Tag: 200-300

Toda, Yasunori; Tanaka, Katsumi; Matsuda, Riki; Suga, Hiroyuki published an article in 2019, the title of the article was Visible-light-triggered Catalytic Halohydrin Synthesis from Epoxides and Trichloroacetonitrile by Copper and Iron Salts.Related Products of 5455-98-1 And the article contains the following content:

Preparation of vicinal halohydrins by the ring-opening reaction of epoxides under visible-light conditions using copper or iron chlorides catalyst was described. The use of trichloroacetonitrile as a chloride source enabled catalytic HCl generation under the mild conditions. This method can also be applied to the aziridine ring-opening reaction. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Related Products of 5455-98-1

The Article related to epoxide trichloroacetonitrile metal chloride catalyst regioselective photochem ring opening, chlorohydrin preparation, Aliphatic Compounds: Alcohols and Thiols and other aspects.Related Products of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Tinland, Bernard published an article in 1973, the title of the article was Theoretical EHT [extended Hueckel theory] study of structure-activity relations in a series of sulfonamides.Electric Literature of 97-09-6 And the article contains the following content:

The carbonic anhydrase inhibitory activities of 17 sulfonamides were compared with their structures, based on quantum chem. calculations performed within the framework of the extended Hueckel theory. Correlations were found between the activity of mols. and the reduced Mulliken overlap populations relative to the SO2 group. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Electric Literature of 97-09-6

The Article related to sulfonamide structure activity, quantum chem drug activity, carbonic anhydrase sulfonamide, Pharmacodynamics: Structure-Activity and other aspects.Electric Literature of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 15, 2022, Sun, Feifei; Tan, Haiguang; Abdallah, Mohamed F.; Li, Yanshen; Zhou, Jinhui; Li, Yi; Yang, Shupeng published an article.Name: N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was A novel calibration strategy based on isotopic distribution for high-throughput quantitative analysis of pesticides and veterinary drugs using LC-HRMS. And the article contained the following:

Preparation of calibration curves is a critical step for large-scale quantification. However, this procedure is time-consuming, labor intensive. Herein, a novel isotopologue multipoint calibration (IMC) strategy, was proposed and demonstrated for the simultaneous quantitation of 120 pesticides and 83 veterinary drugs in surface water samples using Liquid Chromatog.-High Resolution Mass Spectrometry (LC-HRMS). In this strategy, the natural isotopic distribution was used to generate external calibration curves, eliminating the need of analyst’s adjustment and many sets of chem. standard solutions required in external calibration curves. Addnl., this strategy was comprehensively validated, and the results indicated this strategy had better performance in both accuracy and precision, fully meeting the requirements for the quant. anal. Interestingly, for the samples with high concentration beyond the upper limit of quantitation, the IMC strategy could avoid samples dilution by monitoring the less abundant isotopic channels. Furthermore, the IMC method was successfully applied in the surface water samples collected from Anhui province, China. Among which, sulfamethoxazole and imidacoprid were the main contributors. In conclusion, we present a promising LC-HRMS strategy for the accurate quantitation of small mols., which has a potential application in food and environmental anal. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Name: N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to pesticide veterinary drug isotopic distribution calibration, high resolution mass spectrometry, isotope distribution, quantitative analysis, water environment pollution, Waste Treatment and Disposal: Other and other aspects.Name: N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nelson, G. L.; Webb, J. L. published an article in 1973, the title of the article was Oxygen index of liquids. Halogen compounds.Application of 97-09-6 And the article contains the following content:

The oxygen indices of 150 halogenated compounds are reported and the effectiveness of F, Cl, Br, and I substituents on fire retardancy compared. All halogens were more effective in aromatic compounds than in aliphatic materials. On average, the introduction of a single halogen atom into aromatic compounds increased the oxygen index 1.5 unit/F atom. 4.3 units/Cl atom, 7.4 units/Br atom, and 6.5 units/I atom. The introduction of greater numbers of halogen atoms in aromatic compounds led to a nonlinear increase in oxygen index. Particularly in the case of F and Cl, highly specific structural effects were seen. Halogen can be particularly effective for aromatic systems containing other electron-withdrawing groups. Perhaps this is due to the increased difficulty in oxidation imposed on an already electron-poor organic system. Polyacromaticity had a strong enhancement of fire retardancy. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application of 97-09-6

The Article related to oxygen index halogen compound, fire retardancy halogen compound, safety fire halogen compound, Propellants and Explosives: General and other aspects.Application of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 30, 2022, Ruan, Weifeng; Wang, Jiaxi; Huang, Jie; Tai, Yiping; Wang, Rui; Zhu, Weipeng; Yang, Yang published an article.HPLC of Formula: 144-80-9 The title of the article was The in vivo and vitro degradation of sulfonamides in wetland plants reducing phytotoxicity and environmental pollution. And the article contained the following:

Aquatic plants can be used for in situ remediation of water-borne pharmaceutical compounds; however, such information and that of the potential risks of metabolites released into the environment are limited. This study determined the capacity of Canna indica and Acorus calamus used in the remediation of water-borne sulfonamides (SA). The tolerance, removal, accumulation, and biotransformation of various water-borne SAs were investigated in vivo by exposing plants to SA solutions (50 μg/L and 500 μg/L). After 28 days, C. indica removed more SAs (89.3-97.8%) than A. calamus (12.8-84.6%) and non-planted systems (8.0-69.3%). The SA removal results, except from the A. calamus system with 500 μg/L SA, fit the first-order kinetics model. The estimated half-lives of all SAs were 3-40 h and 2-60 h in the C. indica and A. calamus systems, resp. In vivo biotransformation and rhizosphere degradation were the major phyto-removal mechanisms, constituting 24.9-81.1% and 0.0-37.1% of all SAs in the C. indica and A. calamus systems, resp. SA acetyl metabolites were detected only in plant tissues supporting evidence for plant metabolic processes without risk into the environment. SA metabolism including oxidation, methylation, and conjugation via acetylation was potentially beneficial to accumulation and tolerate stress of antibiotic. Canna indica was more suitable for cleaning SA. Our findings better clarify the potential and low risks of phytoremediation in antibiotic-contaminated waters. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).HPLC of Formula: 144-80-9

The Article related to sulfonamide wetland phytotoxicity biol wastewater treatment, aquatic pollution, detoxification, environmental risk, metabolism in vivo, phytoremediation, Placeholder for records without volume info and other aspects.HPLC of Formula: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 15, 2021, Kong, Ming; Bu, Yuan-Qing; Zhang, Qin; Zhang, Sheng-Hu; Xing, Li-Qun; Gao, Zhan-Qi; Bi, Feng-Zhi; Hu, Guan-Jiu published an article.HPLC of Formula: 144-80-9 The title of the article was Distribution, abundance, and risk assessment of selected antibiotics in a shallow freshwater body used for drinking water, China. And the article contained the following:

With rapid improvements in industrialization and urbanization, antibiotics are now extensively used to prevent and treat human and animal diseases and husbandry and aquaculture. Some research has been conducted to assess the environmental distribution and risk level of antibiotics, but their distribution remains largely uncharacterized. Thus, this study investigated the distribution and abundance of 39 antibiotics belonging to five groups, and their associated risks in surface water around Luoma Lake in the north of Jiangsu province, China. Nineteen antibiotics were detected, at a detection frequency (DF) ranging from 2.27% to 100%. The total antibiotics (ΣABs) concentrations ranged from 34.91 to 825.93 ng/L, with a median concentration of 195.45 ng/L. Among these antibiotics, chlortetracycline (DF: 100%; median: 172.02 ng/L) was the dominant antibiotic, accounting for a median percentage of 91.0% of ΣABs concentrations Spearman rank correlation method found a significant correlation between clindamycin (DF: 72.7%; median: 2.01 ng/L) and lincomycin (DF: 79.5%; median: 4.58 ng/L). The ecol. risk quotient (RQ) values for two out of 44 sampling sites were higher than 1, indicating a high risk; 11.4% of the RQ values fell between 0.1 and 1, indicating a medium risk. Moreover, roxithromycin was found to be the dominant contributor to the ecol. risk, accounting for a median of 79.7% of ΣABs. However, the total non-carcinogenic (<6.54 x 10-4) and carcinogenic risks (<1.64 x 10-7) of ΣABs were negligible at the detected concentrations The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).HPLC of Formula: 144-80-9

The Article related to antibiotics drinking water shallow freshwater risk assessment china, antibiotic residues, ecological risk, health risk, luoma lake, spatial distribution, Placeholder for records without volume info and other aspects.HPLC of Formula: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 15, 2022, Matamoros, V.; Casas, M. Escola; Mansilla, S.; Tadic, Dj.; Canameras, N.; Carazo, N.; Portugal, J.; Pina, B.; Diez, S.; Bayona, J. M. published an article.HPLC of Formula: 144-80-9 The title of the article was Occurrence of antibiotics in Lettuce (Lactuca sativa L.) and Radish (Raphanus sativus L.) following organic soil fertilisation under plot-scale conditions: Crop and human health implications. And the article contained the following:

Recent studies have demonstrated the crop uptake of antibiotics (ABs) from soils treated with AB-carrying fertilisers. However, there is a lack of plot-scale studies linking their effects at the agronomic and metabolomic/transcriptomic level to their impact on human health. This paper assesses the plant uptake of 23 ABs following two productive cycles of lettuce and radish cropped with sewage sludge, pig slurry, the organic fraction of municipal solid waste, or chem. fertilisation under plot-scale conditions (32 plots spanning 3-10 m2 each). AB uptake by plants depended on both the vegetable and the AB class and was higher in radish than in lettuce edible parts. Levels ranged from undetectable to up to 76 ng/g (fresh weight). Repetitive organic fertilisation resulted in an increase in the concentration of ABs in lettuce leaves, but not in radish roots. Significant metabolomic and transcriptomic changes were observed following soil fertilisation. Nevertheless, a human health risk assessment indicates that the occurrence of ABs in lettuce or radish edible parts does not pose any risk. To our knowledge, this is the first holistic plot-scale study demonstrating that the use of organic fertilisers containing ABs is safe for crop security and human health. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).HPLC of Formula: 144-80-9

The Article related to lettuce radish organic soil fertilization antibiotic occurrence health implication, antibiotics, crops, human health risk, metabolomics, transcriptomics, Placeholder for records without volume info and other aspects.HPLC of Formula: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 20, 2022, Wang, Yu-Qing; Hu, Li-Xin; Zhao, Jia-Hui; Han, Yu; Liu, You-Sheng; Zhao, Jian-Liang; Yang, Bin; Ying, Guang-Guo published an article.Reference of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Suspect, non-target and target screening of pharmaceuticals and personal care products (PPCPs) in a drinking water system. And the article contained the following:

Drinking water quality and safety are very important in protecting human health. Chem. contaminants in drinking water system have become an increasing concern. Our knowledge about what chems. are present in drinking water is still limited. Here we screened chems. of emerging concern in a conventional drinking water system based on suspect, non-target screening and target anal., and assessed their variations in different seasons and different treatment units. Overall, 720 chems. were identified with HRMS databases from the suspect and non-target screening and 48 chems. in five categories were further confirmed with the high confidence level, with predominance of pharmaceuticals and personal care products (PPCPs) and pesticides. Four compounds are newly found in aquatic environment with no literature or chem. occurrence data record. Temporal variations and variable removals were observed for these chems. in the system. Target anal. of 110 PPCPs showed detection of 21, 19 and 22 compounds in the drinking water treatment plant with a concentration range of 0.11-844 ng/L in the three seasons, but only 8, 9 and 15 compounds detected in tap water (0.16-32.5 ng/L). The variations of the detected chems. were less obvious in tap water, with most having concentrations below 2 ng/L. The results indicated efficient removal for most PPCPs in the drinking water system. The findings from this study demonstrated the strong capability of combined non-target screening and target anal. in identifying and assessing various organic chems. in drinking water system. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Reference of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to pharmaceutical personal care product detection drinking water system, drinking water, emerging contaminants, suspect screening, target analysis, water, Placeholder for records without volume info and other aspects.Reference of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 2, 2022, Song, Xue-Chao; Dreolin, Nicola; Damiani, Tito; Canellas, Elena; Nerin, Cristina published an article.Safety of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Prediction of Collision Cross Section Values: Application to Non-Intentionally Added Substance Identification in Food Contact Materials. And the article contained the following:

The synthetic chems. in food contact materials can migrate into food and endanger human health. In this study, the traveling wave collision cross section in nitrogen values of more than 400 chems. in food contact materials were exptl. derived by traveling wave ion mobility spectrometry. A support vector machine-based collision cross section (CCS) prediction model was developed based on CCS values of food contact chems. and a series of mol. descriptors. More than 92% of protonated and 81% of sodiated adducts showed a relative deviation below 5%. Median relative errors for protonated and sodiated mols. were 1.50 and 1.82%, resp. The model was then applied to the structural annotation of oligomers migrating from polyamide adhesives. The identification confidence of 11 oligomers was improved by the direct comparison of the exptl. data with the predicted CCS values. Finally, the challenges and opportunities of current machine-learning models on CCS prediction were also discussed. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Safety of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to nonintentional substance food contact collision crossection svm, nias, collision cross section, food contact materials, ion mobility, machine learning, Placeholder for records without volume info and other aspects.Safety of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sharma, Priyanka; Joshi, Tushar; Mathpal, Shalini; Chandra, Subhash; Tamta, Sushma published an article in , the title of the article was In silico identification of antidiabetic target for phytochemicals of A. marmelos and mechanistic insights by molecular dynamics simulations.HPLC of Formula: 456-12-2 And the article contains the following content:

The leaves and fruits of Aegle marmelos (L.) have antidiabetic activity. However, the mode of action and mols. having antidiabetic activity are not known. Hence, we conducted mol. docking of phytochems. with various mol. antidiabetic targets to find the same. Docking prioritized Dipeptidyl peptidase-4 (DPP-4) as the main target for phytochems. of Aegle marmelos. DPP-4 inactivates intestinal peptides, glucagon-like peptide-1 (GLP-1), and Gastric inhibitory polypeptide (GIP). GLP-1 and GIP stimulate a decline in blood glucose levels, but DPP-4 inhibits their functions resulting high level of glucose. Hence inhibiting the activity of DPP-4 is a well-known strategy to treat Type 2 diabetes. Therefore, to find a mechanism that may be involved to act as a natural inhibitor of DPP-4, we screened five phytochems. out of seventy-three based on Virtual Screening, ADMET Drug-likeness anal., and PAINS filtering. Further, all five phytochems., i.e. Aegeline, Citral, Marmesinin, Auraptene, β-Bisabolene, and reference compound subjected MDS for analyzing the stability of docked complexes to assess the fluctuation and conformational changes during protein-ligand interaction. The values of RMSD, RG, RMSF, SASA, and Gibbs energy revealed the good stability of these phytochems. in the active site pocket of DPP-4 in comparison to reference Addnl., we have done the pharmacophore anal., which revealed many common pharmacophore features between screened phytochems. of A. marmelos and reference mol. Our results show that these phytochems. are potential antidiabetic candidates and can be further modified and evaluated to develop more effective antidiabetic drugs against DPP-4 to treat Type 2 Diabetes. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).HPLC of Formula: 456-12-2

The Article related to aegle marmelos phytochem antidiabetic mol dynamics simulation, aegle marmelos, dpp-4, type 2 diabetes, igemdock, molecular dynamics simulations, Placeholder for records without volume info and other aspects.HPLC of Formula: 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics