Tag: 200-300

On June 19, 2014, Ahmed, Mahbub; Ashall-Kelly, Alexander; Bloomfield, Graham Charles; Gueritz, Louisa; McKenna, Jeffrey; McKenna, Joseph; Mutton, Simon; Parmar, Rakesh; Sheperd, Jon; Wright, Paul published a patent.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Preparation of tricyclic compounds as CFTR channel inhibitors for treating polycystic kidney disease and diarrhea. And the patent contained the following:

The invention provides tricyclic compounds of general formula I or a pharmaceutical salt thereof, their use for inhibiting the CFTR channel, and methods of treating disease using same, particularly polycystic kidney disease and diarrhea. For I, R1 is Ph, (C4-C7)cycloalkenyl or a 5-6-membered heteroaryl ring, all optionally substituted; R2 is (C1-C6)alkyl, (C3-C7)cycloalkyl, (C4-C7)cycloalkenyl, etc., all optionally substituted; each R3 independently is Me or ethyl; R4 is hydrogen, (C1-C4)alkyl, halo(C1-C4)alkyl, etc.; R4′ is H or methyl; R4a is hydrogen, (C1-C4)alkyl, halo(C1-C4)alkyl, etc.; and X is O, NH, NMe, or -CH2-O- wherein the O atom is attached to the -C(R4)(R4′) atom of the ring. Pharmaceutical compositions containing I, alone or in combination with other active agents, are also disclosed. Synthetic procedures for preparing I are exemplified. Example compound (R)-II was prepared by reacting intermediate III with 5-methylfuran-2-carboxaldehyde and subjecting the racemate formed to chiral separation Using the Ion Works Quatro assay (R)-II had a CFTR IC50 of 1.58 μM. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to tricyclic compound preparation cftr channel inhibitor polycystic kidney disease, diarrhea treatment tricyclic compound cftr channel inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mamat, Marhaba; Liu, Changhong; Abdukerem, Dilshat; Abdukader, Ablimit published an article in 2021, the title of the article was A visible-light-induced thiol addition/aerobic oxidation cascade reaction of epoxides and thiols for the synthesis of β-hydroxylsulfoxides.COA of Formula: C11H9NO3 And the article contains the following content:

A photochem. thiol addition/aerobic oxidation cascade reaction had been developed. This protocol enabled efficient oxidative coupling of epoxides and thiols to access structurally valuable β-hydroxylsulfoxides RSO2CH2C(R1R2)OH [R = 4-MeC6H4, 4-ClC6H4, 4-MeOC6H4, etc.; R1 = H, Me; R2 = Me, Et, CO2Et, etc.]. A broad range of functional groups were compatible to obtain moderate to good yields of the target products. Mechanistic studies revealed a sequential reaction pathway involving base-promoted thiol addition of thiols to epoxides and visible-light-induced aerobic oxygenation of thioethers. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).COA of Formula: C11H9NO3

The Article related to beta hydroxylsulfoxide preparation, epoxide thiol cascade addition aerobic oxidation rose bengal catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfoxides and Sulfones and other aspects.COA of Formula: C11H9NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 15, 2019, Wu, Chenggui; Yang, Xinjun; Shang, Yong; Cheng, Hong-Gang; Yan, Wei; Zhou, Qianghui published an article.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Synthesis of Benzofused Dioxabicycle Scaffolds via a Catellani Strategy. And the article contained the following:

Reported is a modular strategy for the preparation of the unique benzofused dioxabicycle scaffolds involving a Catellani reaction of aryl iodides, epoxides, and terminal alkynes and an oxa-cyclization. This is a mild, scalable, chemoselective, and atom-economical protocol, compatible with various functionalized aryl iodides, epoxides, and terminal alkynes. With the ability to build up the mol. complexity rapidly and efficiently from feedstock chems., this method will have wide applications in organic synthesis. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to benzofused dioxabicycle preparation chemoselective regioselective, aryl iodide epoxide terminal alkyne catellani reaction oxacyclization, Heterocyclic Compounds (More Than One Hetero Atom): Dioxoles, Oxathioles, Dithioles and other aspects.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 7, 2021, Alvarez-Miguel, Lucia; Burgoa, Jesus Damian; Mosquera, Marta E. G.; Hamilton, Alex; Whiteoak, Christopher J. published an article.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Catalytic Formation of Cyclic Carbonates using Gallium Aminotrisphenolate Compounds and Comparison to their Aluminium Congeners: A Combined Experimental and Computational Study. And the article contained the following:

The use of gallium aminotrisphenolate compounds as catalysts for the synthesis of cyclic carbonates from epoxides and CO2 was reported. The results showed that they were highly active and more so than the corresponding aluminum congeners. The catalyst system was applicable at low and elevated temperatures across a wide substrate scope including terminal, internal, multiple and fully deuterated epoxides. Applying low catalyst loadings allowed for a TON of 344,000 to be obtained, highlighting their stability. A DFT investigation confirmed that the gallium catalysts have lower energetic profiles compared to the aluminum congeners. Measurement of the Lewis acidity of both the gallium and aluminum aminotrisphenolate compounds using the Gutmann-Beckett method provided the exptl. proof that the gallium compounds were more Lewis acidic than their aluminum congeners. Finally, Ab-Initio Mol. Dynamic (AIMD) simulations investigated and quantified the dynamic behavior of the catalytic systems, highlighting an important increase in fluxionality in some cases which helps to explain the increase in catalytic activity. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to gallium aminotrisphenolate catalyst preparation lewis acidity, epoxide carbon dioxide gallium catalyst, cyclic carbonate preparation, Heterocyclic Compounds (More Than One Hetero Atom): Dioxoles, Oxathioles, Dithioles and other aspects.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 1, 2021, Cysewski, Piotr; Jelinski, Tomasz; Procek, Dominika; Dratwa, Aleksandra published an article.Application In Synthesis of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Solubility of Sulfanilamide and Sulfacetamide in neat solvents: Measurements and interpretation using theoretical predictive models, first principle approach and artificial neural networks. And the article contained the following:

Solubilities of Sulfanilamide and Sulfacetamide in neat solvents were both measured and collected from the literature. The set comprising 35 systems was interpreted in terms of the empirical and semi-empirical predictive models including Buchowski-Ksiazczak model (λh-equation), extended Buchowski’s model (λβ-equation), modified Apelblat equation, van’t Hoff-Yaws model, Non-Random Two Liquid (NRTL) model, Wilson model and the Weibull two-parameter extrapolation model. The advantage of corrected Akaike information criterion was used for precise quantification of the quality of each model. It turned out that the lowest values of this measure were found for the Buchowski-Ksiazczak approach indicating the best correlation with exptl. solubility data. Interestingly, λβ-equation and van’t Hoff-Yaws model give a fitting of almost the same quality but were slightly less accurate compared to λh-equation. The results of applied COSMO-RS computations suffered seriously from inaccuracies providing only a qual. guess of solubility Hence, machine learning procedure was applied for building a non-linear fully predictive model. The set of used mol. descriptors comes from COSMO-RS computations and characterizes intermol. interactions in pure solvents. Based on the quality of obtained machine learning model it is possible to confirm that the selected set of descriptors can be used for solubility modeling and carries the most important information necessary for quantifying of saturated solutions The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Application In Synthesis of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to solubility sulfanilamide sulfacetamide solvent theor model artificial neural network, Phase Equilibriums, Chemical Equilibriums, and Solutions: Nonelectrolytic Solutions and other aspects.Application In Synthesis of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Qiao; Yuan, Hao-Yu; Lin, Xiao-Tao; Fukaya, Norihisa; Fujitani, Tadahiro; Sato, Kazuhiko; Choi, Jun-Chul published an article in 2020, the title of the article was Calcium carbide as a dehydrating agent for the synthesis of carbamates, glycerol carbonate, and cyclic carbonates from carbon dioxide.Synthetic Route of 102-07-8 And the article contains the following content:

Carbon dioxide (CO2) is a nontoxic and inexpensive C1 building block, which can be used for the synthesis of valuable chems. such as aromatic carbamates from anilines and methanol (MeOH), glycerol carbonate from glycerol, and cyclic carbonates from diols. However, these reactions generate water as the byproduct and suffer from thermodn. limits, which lead to low yields. Calcium carbide (CaC2) is a renewable chem., which can be recycled from calcium that is abundant in the Earth’s crust. Furthermore, CaC2 rapidly reacts with water. The authors used CaC2 as a dehydrating agent for the direct synthesis of carbamates (including polyurethane precursors) from amines, CO2, and MeOH. All reagents were com. available. In addition, CaC2 was employed for the synthesis of glycerol carbonate from glycerol and CO2 with a zinc catalyst and N-donor ligand. A similar protocol was applied to synthesize cyclic carbonates from diols and CO2. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Synthetic Route of 102-07-8

The Article related to carbonate glycerol carbonate carbamate preparation calcium carbide carbon dioxide, Heterocyclic Compounds (More Than One Hetero Atom): Dioxoles, Oxathioles, Dithioles and other aspects.Synthetic Route of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Marshall, Sarah R.; Singh, Anmol; Wagner, Jacqueline N.; Busschaert, Nathalie published an article in 2020, the title of the article was Enhancing the selectivity of optical sensors using synthetic transmembrane ion transporters.Synthetic Route of 102-07-8 And the article contains the following content:

Herein, we introduce a new method to optimize the properties of optical sensors, coined the transporter-liposome-fluorophore (TLF) approach. It is shown that this approach can greatly improve the selectivity of the sensor, increase the dynamic range and maintain the sensitivity of the original fluorophore. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Synthetic Route of 102-07-8

The Article related to enhancing selectivity optical sensor synthetic transmembrane ion transporter, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Luminescence and other aspects.Synthetic Route of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2012, Reddy, Pingili Krishna; Mukkanti, K.; Rao, Dodda Mohan published an article.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Synthesis of antibiotic linezolid analogues. And the article contained the following:

New oxazolidinones were synthesized and were evaluated for antibacterial activity against S. aureus, S. citreus, P. vulgaris, S. typhimurium, and K. pneumoniae. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to oxazolidinone antibiotic linezolid analog preparation antibacterial, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 1, 2021, Rahimpour, Elaheh; Acree, William E. Jr.; Jouyban, Abolghasem published an article.Synthetic Route of 144-80-9 The title of the article was Prediction of sulfonamides’ solubilities in the mixed solvents using solvation parameters. And the article contained the following:

The exptl. solubility data of various sulfonamides in the binary solvent systems at various temperatures are collected from the literature and fitted to Jouyban-Acree model as an accurate cosolvency model for providing solubility prediction tools. In order to obtain predictive cosolvency models, the Jouyban-Acree model is combined with physicochem. parameters of the Abraham solvation parameters and the Hansen solubility parameters. Based on these computations, the generally trained versions of the combined models are proposed which enable one to predict the solubility of sulfonamides in the binary solvent mixtures at various temperatures with reasonable error levels. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Synthetic Route of 144-80-9

The Article related to sulfonamide solubility binary solvent system solvation parameter, Phase Equilibriums, Chemical Equilibriums, and Solutions: Nonelectrolytic Solutions and other aspects.Synthetic Route of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 19, 2020, Soccio, Michelina; Mazzoni, Rita; Lucarelli, Carlo; Quattrosoldi, Silvia; Cingolani, Andrea; Fiorini, Maurizio; Lotti, Nadia; Tabanelli, Tommaso published an article.Recommanded Product: 1,3-Diphenylurea The title of the article was Urea and Polyurea Production: An Innovative Solvent- and Catalyst-Free Approach through Catechol Carbonate. And the article contained the following:

The peculiar reactivity of catechol carbonate (CC) with amines and polyamines in both solvent- and catalyst-free conditions is herein described. In all the tests performed at room temperature, CC conversion reached 100% in a few seconds leading to the selective formation of the corresponding 2-hydroxyphenylcarbamate. This compound is further rapidly converted to the disubstituted urea by the consecutive nucleophilic attack of another amine. Noteworthy, the application of this approach can be successfully extended to the one-pot bioamine-based synthesis of polyurea as herein proposed for the first time in the literature. The reaction is of general purpose for primary amines, and catechol can be easily recovered by sublimation as pure crystals ready to be recycled for the synthesis of new CC. An exception is related to the reactivity of secondary amine, which leads to the selective formation of substituted phenolic carbamates (e.g., 2-hydroxyphenyl diethylcarbamate), suitable as intermediates in medicinal chem. Superior reactivity is displayed by catechol carbonate toward aminolysis yielding urea and polyurea in mild, solvent- and catalyst-free conditions. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Recommanded Product: 1,3-Diphenylurea

The Article related to urea production solvent catalyst free catechol carbonate amine, polyurea catechol carbonate diamine polym green chem, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Recommanded Product: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics