Tag: 200-300

Low-temperature bleaching of cotton induced by glucose oxidase enzymes and hydrogen peroxide activators was written by Tavccer, Petra Forte. And the article was included in Biocatalysis and Biotransformation in 2012.Computed Properties of C10H16N2O4 This article mentions the following:

Glucose oxidase enzymes were used to produce hydrogen peroxide from glucose and oxygen in aqueous solutions Different working conditions, i.e., temperature, aeration with liquefied air, presence of cotton fiber and time of enzyme activity, were tested in order to obtain a solution with the highest possible concentration of hydrogen peroxide. The hydrogen peroxide produced was transformed into different peracids which could bleach the cotton fabric under mild conditions, at a pH between 7 and 8 and at a temperature of around 60°C. The conversion or activation of hydrogen peroxide was conducted with the bleach activators TAED, NOBS and TBBC. The concentrations of hydrogen peroxide and peracids in the solutions were measured with sodium thiosulfate titrations The results indicated that the formation of hydrogen peroxide with glucose oxidase was effective under optimal conditions, which are 50°C, pH 4.6 and aeration. Convenient activators for the conversion of hydrogen peroxide into peracids were TAED and TBBC, which enabled attainment of a relatively high degree of whiteness at pH 7.5 and temperature 50°C. Using the activator NOBS under these conditions did not provide enough peracid to markedly improve whiteness. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Computed Properties of C10H16N2O4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Computed Properties of C10H16N2O4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Deep Eutectic Solvent Mediated Carbonylation of Amines and Alcohols by Using Dimethyl Carbonate: Selective Symmetrical Urea and Organic Carbonate Synthesis was written by Karimi, Farzaneh;Shariatipour, Monire;Heydari, Akbar. And the article was included in ChemistrySelect in 2021.HPLC of Formula: 2387-23-7 This article mentions the following:

This work presented one-pot synthesis of sym. organic carbonates and ureas by employing cheap and biodegradable deep eutectic solvent as the catalyst and reaction media. The effect of different reaction parameters such as temperature, DMC/amines and alcs. ratio and reaction time were investigated on the reaction efficiency. This new protocol provided a simple, fast, and sustainable approach and proceeded with high efficiency with aliphatic and aromatic amines and alcs. as well. Finally, applicability of this methodol. was also examined for reaction of nucleophiles such as Ph hydrazine and Ph glycine with di-Me carbonate. Interestingly, it was found that this reaction system obtained good yields of product for both of them. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7HPLC of Formula: 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.HPLC of Formula: 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Actual contamination of the Danube and Sava Rivers at Belgrade (2013) was written by Antonijevic, Milan D.;Arsovic, Marija;Caslavsky, Josef;Cvetkovic, Vesna;Dabic, Predrag;Franko, Mladen;Ilic, Gordana;Ivanovic, Milena;Ivanovic, Nevena;Kosovac, Milica;Medic, Dragana;Najdanovic, Slobodan;Nikolic, Milica;Novakovic, Jovana;Radovanovic, Tatjana;Ranic, Durdina;Sajatovic, Dojan;Spijunovic, Gorica;Stankov, Ivana;Tosovic, Jelena;Trebse, Polonca;Vasiljevic, Olivera;Schwarzbauer, Jan. And the article was included in Journal of the Serbian Chemical Society in 2014.Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) This article mentions the following:

This study was focussed on a comprehensive investigation on the state of pollution of the Danube and Sava Rivers in the region of Belgrade. Different complementary anal. approaches were employed covering both i) organic contaminants in the river water by target analyses of hormones and neonicotinoids as well as non-target screening analyses and ii) heavy metals in the sediments. Finally, some common water quality parameters were analyzed. The overall state of pollution is on a moderate level. Bulk parameters did not reveal any unusual observations. Moreover, quantification of preselected organic contaminants did not indicate to elevated pollution. More significant contaminations were registered for chromium, nickel, zinc and partially copper in sediments with values above the target values according to Serbian regulations. Lastly, non-target screening anal. revealed a wider spectrum of organic contaminants comprising pharmaceuticals, tech. additives, personal care products and pesticides. The study presented a comprehensive view on the state of pollution of the Sava and Danube Rivers and is the base for setting up further monitoring programs. As a superior outcome, it was illustrated how different chem. analyses can result in different assessments of the river quality. A comparison of target and non-target analyses pointed to potential misinter-pretation of the real state of pollution. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Application In Synthesis of N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide)

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Buildup of Redox-Responsive Hybrid from Polyoxometalate and Redox-Active Conducting Oligomer: Its Self-Assemblies with Controllable Morphologies was written by She, Shan;Huang, Zehuan;Yin, Panchao;Bayaguud, Aruuhan;Jia, Hongli;Huang, Yichao;Wei, Yen;Wei, Yongge. And the article was included in Chemistry – A European Journal in 2017.Related Products of 2387-23-7 This article mentions the following:

A redox-responsive hybrid of polyoxometalate and conducting oligomer including its self-assemblies with controllable morphologies are reported. To this end, a hybrid mol., containing a Lindqvist hexamolybdate as the polar head group and N,N’-bis(4′-amino-2,6-dimethylphenyl)-1,4-quinonediimine as the redox-responsive and aggregating group, was prepared This hybrid exhibits redox-responsive behavior with controllable assembling morphol. transition from spherical vesicles to short cylindrical vesicles. Besides, the hybrid-based self-assemblies are transferred to the surface, thus the surface wettability can be well-tuned owing to the morphol. transitions of the self-assemblies. By marrying conducting materials with polyoxometalate chem., this research opens a new horizon of polyoxometalate-based self-assembled systems with potential applications in functional materials. In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Related Products of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Related Products of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Experimental evaluation of the effect of particle properties on the segregation of ternary powder mixtures was written by Asachi, Maryam;Hassanpour, Ali;Ghadiri, Mojtaba;Bayly, Andrew. And the article was included in Powder Technology in 2018.Application of 10543-57-4 This article mentions the following:

Segregation of components, especially the low content level of a highly active substance, has serious deleterious effects on powder formulation. This study investigates the effect of particle properties, particularly size, shape, d. and cohesion, on the segregation of laundry detergent powders. Tetraacetylethylenediamine (TAED) particles, spray-dried synthetic detergent powder referred to as Blown Powder (BP) and Enzyme Placebo Granules (EP granules) are used as a model formulation. The segregation of components is evaluated using image processing of the photog. records taken from the front face of a two-dimensional heap of powders. Coefficient of variation concept is considered as segregation index. It is shown that EP granules, the component used as low-level ingredient (< 2 wt%) in the ternary mixture, are prone to extensive segregation due to their higher d. as compared to BP and TAED particles. Desired properties for segregation minimisation of EP granules have been further investigated. It is found that the segregation of EP granules can be reduced noticeably by applying a thin layer of a sticky liquid on them before mixing with the rest of powders with full particle size distribution of the components. Polyethylene glycol has been used for this purpose. Addition of 2.5 wt% gives an optimum level to reduce the segregation of EP granules without compromising the flowability of the mixture as well as EP granules themselves. In the experiment, the researchers used many compounds, for example, N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4Application of 10543-57-4).

N,N-(Ethane-1,2-diyl)bis(N-acetylacetamide) (cas: 10543-57-4) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Application of 10543-57-4

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

HFIP Mediates a Direct C-C Coupling between Michael Acceptors and Eschenmoser’s salt was written by Lemmerer, Miran;Riomet, Margaux;Meyrelles, Ricardo;Maryasin, Boris;Gonzalez, Leticia;Maulide, Nuno. And the article was included in Angewandte Chemie, International Edition in 2022.HPLC of Formula: 116332-61-7 This article mentions the following:

A direct C-C coupling process that merges Michael acceptors and Eschenmoser’s salt was presented. Although reminiscent of the Morita-Baylis-Hillman reaction, this process requires no Lewis base catalyst. The underlying mechanism was unveiled by a combination of kinetic, isotopic labeling experiments as well as computational investigations, which showcased the critical role of HFIP as a superior mediator for proton-transfer events as well as the decisive role of the halide counterion. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7HPLC of Formula: 116332-61-7).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.HPLC of Formula: 116332-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Copper-catalyzed and additive free decarboxylative trifluoromethylation of aromatic and heteroaromatic iodides was written by Johansen, Martin B.;Lindhardt, Anders T.. And the article was included in Organic & Biomolecular Chemistry in 2020.Category: amides-buliding-blocks This article mentions the following:

A copper-catalyzed decarboxylative trifluoromethylation of (hetero)aromatic iodides RI (R = 4-cyanophenyl, naphthalen-1-yl, 1-benzyl-1H-pyrazol-4-yl, etc.) has been developed. Importantly, this new copper-catalyzed reaction operates in the absence of any ligands and metal additives. The protocol shows good functional group tolerance and is compatible with heteroaromatic systems. The reaction proved scalable to a 15 mmol scale with increased yield. Finally, late-stage installation of the trifluoromethyl functionality afforded the 2,2,2-trifluoro-N-(3-(4-iodophenoxy)-3-phenylpropyl)-N-methylacetamide variant of the antidepressant agent, Prozac, demonstrating the applicability of the developed method. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Category: amides-buliding-blocks).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

N-Arylsulfonylquinone imines was written by Burmistrov, S. I.;Titov, E. A.. And the article was included in Zhurnal Obshchei Khimii in 1952.Formula: C13H13NO3S This article mentions the following:

N-Arylsulfonyl-p-quinone imines, derivatives of p-quinone, liberated iodine quantitatively from acid KI solutions; they form indophenols with PhOH and 1-C₁₀H₇OH; the arylsulfonyl group is cleaved as an anion of arylsulfinic acid. To 64.2 g. p-HOC₆H₄NH₂.HCl, 84.8 g. Na₂CO₃, and 400 ml. H₂O was added 76.2 g. p-MeC₆H₄SO₂Cl, and the mixture heated on a steam bath 2.5 hrs., then cooled, yielding 103 g. p-(p-tolylsulfonamido)phenol, m. 144.5° (from H₂O). This (10 g.) added at room temperature to 5.7 g. K₂Cr₂O₇.2H₂O in 175 ml. 20% H₂SO₄ and stirred 50 min., then dilute with H₂O, yielded a precipitate which was washed with H₂O and EtOH to remove unreacted material; crystallization of the product in small portions from EtOH gave 79-84% N-(p-tolylsulfonyl)-p-quinoneimine (I), m. 126.5°, orange-yellow, giving a blue color with PhOH and a violet color with 1-naphthol in ammoniacal solution Heating with 20% H₂SO₄ gives p-quinone. The imine can be also prepared by oxidation with CrO₃ in AcOH, but PbO₂ gave very low yields. The use of PhSO₂Cl in the above sequence gave pink p-(phenylsulfonamido)phenol, m. 155°; this oxidized as above, gave yellow 70% N-(phenylsulfonyl)-p-quinone imine, m. 137°. Similarly was prepared N-(p-tolylsulfonamido)-1-naphthol, m. 183° (from xylene), which oxidized to the corresponding naphthoquinone imine, m. 156°, in contrast to the 1st 2 analogs, does not liberate iodine quantitatively from KI nor does it give blue color with PhOH in NH₄OH solution, but does give a blue color with 1-naphthol. Shaking 4.36 g. I with 2.4 g. PhOH in NH₄OH, followed by filtration after the color is stabilized, and neutralization of the solution with AcOH gave red-brown indophenol, p-OC₆H₄:NC₆H₄OH, m. 160°; evaporation of the aqueous solution gave p-C₆H₄SO₂H, m. 85°. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Formula: C13H13NO3S).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Formula: C13H13NO3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

A selenium-catalysed para-amination of phenols was written by Yan, Dingyuan;Wang, Guoqiang;Xiong, Feng;Sun, Wei-Yin;Shi, Zhuangzhi;Lu, Yi;Li, Shuhua;Zhao, Jing. And the article was included in Nature Communications in 2018.Recommanded Product: 1146-43-6 This article mentions the following:

Se-catalyzed para-amination of phenols was reported while, in contrast, the reactions with sulfur donors were stoichiometric. A catalytic amount of phenylselenyl bromide smoothly converts N-aryloxyacetamides to N-acetyl p-aminophenols. When the para position was substituted (for example, with tyrosine), the dearomatization occurred and 4,4-disubstituted cyclodienone products were obtained. A combination of exptl. and computational studies was conducted and suggested the weaker Se-N bond plays a key role in the completion of the catalytic cycle. Our method extends the selenium-catalyzed processes to the functionalization of aromatic compounds Finally, the mild nature of the para-amination reaction was demonstrated by generating an AIEgen 2-(2′-hydroxyphenyl)benzothiazole (HBT) product in a fluorogenic fashion in a PBS buffer. In the experiment, the researchers used many compounds, for example, N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6Recommanded Product: 1146-43-6).

N-(4-Hydroxyphenyl)-4-methylbenzenesulfonamide (cas: 1146-43-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Recommanded Product: 1146-43-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Investigation of drug delivery in rats via subcutaneous injection: Case study of pharmacokinetic modeling of suspension formulations was written by Chiang, Po-Chang;Nagapudi, Karthik;Fan, Peter W.;Liu, Jia. And the article was included in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2019.Related Products of 2387-23-7 This article mentions the following:

With the rising cost of drug research, “do more with less” has become a new emphasis in the pharmaceutical industry. Consequently, the early anal. of pharmacokinetic/pharmacodynamic, efficacy, and safety parameters for a new drug target is critical for ensuring informed decision-making as soon as possible during the drug discovery process. When absorption, distribution, metabolism, and excretion properties of compounds are suboptimal which is especially true during the early stages of drug discovery, obtaining the desired exposure can be challenging via the most common routes (oral, i.v.). Therefore, s.c. (SC) injection is often explored as an alternate route of delivery. Although SC injection is used widely in the industry, information about how to model and predict the absorption of drugs administered via SC injection is not readily available. In the current research, we analyzed the absorption behavior of 12 model compounds covering a wide range of physicochem. properties following SC injection. We introduced a compound-specific parameter, the absorption factor from single SC injections of suspension doses of each compound, to aid in modeling and predicting of drug absorption profiles. The pharmacokinetic models derived in this study are capable of describing and predicting the absorption properties of SC injection for individual compounds In the experiment, the researchers used many compounds, for example, 1,3-Dicyclohexylurea (cas: 2387-23-7Related Products of 2387-23-7).

1,3-Dicyclohexylurea (cas: 2387-23-7) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Related Products of 2387-23-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics