Tag: 200-300

Somanathan, Ratnasamy; Aguilar, Hugo R.; Ventura, G. Rodriguez; Smith, Kevin M. published an article in 1983, the title of the article was Syntheses of natural hydroxyamides using trimethylsilyl cyanide.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide And the article contains the following content:

Addition of Me3SiCN to p-anisaldehyde gave 64% p-MeOC6H4CH(CN)OSiMe3, which was reduced to give p-MeOC6H4CH(OH)CH2NH2 (I). Acylation of I with RCOCl gave 77-92% tembamide (I, R = Ph), aegeline (I, R = styryl), and I [R = 3-pyridyl, Me(CH2)7]. The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

The Article related to silyl cyanide synthetic reagent, hydroxyamide naturally occurring, amide hydroxy naturally occurring, tembamide aegeline, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Application In Synthesis of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 16, 1980, Swinehart, Jacquelyn A.; Stermitz, Frank R. published an article.HPLC of Formula: 456-12-2 The title of the article was Constituents of Zanthoxylum. Part 4. Bishordeninyl terpene alkaloids and other constituents of Zanthoxylum culantrillo and Z. coriaceum. And the article contained the following:

Thin-layer chromatog. and NMR, UV, and mass spectrometry revealed the new alkaloid, culantraramine (I), in Z. culantrillo stems, together with (+)-eudesmin, (-)-epieudesmin, hordenine, (-)-N-methyliscorydine, magnoflorine, candicine, skimmianine, synephrine, tembetarine, and a dihydroxydimethoxytetrahydroprotoberberine. Isolated from Z. coriaceum were (-)-N-methylisocorydine, dihydrochelerythrine, chelerythrine, N-methylcanadine, (±)-aegeline, and (±)-alfileramine (II). The experimental process involved the reaction of N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide(cas: 456-12-2).HPLC of Formula: 456-12-2

The Article related to zanthoxylum bishordeninyl terpene alkaloid structure, culantraramine zanthoxylum structure, Alkaloids: Alkaloids Containing Two Nitrogen Atoms In A Simple Combination Of Those Found In Subsections 2, 3, and 4 and other aspects.HPLC of Formula: 456-12-2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 10, 2019, Liu, Kai; Li, Nian; Ning, Yunyun; Zhu, Chengjian; Xie, Jin published an article.Recommanded Product: 97-09-6 The title of the article was Gold-Catalyzed Oxidative Biaryl Cross-Coupling of Organometallics. And the article contained the following:

A general dimeric gold-catalyzed oxidative cross-coupling of arylboronates ArB(-OCH2C(CH3)2CH2O-) (Ar = 3-methoxyphenyl, naphthalen-2-yl, 8-thiatricyclo[7.4.0.0(2,7)]trideca-1(13),2(7),3,5,9,11-hexaen-6-yl, etc.) and arylsilanes Ar1Si(CH3)3 (Ar1 = 4-iodophenyl, 4-(trifluoromethanesulfonyloxy)phenyl, 2,3-dimethylphenyl, etc.) without an external base for the synthesis, with excellent functional-group tolerance of asym. biaryls ArAr1 was reported. Both coupling partners are readily available, bench-stable, and non-toxic. A broad array of (pseudo)halogenated and borylated coupling partners can be successfully applied to this site-specific biaryl coupling with unprecedented versatility. Its synthetic value has been substantiated by concise preparation of several π-conjugated organic materials and pharmacophores. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Recommanded Product: 97-09-6

The Article related to biaryl preparation green chem, boronate aryl silane oxidative suzuki miyaura gold catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Recommanded Product: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 29, 1980, Elliott, Arthur J.; Gibson, Martin S. published an article.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide The title of the article was Hydrazides and thiohydrazides as sources of condensed oxadiazines and thiadiazines, including novel azo derivatives based on dithizone. And the article contained the following:

Condensation reactions of N’-phenylbenzohydrazide, N’-phenylbenzothiohydrazide, and dithizone with a variety of activated aromatic and heteroaromatic 1,2-dihalo and 1-halo-2-nitro compounds are described in which the hydrazide or thiohydrazide functions as a bidentate nucleophile. These reactions lead to derivatives of the 4H-1,3,4-benzoxadiazines e.g. I, and 4H-1,3,4-benzothiadiazines and analogous pyrimido-, pyrazino-, and quinoxalinooxadiazines and -thiadiazines, which are representative of new ring systems. The corresponding reaction of N’-phenylbenzothiohydrazide with chloranil proceeds with expulsion of S. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to cyclocondensation hydrazide thiohydrazide, oxadiazine condensed, thiadiazine condensed, benzoxadiazine, benzothiadiazine, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Three, Four, Or Five Hetero Atoms and other aspects.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 28, 2021, Przybylek, Maciej; Walczak, Patrycja; Ziolkowska, Dorota; Grela, Izabela; Cysewski, Piotr published an article.Product Details of 144-80-9 The title of the article was Studies on the solid-liquid equilibria and intermolecular interactions Urea binary mixtures with Sulfanilamide and Sulfacetamide. And the article contained the following:

The binary phase diagrams of Sulfanilamide-Urea (SN-U) and Sulfacetamide-Urea (SC-U) were measured using differential scanning calorimetry technique (DSC). Both examined mixtures were found to form simple binary eutectics. The limited miscibility in the solid state observed by DSC, proving inability of co-crystallization in new multi-mol. form, was also confirmed using PXRD and FTIR-ATR measurements of solid dispersions obtained via liquid assisted co-grinding. The lack of intermol. complex formation in the crystals does not imply the lack of interactions in the liquid state. Detailed characteristics of potential homo- and hetero-mol. pairs were offered using ab initio and the first principle quantum chem. computations. The obtained results happened to be strongly dependent on the applied level of theory. The importance of including the zero point energy contributions and electron correlation corrections was emphasized. It was found that the mole fraction of hetero-complexes with urea is the highest among all other constituents of studied systems at their eutectic points. Finally, the importance of intermol. interaction leading to complexes formation in the liquid state at saturated position was documented by computed values of solvation Gibbs free energy. Based on computed trends it was inferred that the eutectic mixtures can be interpreted as such equilibrium for which mutual solvation of all components is maximized. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Product Details of 144-80-9

The Article related to sulfanilamide sulfacetamide urea solid liquid equilibrium intermol interaction, Thermodynamics, Thermochemistry, and Thermal Properties: Calorimetry, Thermal Analysis, Thermogravimetry and other aspects.Product Details of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 27, 2022, Chen, Yantao; Kollback, Johanna; Aurell, Carl-Johan published an article.COA of Formula: C13H12N2O The title of the article was An Improved Synthesis of 1λ;6,2,4,6-Thiatriazine-1,3,5-trione Derivatives – the Sulfonimidamide-featured Triazinones. And the article contained the following:

N,N’-dicarbamoylation of 4-methylbenzenesulfonimidamide with carbonyldiimidazole, followed by a mono-nucleophilic substitution with amines and subsequential ring closure in one-pot, afforded 1λ6,2,4,6-thiatriazine-1,3,5-trione derivatives I [R = cyclohexyl, Ph, 3-pyridyl, etc.] in up to 83% yields. The protocol also worked well for aliphatic sulfonimidamides, such as Me sulfonimidamide. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).COA of Formula: C13H12N2O

The Article related to thiatriazine dione derivative preparation, amine thiatriazine dione oxide tandem diacylation nucleophilic substitution cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Three Or More Hetero Atoms and other aspects.COA of Formula: C13H12N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 30, 2015, Huang, Min-yi; Xu, Wei; Huang, Jun-jun; Huang, Ya-jian; Yuan, Mu published an article.Formula: C11H9NO3 The title of the article was Synthesis, crystal structure and biological activity of N-(2-hydroxy-3-(4-(2-methoxyphenyl)-piperazin-1-yl)propyl)quinoxaline-2-methanamide. And the article contained the following:

The title compound N-(2-hydroxy-3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)-quinoxaline-2-methanamide (I, C23H27N5O3, Mr = 421.50) was synthesized via a four-step reaction and characterized by 1H NMR, 13C NMR, ESIMS and single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/n with a = 12.108(2), b = 12.639(3), c = 14.601(3) Å, β = 104.87(3)°, V = 2,159.6(8) Å3, Z = 4, Dc = 1.296 g/cm3, S = 1.023, μ = 0.088 mm-1, F(000) = 896, R = 0.0392 and wR = 0.0983 for 2,836 observed reflections with I>2σ (I). The single-crystal X-ray structural anal. reveals that I is stabilized by intramol. and intermol. hydrogen bonds together with π-π interactions. The bioassay showed that I exhibited high selective activity for α1A/D vs. α1B-adrenoceptors subtype. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Formula: C11H9NO3

The Article related to methoxyphenylpiperazinylpropyl quinoxalinecarboxamide preparation adrenoceptor antagonistic activity crystal mol structure, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Formula: C11H9NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2021, Zeng, Honglan; Du, Hongyan; Gong, Xu; Zhang, Jie; Han, Wei published an article.Related Products of 102-07-8 The title of the article was Palladium-Catalyzed Aerobic Oxidative Carbonylation of Amines Enables the Synthesis of Unsymmetrical N,N’-Disubstituted Ureas. And the article contained the following:

A ligand-free palladium-catalyzed aerobic oxidative carbonylation of amines for the synthesis of ureas, particular unsym. N,N’-disubstituted ureas, which cannot be accessed by any other palladium-catalyzed oxidative carbonylation of amines to date, is presented. An array of sym. and unsym. ureas were straightforwardly synthesized by using inexpensive, readily available, stable, and safe amines with good to excellent yields under a pressure of 1 atm. This novel method employs oxygen as the sole oxidant and offers an attractive alternative to transition-metal-based oxidant systems. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Related Products of 102-07-8

The Article related to unsym disubstituted urea preparation, amine aerobic oxidative carbonylation palladium catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Related Products of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Li, Jian; He, Wang; Lei, Pan; Song, Jiacheng; Huo, Jiyou; Wei, Hongbo; Bai, Hongjin; Xie, Weiqing published an article in 2021, the title of the article was 2,2,2-Trifluroenthanol promoted synthesis of unsymmetrical ureas from dioxazolones and amines via tandem Lossen rearrangement/condensation process.Computed Properties of 102-07-8 And the article contains the following content:

A 2,2,2-trifluroenthanol (TFE) promoted synthesis of unsym. ureas was described. This approach enabled the construction of a variety of ureas from the readily prepared and easy-to-handle dioxazolones and amines via tandem Lossen rearrangement/condensation process. The reaction featured mild conditions for the urea synthesis under metal-free conditions, which was successively applied in the scale-up synthesis of herbicides monuro and isoproturon. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Computed Properties of 102-07-8

The Article related to unsym urea preparation, dioxazolone amine tandem lossen rearrangement condensation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Computed Properties of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ahmed, Riyaz; Gupta, Ria; Akhter, Zaheen; Kumar, Mukesh; Singh, Parvinder Pal published an article in 2022, the title of the article was TCT-mediated click chemistry for the synthesis of nitrogen-containing functionalities: conversion of carboxylic acids to carbamides, carbamates, carbamothioates, amides and amines.Category: amides-buliding-blocks And the article contains the following content:

Reported a s-trichlorotriazine (TCT, also known as cyanuric chloride) mediated one-pot general method for the conversion of carboxylic acids into ubiquitous functionalities such as carbamides, carbamates, carbamothioates, amides and amines. The TCT-mediated activation of acids followed by azidation and heating led to the isocyanate formation via Curtius rearrangement which involved click chem. in the presence of nucleophiles and provided the coupled product. The TCT were employed at ≤40 mol% with respect to the starting materials; however, its bulk availability and low cost provide a unique opportunity towards its applicability in the synthesis of functional mols. The optimized conditions was successfully demonstrated for gram scale synthesis and late-stage functionalization of natural products and drugs such as podophyllotoxin, eugenol, diosgenin, geraniol and fluvoxamine. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Category: amides-buliding-blocks

The Article related to benzoic acid amine cyanuric chloride azidation click chem, phenylurea preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics