Tag: 200-300

On June 30, 2021, Yazdanfar, Najmeh; Shamsipur, Mojtaba; Ghambarian, Mahnaz published an article.HPLC of Formula: 144-80-9 The title of the article was Determination of sulfonamide residues in animal foodstuffs by magnetic dispersive solid-phase extraction using magnetic carbon nanocomposites coupled with ion pair-dispersive liquid-liquid micro-extraction combined with HPLC-DAD. And the article contained the following:

Abstract: In this study, magnetic-dispersive solid-phase extraction coupled with ion pair-dispersive liquid-liquid micro-extraction (MSPE-i-DLLME) was used to the pre-concentration and extraction of five sulfonamides residues (sulfadiazine, sulfathiazole, sulfacetamide, sulfamethazine and sulfamethoxazole) in animal foodstuffs. The sulfonamides are extracted using magnetic carbon nanocomposite and then eluted with acetonitrile. In the DLLME step, the target analytes are collected in 1-octanol containing 10% Aliquat-336 (as extraction solvent). Finally, the compounds are quantified by HPLC with DAD detection. The extraction parameters optimized using the one at the time and central composite design methods. Under the optimized conditions: sample solution volume was 100 mL; initial pH: 12, amounts of MCNs: 30 mg; desorption solvent (ACN) volume, 1 mL; desorption condition, 10 min sonication at two step; extraction solvent (1-octanol + 10% aliquat) volume, 115μL; pH of DLLME step, 3; salt effect, 24.6%, (w/v) NaCl; centrifuge, 5 min, 4000 rpm. In these extraction conditions, the proposed procedure represented good pre-concentration factors between 130 and 490; detection limits in the range from 0.01 to 5μg kg-1 (at S/N = 3), and linear response in the 0.1-400μg kg-1 concentration range. The method is successfully applied to the determination of sulfonamides residues in animal foodstuffs. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).HPLC of Formula: 144-80-9

The Article related to sulfonamide residue foodstuff mspe i dllme mcn hplc dad, Food and Feed Chemistry: Analysis and other aspects.HPLC of Formula: 144-80-9

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On July 17, 2020, Preetha, Bhadra published a patent.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the patent was Biopesticide composition based on bael extract for treating aphids in plant and preparation method thereof. And the patent contained the following:

The invention relates to a biopesticide composition having less harmful side effects for normal cells, and reducing the use of pesticides based on synthetic drugs. The composition contains the following components: 15-25% of aegeline; 15-25% of skimmianine (1); 15-25% of d-limonene; 15-25% of marmelosin and 15-25% of allocryptopine. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to plant aphid bael extract biopesticide composition, Agrochemical Bioregulators: Plant and other aspects.Reference of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

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On March 31, 2022, Igualada, Carmen; Giraldo, Jennifer; Font, Guillermina; Yusa, Vicent published an article.Computed Properties of 144-80-9 The title of the article was Validation of a multi-residue UHPLC-HRMS method for antibiotics screening in milk, fresh cheese, and whey. And the article contained the following:

The aim of this study was to develop a UHPLC-HRMS methodol. as a suitable tool for the screening of antibiotics in milk, fresh cheese, and whey. Compounds were analyzed using an Orbitrap Exactive analyzer working at a resolving power of 50,000 FWHM in full scan, both in pos. and neg. electrospray ionization mode, and a high mass accuracy (<5 ppm) and a retention time deviation of ±2.5% were set as identification criteria. The multiclass method was developed for the simultaneous determination of 36 substances from different antibiotic groups (β-lactams, lincosamides, macrolides, quinolones, sulfonamides, and tetracyclines) and the quantification was performed by using matrix-matched calibration curves corrected by the corresponding internal standards Matrix effect and recovery percentages were also calculated prior to the selection of internal standard After comparing different sample preparation procedures, a quick and easy extraction with acetate buffer at pH 5.2 and acetonitrile (20/80, volume/volume), followed by C18 dispersive Solid Phase Extraction (dSPE) bulk sorbent was selected. The detection capabilities (CCβs) were established at 25% or 50% of the Maximum Residue Limit (MRL) set in milk (no regulation for cheese and whey), and precision (repeatability and reproducibility) and trueness (recovery) were satisfactory according to Commission Decision 2002/657/EC. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Computed Properties of 144-80-9

The Article related to antibiotics milk fresh cheese whey uhplchrms, Food and Feed Chemistry: Analysis and other aspects.Computed Properties of 144-80-9

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Amide – an overview | ScienceDirect Topics

On January 31, 2020, Uslu, Azize Gizem; Maz, Tugce Gur; Nocentini, Alessio; Banoglu, Erden; Supuran, Claudiu T.; Caliskan, Burcu published an article.Formula: C6H5ClN2O4S The title of the article was Benzimidazole derivatives as potent and isoform selective tumor-associated carbonic anhydrase IX/XII inhibitors. And the article contained the following:

We describe the synthesis of a series of 2-arylbenzimidazole derivatives bearing sulfonamide functionality (4a-d, 7a-c and 10) as well as hydroxamic acid (15a-b), carboxylic acid (16a-b), carboxamide (17a-b) and boronic acid (22a-b and 26) functionalities, which act as human carbonic anhydrase (hCA, EC 4.2.1.1) inhibitors. The newly synthesized benzimidazole derivatives were evaluated against 4 physiol. relevant CA isoforms (hCA I, II, IX, and XII), and especially the sulfonamide-containing benzimidazoles demonstrated intriguing inhibitory activity against tumor associated CA IX and XII with KI values in the range of 5.2-29.3 nM and 9.9-41.7 nM, resp. Notably, compound 4c was the most potent and selective CA IX (KI = 6.6 nM) and XII (KI = 9.9 nM) inhibitor with a significant selectivity ratio over cytosolic CA I and II isoforms in the range of 3.4-25.2. In addition, compounds having hydroxamic acid (15a-b) or carboxylic acid (16a-b) functionalities resulted in greater selectivity ratios for CA IX/XII over CAI/II in the range of 4.1-121.5 although with KI values in lower micromolar potency (KIs = 0.36-0.85μM for CA IX/XII). The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Formula: C6H5ClN2O4S

The Article related to benzimidazole derivative preparation carbonic anhydrase inhibitor cancer, benzimidazole, carbonic anhydrase, carboxylic acid, hydroxamic acid, sulfonamide, Pharmacology: Structure-Activity and other aspects.Formula: C6H5ClN2O4S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 15, 2017, Liu, Tingting; Wan, Yichao; Liu, Renshuai; Ma, Lin; Li, Minyong; Fang, Hao published an article.COA of Formula: C6H5ClN2O4S The title of the article was Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors. And the article contained the following:

The B-cell lymphoma-2 (Bcl-2) family proteins are attractive targets for cancer therapy. In the previous work, the structure-activity relationship of WL-276 was studied. According to the results, rhodanine derivatives show potent binding affinity for Bcl-2 and Mcl-1 protein and show weaker activity against Bcl-XL protein. Based on the previous results, a new class of indole-3-carboxylic acid-based derivatives were designed and synthesized as Bcl-2/Mcl-1 dual inhibitors. Among them, compound I has a Ki value of 0.26 μM for Bcl-2 protein and is better than WL-276. Furthermore, it inhibits the myeloid cell leukemia sequence 1 (Mcl-1) protein with a Ki value of 72 nM. Especially, compound II can selectively acting on Bcl-2 and Mcl-1 protein but not Bcl-XL protein, which has great significance for developing dual inhibitors targeting Bcl-2 and Mcl-1 protein, as well as specific antitumor abilities in cells. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).COA of Formula: C6H5ClN2O4S

The Article related to indolecarboxylate bcl2 mcl1 inhibitor antitumor neoplasm, anti-tumor, bcl-2/mcl-1, indole-3-carboxylic acid-based derivatives, inhibitors, Pharmacology: Structure-Activity and other aspects.COA of Formula: C6H5ClN2O4S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 1985, De Benedetti, Pier G.; Menziani, M. Cristina; Frassineti, Chiara published an article.Reference of 3-Nitro-4-chlorobenzenesulfonamide The title of the article was A quantum chemical QSAR study of carbonic anhydrase inhibition by sulfonamides. Sulfonamide carbonic anhydrase inhibitors: quantum chemical QSAR. And the article contained the following:

MO indexes were computed (CNDO/2) for 3 series of sulfonamide inhibitors, (in their neutral and anionic forms) of carbonic anhydrase  [9001-03-0]. Linear regression analyses between the calculated indexes and both physico-chem. and enzyme inhibition data gave good correlations which allowed the testing of predictive and diagnostic aspects of the quant. structure-activity relationships employing quantum chem. indexes. Results indicated that the mol. size affects the inhibitory power among the different sulfonamide derivatives (aliphatic, arylic and bridged diarylic) but not significantly within each mol. series. Results indicated further that the MO indexes are good predictors of the various exptl. mol. properties and suggest that the less electron-rich the sulfamoyl group is, the more favored are both the hydrophobic and hydrophilic steps leading to enzyme inhibition. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Reference of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to carbonic anhydrase inhibition sulfonamide qsar, qsar sulfonamide derivative, structure activity sulfonamide derivative, mo sulfonamide, Pharmacology: Structure-Activity and other aspects.Reference of 3-Nitro-4-chlorobenzenesulfonamide

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pawar, Rahul S.; Grundel, Erich published an article in 2017, the title of the article was Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs).Related Products of 456-12-2 And the article contains the following content:

A review. The multi-billion dollar dietary supplement industry is global in reach. The industry has been criticized for problems related to poor quality control, safety, misbranding, and adulteration. In this review, we describe how the US Food and Drug Administration (FDA) regulates dietary supplements within the framework of the Federal Food, Drug, and Cosmetic Act (FD&C Act). The Dietary Supplement Health and Education Act of 1994 (DSHEA), which amended the FD&C Act, gave the FDA the authority to promulgate Good Manufacturing Practices for dietary supplements and required that manufacturers provide the FDA information supporting a conclusion that the ingredients are reasonably expected to be safe if the dietary ingredients were not marketed in the USA before 15 Oct. 1994. Recent amendments to the FD&C Act require that serious dietary-supplement-related adverse events be reported to the FDA and provide the agency with mandatory recall authority. We discuss the presence of naturally occurring (e.g. Ephedra, Citrus aurantium, Acacia) and synthetic (e.g. β-methylphenethylamines, methylsynephrine, α-ethyl-phenethylamine) biol. active phenethylamines (PEAs) in dietary supplements and of PEA drugs (e.g. clenbuterol, fenfluramine, sibutramine, lorcaserin) in weight-loss products. Regulatory actions against manufacturers of products labeled as dietary supplements that contain the aliphatic amines 1,3-dimethylamine and 1,3-dimethylbutylamine, and PEAs such as β-methylphenethylamine, aegeline, and Dendrobium illustrate the FDA’s use of its authority under the FD&C Act to promote dietary supplement safety. Published 2016. This article is a U. S. Government work and is in the public domain in the USA. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Related Products of 456-12-2

The Article related to phenethylamine dietary supplement regulation review, dshea, adulteration, dietary supplements, new dietary ingredient, phenethylamine, Food and Feed Chemistry: Reviews and other aspects.Related Products of 456-12-2

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Amide – an overview | ScienceDirect Topics

On December 1, 2015, Wang, Gang; Wang, Yutao; Wang, Lei; Han, Leiqiang; Hou, Xuben; Fu, Huansheng; Fang, Hao published an article.Product Details of 97-09-6 The title of the article was Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors. And the article contained the following:

Anti-apoptotic B-cell lymphoma-2 (Bcl-2) proteins are promising targets for cancer therapy. In the present study, a series of imidazolidine-2,4-dione derivatives were designed and synthesized to test their inhibitory activities against anti-apoptotic Bcl-2 proteins. Among them, compound 8k had better growth inhibitory effects on K562 and PC-3 cell lines compared to lead compound WL-276. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Product Details of 97-09-6

The Article related to imidazolidine dione derivative preparation bcl2 inhibitor antitumor leukemia, antitumor, bcl-2, imidazolidine-2,4-dione, inhibitors, Pharmacology: Structure-Activity and other aspects.Product Details of 97-09-6

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Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 20, 2002, Li, Maojin; Hu, Junfeng; Li, Guozhen; Xie, Lin published an article.HPLC of Formula: 97-09-6 The title of the article was Antagonism of rhizoma gastrodiae to lead-induced damage of hippocampus in rats. And the article contained the following:

The antagonism of rhizoma gastrodiae (RGT) to the impairment of learning and memory ability induced by Lead was studied in rats. 36 Wistar rats were randomly divided into 3 groups, 12 rats in every group, (1) control group: treated with distilled water; lead group: treated with lead acetate(0.1 g/kg d); (3)lead-RGT group:lead acetate(0.1 g/kg d)+RGT(4.0 g/kg d). The ability of learning and memory of the rats was measured monthly by swimming test; 3 mo later, the rats were decapitated and nitric oxide(NO) and total antioxidative capacity(TAOC) in hippocampus were measured immediately and the examination for pathol. was also made. In swimming test, the number of seeking for anchorage in lead group(1, 2, 3 mo: 10.10±1.10, 7.80±1.32, 5.40±0.97 resp.) were significantly decreased, compared with the control(P < 0.01). The number of seeking for anchorage in RGT-lead group(1, 2, 3 mo: 11.90±0.95, 10.90±0.95, 9.7±0.96 resp.) were significantly increased, compared with lead group(P < 0.01). NO(0.733±0.015) μmol/g pro and TAOC(0.945±0.017) U/mg pro in hippocampus of lead group were significantly decreased compared with the control(P < 0.01) whereas NO(0.769±0.021) μmol/g pro and TAOC(0.986±0.010) U/mg pro in hippocampus of RGT-lead group were significantly increased compared with lead group(P < 0.01). Pathol. examination showed that in lead group, marked atrophy in hippocampus, cellular denaturation and necrosis, dissolution and disappearance in axon were found. In lead-RGT group, the atrophy of hippocampus was not obvious, the cell morphol. was nearly normal, no obvious abnormal changes were seen. RGT is antagnostic to the impairment of hippocampus and of learning and memory ability induced by lead. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).HPLC of Formula: 97-09-6

The Article related to lead gastrodia tianma hippocampus damage, Pharmaceuticals: Pharmacognostic Products and other aspects.HPLC of Formula: 97-09-6

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Amide – an overview | ScienceDirect Topics

Kim, Hye Jin; Seo, Young Ju; Htwe, Khin Myo; Yoon, Kee Dong published an article in 2021, the title of the article was Chemical constituents from Aegle marmelos fruits.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

Aegle marmelos (Rutaceae) is a deciduous shrub or tree and typically known as bael throughout Southeast Asia and has been used as a medicinal plant and a food ingredient. In this study eight compounds were determined to be O-(3,3-dimethylallyl) halfordinol (1), (R)-aegeline (2), (R)-marmeline (3), imperatorin (4), xanthotoxol (5), valencic acid (6), vanillic acid (7) and rutin (8). The chem. structures of the isolates were elucidated through spectroscopic evidence including 1D, 2D NMR, ESI-Q-TOF-MS and optical rotation. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegle marmelos fruit chem constituent, Pharmaceuticals: Pharmacognostic Products and other aspects.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics