by reaction with 4-chlorophenol, 4-bromobenzaldehyde, 4-bromoaniline, 2-chlorotoluene and 1-bromo-2-methoxybenzene, resp. Structures of the synthesized compounds were confirmed by spectroscopic and elemental anal. data. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Application of 1146-43-6).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Application of 1146-43-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mesomorphic and geometrical orientation study of the relative position of fluorine atom in some thermotropic liquid crystal systems was written by Ahmed, H. A.;Hagar, M.;Alhaddad, O. A.. And the article was included in Liquid Crystals in 2020.Application of 2387-23-7 This article mentions the following:

New series of the Schiff base/esters, 4-((2′-or 3′-fluorophenylimino)methyl)phenyl-4”-alkoxy benzoates and 4-((3-fluorophenyl)diazenyl)phenyl 4”-alkoxy benzoates, I [X = C, N; R¹ = hexyl, octyl, decyl, etc.; R² = 2-F, 3-F ] were prepared and their mesophase behavior investigated. The type of the mesophase and its transition temperature were determined by differential scanning calorimetry (DSC) and polarised optical microscopy (POM). The optimized structures of Schiff base/ester and their azo/ester groups were deduced theor. by d. functional theory (DFT). Each group of homologues differed from the other by the position of the fluorine atom on the terminal benzene ring, in addition to laterally neat homologues. Comparative studies revealed that the position and orientation of the lateral fluorine atom as well as the type of the linking core not only affected the melting temperature but also the mesophase stability. DFT results showed that the type and stability of the mesophase could be illustrated in the terms of calculated dipole moment, polarisability, thermal energy and mol. electrostatic potential. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Application of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Application of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Effect of cationic gelatin protein on hydrogen peroxide decomposition rate was written by Tang, Jun-ling;Wang, Xue-yan. And the article was included in Ranzheng Jishu in 2016.Reference of 10543-57-4 This article mentions the following:

For the purpose of improving the control of the hydrogen peroxide decomposition rate, the prediction of the bleaching results, and the optimization of cotton fabric bleaching process, a self-made cationic gelatin protein agent was used in cotton hydrogen peroxide bleaching and hydrogen peroxide decomposition rate was calculated The influence of self-made cationic gelatin protein agent, stabilizing agent sodium silicate and activator TAED on the hydrogen peroxide decomposition rate was compared. The results showed that cationic gelatin protein could promote the decomposition of hydrogen peroxide effectively and the decomposition rate was closed to TAED under low temperature and low alkali. The cationic gelatin protein acted as an activator in bleaching process. It provided a theor. basis for the cationic gelatin protein agent application in hydrogen peroxide bleaching with low temperature and low alkali. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Reference of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.Reference of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Diverse Oxidative C(sp²)-N Bond Cleavages of Aromatic Fused Imidazoles for Synthesis of α-Ketoamides and N-(pyridin-2-yl)arylamides was written by Xu, Fangzhou;Wang, Yanyan;Xun, Xiwei;Huang, Yun;Jin, Zhichao;Song, Baoan;Wu, Jian. And the article was included in Journal of Organic Chemistry in 2019.Recommanded Product: 2387-23-7 This article mentions the following:

An efficient and chemoselective C(sp²)-N bond cleavage of aromatic imidazo[1,2-a]pyridine mols. is developed. A broad scope of amide compounds such as α-ketoamides and N-(pyridin-2-yl)arylamides are afforded as the final products in up to quant. yields. Diverse C-N bond cleavages are controlled by the oxidative species used in this transformation, with various amide products afforded in a chemoselective fashion. A preliminary study indicated that some α-ketoamides exhibit anti-Tobacco Mosaic Virus activity for potential use in plant protection. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Recommanded Product: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Recommanded Product: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Visible light mediated synthesis of 4-aryl-1,2-dihydronaphthalene derivatives via single-electron oxidation or MHAT from methylenecyclopropanes was written by Liu, Jiaxin;Wei, Yin;Shi, Min. And the article was included in Organic Chemistry Frontiers in 2021.HPLC of Formula: 192436-83-2 This article mentions the following:

A direct single-electron oxidation of methylenecyclopropanes (MCPs) I (R = H, 2-Me, 3-OMe, 4-F, etc.; R¹ = H, 2-Me, 3-Cl, 4-F, etc.) for the rapid construction of 4-aryl-1,2-dihydronaphthalene derivatives II (R² = H, 5-Me, 6-OMe, 7-F, etc.; R³ = H, F) and III (R⁴ = R⁵ = H, F) by merging visible light photoredox catalysis and cobalt catalysis was reported. In MeCN with Et₃N·3HF (1.0 equivalent), the fluorination of MCPs I can be realized in the presence of 9-mesityl-10-methylacridinium perchlorate and Co(dmgH)₂PyCl, affording fluorinated 4-aryl-1,2-dihydronaphthalene derivatives II (R³ = F) in moderate yields. In MeCN/HFIP (7 : 3), 4-aryl-1,2-dihydronaphthalene derivatives II (R³ = H) and III were obtained in good yields through a metal-catalyzed hydrogen atom transfer process under similar conditions. In the experiment, the researchers used many compounds, for example, 4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2HPLC of Formula: 192436-83-2).

4-Bromo-N-methoxy-N-methylbenzamide (cas: 192436-83-2) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.HPLC of Formula: 192436-83-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics