Tag: 200-300

On January 7, 2022, Rostami, Ali; Ebrahimi, Amirhossein; Sakhaee, Nader; Golmohammadi, Farhad; Al-Harrasi, Ahmed published an article.Computed Properties of 102-07-8 The title of the article was Microwave-Assisted Electrostatically Enhanced Phenol-Catalyzed Synthesis of Oxazolidinones. And the article contained the following:

An electrostatically enhanced phenol is utilized as a straightforward, sustainable, and potent one-component organocatalyst for the atom-economic transformation of epoxides to oxazolidinones under microwave irradiation Integrating a pos. charged center into phenols over a modular one-step preparation gives rise to a bifunctional system with improved acidity and activity, competent in rapid assembly of epoxides and isocyanates under microwave irradiation in a short reaction time (20-60 min). A careful assessment of the efficacy of various pos. charged phenols and anilines and the impact of several factors, such as catalyst loading, temperature, and the kind of nucleophile, on catalytic reactivity were examined Under neat conditions, this one-component catalytic platform was exploited to prepare more than 40 examples of oxazolidinones from a variety of aryl- and alkyl-substituted epoxides and isocyanates within minutes, where up to 96% yield and high degree of selectivity were attained. DFT calculations to achieve reaction barriers for different catalytic routes were conducted to provide mechanistic understanding and corroborated the exptl. findings in which concurrent epoxide ring-opening and isocyanate incorporation were proposed. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Computed Properties of 102-07-8

The Article related to oxazolidinone preparation microwave irradiation, epoxide isocyanate cycloaddition electrostatically enhanced phenol catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Computed Properties of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 3, 2020, Nishiyori, Ryuichi; Okuno, Ken; Shirakawa, Seiji published an article.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Triethylamine Hydroiodide as a Bifunctional Catalyst for the Solvent-Free Synthesis of 2-Oxazolidinones. And the article contained the following:

Among the wide variety of heterocycles, 2-oxazolidinones are recognized as some of the most important heterocyclic compounds in medicinal chem. Therefore, the development of a practical method for their synthesis would be an important development. Herein, we report an efficient method for the synthesis of 2-oxazolidinones under solvent-free conditions using triethylamine hydroiodide as a simple and effective bifunctional organocatalyst. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to epoxide isocyanate triethylamine hydroiodide cyclization catalyst, oxazolidinone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 31, 2022, Hyder, M.; O’Donnell, A. D.; Chippindale, A. M.; German, I. M.; Harries, J. L.; Shebanova, O.; Hamley, I. W.; Hayes, W. published an article.Name: 1,3-Diphenylurea The title of the article was Tailoring viscoelastic properties of dynamic supramolecular poly(butadiene)-based elastomers. And the article contained the following:

The discovery and development of new adhesive materials is critical for real-world applications of polymeric composite materials. Herein, we report the design and synthesis of a library of structurally related phase-separated supramol. polyurethanes whose mech. properties and adhesive characteristics can be enhanced through minor structural modifications of the polymer end-group. The interplay between phase separation of the hard domain polar end-groups and soft polybutadiene domains, coupled with tuneable self-assembly afforded by the polar end-groups, gives rise to a class of materials with tuneable mech. properties. Exceptionally strong supramol. adhesives and mech. robust self-healing elastomers were identified. The mech. properties were investigated through tensile testing. Finally, rheol. anal. of the supramol. materials was used to identify suitable healing and adhesive temperatures in addition to elucidate the supramol. polyurethanes’ thermal-responsive nature. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Name: 1,3-Diphenylurea

The Article related to polybutadiene elastomer synthesis phase separation viscoelastic property, Synthetic Elastomers and Natural Rubber: Physical Properties and Testing and other aspects.Name: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 31, 2021, Vala, Anand; Parmar, Nirali; Soni, Jigar Y.; Kotturi, Sharadsrikar; Guduru, Ramakrishna published an article.HPLC of Formula: 102-07-8 The title of the article was 1,4,2-Dioxazol-5-ones as Isocyanate Equivalents: An Efficient Synthesis of 2-Quinolinones via β-Keto Amides. And the article contained the following:

Under thermal conditions, 1,4,2-dioxazol-5-ones were known to undergo decarboxylation followed by Lossen’s rearrangement to yield isocyanates. A safe and efficient method for the generation and capture of isocyanates to gave β-keto amides I [R1 = H, 3-Cl, 4-OMe; R2 = H, 4-Br, 4-F, etc.] was established. The β-keto amides I were efficiently converted into quinolin-2-ones II [R1 = H, 3-Cl, 4-OMe; R2 = H, 4-Br, 4-F, etc.] in good to excellent yields. Importantly, the method was transition metal-free and involved a simple two-step procedure that could be of interest to the pharmaceutical industry. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).HPLC of Formula: 102-07-8

The Article related to quinolinone preparation, beta keto amide preparation polyphosphoric acid cyclization, dioxazolone acetophenone thermal degradation isocyanate in situ trapping, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.HPLC of Formula: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 10, 2016, Bergman, Ylva Elisabet; Lessene, Romina; Ganame, Danny; Foitzik, Richard Charles; Morrow, Benjamin Joseph; Camerino, Michelle Ang; Walker, Scott Raymond; Lagiakos, H. Rachel; Feutrill, John; Stupple, Paul Anthony published a patent.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Preparation of aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived PRMT5 inhibitors. And the patent contained the following:

The invention relates to compounds of formula I, II and III as PRMT5-inhibitors; their preparation and use in the treatment of cancer and hemoglobinopathy. Compounds of formula I, II and III wherein n = 1 and 2; R is H and Me; R1 is halo and Me; R2a and R2b are independently F, H, Me and CH2OH; R2c and R2n are independently F, H, Me and CH2OH; R3a and R3b are independently H and Me; R4a is OH, NH2, CONH2 and CH2OH; R4b is H and Me; R5 is H and Me; A is (un)substituted Ph, (un)substituted naphthyl; and (un)substituted C5-12 heteroaryl, are claimed. Example compound IV was prepared by acylation of 1-amino-3-((2,3-dihydro-1H-inden-2-yl)amino)propan-2-ol with 4-chlorobenzoic acid. The invention compounds were evaluated for their PRMT5 inhibitory activity. From the assay, it was determined that example IV exhibited IC50 value of 0.792 μM. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to aminoindane aminotetrahydronaphthalene aminobenzocyclobutane preparation prmt5 inhibitor treatment cancer hemoglobinopathy, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 5, 2021, Wang, Huihong; Cao, Fei; Gao, Weiwei; Wang, Xiaodong; Yang, Yuhang; Shi, Tao; Wang, Zhen published an article.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Pd(II)-Catalyzed Annulation Reactions of Epoxides with Benzamides to Synthesize Isoquinolones. And the article contained the following:

Epoxides as alkylating reagents were unprecedentedly applied in Pd(II)-catalyzed C-H alkylation and oxidative annulation of substituted benzamides to synthesize isoquinolones I [R = 7-Me, 6-t-Bu, 6,8-di-OMe, etc.; R1 = Me, n-pentyl, Bn, etc.; R2 = OMe, OEt, OBn, etc.] rather than isochromans, which was accomplished through alerting the previously reported reaction mechanism by the addition of oxidant and TEA. Under these conditions, various isoquinolones were prepared with yields up to 92%. In addition, this methodol. was successfully employed in the total syntheses of rupreschstyril, siamine, and cassiarin A in an expedient fashion. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to isoquinolone preparation, epoxide benzamide ch alkylation oxidative annulation palladium catalyst, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 1, 2018, Peters, Edward Norman published a patent.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Epoxy hardener composition and associated forming method, uncured and cured epoxy resin compositions, and article. And the patent contained the following:

A hardener composition comprising: (A) 1 to 80% of a hydroxyl-diterminated poly(phenylene ether) having an intrinsic viscosity of 0.03 to 0.2 dL per g measured by Ubbelohde viscometer at 25° in chloroform; and (B) 20 to 99% of an anhydride having structure I wherein q is zero or 1, Ra is C1-C6-alkyl, and X is -CH2-, -(CH2)2-, -O-, or -S-; wherein the hardener composition exhibits a single glass transition temperature from -80 to 200°, wherein the single glass transition temperature has a value of -46 to 110°; and wherein the hardener composition comprises zero to 1% of solvents for the hydroxyl-diterminated poly(phenylene ether). Also disclosed are a method of forming the hardener composition, a curable epoxy composition incorporating the hardener composition, a cured composition formed from the curable epoxy composition, and an article that includes the cured composition The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to polyoxyphenylene anhydride epoxy hardener composition long pot life, Plastics Manufacture and Processing: Formulating Procedures and Compositions and other aspects.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 1, 2020, Tong, Yutao; Cheng, Ruihua; Yu, Lingling; Liu, Boping published an article.Formula: C11H9NO3 The title of the article was New strategies for synthesis of amino-functionalized poly(propylene carbonate) over SalenCo(III)Cl catalyst. And the article contained the following:

New strategies for synthesis of amino-functionalized poly(propylene carbonate) (PPC) were applied by terpolymn. of carbon dioxide, propylene oxide, with (a) N-(2,3-epoxypropyl)-2-phthalimide (Monomer A)/N-(2-oxiranylmethyl)-1 or (b) N-(2-oxiranylmethyl)-1,1-dimethylethyl ester (Monomer B) over SalenCo(III)Cl/PPNCl catalysts system, followed by the removal of the resp. protecting groups. The SalenCo(III)Cl presented high activity and yielded the terpolymer with high polycarbonate selectivity, carbonate linkage content, as well as high head-to-tail stereoregularity (>99%). In terpolymn., the Monomer A contents in PPC-Pht were easily regulated up to 12.0 mol%. However, the protecting groups could not be completely removed because of the degradation of PPC-NH2-A during the deprotection process. Meanwhile, when terpolymn. with Monomer B, PPC-butoxy carbonyl was obtained varied the Monomer B contents from 1.3 to 4.5 mol%, and could be transformed completely into the amino-functionalized PPC-NH2-B without significant backbone degradation The contact angles of the functionalized PPC-NH2s prepared by two strategies showed the expected increase in hydrophilicity with the increasing content of amino entities. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Formula: C11H9NO3

The Article related to polypropylene carbonate amino functionalized salen catalyst, Plastics Manufacture and Processing: Formulating Procedures and Compositions and other aspects.Formula: C11H9NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 22, 2020, Park, Nathaniel H.; Zubarev, Dmitry Yu.; Hedrick, James L.; Kiyek, Vivien; Corbet, Christiaan; Lottier, Simon published an article.Safety of 1,3-Diphenylurea The title of the article was A Recommender System for Inverse Design of Polycarbonates and Polyesters. And the article contained the following:

The convergence of artificial intelligence and machine learning with material science holds significant promise in rapidly accelerating the development timelines of new high-performance polymeric materials. Within this context, we report an inverse design strategy for polycarbonate and polyester discovery based on a recommendation system that proposes polymerization experiments that are likely to produce materials with targeted properties or characteristics. Following the recommendations of the system driven by the historical ring-opening polymerization results, we carried out experiments targeting specific ranges of monomer conversion and dispersity for polyesters or polycarbonates. The results of the experiments were in close agreement with the recommendation targets with few false negatives or positives obtained for each class. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Safety of 1,3-Diphenylurea

The Article related to recommender system design polycarbonate polyester, Chemistry of Synthetic High Polymers: Ring-Opening and Other Polymerizations and other aspects.Safety of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 7, 2020, Koopmans, Carsten; Laemmerhold, Kai; Guertler, Christoph; Frick-Delaittre, Elena; Wolf, Aurel; Simon, Joachim; Wang, Min; Thiel, Daniel; Leitner, Walter published a patent.HPLC of Formula: 5455-98-1 The title of the patent was Method for the production of thermoplastic polyoxazolidinone polymers. And the patent contained the following:

The invention relates to a process for producing thermoplastic polyoxazolidinones, comprising copolymerization of a diisocyanate compound (A) with a bisepoxide compound (B) in the presence of a catalyst (C) and a compound (D) in a solvent (E), characterized in that, the bisepoxide compound (B) comprises isosorbide diglycidyl ether, the catalyst (C) is selected from the group consisting of alkali halogenides and earth alkali halogenides, and transition metal halogenides, the compound (D) is selected from the group consisting of monofunctional isocyanate, monofunctional epoxide, and wherein the process comprises: (a) placing the solvent (E) and the catalyst (C) in a reactor to provide a mixture; and (b) adding the diisocyanate compound (A), the bisepoxide compound (B), and the compound (D) to the mixture resulting from step (a). Thermoplastic polyoxazolidinone obtainable by the inventive process is also claimed. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).HPLC of Formula: 5455-98-1

The Article related to thermoplastic polyoxazolidinone polymerization, Chemistry of Synthetic High Polymers: Ring-Opening and Other Polymerizations and other aspects.HPLC of Formula: 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics