Tag: 200-300

On February 5, 2021, Wang, Xia; Yang, Peng; Hu, Bo; Zhang, Qian; Li, Dong published an article.SDS of cas: 102-07-8 The title of the article was Hypervalent Iodine Reagent-Promoted Hofmann-Type Rearrangement/Carboxylation of Primary Amides. And the article contained the following:

A novel transformation of primary amides RC(O)NH2 (R = Ph, thiophen-2-yl, Bu, cyclopropyl, etc.) to secondary amides RNHC(O)R1 (R1 = methyltrifluoromethyl, Et, Ph, etc.) promoted by hypervalent iodine reagents Ph(I)(OC(O)R1)2 was developed. The hypervalent iodine reagent-mediated Hofmann-type rearrangement generated an isocyanate intermediate, which was subsequently trapped by an in situ generated carboxylic acid from the hypervalent iodine reagent to provide the corresponding secondary amides. This method provided a facile and efficient route for the synthesis of secondary amides from primary amides and also revealed novel reactivities of hypervalent iodine reagents. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).SDS of cas: 102-07-8

The Article related to secondary amide preparation, primary amide hypervalent iodine reagent hofmann rearrangement carboxylation, General Organic Chemistry: Synthetic Methods and other aspects.SDS of cas: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 1, 2020, Yoo, Kwangho; Lee, Jooyeon; Park, Myung Hwan; Kim, Youngjo; Kim, Hyun Jin; Kim, Min published an article.Formula: C13H12N2O The title of the article was Ir-Catalyzed C-H Amidation Using Carbamoyl Azides for the Syntheses of Unsymmetrical Ureas. And the article contained the following:

An iridium-catalyzed C-H amidation for the syntheses of unsym. urea was developed using carbamoyl azides (R(R’)N-C(O)-N3) as the nitrogen source. A combination of iridium and silver gave an active catalyst for C-N bond formation. A variety of urea derivatives were synthesized using carbamoyl azides with only dinitrogen byproducts. Finally, the use of the transient directing group strategy with carbamoyl azides extended the substrate scope of the catalytic C-H amidation to yield aldehyde-containing unsym. ureas. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Formula: C13H12N2O

The Article related to carbamoyl azide benzamide directing group iridium silver catalyst amidation, unsym urea preparation, General Organic Chemistry: Synthetic Methods and other aspects.Formula: C13H12N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 29, 2022, Matsutani, Takanari; Aoyama, Kotaro; Moriuchi, Toshiyuki published an article.Electric Literature of 102-07-8 The title of the article was Oxovanadium(V)-Catalyzed Synthesis of Ureas from Disilylamines and Carbon Dioxide under Ambient Pressure. And the article contained the following:

Here, a com. available easy-to-handle oxovanadium(V) compound is demonstrated to serve as an efficient catalyst for the synthesis of ureas RNHC(O)NHR (R = n-hexyl, cyclohexyl, Ph, PhCH2CH2, etc.) from disilylamines RN(SiMe3)2 and carbon dioxide under ambient pressure. The catalytic activation of carbon dioxide proceeds without any additives, demonstrating a broad substrate scope and easy scalability to validate this catalytic activation of carbon dioxide. This catalytic system can be applied to the synthesis of unsym. ureas and chiral urea with retention of chirality. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Electric Literature of 102-07-8

The Article related to urea preparation, amine disilyl preparation carbonylation carbon dioxide oxovanadium catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 30, 1979, Patra, A.; Mukhopadhyay, A. K.; Ghosh, A. published an article.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Constituents of Aegle marmelos: carbon-13 NMR spectra of aurapten and marmin. And the article contained the following:

Chem. reinvestigation of A. marmelos yielded aurapten, marmin, umbelliferone, and lupeol from the bark and lupeol, sitosterol, and aegeline from the leaves. 13C NMR shifts of aurapten and marmin are discussed. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegle aurapten marmin nmr, aegelin aegle, umbelliferone aegle, lupeol aegle, sitosterol aegle, Plant Biochemistry: Composition and Products and other aspects.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lukowska-Chojnacka, Edyta; Plenkiewicz, Jan published an article in 2011, the title of the article was Simple synthesis of 尾-acetoxy thiocyanates from oxiranes.Quality Control of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione And the article contains the following content:

A convenient and simple method for the preparation of previously unknown 尾-acetoxy thiocyanates by regioselective ring opening of the corresponding oxiranes with thiocyanate anion followed by acetylation is described. The shorter reaction times, better yields of the products, and easy workup are the advantages of this methodol. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Quality Control of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to oxirane ammonium thiocyanate regioselective ring opening, acetoxy thiocyanate preparation, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nigam, Vinita; Vanisha, Nambiar published an article in 2018, the title of the article was Evaluation of antioxidant profile of wild and cultivated varieties of Aegle marmelos (L) correa leaves used as anti-diabetic agent.Recommanded Product: 456-12-2 And the article contains the following content:

Aim: The objective of the present study was to evaluate the total antioxidant activity of the wild variety of AM leaves from forest of Gir Somnath, Gujarat, India and cultivated variety from Central Horticultural Experiment Station, Vejalpur, Panchmahals, Gujarat to assess the role of this plant in ethanomedicine in India. Methods: The methanolic extracts of the leaves were screened for total antioxidant capacity through Ferric Reducing Antioxidant Potential (FRAP) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay; Total Phenol content (TPC) through spectrophotometric technique based on Folin Ciocalteau assay and for qual. estimation of phenols, High performance Liquid Chromatog. (HPLC) was used. Results: TPC of wild and cultivated variety was 7.6% and 6.5% resp. FRAP values and IC50 value (DPPH) for wild and cultivated variety were found to be 14.65渭mol/l and 11.80渭mol/l; 437渭g/mL and 620渭g/mL resp. Wild variety was found to be superior to the cultivated one. Conclusion: This study proved that the leaves of AM leaves have high antioxidant component. AM could be used as a potential preventive intervention for free radical mediated diseases such as diabetes and as neutraceutical in medicinal formulation. Further intervention trials are needed to prove the therapeutic potential of these leaves. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: 456-12-2

The Article related to antioxidant aegle correa leaves antidiabetic sugar ethanomedicine neutraceutical gujarat, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 21, 2020, McKay, Alasdair I.; Altalhi, Weam A. O.; McInnes, Lachlan E.; Czyz, Milena L.; Canty, Allan J.; Donnelly, Paul S.; O’Hair, Richard A. J. published an article.Application of 102-07-8 The title of the article was Identification of the Side Products That Diminish the Yields of the Monoamidated Product in Metal-Catalyzed C-H Amidation of 2-Phenylpyridine with Arylisocyanates. And the article contained the following:

The Ru(II)-catalyzed amidation of 2-arylpyridines with aryl isocyanates via C-H bond activation is less efficient than described previously, due to the formation of a series of side products, which were readily identified using direct infusion electrospray mass spectrometry and high-performance liquid chromatog.-mass spectrometry. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application of 102-07-8

The Article related to aryl pyridylbenzamide preparation, phenylpyridine arylisocyanate amidation ruthenium catalyst, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2022, Bardakova, Kseniia N.; Kholkhoev, Bato Ch.; Farion, Ivan A.; Epifanov, Evgenii O.; Korkunova, Olga S.; Efremov, Yuri M.; Minaev, Nikita V.; Solovieva, Anna B.; Timashev, Peter S.; Burdukovskii, Vitaliy F. published an article.Name: 1,3-Diphenylurea The title of the article was 4D Printing of Shape-Memory Semi-Interpenetrating Polymer Networks Based On Aromatic Heterochain Polymers. And the article contained the following:

Most of the presently known thermosensitive shape-memory polymers suitable for 4D printing have insufficient mech. strength and thermal stability that restricts their potential areas of application. Here, new photosensitive compositions (PSCs) based on aromatic heterochain polymers – poly-N,N’-(m-phenylene)isophthalamide (MPA) or poly-2,2′-(p-oxydiphenylene)-5,5′-dibenzimidazole (OPBI) – for DLP printing are proposed. Thermal post-curing and supercritical carbon dioxide (scCO2) are used for post-processing of the structures. During the scCO2 treatment the removal of unreacted monomeric component (N,N-dimethylacrylamide) and its uncrosslinked oligomers is accompanied by the preservation of the initial degree of crosslinking. The more stable shrinkage is observed for the combined post-processing method (T°+scCO2) in the case of OPBI-PSC and after the heat treatment for MPA-PSC specimens. The method of post-processing and the nature of the heterochain polymer strongly affect the mech. properties and thermal resistance of the structures. The tensile strength has the maximum value after the thermal post-treatment (101.1 ± 7.1 and 78.4 ± 5.1 MPa of OPBI-PSC and MPA-PSC, resp.). The intense destruction of the materials is observed at 393 and 408°C for MPA-PSC and OPBI-PSC, resp. Moreover, the 4D-printed structures exhibit excellent shape memory performance at transition temperatures >100°C, thus have a great potential for the use in aerospace, robotics, sensorics. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Name: 1,3-Diphenylurea

The Article related to polybenzimidazole semi interpenetrating polymer network shape memory property, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Name: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 3, 2014, Spear, Kerry L.; Campbell, Una published a patent.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Preparation of piperidinylindoline derivatives for use as nervous system agents. And the patent contained the following:

Title compounds I [R1 = halo, OH, CN, (un)substituted alkyl, aryl, etc.; R2 = H, halo, OH, alkyl, etc.; or R1 and R2 are taken together with the C atom to which they are attached to form an (un)substituted alkenyl, cycloalkyl or heterocyclyl; R3 = H, OH, halo, CN, alkyl, etc.; R5 = (un)substituted alkyl, cycloalkyl, aryl, heteroaryl, etc.; each X independently = CH or N; Y = absent, O, NH, N-alkyl, or (un)substituted alkylene], and their pharmaceutically acceptable salts, are prepared and disclosed as nervous system agents. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in CAMP assays on CHO cells expressing the human NOP/MOP receptors (data given). The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to piperidinylindoline preparation nervous system agent, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 13, 2021, Kawamata, Yu; Hayashi, Kyohei; Carlson, Ethan; Shaji, Shobin; Waldmann, Dirk; Simmons, Bryan J.; Edwards, Jacob T.; Zapf, Christoph W.; Saito, Masato; Baran, Phil S. published an article.Synthetic Route of 5455-98-1 The title of the article was Chemoselective Electrosynthesis Using Rapid Alternating Polarity. And the article contained the following:

Challenges in the selective manipulation of functional groups (chemoselectivity) in organic synthesis have historically been overcome either by using reagents/catalysts that tunably interact with a substrate or through modification to shield undesired sites of reactivity (protecting groups). Although electrochem. offers precise redox control to achieve unique chemoselectivity, this approach often becomes challenging in the presence of multiple redox-active functionalities. Historically, electrosynthesis has been performed almost solely by using d.c. (DC). In contrast, applying a.c. (AC) has been known to change reaction outcomes considerably on an anal. scale but has rarely been strategically exploited for use in complex preparative organic synthesis. Here we show how a square waveform employed to deliver elec. current-rapid alternating polarity (rAP)-enables control over reaction outcomes in the chemoselective reduction of carbonyl compounds, one of the most widely used reaction manifolds. The reactivity observed cannot be recapitulated using DC electrolysis or chem. reagents. The synthetic value brought by this new method for controlling chemoselectivity is vividly demonstrated in the context of classical reactivity problems such as chiral auxiliary removal and cutting-edge medicinal chem. topics such as the synthesis of PROTACs. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Synthetic Route of 5455-98-1

The Article related to electrochem chemoselective reduction ketone rapid alternating polarity, Heterocyclic Compounds (One Hetero Atom): General and other aspects.Synthetic Route of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics