Tag: 200-300

On August 5, 2021, Hain, Ethan; Adejumo, Hollie; Anger, Bridget; Orenstein, Joseph; Blaney, Lee published an article.HPLC of Formula: 144-80-9 The title of the article was Advances in antimicrobial activity analysis of fluoroquinolone, macrolide, sulfonamide, and tetracycline antibiotics for environmental applications through improved bacteria selection. And the article contained the following:

The widespread use of antibiotics has led to their ubiquitous presence in water and wastewater and raised concerns about antimicrobial resistance. Clin. antibiotic susceptibility assays have been repurposed to measure removal of antimicrobial activity during water and wastewater treatment processes. The corresponding protocols have mainly employed growth inhibition of Escherichia coli. The present work focused on optimizing bacteria selection to improve the sensitivity of residual antimicrobial activity measurements by broth microdilution assays. Thirteen antibiotics from four classes (i.e., fluoroquinolones, macrolides, sulfonamides, tetracyclines) were investigated against three gram-neg. organisms, namely E. coli, Mycoplasma microti, and Pseudomonas fluorescens. The min. inhibitory concentration (MIC) and half-maximal inhibitory concentration (IC50) were calculated for each antibiotic-bacteria pair. P. fluorescens produces a fluorescent siderophore, pyoverdine, that was used to assess sublethal effects and further enhance the sensitivity of antimicrobial activity measurements. The optimal antibiotic-bacteria pairs were as follows: fluoroquinolone-E. coli (growth inhibition); macrolide- and sulfonamide-M. microti (growth inhibition); and, tetracycline-P. fluorescens (pyoverdine inhibition). Compared to E. coli growth inhibition, the sensitivity of antimicrobial activity anal. was improved by up to 728, 19, and 2.7 times for macrolides (tylosin), sulfonamides (sulfamethoxazole), and tetracyclines (chlortetracycline), facilitating application of these bioassays at environmentally-relevant conditions. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).HPLC of Formula: 144-80-9

The Article related to fluoroquinolone macrolide sulfonamide tetracycline antibiotics antimicrobial activity, bioassay, contaminants of emerging concern, half-maximal inhibitory concentration (ic(50)), minimum inhibitory concentration (mic), pharmaceutical and other aspects.HPLC of Formula: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2022, Wang, Yifan; Wang, Linfang; Liu, Ruimin; Li, Lin; Cao, Leiping; Jiao, Lijun; Xia, Xinghui published an article.Product Details of 144-80-9 The title of the article was Source-specific risk apportionment and critical risk source identification of antibiotic resistance in Fenhe River basin, China. And the article contained the following:

A comprehensive understanding of the sources and distribution of antibiotic resistance risk is essential for controlling antibiotic pollution and resistance. Based on surface water samples collected from the Fenhe River basin in the flood season, using the pos. matrix factorization (PMF) model, the risk quotient (RQ) method and the multiple attribute decision making (MADM) method, the resistance risk and source-specific resistance risk of antibiotics were analyzed in this study. The results showed that sulfonamides (SAs) were the dominant antibiotics with a mean concentration of 118.30 ng/L, whereas tetracyclines (TCs) and macrolides (MLs) had the highest detection frequencies (100%). The significant resistance risk rate of antibiotics in the entire river basin was 48%, but no high risk occurred. The significant resistance risk rate of quinolones (QNs) was the highest (100%), followed by that of MLs and TCs. Owing to human activities, the most serious resistance risk occurred in the midstream of the river basin. The resistance risk was the lowest upstream. The antibiotics were mainly contributed by six sources. Pharmaceutical wastewater was the main source, accounting for 30%, followed by livestock discharge (22%). The resistance risk from the six sources showed clear differences, but none of the sources caused a high risk of antibiotic resistance. Pharmaceutical wastewater poses the greatest risk of antibiotic resistance in the Fenhe River basin and is widely distributed. The second greatest source was livestock discharge, which was mainly concentrated in the upstream and midstream areas. The critical sources upstream, midstream, and downstream were all pharmaceutical wastewater, whereas the sequences of other sources were different because different areas were affected by different human activities. The proposed method might provide an important reference for the identification the key source of antibiotics and management of antibiotic pollution, as well as help for the management of antibiotics in Fenhe and Shanxi Province. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Product Details of 144-80-9

The Article related to antibiotic resistance risk apportionment source identification river basin china, antibiotics, critical risk source identification, fenhe river basin, positive matrix factorization, resistance risk, source-specific risk apportionment and other aspects.Product Details of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 15, 2022, Cunat, Alejandro; Alvarez-Ruiz, Rodrigo; Morales Suarez-Varela, Maria M.; Pico, Yolanda published an article.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Suspected-screening assessment of the occurrence of organic compounds in sewage sludge. And the article contained the following:

The profiling of emerging organic pollutants present in sludge and generated during wastewater treatment is much more limited than in water. This is mainly due to the difficulty of sludge anal. because of its high content of organic matter and interfering compounds In this study, a generic extraction method using a mixture of buffered water (pH 4.1) and solid phase extraction (SPE) clean-up was applied to samples of sludge obtained in different treatment plants. This extraction was followed by determination of the contaminants by ultra-high performance liquid chromatog. coupled to high resolution mass spectrometry (UHPLC-HRMS), using suspected screening to detect the most relevant organic compounds that access the environment through sludge application. This screening (including >3000 substances, such as, pharmaceuticals, pesticides, metabolites and industrial chems.) tentatively identified 122 compound and assigned most probable structure to 39. The set of compounds assigned to a probable structure was increased in 14 compounds by searching in a free database of metabolites. Fifteen compounds were unequivocally confirmed against the anal. standard Pharmaceuticals and personal care products (PPCPs), with 31 substances identified and 8 confirmed were the main group of compounds Compounds frequently detected in all sludge samples include nucleotides such as ATP, amino acids such as phenylalanine, or peptides such as leu-phe. Altogether, the results of this work highlight the interest of HRMS to draw the profile of organic compounds in complex matrixes. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to suspected screening assessment occurrence organic compound sewage sludge, contaminants, emerging contaminants, high resolution mass spectrometry (hrms), pharmaceuticals, tentative identification, wastewater treatment plants (wwtp) and other aspects.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 25, 2022, Qaroush, Abdussalam K.; Alsayyed, Ahed W.; Eftaiha, Ala’a F.; Al-Qaisi, Feda’a M.; Salameh, Bader A. published an article.Recommanded Product: 102-07-8 The title of the article was Green Microwave-Assisted Synthesis of Cyclic/Acyclic Ureas from Propylene Carbonate. And the article contained the following:

Herein, an organocatalyzed synthetic pathway for the preparation of acyclic ureas RHNC(O)NHR (R = Bu, sec-Bu, Ph, cyclohexyl, cyclohexylmethyl, benzyl)/cyclic ureas I (n = 1, 2) from their parent primary aliphatic or aromatic monoamines NH2(CH2)nCH2NH2/diamines RNH2 with propylene carbonate as a carbonylating agent obtaining reasonable to very good yields with high selectivity has been described. This method is considered green as nine out of twelve green chem. principles (GCPs) are fulfilled. Most importantly, the absence of solvent and, energy-efficient pathway, in addition to the ease of synthesis and separation, under fast reaction times down to a few minutes together with the straightforward workup with min. use of organic solvents are described. This method was successful in preparing 1,3-diphenylurea from aniline giving 8% yield in 10 min, which was not previously reported using aromatic amines with carbonate esters. The method is applicable for primary rather than secondary amines, which implies high chemoselectivity of the former for the synthesis of urea compounds The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Recommanded Product: 102-07-8

The Article related to acyclic urea preparation green chem microwave chemoselective, primary amine propylene carbonate carbonylation diazabicycloundecene catalyst, cyclic urea preparation green chem microwave chemoselective, diamine primary propylene carbonate carbonylation diazabicycloundecene catalyst and other aspects.Recommanded Product: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On July 31, 2020, Ebrahimi, Amirhossein; Rezazadeh, Mostafa; Khosravi, Hormoz; Rostami, Ali; Al-Harrasi, Ahmed published an article.Application of 5455-98-1 The title of the article was An Aminopyridinium Ionic Liquid: A Simple and Effective Bifunctional Organocatalyst for Carbonate Synthesis from Carbon Dioxide and Epoxides. And the article contained the following:

An aminopyridinium ionic liquid was presented as a green, tunable, and active metal-free one-component catalytic system for the atom-efficient transformation of oxiranes and CO2 to cyclic carbonates. Inclusion of a pos. charged moiety into aminopyridines, through a simple single-step synthesis, provided a one-component ionic liquid catalytic system with superior activity; effective in ring opening of epoxide, CO2 inclusion, and stabilization of oxoanionic intermediates. An efficiency assessment of a variety of pos. charged aminopyridines was pursued, and the impact of temperature, catalyst loading, and the kind of nucleophile on the catalytic performance was also investigated. Under solvent-free conditions, this bifunctional organocatalytic system was used for the preparation of 18 examples of cyclic carbonates from a broad range of alkyl- and aryl-substituted oxiranes and CO2, where up to 98% yield and high selectivity were achieved. DFT calculations validated a mechanism in which nucleophilic ring-opening and CO2 inclusion occur simultaneously towards cyclic carbonate formation. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application of 5455-98-1

The Article related to aminopyridinium ionic liquid organocatalyst preparation green chem, oxirane carbon dioxide aminopyridinium iodide organocatalyst cycloaddition reaction mechanism, dioxolanone preparation, carbon dioxide, hydrogen-bond donors, ionic liquids, organocatalysis, ring-opening reactions and other aspects.Application of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 1, 2022, Wang, Juanqiang; Zhao, Wentao; Guo, Wenping; Li, Yingying; Jiang, Rui; Li, Huichen; Wang, Shouwei; Li, Zhigang published an article.Application of 144-80-9 The title of the article was Simultaneous screening and analysis of 155 veterinary drugs in livestock foods using ultra-high performance liquid chromatography tandem quadrupole linear-ion-trap mass spectrometry. And the article contained the following:

Veterinary drugs are widely used to improve the health and growth of livestock. The supervision of these residues is necessary to ensure food safety. A high-throughput method based on Oasis PRiME HLB with solid phase extraction for simultaneous qual. and quant. anal. of 155 veterinary drugs in livestock foods was developed by the ultra-high performance liquid chromatog. tandem quadrupole linear-ion-trap mass spectrometry (UHPLC-QTRAP-MS). The limits of detection and quantification ranged from 0.5 μg/kg to 5 μg/kg and 2 μg/kg to 20 μg/kg, resp. For over 85% of the analytes, the recoveries were between 60% and 120%. The pos. simulated samples perfectly matched with a purity fit value over 70% from the self-built library. The screening results of UHPLC-QTRAP-MS were almost consistent with UHPLC tandem quadrupole-exactive orbitrap mass spectrometry (UHPLC-Q-Exactive Orbitrap/MS). The evaluated UHPLC-QTRAP-MS method was powerful and reliable for the screening and quantification of veterinary drugs in real samples. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Application of 144-80-9

The Article related to livestock food veterinary drug ultra high performance liquid chromatog, livestock foods, multi-residue analysis, qualitative screening, quantitative analysis, ultra-high performance liquid chromatography tandemquadrupole linear-ion-trap mass spectrometry, veterinary drugs and other aspects.Application of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 28, 2018, Sapegin, Alexander; Kalinin, Stanislav; Angeli, Andrea; Supuran, Claudiu T.; Krasavin, Mikhail published an article.Recommanded Product: 97-09-6 The title of the article was Unprotected primary sulfonamide group facilitates ring-forming cascade en route to polycyclic [1,4]oxazepine-based carbonic anhydrase inhibitors. And the article contained the following:

4-Chloro-3-nitrobenzenesulfonamide reacted cleanly at room-temperature with a range of bis-electrophilic phenols bearing an NH-acidic functionality (secondary carboxamide or pyrazole) in the ortho-position. This produced a novel class of [1,4]oxazepine-based primary sulfonamides which exhibited strong inhibition of therapeutically relevant human carbonic anhydrases. 2-Chloronitrobenzene did not enter a similar cyclocondensation process, even under prolonged heating. Thus, the primary sulfonamide functionality plays a dual role by enabling the [1,4]oxazepine ring construction and acting as a enzyme prosthetic zinc-binding group when the resulting [1,4]oxazepine sulfonamides are employed as carbonic anhydrase inhibitors. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Recommanded Product: 97-09-6

The Article related to oxazepine primary sulfonamide preparation human carbonic anhydrase inhibitor, carbonic anhydrase inhibitors, electron-withdrawing group, isoform-selectivity, nucleophilic aromatic substitution, primary sulfonamide, reactivity-matched substrates, smiles rearrangement and other aspects.Recommanded Product: 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 15, 2020, Parasram, Marvin; Shields, Benjamin J.; Ahmad, Omar; Knauber, Thomas; Doyle, Abigail G. published an article.Recommanded Product: 5455-98-1 The title of the article was Regioselective Cross-Electrophile Coupling of Epoxides and (Hetero)aryl Iodides via Ni/Ti/Photoredox Catalysis. And the article contained the following:

A cross-electrophile coupling reaction of epoxides and (hetero)aryl iodides that operates via the merger of three catalytic cycles involving a Ni-, Ti-, and organic photoredox catalyst has been developed. Three distinct classes of epoxides, styrene oxides, cyclic epoxides, and terminal aliphatic epoxides, underwent coupling in moderate to good yield and high regioselectivity with the use of three different nitrogen-based ligands for Ni under otherwise identical reaction conditions. The mild reaction conditions accommodate a broad scope of abundant and complex coupling partners. Mechanistic studies suggest that when styrene oxides are employed radical intermediates are involved via Ti-radical ring opening of the epoxide. Conversely, for terminal aliphatic epoxides, involvement of an iodohydrin intermediate enables the formation of the unexpected linear product. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Recommanded Product: 5455-98-1

The Article related to arylalkyl alc regioselective preparation, epoxide hetero aryl iodide cross electrophile coupling photoredox catalyst, arylation, cross-electrophile coupling, epoxides, nickel catalysis, photochemistry, photoredox catalysis, radical chemistry, titanium catalysis and other aspects.Recommanded Product: 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cai, Bao-Gui; Li, Qian; Zhang, Qiong; Li, Lei; Xuan, Jun published an article in 2021, the title of the article was Synthesis of trisubstituted hydroxylamines by a visible light-promoted multicomponent reaction.Related Products of 102-07-8 And the article contains the following content:

A green and efficient method for the synthesis of trisubstituted hydroxylamines I [R1 = H, Me, F, etc.; R2 = Me, iPr, tBu, admantyl; R3 = Me, cyclopentyl, methylallyl, etc.; Ar = Ph, 2-naphthyl, 4-MeC6H4, etc.] via three component reaction of β-keto esters, 2-nitrosopyridine and aryldiazoacetates was developed. Also, trisubstituted hydroxylamines II [R4 = H, Me, Br, etc.; R5 = Me, iPr, tBu, admantyl; R6 = Me, cyclopentyl, methylallyl, etc.; Ar1 = Ph, 4-MeOC6H4, 4-ClC6H4, etc.] were developed via multicomponent reaction of β-keto esters, 2-nitrosopyridine, cyclic ethers and aryldiazoacetates. Both reactions were occurred under sole blue LED irradiation in the absence of addnl. catalysts and additives. Two different kinds of trisubstituted hydroxylamines I and II could be easily obtained by simply changing the reaction media used. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Related Products of 102-07-8

The Article related to trisubstituted hydroxylamine green preparation, keto ester nitrosopyridine diazoacetate three component visible light promoted, hydroxylamine trisubstituted green preparation, ester nitrosopyridine diazoacetate cyclic ether multicomponent visible light promoted and other aspects.Related Products of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 1, 2020, Liu, Lulu; Liu, Renshuai; Yang, Xinying; Hou, Xuben; Fang, Hao published an article.Application of 97-09-6 The title of the article was Design, synthesis and biological evaluation of tyrosine derivatives as Mcl-1 inhibitors. And the article contained the following:

The upregulation of the protein myeloid cell leukemia-1 (Mcl-1) is closely associated with various human cancers, which can result in the evasion of apoptosis and a low survival rate. Therefore, developing Mcl-1 inhibitors has become a promising paradigm for cancer therapy. Herein, we designed and synthesized a novel series of tyrosine derivatives, among which compounds (I) (R1 = 3,5-di-Me-4-Cl-Ph, X = H, R2 = OBut, n = 2; R1 = 3,5-di-Me-4-Cl-Ph, X = H, R2 = Ph, n = 1; R1 = naphthyl, X = Br, R2 = 4-Me-benzyl, n = 1) exhibited very high binding affinity to Mcl-1 with Ki values of 0.18, 0.27 and 0.23μM, resp. Interestingly, compound I (R1 = 3,5-di-Me-4-Cl-Ph, X = H, R2 = Ph, n = 1) showed not only potent activity against Mcl-1 but also considerable selectivity over Bcl-2 and Bcl-xL, which was rationalized by mol. docking and fragment-centric topog. mapping (FCTM). It is worth noting that compounds I (R1 = 3,5-di-Me-4-Cl-Ph, X = H, R2 = OBut, n = 2; R1 = 3,5-di-Me-4-Cl-Ph, X = H, R2 = Ph, n = 1; R1 = naphthyl, X = Br, R2 = 4-Me-benzyl, n = 1) displayed potent antiproliferative activity against several cancer cell lines and could induce apoptosis of KM3 and HepG2 cells in a dose-dependent manner. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application of 97-09-6

The Article related to peptidomimetic tyrosine synthesis drug design apoptosis, mol docking mcl1 inhibitor peptidomimetic, tyrosine methyl ester bromoalkane condensation benzenesulfonamide amidation coupling, apoptosis, cancer, mcl-1 inhibitors, tyrosine derivatives and other aspects.Application of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics