Tag: 200-300

On October 27, 2020, Lin, Binhong; Jadrich, Caleb N.; Pane, Vince E.; Arrechea, Pedro L.; Erdmann, Tim; Dausse, Charles; Hedrick, James L.; Park, Nathaniel H.; Waymouth, Robert M. published an article.Category: amides-buliding-blocks The title of the article was Ultrafast and Controlled Ring-Opening Polymerization with Sterically Hindered Strong Bases. And the article contained the following:

The controlled anionic ring-opening polymerization of lactones and siloxanes is carried out in continuous-flow reactors. Anionic ring-opening polymerization of cyclic esters with strong, soluble bases such as potassium tert-butoxide (KOtBu) is typically performed as batch reactions, leading to broad dispersity and poor control over the mol. weight (Mn) mainly because of transesterification reactions. Although reactions with strong bases give rise to “uncontrolled” polymerizations, a variety of transition metal-based and organocatalysts have been developed with the goal of reliably controlling the dispersity and Mn. Herein, we show that the rapid mixing and short residence times accessible with a continuous-flow apparatus can enable the controlled polymerization of low-reactivity monomers such as δ-valerolactone and ε-caprolactone on millisecond time scales using a base [such as KOtBu or potassium bis(trimethylsilyl)amide (KHMDS)] in conjunction with a primary alc. These reactions exhibit characteristics capable of producing narrow dispersity with predictable mol. weights and can rapidly generate well-defined block copolymers with residence times below 0.1 s. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Category: amides-buliding-blocks

The Article related to ultrafast controlled ring opening polymerization sterically hindered strong base, Chemistry of Synthetic High Polymers: Ring-Opening and Other Polymerizations and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 6, 2020, Jurrat, Mark; Pointer-Gleadhill, Benjamin J.; Ball, Liam T.; Chapman, Andy; Adriaenssens, Louis published an article.Application In Synthesis of 1,3-Diphenylurea The title of the article was Polyurethanes and Polyallophanates via Sequence-Selective Copolymerization of Epoxides and Isocyanates. And the article contained the following:

Aryl isocyanates are introduced as comonomers for ring opening copolymerization (ROCOP) with epoxides. Informed by studies of reaction kinetics, we show that divergent sequence selectivity for AB- and ABB-type copolymers can be achieved with a single dimagnesium catalyst. The resulting materials resp. constitute a new class of polyurethane (PU) and a new class of material featuring an unprecedented backbone structure, the polyallophanate (PA). The successful use of isocyanate comonomers in this way marks a new direction for the field of ROCOP, while providing distinct opportunities for expansion of PU structural diversity. Specifically, the methodol. reported herein delivers PUs featuring fully substituted (tertiary) carbamyl nitrogen atoms, a structural motif that is almost inaccessible via extant polymerization strategies. Thus, in one step from com. available comonomers, our methodol. expands the scope of ROCOP and gives access to diverse materials featuring both privileged (PU) and unexplored (PA) microstructures. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application In Synthesis of 1,3-Diphenylurea

The Article related to polyurethane polyallophanate sequence copolymerization epoxide isocyanate, Chemistry of Synthetic High Polymers: Ring-Opening and Other Polymerizations and other aspects.Application In Synthesis of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 23, 2014, Qin, Bing; Li, Xin; Liang, Bo published a patent.Electric Literature of 5455-98-1 The title of the patent was Novel cyclic acetal, cyclic ketal diamines epoxy curing agents and degradable polymers and composites based thereon. And the patent contained the following:

The title curing agent can generate a degradable crosslinked polymer by performing polymerization reaction with an epoxy resin. The degradable crosslinked polymer can be degraded in a mixed system of acid and solvent under the condition of heating and stirring. This reinforced composite is prepared using the curing agent, the epoxy resin, and auxiliary materials. This reinforced composite can be degraded in a mixed system of acid and solvent under the condition of heating and stirring, and can be recovered and reutilized after neutralization. This reinforced composite has high mech. performance, and wide range of application. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Electric Literature of 5455-98-1

The Article related to degradable cyclic acetal ketal diamine crosslinking agent epoxy resin, Plastics Manufacture and Processing: Formulating Procedures and Compositions and other aspects.Electric Literature of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 19, 2014, Ahmed, Mahbub; Ashall-Kelly, Alexander; Gueritz, Louisa; McKenna, Jeffrey; McKenna, Joseph; Mutton, Simon; Parmar, Rakesh; Shepherd, Jon; Wright, Paul published a patent.Recommanded Product: 5455-98-1 The title of the patent was Azacycloalkanopyrrolopyrimidinedione derivatives as CFTR modulators and their preparation. And the patent contained the following:

The invention provides a compound of formula I or a pharmaceutically acceptable salt thereof;a nd its therapeutic uses. The invention further provides a combination of pharmacol. active agents and a pharmaceutical composition Compounds of formula I wherein A is (CHR4)n; R1 is (un)substituted Ph, (un)substituted C4-7 cycloalkenyl and (un)substituted 5- to 6- membered heteroaryl; R2 is (un)substituted C1-6 alkyl, (un)substituted C3-7 cycloalkyl, (un)substituted C4-7 cycloalkenyl, etc.; R3 is Me and Et; when X is S, then Z is CHR4a and n is 1; when X is CHR4b, then Z is NR5 and N is 1 and 2; when Z is CHR4b, then Z is CHR4a and n is 0, 1 and 2; when X is C=CH2, CF2 and C(CH3)2, then Z is CHR4a and n is 0 and 1; R4 is H, C1-4 alkyl,C1-4 haloalkyl, Ph, etc.; R4a is H, C1-4 alkyl, C1-4 hydroxyalkyl, etc.; R4b is H and Me; R5 is H and C1-4 alkyl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by cyclization of 6-(2-mercaptoethyl)-1,3-dimethyl-5-phenyl-1,6-dihydropyrrolo[3,4-d]pyrimidine-2,4-dione with 5-methylfuran-2-carboxaldehyde. The invention compounds were evaluated for their CFTR modulatory activity (some data given). The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Recommanded Product: 5455-98-1

The Article related to azacycloalkanopyrrolopyrimidinedione preparation cftr modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 9, 2018, Mueller, Thomas Ernst; Guertler, Christoph; Koopmans, Carsten; Marker, Volker; Rangheard, Claudine; Leitner, Walter published a patent.Recommanded Product: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Method for production of polyoxazolidinone, and spun fiber comprising polyoxazolidinone. And the patent contained the following:

A method for production of polyoxazolidinone compounds comprises reaction of at least one biscarbamate compound (A) with at least one bisepoxide compound (B) in the presence of at least one base (D), at least one Lewis acid catalyst (E), and optionally at least one compound (C), wherein the compound (C) comprising a mono-carbamate group, a mono-isocyanate group and/or a mono-epoxide group, and wherein the base (D) has a pKb value of ≤ 9. The invention also relates to a polyoxazolidinone compound produced according to the method, and a spun fiber comprising the polyoxazolidinone compound Thus, di-Me diphenylmethane-4,4′-dicarbamate (5.62 g, 17.9 mmol) and resorcinol diglycidyl ether (in resin form, Denacol EX 201, 3.65 g, 16.4 mmol) in o-dichlorobenzene (20 mL) were heated to 180° while stirring at 400 rpm, followed by addition of tert-butyliminotri(pyrrolidino)phosphorane (55 μL, 1% mol relative to biscarbamate) and tetraphenylstibonium bromide (0.18 g, 2% mol relative to biscarbamate), stirring for 480 min, adding 4-tert-butylphenyl glycidyl ether (1.5 mL, 6 mmol), o-dichlorobenzene (10 mL) and N-methyl-2-pyrrolidinone (5 mL), and stirring for another 60 min to obtain a polyoxazolidinone (chemoselectivity to oxazolidinone > 98%, 5-oxazolidinone regioisomer content of 50%, and 4-oxazolidinone content of 50%.). The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Recommanded Product: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to biscarbamate bisepoxide polymerization polyoxazolidinone synthesis fiber, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Recommanded Product: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 8, 2018, there was a patent about biscarbamate bisepoxide polymerization polyoxazolidinone synthesis fiber.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Method for production of polyoxazolidinone, and spun fiber comprising polyoxazolidinone. And the patent contained the following:

A method for production of polyoxazolidinone compounds comprises reaction of at least one biscarbamate compound (A) with at least one bisepoxide compound (B) in the presence of at least one base (D), at least one Lewis acid catalyst (E), and optionally at least one compound (C), wherein the compound (C) comprising a mono-carbamate group, a mono-isocyanate group and/or a mono-epoxide group, and wherein the base (D) has a pKb value of ≤ 9. The invention also relates to a polyoxazolidinone compound produced according to the method, and a spun fiber comprising the polyoxazolidinone compound Thus, di-Me diphenylmethane-4,4′-dicarbamate (5.62 g, 17.9 mmol) and resorcinol diglycidyl ether (in resin form, Denacol EX 201, 3.65 g, 16.4 mmol) in o-dichlorobenzene (20 mL) were heated to 180° while stirring at 400 rpm, followed by addition of tert-butyliminotri(pyrrolidino)phosphorane (55 μL, 1% mol relative to biscarbamate) and tetraphenylstibonium bromide (0.18 g, 2% mol relative to biscarbamate), stirring for 480 min, adding 4-tert-butylphenyl glycidyl ether (1.5 mL, 6 mmol), o-dichlorobenzene (10 mL) and N-methyl-2-pyrrolidinone (5 mL), and stirring for another 60 min to obtain a polyoxazolidinone (chemoselectivity to oxazolidinone > 98%, 5-oxazolidinone regioisomer content of 50%, and 4-oxazolidinone content of 50%.). The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to biscarbamate bisepoxide polymerization polyoxazolidinone synthesis fiber, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 18, 2016, Mueller, Thomas Ernst; Guertler, Christoph; Basu, Susmit; Rangheard, Claudine; Rivillo, David; Leitner, Walter; Koehler, Burkhard published a patent.Synthetic Route of 5455-98-1 The title of the patent was Manufacturing of polyoxazolidinone compounds with high stability by reacting a biscarbamate compounds with a bisepoxide compounds. And the patent contained the following:

The present invention relates to polyoxazolidinone compounds, a method for the production of polyoxazolidinone compounds, comprises the step of reacting a biscarbamate compound with a bisepoxide compound in the presence of a mono-carbamate, a mono-isocyanate and/or a mono-epoxide compound as chain regulator and a suitable base having a pKb value of ≤ 9 as catalyst. The invention further relates to the use of polyoxazolidinone compounds with high thermal stability. Thus, a mixture of O,O’-Dimethyl-4,4′-methylendiphenyl-1,1′-dicarbamate 6.33 g, 4,4′-isopropylidenediphenol diglycidyl ether 3.45 g, 4-tert-butylphenyl glycidyl ether 5.20 g and DBU 16.5 mg was admixed and heated 180° to get polyoxazolidinone with Tg 127 and thermal stability until 389°. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Synthetic Route of 5455-98-1

The Article related to polyoxazolidinone bisepoxide isocyanate thermal stability, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Synthetic Route of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 1, 2020, Pacheco, Kelvin A.; Bresciani, Antonio E.; Nascimento, Claudio A. O.; Alves, Rita M. B. published an article.COA of Formula: C13H12N2O The title of the article was Assessment of property estimation methods for the thermodynamics of carbon dioxide-based products. And the article contained the following:

Carbon dioxide can be used as feedstock to produce chems. It represents a stimulating defiance to manufacture novel cost competitive materials with less environmental impact, besides to investigate new opportunities for catalysts and industrial chem. The contribution of carbon dioxide conversion goes beyond lowering global warming, by reducing fossil resource depletion or even yielding more benign production pathways. Albeit promising, the literature data regarding the quantity of energy needed to convert carbon dioxide into chems. is limited and narrowed to the most studied processes and products. In order to understand and model the formation of species using carbon dioxide as raw material, some basic thermodn. data are needed. The development of detailed reaction schemes in the field is also scarce. To enhance and further complete the database of the products obtained from carbon dioxide, this study investigates different procedures to estimate the basic thermodn. properties of the reactants and products of these reactions. To date various methods have been developed and introduced to determine the gas-phase standard enthalpies of formation and Gibbs energy. Among them, group additivity and semi-empirical methods are widely employed due to their accuracy and effort time for implementation compared to more rigorous methods. Semi empirical quantum-chem. methods were compared with group additivity methods. Available literature data were used to select the best method for property estimation of the whole set of species, whereby produced from carbon dioxide. The products from carbon dioxide were categorized in sixteen chem. classes, the reaction enthalpy for the direct route to manufacture the products were assessed and indicate a large difference among the classes. The results of this investigation show that semi empirical quantum-chem. methods revealed to be more accurate for the studied species; addnl., the method demonstrates robustness in estimating the properties. Together, these results provide important insights into the thermodn. of carbon dioxide related products. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).COA of Formula: C13H12N2O

The Article related to carbon dioxide product thermodn property, Thermodynamics, Thermochemistry, and Thermal Properties: Thermochemical Properties and other aspects.COA of Formula: C13H12N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 23, 2009, Leito, Ivo; Raamat, Elin; Kutt, Agnes; Saame, Jaan; Kipper, Karin; Koppel, Ilmar A.; Koppel, Ivar; Zhang, Min; Mishima, Masaaki; Yagupolskii, Lev M.; Garlyauskayte, Romute Yu.; Filatov, Andrey A. published an article.Reference of 3-Nitro-4-chlorobenzenesulfonamide The title of the article was Revision of the Gas-Phase Acidity Scale below 300 kcal/mol-1. And the article contained the following:

The gas-phase acidity (GA) scale from (CF3CO)2NH to (C2F5SO2)2NH-about a 24 kcal/mol-1 range of gas-phase acidities-was reexamined using the Fourier transform ion cyclotron resonance equilibrium measurement approach. Some additions and modifications to the standard methodol. of GA measurements were introduced (estimation of partial pressures from mass spectra of the compounds, instead of the pressure gauge readings and use of long reaction times) to achieve higher reliability. Gas-phase acidities of 18 compounds were determined for the first time. The results reveal a contraction of the previously published values in this part of the scale. In particular, the GA values of (CF3SO2)2NH and (C2F5SO2)2NH (important components of lithium ion battery electrolytes and ionic liquids) were revised toward stronger acidities from 291.8 kcal/mol-1 to 286.5 kcal/mol-1 and from 289.4 kcal/mol-1 to 283.7 kcal/mol-1 (i.e., by 5.3 and 5.7 kcal/mol-1), resp. Exptl. and computational evidence is presented in support of the current results. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Reference of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to gas phase acidity ga scale revision, Physical Organic Chemistry: Acid-Base, Tautomerism, and Other Equilibrium Studies and other aspects.Reference of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 1, 2016, Gampe, Christian M.; Kahne, Daniel Evan; Kahne, Suzanne Walker; Qiao, Yuan; East, Stephen; Parkes, Alastair L.; Southey, Michelle; Hunter, James; Whittaker, Mark; Arthuis, Martin published a patent.Application of 5455-98-1 The title of the patent was Preparation of 6H,7H-pyrazolo[1,5-a][1,3,5]triazin-7-one derivatives as inhibitors of bacterial glycosyl transferases. And the patent contained the following:

The title compounds of formula I [A = independently each (un)substituted C2-6 alkyl, aryl, carbocyclyl, 5-membered heteroaryl, or 6-membered heteroaryl; B = independently H or each (un)substituted alkyl, alkenyl, alkynyl, aryl, carbocyclyl, heterocyclyl, or heteroaryl; Y = a bond or each (un)substituted C1-6-alkylene, C3-6 carbocyclylene, or heterocyclylene; X = a bond, O, CH2, NRNX, NRNX-C(O)-NRNX, or (un)substituted heterocyclylene; L = a bond, O, C(O), NRLBC(O), C(O)NRLB, NRLB, or SO2; each RLB = independently H or each (un)substituted alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl, or RLB and B are taken together with their intervening atoms to form an (un)substituted heterocyclic ring; R1 = H, halogen, or (un)substituted substituted C1-6 alkyl; RN1 = H, (un)substituted C1-6 alkyl, or a nitrogen protecting group; RNX = H, (un)substituted C1-6 alkyl, or a nitrogen protecting group], pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof are prepared The invention also provides pharmaceutical compositions of the compounds I for human and veterinary use. The compounds I are useful for inhibiting bacterial growth and therefore are useful in treating and/or preventing bacterial infections. Thus, 100 mg 2-(4-tert-butylphenyl)-4-(methylsulfanyl)-6H,7H-pyrazolo[1,5-a][1,3,5]triazin-7-one and 190 mg N-(3-aminopropyl)-4-chloro-3-methylaniline were dissolved in 4 mL 1,4-dioxane, heated to 130° in a microwave for 11 h, then concentrated, and purified using HPLC to give 7.9 mg 2-(4-tert-butylphenyl)-4-[[3-[(4-chloro-3-methylphenyl)amino]propyl]amino]-6H,7H-pyrazolo[1,5-a][1,3,5]triazin-7-one (II) (5% yield). II showed min. inhibitory concentration of 3.1, 2, and 4 μg/mL against methicillin-susceptible Staphylococcus aureus Newman, S. aureus 29213, and S. aureus 43300 at 24 h, resp. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application of 5455-98-1

The Article related to bacterial infection prevention treatment pyrazolotriazinone preparation, pyrazolotriazinone preparation inhibitor bacterial glycosyl transferase antibacterial, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics