Tag: 200-300

On January 31, 2022, Guemues, Mehmet; Babacan, Semsi N.; Demir, Yeliz; Sert, Yusuf; Koca, Irfan; Guelcin, Ilhami published an article.Product Details of 144-80-9 The title of the article was Discovery of sulfadrug-pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors. And the article contained the following:

Human carbonic anhydrase (hCA) isoenzymes are zinc ion-containing, widespread metalloenzymes and they classically play a role in pH homeostasis maintenance. CA inhibitors suppress the CA activity and their usage has been clin. established as antiglaucoma agents, antiepileptics, diuretics, and in some other disorders. Alzheimer鈥瞫 disease (AD) is a slowly progressive neurodegenerative disorder and a fatal disease of the brain. An advanced method to cure AD includes the strategy to design acetylcholinesterase (AChE) inhibitors. A novel series of pyrrole-3-one derivatives containing sulfa drugs (5a-i) were determined to be highly potent inhibitors for AChE and hCA I and hCA II (inhibitory constant [Ki] values are in the range of 6.50 卤 1.02-37.46 卤 4.12 nM, 1.20 卤 0.19-44.21 卤 1.09 nM, and 8.93 卤 1.58-46.86 卤 8.41 nM for AChE, hCA I, and hCA II, resp.). The designed compounds often show a more effective inhibition than the chems. used as the standard Among these compounds, 5f was the most effective compound against hCA I, and compound 5e was the most effective compound against hCA II. It was determined that compound 5c was the most effective inhibitor for AChE. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Product Details of 144-80-9

The Article related to alzheimer disease carbonic anhydrase acetylcholinesterase inhibitor, acetylcholinesterase, carbonic anhydrase, enzyme inhibition, pyrrole-3-one, sulfa drug, Placeholder for records without volume info and other aspects.Product Details of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gu, Zheng-Yang; Chen, Jie; Xia, Ji-Bao published an article in 2020, the title of the article was Pd-catalyzed amidation of 1,3-diketones with CO and azides via a nitrene intermediate.HPLC of Formula: 102-07-8 And the article contains the following content:

An efficient Pd-catalyzed amidation of 1,3-diketones has been developed using carbon monoxide and organic azides. This reaction provides a step-economic approach to produce 尾-ketoamides from readily available compounds under mild ligand-, oxidant-, and base-free conditions. The mechanistic studies showed that the reaction occurred through an in situ generated isocyanate intermediate. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).HPLC of Formula: 102-07-8

The Article related to beta ketoamide preparation, diketone azide carbon monoxide amidation palladium catalyst, General Organic Chemistry: Synthetic Methods and other aspects.HPLC of Formula: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 20, 2015, Pant, Kritee; Groeger, Dominic; Bergmann, Ralf; Pietzsch, Jens; Steinbach, Joerg; Graham, Bim; Spiccia, Leone; Berthon, Fannely; Czarny, Bertrand; Devel, Laurent; Dive, Vincent; Stephan, Holger; Haag, Rainer published an article.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Synthesis and Biodistribution Studies of 3H- and 64Cu-Labeled Dendritic Polyglycerol and Dendritic Polyglycerol Sulfate. And the article contained the following:

Dendritic polyglycerol sulfate (dPGS) is a biocompatible, bioactive polymer which exhibits anti-inflammatory activity in vivo and thus represents a promising candidate for therapeutic and diagnostic applications. To investigate the in vivo pharmacokinetics in detail, dPGS with a mol. weight of approx. 10 kDa was radiolabeled with 3H and 64Cu, and evaluated by performing biodistribution studies and small animal positron emission tomog. (PET). 3H-labeling was accomplished by an oxidation-reduction process with sodium periodate and [3H]-borohydride. 64Cu-labeling was achieved by conjugation of isothiocyanate- or maleimide-functionalized copper(II)-chelating ligands based on 1,4-bis(2-pyridinylmethyl)-1,4,7-triazacyclononane (DMPTACN) to an amino functionalized dPGS scaffold, followed by reaction with an aqueous solution containing 64CuCl2. Independent biodistribution by radioimaging and PET imaging studies with healthy mice and rats showed that the neutral dPG was quant. renally eliminated, whereas the polysulfated analogs accumulated mainly in the liver and spleen. Small amounts of the dPGS derivatives were slowly excreted via the kidneys. The degree of uptake by the reticuloendothelial system (RES) was similar for dPGS with 40% or 85% sulfation, and surface modification of the scaffold with the DMPTACN chelator did not appear to significantly affect the biodistribution profile. On the basis of our data, the applicability of bioactive dPGS as a therapeutic agent might be limited due to organ accumulation even after 3 wk. The inert characteristics and clearance of the neutral polymer, however, emphasizes the potential of dPG as a multifunctional scaffold for various nanomedical applications. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to tritium copper 64 dendrimer polyglycerol sulfate chelator biodistribution preparation, Pharmaceuticals: Formulation and Compounding and other aspects.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Della Casa de Marcano, D.; Hasegawa, M.; Castaldi, A. published an article in 1972, the title of the article was Neutral compounds and alkaloids of Zanthoxylum ocumarense.Computed Properties of 456-12-2 And the article contains the following content:

Bark of Z. ocumarense was extracted with benzene and chromatographed on Al2O3. A mixture of n-alkanes (C21H44-C33H68) lupeol, 尾-amyrin and 2 amides (I, m. 149-51掳, and II, m. 175-6掳) were detected. The bark was again extracted with hot MeOH to yield 3 quaternary bases, N-methyl-伪-(-)-canadine, (+)-laurifoline, and cheleritrine, 2 alkaloids, C20H16NO5Cl (III), m. 245掳, and C15H11NO3 (IV), m. 216掳; and hesperidin. III was obtained in low yield, and IV proved unstable. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Computed Properties of 456-12-2

The Article related to zanthoxylum composition, alkaloid zanthoxylum, alkane zanthoxylum, amide zanthoxylum, Plant Biochemistry: Composition and Products and other aspects.Computed Properties of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 17, 2020, Borchardt, Allen; Brady, Thomas P.; Chen, Zhi-Yong; Do, Quyen-Quyen Thuy; Jiang, Wanlong; Tari, Leslie W. published a patent.Computed Properties of 5455-98-1 The title of the patent was Compositions and methods for the treatment of human immunodeficiency virus. And the patent contained the following:

Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral gp120 receptor (e.g., temsavir, BMS-818251, DMJ-ll-121, BNM-IV-147, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin- binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., HIV infections). The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Computed Properties of 5455-98-1

The Article related to composition treatment human hiv antiviral immunosuppression conjugate drug antibody, Pharmaceuticals: Formulation and Compounding and other aspects.Computed Properties of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Changpeng; Ling, Liang; Luo, Meiming; Zeng, Xiaoming published an article in 2021, the title of the article was Chromium-Catalyzed Ligand-Free Amidation of Esters with Anilines.Reference of 1,3-Diphenylurea And the article contains the following content:

Amides are important structural motifs in pharmaceutical and agrochem. chem. because of the intriguing biol. active properties. Author’s report here the amidation of com. available esters with anilines that was promoted by low-cost and air-stable chromium(III) pre-catalyst combined with magnesium, providing access to amides. This reaction occurs without the use of external ligands in a simple operation. Mechanistic studies indicate that a reactive aminated Cr species responsible for the amidation can be considered, which may be formed by reaction of low-valent Cr with aniline followed by reduction with hydrogen evolution. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Reference of 1,3-Diphenylurea

The Article related to secondary amide tertiary preparation chromium catalyst, ester aniline amidation, General Organic Chemistry: Synthetic Methods and other aspects.Reference of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Dan-Dan; Niu, Liang-Feng; Ju, Zhi-Yu; Xu, Zhihong; Wu, Changzeng published an article in 2016, the title of the article was Palladium-Catalyzed C(sp2)-H Bond Alkylation of Ketoximes by Using the Ring-Opening of Epoxides.Electric Literature of 5455-98-1 And the article contains the following content:

A palladium-catalyzed ortho-directed alkylation of O-Me ketoximes that proceeds through a regioselective ring-opening reaction of epoxides has been demonstrated. This C(sp2)-H activation/alkylation protocol was carried out in pivalic acid/1,1,1,3,3,3-hexafluoro-2-propanol (PivOH/HFIP, 2:8) as the solvent and was applied to various O-Me ketoximes that contain either electron-donating or electron-withdrawing groups. Moreover, different types of epoxides were used in this alkylation reaction, which proceeded smoothly to give the corresponding products in moderate to good yields. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Electric Literature of 5455-98-1

The Article related to regioselective palladium catalyst alkylation ketoxime ring opening epoxide, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 16, 2019, Xu, Jian-Xing; Wu, Xiao-Feng published an article.Synthetic Route of 5455-98-1 The title of the article was Cobalt-Catalyzed Alkoxycarbonylation of Epoxides to 尾-Hydroxyesters. And the article contained the following:

Herein, the authors developed a new and practical catalytic system for the carbonylative synthesis of 尾-hydroxyesters. By using simple, cheap, and air-stable cobalt(II) bromide as the catalyst, combined with pyrazole and catalytic amount of manganese, active cobalt complex can be generated in situ and can catalyze various epoxides to give the corresponding 尾-hydroxyesters in moderate to excellent yields. Mechanism studies indicate that pyrazole plays a crucial role in this reaction. Moreover, with the addition of the catalytic amount of manganese, the active cobalt catalyst can be regenerated, which provides a possibility for reusing the cobalt catalyst. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Synthetic Route of 5455-98-1

The Article related to hydroxyester beta preparation cobalt catalyst epoxide alkoxycarbonylation, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 18, 2022, Ondari, Mark E.; Klosin, Jerzy; Kruper, William R.; Lysenko, Ivan; Thomas, Pulikkottil J.; Cheng, Kevin; Abboud, Khalil A.; Kruper, William J. published an article.Quality Control of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Diol-Ritter Reaction: Regio- and Stereoselective Synthesis of Protected Vicinal Aminoalcohols and Mechanistic Aspects of Diol Monoester Disproportionation. And the article contained the following:

Herein, a mechanism-based study of the less known diol-Ritter reaction had provided a highly regioselective procedure for the synthesis of 1-vic-amido-2-esters from either terminal epoxides or 1,2-diols via Lewis Acid-catalyzed monoesterification. When treated with stoichiometric Lewis Acid catalyst (BF3), these diol monoesters form dioxonium cation intermediates that are ring-opened with nitrile nucleophiles to form nitrilium intermediates, which undergo rapid and irreversible hydration to give the desired amidoesters. Diester byproduct formation was irreversible and appears to occur through a disproportionation of diol monoester. With chiral epoxide starting materials, the formation of amidoester occurs with retention of configuration and no apparent erosion of optical purity as determined by single-crystal X-ray analyzes and chiral chromatog., resp. The direct access to chiral vic-amidoesters was especially practical with regard to the synthesis of Gram-pos., antibacterial, oxazolidinone analogs of the Zyvox antimicrobial family. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Quality Control of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to protected vicinal aminoalc regioselective stereoselective preparation, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics