Tag: 200-300

On December 17, 2021, Arisawa, Mieko; Mizuno, Taro; Nozawa-Kumada, Kanako; Itto-Nakama, Kaori; Furuta, Miyu; Tanii, Saori published an article.Application of 102-07-8 The title of the article was Rhodium-Catalyzed Synthesis of Unsymmetric Di(heteroaryl)ureas Involving an Equilibrium Shift. And the article contained the following:

Unsym. di(heteroaryl)ureas such as Ar1NHC(O)NHAr2 [Ar1 = pyrimidin-2-yl, 4-methoxyphenyl, 4,6-dimethylpyrimidin-2-yl, etc.; Ar2 = Ph, 4-pyridyl, 4-methoxy-2-pyridyl, etc.] were efficiently synthesized from two sym. ureas, Ar1NHC(O)NHAr1 and Ar2NHC(O)NHAr2, by rhodium-catalyzed exchange reactions. The equilibrium in some of the reactions could be shifted to the formation of unsym. ureas by the aggregation of the dimers formed by inter- and intramol. hydrogen bonding. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application of 102-07-8

The Article related to di heteroaryl urea preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 5, 2015, Gautam, Sudeep; Ishrat, Nayab; Singh, Rohit; Narender, Tadigoppula; Srivastava, Arvind K. published an article.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling, and contributes to a cytoskeletal rearrangement through PI3K/Rac1. And the article contained the following:

Aegeline is an alkaloidal-amide, isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus. Here we delineate, aegeline enhanced GLUT4 translocation mediated 2-deoxy-glucose uptake in both time and concentration-dependent manner. 2-deoxy-glucose uptake was completely stymied by the transport inhibitors (wortmannin and genistein) in C2C12 myotubes. Pharmacol. inhibition of Akt (also known as protein kinase B) and Ras-related C3 botulinum toxin substrate 1 (Rac1) suggest that both Akt and Rac1 operate aegeline-stimulated glucose transport via distinct parallel pathways. Moreover, aegeline activates p21 protein-activated kinase 1 (PAK1) and cofilin (an actin polymerization regulator). Rac1 inhibitor (Rac1 inhib II) and PAK1 inhibitor (IPA-3) completely blocked aegeline-induced phosphorylation of cofilin and p21 protein-activated kinase 1 (PAK1). In summary, these findings suggest that aegeline stimulates the glucose transport through Akt and Rac1 dependent distinct parallel pathways and have cytoskeletal roles via stimulation of the PI3-kinase-Rac1-PAK1-cofilin pathway in the skeletal muscle cells. Therefore, multiple targets of aegeline in the improvement of insulin sensitivity of the skeletal muscle cells may be suggested. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegeline antidiabetic aegle leaf extract akt rac1 signaling diabetes, aegeline, aegle marmelos, c2c12 myotubes, cofilin, glucose uptake, insulin resistance, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 15, 2013, Karmase, Aniket; Birari, Rahul; Bhutani, Kamlesh K. published an article.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Evaluation of anti-obesity effect of Aegle marmelos leaves. And the article contained the following:

The study was carried out to investigate the anti-obesity effects of Aegle marmelos leaves extracts and its phytochem. constituents in vitro and in vivo. The dichloromethane (DCM), Et acetate (EtOAc) and n-butanol extracts of A. marmelos leaves were studied for their lipolytic effect. Lipolysis was measured by determining the amount of glycerol released at 12 h and 24 h at 50 μg/mL and 100 μg/mL concentrations Phytochem. investigation of the most active DCM extract yielded 14 compounds The isolated compounds were evaluated for their lipolytic effects at 50 μM and 100 μM. The most active compounds, umbelliferone and esculetin were further screened for their antiobesity effects in vivo in the high fat diet (HFD) induced obese rat model. Umbelliferone and esculetin reduced body weight, total triglyceride (TG), total cholesterol (TC) and glucose level in their resp. HFD groups. A. marmelos DCM extract and compounds isolated from it have the potential of counteracting the obesity by lipolysis in adipocytes. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegle umbelliferone esculetin antiobesity agents lipolysis obesity, adipocytes, aegle marmelos, anti-obesity, high fat diet, lipolysis, rat model, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Recommanded Product: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gopalan, D. H.; Vani, M.; Manikandan, S.; Vijayakumar, V. published an article in 2021, the title of the article was An immunohistochemical and biochemical evidences of pancreatic β-cell regeneration in type 2 diabetic rats after treated with Aegle marmelos leaf extract and Aegeline.Category: amides-buliding-blocks And the article contains the following content:

The study aims to investigate the Immunohistochem. changes in pancreatic beta cells in fructose fed, streptozocin (STZ) induced Type 2 Diabetes (T2DM) rats treated with various doses of leaf extract of Aegle marmelos (AAM) and Aegeline (AG). 42 adult male wistar albino rats were separated into 7 groups, including Vehicle Control (VC); T2DM; T2DM + AAM 250 mg/kg; T2DM + AAM 500 mg/kg; T2DM + AG 20mg/kg; T2DM + AG 50 mg/kg and T2DM + AG 100 mg/kg. Exptl. T2DM was created by a single dose of 40 mg/kg STZ injection intra-peritoneally along with 10% of fructose solution given orally for 30 days. Calculated dosages of AAM and AG were given with oral gavage for 30 days. Pancreas was harvested and processed. Slides were stained using hematoxylin and eosin (H & E) stains. Insulin expressing beta-cells was analyzed using immunohistochem. Fructose fed, STZ induced rats showed degenerative expressions in beta-cells. In STZ treated rats, AG reduced the blood glucose concentration and serum insulin levels at the maximum functional dose compared to AAM. The immunohistochem. information suggests that the AG at 100 mg/kg dose has the capability of making the dormant cells to reproduce to restore the lost cells of islets of Langerhans. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

The Article related to diabetics aegle marmelos leaf extract aegeline pancreatic beta cell, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 15, 2007, Narender, T.; Shweta, S.; Tiwari, P.; Reddy, K. Papi; Khaliq, T.; Prathipati, P.; Puri, A.; Srivastava, A. K.; Chander, R.; Agarwal, S. C.; Raj, K. published an article.Category: amides-buliding-blocks The title of the article was Antihyperglycemic and antidyslipidemic agent from Aegle marmelos. And the article contained the following:

The plant Aegle marmelos belongs to the family of Rutaceae. From the leaves of A. marmelos an alkaloidal-amide, Aegeline, was isolated and found to have antihyperglycemic activity as evidenced by lowering the blood glucose levels by 12.9% and 16.9% at 5 and 24 h, resp., in sucrose challenged streptozotocin induced diabetic rats (STZ-S) model at the dose of 100 mg/kg body weight Aegeline 2 has also significantly decreased the plasma triglyceride (Tg) levels by 55% (P < 0.001), total cholesterol (TC) by 24% (P < 0.05), and free fatty acids (FFA) by 24%, accompanied with increase in HDL-C by 28% and HDL-C/TC ratio by 66% in dyslipidemic hamster model at the dose of 50 mg/kg body weight The reasonable mapping of compound 2 to validated pharmacophoric hypothesis and 3D QSAR model with an estimated activity (283 nM) suggest that the compound 2 might be a β3-AR agonist. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Category: amides-buliding-blocks

The Article related to aegle alkaloid aegeline antidyslipidemic antihyperglycemic, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Waleed, Hadeer Q.; Csecsi, Marcell; Konyhas, Vivien; Boros, Zsanett R.; Viskolcz, Bela; Fejes, Zsolt; Fiser, Bela published an article in 2022, the title of the article was Aliphatic tertiary amine catalyzed urethane formation – a combined experimental and theoretical study.Application In Synthesis of 1,3-Diphenylurea And the article contains the following content:

A kinetic and mechanistic investigation of the alcoholysis of Ph isocyanate (PhNCO) using stoichiometric butan-1-ol (BuOH) in acetonitrile in the presence of different tertiary amine catalysts was performed. The reaction mechanisms in the absence and presence of exptl. applied catalysts were described by using the G3MP2BHandHLYP composite method. The apparent activation energies obtained from the calculations were in good agreement with the exptl. data (ΔΔE = <2 kJ mol-1). Both exptl. and theor. results proved the important effect of tertiary amine catalysts on urethane formation. These results can aid in polyurethane catalyst design and development. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application In Synthesis of 1,3-Diphenylurea

The Article related to phenylisocyanate butanol tertiary amine alcoholysis kinetics mechanism, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Application In Synthesis of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 26, 2017, Peters, Edward Norman; Na, Ying; Ma, Shuailei; Yang, Jian published a patent.Electric Literature of 5455-98-1 The title of the patent was Method for production of cured epoxy material and composite core for aluminum conductor composite core reinforced cable. And the patent contained the following:

A method of forming a cured epoxy material comprises reacting a phenylene ether oligomer with an anhydride hardener to form a first product, adding an epoxy resin to the first product to form a second product, and curing the second product. The method provides an improved balance of heat resistance and toughness relative to corresponding methods in which the phenylene ether oligomer is pre-reacted with the epoxy resin prior to addition of hardener, and in which all components are mixed simultaneously. The cured epoxy material can be used in the composite core of an aluminum conductor composite core reinforced cable. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Electric Literature of 5455-98-1

The Article related to oligophenylene ether anhydride hardener prereaction epoxy resin curing, aluminum conductor epoxy resin composite core reinforced cable, Plastics Manufacture and Processing: Formulating Procedures and Compositions and other aspects.Electric Literature of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 22, 2020, Harrier, Danielle D.; Kenis, Paul J. A.; Guironnet, Damien published an article.Computed Properties of 102-07-8 The title of the article was Ring-Opening Polymerization of Cyclic Esters in an Aqueous Dispersion. And the article contained the following:

Aqueous polymer dispersions are commodity materials produced on a multimillion-ton scale annually. Today none of these materials are biodegradable because the process by which they are made is not compatible with the synthesis of biodegradable polymers. Herein, we report a droplet microfluidic encapsulation strategy for protecting a water incompatible ring-opening polymerization (ROP) catalyst from the aqueous phase, yielding biodegradable polymer particles dispersed in water. Polymerization yields 300μm sized particles comprised of biodegradable poly(δ-valerolactone) with mol. weights up to 19.5 kg mol-1. The success of this approach relies on simultaneous precise control of the kinetics of polymerization, the rate of mass transfer, and fluid mechanics. The power of this methodol. was demonstrated by the synthesis of cross-linked polymer particles through the copolymerization of bis(ε-caprolactone-4-yl)propane and δ-valerolactone, producing cross-linked polymer particles with mol. weights reaching 65.3 kg mol-1. Overall, this encapsulation technique opens the door for the synthesis of biodegradable polymer latex and processable, biodegradable elastomers. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Computed Properties of 102-07-8

The Article related to ring opening polymerization cyclic ester aqueous dispersion microfluidic encapsulation, Chemistry of Synthetic High Polymers: Ring-Opening and Other Polymerizations and other aspects.Computed Properties of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 31, 2017, Lv, Jiang-bo; Ma, Jing-zhi; Cheng, Kang; Chen, Chang; Hu, Jiang-huai; Zeng, Ke; Yang, Gang published an article.Computed Properties of 5455-98-1 The title of the article was Insights into phthalonitrile/epoxy blends modification system from non-competitive cure system based on alicyclic anhydride. And the article contained the following:

A series of polymer blends were prepared from 1,3-bis(3,4-dicyanophenoxy)benzene (3BOCN) and epoxy resin with Me tetrahydrophthalic anhydride as curing agent. The curing behavior and curing kinetics of the blends were studied by differential scanning calorimetry. The apparent activation energy of the blends with various contents of 3BOCN was higher than that of the blends without 3BOCN. A model experiment suggested that there is no obvious reaction between phthalonitrile and epoxy. The thermal and mech. properties of the polymer blends were evaluated. The polymer blends exhibit high storage modulus and char yield compared with the neat epoxy. The polymer blends show ductile fracture morphol. by SEM images. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Computed Properties of 5455-98-1

The Article related to phthalonitrile oligomeric plasticizer alicyclic anhydride cured epoxy blend property, Plastics Manufacture and Processing: Formulating Procedures and Compositions and other aspects.Computed Properties of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Rassou, Somasoudrame; Illy, Nicolas; Tezgel, Ozgul; Guegan, Philippe published an article in 2018, the title of the article was Anionic ring-opening polymerization of N-glycidylphthalimide: Combination of phosphazene base and activated monomer mechanism.Computed Properties of 5455-98-1 And the article contains the following content:

Anionic ring-opening polymerization of glycidyl phthalimide, initiated with alc.-phosphazene base systems and based on monomer activation with a Lewis acid (iBu3Al), has been studied. No propagation occurred for initiator: iBu3Al ratios less or equal to 1:3. For larger Lewis acid amounts, the first anionic ring-opening polymerizations of glycidyl phthalimide were observed Polymers were carefully characterized by NMR, MALDI-TOF mass spectrometry, and size exclusion chromatog. and particular attention was given to the detection of eventual transfer or side-reactions. However, polymer precipitation and transfer reaction to aluminum derivative were detrimental to monomer conversion, polymerization control, and limited polymer chain molar masses. The influence of reaction temperature and solvent on polymer precipitation and transfer reactions was studied and reaction conditions have been optimized leading to afford end-capped poly(glycidyl phthalimide) with narrow molar mass distributions. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Computed Properties of 5455-98-1

The Article related to anionic ringopening polymerization glycidylphthalimide phosphazene monomer mechanism, Chemistry of Synthetic High Polymers: Ring-Opening and Other Polymerizations and other aspects.Computed Properties of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics