Tag: 200-300

On December 31, 2013, Ali, Mohammad; Zarchi, Karimi; Tarabsaz, Ali published an article.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was A versatile and regioselective synthesis of vicinal azidoalcohols using cross-linked poly(4-vinylpyridine) supported azide ion under solvent-free conditions. And the article contained the following:

A new polymeric reagent, cross-linked poly(4-vinylpyridine) supported azide ion, [P4-VP]N3, was introduced as polymeric reagents for efficient and regioselective conversion of epoxides to azidohydrins in the presence of crosslinked poly(4-vinylpyridine) supported sulfuric acid, [P4-VP]H2SO4, as a solid proton source and as catalyst under solvent-free conditions. The advantages of this polymeric reagent over some of those reported in the literature are easy work-up procedure and regeneration of the reagent. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to versatile regioselective synthesis vicinal azidoalc crosslinked polyvinylpyridine, Chemistry of Synthetic High Polymers: Monomers and Reagents Used In Polymerization and other aspects.Reference of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 28, 2012, Song, Li-feng; Guo, Lin; Tang, Yong; Yin, Yong-bo published an article.SDS of cas: 97-09-6 The title of the article was Preparation of N-Alkyl substituted 3-amino-4-chloro-benzenesulfonamides. And the article contained the following:

N-Alkyl substituted 3-amino-4-chloro-benzenesulfonamides were important intermediates for preparing acid dyes and disperse dyes in peculiar field. The synthesis routes and their advantages and disadvantages of 4-chloro-3-aminobenzenesulfonamide and its N-alkyl substituted compounds were evaluated. Chlorosulfonic acid was replaced by thionyl chloride in the preparation of sulfonic acid chloride and industrial waste acid was reduced largely. Sodium sulfide reduction or iron powder reduction were instead by hydrogenation reduction, the yield was improved with energy saving and environmental protection. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6

The Article related to preparation amino chloro benzenesulfonamide dye, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Dye Intermediates and other aspects.SDS of cas: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 25, 2001, Li, Yan-yun; Yin, Zhen-yan; Hu, Ying-xi; Liu, Xia; Chen, Chi-yang; Liu, Bin published an article.SDS of cas: 97-09-6 The title of the article was Synthesis of 2-nitrophenol-4-sulfonylamide. And the article contained the following:

2-Nitrophenol-4-sulfonylamide was synthesized by sulfochlorination, ammoniation, hydrolysis from o-nitrochlorobenzene being as raw materials. The reaction conditions were optimized in material proportion, reaction temperature, reaction time. The optimum technol. conditions were obtained as the follows: The molar ratio of n(o-C6ClH4NO2):n(HSO3Cl) = 1:4; The raw material has been fed in batches and the ration Na2SO4 is added, reaction temperature is 140°C, reaction time is 6-7 b. The product n (2-nitrochlorobenzene-4-sulfochlorides):n(NH3) = 1:1.5 has been treated with ammonia water at reaction temperature 38-40°C for 2 h, and treated with 30% NaOH solution at 105°C for 3-4 h, and then phase transfer catalyst is added, finally after acidifying, the product can be obtained. The excellent yield was 70%. The three products obtained in above three phases were characterized by IR. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6

The Article related to nitrophenol sulfonylamide preparation, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Dye Intermediates and other aspects.SDS of cas: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 1, 2019, Derf, Asma; Sharma, Ankita; Bharate, Sandip B.; Chaudhuri, Bhabatosh published an article.Computed Properties of 456-12-2 The title of the article was Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. And the article contained the following:

Herein, we have identified yeast Sec22p (ySec22p), a SNARE protein essential for endoplasmic reticulum to Golgi trafficking, as a suppressor of Bax-induced yeast apoptosis and corroborated published observations that ySec22p suppresses α-synuclein’s toxicity in yeast. It has been suggested that compounds which enhance expression, in neurons, of human homologues of ySec22p (Sec22Bp/Sec22p/Sec22A) would prevent synucleinopathies, such as Parkinson’s disease. With the aim of finding a small mol. that would mimic ySec22p, a library of natural products consisting of 394-compounds was screened using yeast cells that express either human α-synuclein or human Bax. The antioxidant aegeline, an alkaloid-amide occurring in the leaves of the plant Aegle marmelos Correa, was the only mol. that overcame apoptosis induced by both α-synuclein and Bax in yeast. Besides, aegeline also prevented growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein or Bax-expressing cells. These results highlight the importance of yeast systems to identify rapidly mols. that may prevent the onset of apoptosis that occurs in Parkinson’s disease. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Computed Properties of 456-12-2

The Article related to aegeline apoptosis ros sec22p mitochondrial membrane potential, aegeline, apoptosis, dna-fragmentation, mitochondrial-membrane-potential, ros, sec22p, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Computed Properties of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 15, 2019, Raheja, Shikha; Girdhar, Amit; Kamboj, Anjoo; Lather, Viney; Pandita, Deepti published an article.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide The title of the article was Aegle marmelos leaf extract ameliorates the cognitive impairment and oxidative stress induced by intracerebroventricular streptozotocin in male rats. And the article contained the following:

Therefore, the present study was attempted to investigate the neuroprotective potential of ethanolic extract of A. marmelos leaves (AME) on STZ induced memory impairment in male rats. Albino Wistar rats were pre-treated orally with AME at the doses 200 and 400 mg/kg for two weeks, followed by intracerebroventricular (i.c.v.) injection of STZ (3 mg/kg) on day 1 and 3. Two weeks after STZ administration, behavioral parameters were monitored using Morris water maze task. Biochem. and histopathol. studies were carried out after three weeks of STZ administration. The levels of oxidative stress markers (malondialdehyde (MDA), glutathione, nitrite, catalase) neuroinflammatory mediators; tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) and acetylcholinesterase (AChE) activity were estimated in hippocampus of rat brain. Donepezil (5 mg/kg) was taken as a standard drug. The levels of MDA, nitrite, TNF-a and IL-6 were significantly increased while glutathione levels were significantly decreased in hippocampus of STZ-treated rats. Further, a significant decrease in the activity of catalase and increase in AChE activity was observed indicating cholinergic hypofunction and neuronal damage in STZ-treated animals. All these alterations were significantly ameliorated by AME in a dose dependent manner. The neuroprotective potential of A. marmelos against STZ induced oxidative stress and cognitive deficit in rats indicates its therapeutic value in Alzheimer’s disease (AD). The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to aegle leaf aegeline neuroprotectant oxidative stress, a. marmelos, alzheimer’s disease, memory impairment, oxidative stress, streptozotocin, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Name: N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 20, 2012, Bhupatbhai, Bagatharia Snehal; Kamleshkumar, Joshi Chinmayi; Mahavirsaran, Saxena Akshaykumar published a patent.Recommanded Product: 456-12-2 The title of the patent was A compound Aegeline inhibiting acetylcholinesterase and a method of screening/identifying the same. And the patent contained the following:

The present invention discloses a compound Aegeline inhibiting acetylcholinesterase using a method of screening/identifying the same for treatment of CNS disorders. The structure of Aegeline is developed with the help of a computer application MDL ISIS Draw. The crystal structure of the acetylcholinesterase is retrieved from the Research Collaborator for Structural Bioinformatics (RSCB) Protein Data Bank (PDB) and prepared by energy minimization, assigning bond orders and optimization of the structure. The screening method utilizes the 3D structure of the target protein acetylcholinesterase binding site to prioritize compounds (ligands) by their likelihood to bind to the said protein. The actual free energy is referred as a score and the highest score denotes more preferable compound for acetylcholinesterase. In comparison with the conventional drugs, at the binding site of acetylcholinesterase, Aegeline proves be more effective and can help in the treatment of memory-related disorders. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Recommanded Product: 456-12-2

The Article related to aegeline acetylcholinesterase inhibitor screening cns disorder treatment, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Recommanded Product: 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 26, 2021, Singh, Amrit Pal; Singh, Lovedeep; Singh, Palwinder; Bhatti, Rajbir published an article.Product Details of 456-12-2 The title of the article was Biological Evaluation of Aegle marmelos Fruit Extract and Isolated Aegeline in Alleviating Pain-Depression Dyad: In Silico Analysis of Aegeline on MAO-A and iNOS. And the article contained the following:

Pain and depression have been assessed to co-occur in up to 80% of patients, and this comorbidity is more debilitating and pricier for the patients as compared to either of these disorders alone. Aegle marmelos is a well-known medicinal plant with a broad spectrum of pharmacol. activities. Aegeline is a relatively unexplored mol. present in Aegle marmelos. Therefore, the current investigation aims to explore the potential of Aegle marmelos fruit extract (AMFE) and isolated aegeline against the reserpine-induced pain-depression dyad. In the current investigation, aegeline was isolated from AMFE, followed by spectroscopic characterization, i.e., using NMR and mass analyses. AMFE (200 mg kg-1 p.o) and aegeline (10 mg kg-1 p.o.) were administered to reserpinized (0.5 mg kg-1 s.c.) mice, and clorgyline (3 mg kg-1 i.p.) was taken as the standard drug. AMFE and aegeline significantly alleviated the reserpine-induced reduction in a pain threshold and an increase in immobility as observed in behavioral tests of pain and depression, resp. In silico mol. docking studies of aegeline showed a good binding interaction at the active sites of MAO-A and iNOS. The in vivo anal. showed that AMFE and aegeline treatment significantly decreased the monoamine oxidase-A (MAO-A) activity, serum interleukin-6 (IL-6) level, and lipid peroxidation, along with an increase in the reduced glutathione level in comparison to the reserpine-treated group. Immunofluorescence studies also showed that AMFE and aegeline abrogated the reserpine-induced increase in iNOS expression. Conclusively, the results delineate that AMFE and aegeline might exert a protective effect via downregulating the MAO-A hyperactivity, IL-6 level, oxidative and nitrosative stress. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Product Details of 456-12-2

The Article related to pain depression aegle marmelos aegeline amfe docking inos maoa, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Product Details of 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ma, Haowen; Feng, Jiajie; Zhou, Wei; Chen, Chen; Deng, Zhuoji; Zhou, Fengtao; Ouyang, Yifan; Zhang, Xinhao; Cai, Qian published an article in 2021, the title of the article was Copper(I)-catalyzed asymmetric intramolecular C-arylation with ureas as the additives: highly enantioselective formation of spirooxindoles.Application of 102-07-8 And the article contains the following content:

An enantioselective synthesis of spirooxindoles I [Y = CH2, O, NMe; R = Me, allyl, Bn, etc.; R1 = H, 5-F, 6-Me, etc.] via copper-catalyzed asym. intramol. C-arylation reaction with ureas as the co-catalysts was developed. By formation of hydrogen bonds with 1,3-dicarbonyl structures, ureas could activate the substrates, stabilize the carbanion intermediates and the products, and fix the syn-configurations of 1,3-dicarbonyl structures. They help enhance the reactivity, prevent side reactions and improve the enantioselectivities. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application of 102-07-8

The Article related to spirooxindole enantioselective preparation, cyclic beta ketoamide preparation copper catalyst ullmann hurtley arylation, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Application of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 15, 2022, Muranaka, Ryo; Liu, Yue; Okada, Itsuumi; Okazoe, Takashi; Tsuda, Akihiko published an article.Quality Control of 1,3-Diphenylurea The title of the article was Photo-on-Demand Phosgenation Reactions with Chloroform for Selective Syntheses of N-Substituted Ureas and Isocyanates. And the article contained the following:

Two new reaction processes involving the in situ oxidative photochem. conversion of CHCl3 to COCl2 allowed selective syntheses of N-substituted ureas and isocyanates from amines. (I) A CHCl3 solution containing an amine and an organic base under O2 bubbling provided the urea derivative under exposure to UV light generated from a low-pressure mercury lamp at 20-40°C. (II) A two-step reaction involving the oxidative photodecomposition of CHCl3 at lower temperatures and subsequent sequential injections of an amine and organic base into the sample solution provided the isocyanate in high yield. The reaction processes of (I) and (II) capitalize on the solution conditions of [COCl2] < [amine] and [COCl2] > [amine], resp., to result in 1:2 and 1:1 reactions. In general, isocyanates, especially aromatic and haloalkyl ones, readily undergo hydrolysis in the presence of an organic base. However, with the advantage of synthesizing the isocyanates in CHCl3 solvent, direct addition of monoalcs. and diols to the as-prepared sample solution containing the diisocyanate allowed the one-pot syntheses of biscarbamates and polyurethanes, resp. The reactions developed in this study are simple, safe, and inexpensive methods of synthesizing N-substituted ureas and isocyanates, and derivatives of isocyanates such as carbamates and polyurethanes. The present new methods can replace current synthetic methods using COCl2 in both academia and industry. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Quality Control of 1,3-Diphenylurea

The Article related to substituted urea isocyanate preparation, chloroform amine phosgenation oxidative photochem, Aliphatic Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Quality Control of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 19, 2012, Pace, Vittorio; Holzer, Wolfgang published an article.Related Products of 5455-98-1 The title of the article was A straightforward and general access to α-phthalimido-α’-substituted propan-2-ones. And the article contained the following:

The regioselective ring opening of the com. available N-(2,3-epoxypropyl)phthalimide with different nucleophiles, to obtain the corresponding phthalimidopropan-2-ols (including a challenging fluorohydrin) followed by the Dess-Martin periodinane oxidation, constitutes a general and widely applicable protocol for the preparation of differently functionalized α-phthalimido-α’-substituted propan-2-ones I [R = Cl, Br, F, etc.]. The incorporation of the substituent in the α’ position takes place in an early stage of the process, thus furnishing a divergent and valuable approach. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Related Products of 5455-98-1

The Article related to regioselective ring opening epoxypropylphthalimide, phthalimidopropanol preparation dess martin oxidation, phthalimidopropanone preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics