Tag: 200-300

On May 22, 2014, Mueller, Thomas Ernst; Guertler, Christoph; Basu, Susmit; Leitner, Walter published a patent.Formula: C11H9NO3 The title of the patent was Production of low and high molecular weight oxazolidinone compounds. And the patent contained the following:

The invention relates to a method for the production of oxazolidinone compounds, comprising the step of slowly reacting an isocyanate compound with an epoxide compound in the presence of a Lewis acid catalyst. The invention further relates to an oxazolidinone compound, obtainable by a method according to the invention, with a color as determined according to ASTM D1209 – 05 (2011) of ≤200 and a molar ratio of the oxazolidinone compound to isocyanurate byproduct o/i of ≥85/15. Lastly, the invention relates to an oligomeric or polymeric oxazolidinone compound, obtainable by a method according to the invention using an isocyanate compound with two or more NCO groups per mol. and an epoxide compound with two or more epoxy groups per mol., comprising at least two units derived from the isocyanate compound and at least two units derived from the epoxide compound, with a color as determined according to ASTM D1209 – 05 (2011) of ≤200. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Formula: C11H9NO3

The Article related to oxazolidinone derivative manufacture epoxide isocyanate reaction lewis acid catalyst, diepoxide diisocyanate copolymer manufacture lewis acid catalyst, discoloration prevention oxazolidinone derivative manufacture lewis acid reaction catalyst and other aspects.Formula: C11H9NO3

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 15, 2015, Mueller, Thomas Ernst; Guertler, Christoph; Basu, Susmit; Leitner, Walter published a patent.Application of 5455-98-1 The title of the patent was Method for the production of oxazolidinone compounds. And the patent contained the following:

The present invention relates to a method for the production of oxazolidinone compounds, comprising the step of slowly reacting an isocyanate compound with an epoxide compound in the presence of a Lewis acid catalyst. The invention further relates to an oxazolidinone compound, obtainable by a method according to the invention, with a color as determined according to ASTM D1209-05 (2011) of ≤200 and a molar ratio of the oxazolidinone compound to isocyanurate byproduct o/i of ≥85/15. Lastly, the invention relates to an oligomeric or polymeric oxazolidinone compound, obtainable by a method according to the invention using an isocyanate compound with two or more NCO groups per mol. and an epoxide compound with two or more epoxy groups per mol., comprising at least two units derived from the isocyanate compound and at least two units derived from the epoxide compound, with a color as determined according to ASTM D1209-05 (2011) of ≤200. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application of 5455-98-1

The Article related to oxazolidinone derivative manufacture epoxide isocyanate reaction lewis acid catalyst, diepoxide diisocyanate copolymer manufacture lewis acid catalyst, discoloration prevention oxazolidinone derivative manufacture lewis acid reaction catalyst and other aspects.Application of 5455-98-1

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 15, 2021, Pinilla Pena, Diana C.; Ruiz Pereyra, Elba N.; Firpo, Guadalupe; Ceballos, Noelia M.; Fueloep, Ferenc; Szakonyi, Zsolt; Iriarte, Ana G.; Pelaez, Walter J. published an article.Electric Literature of 102-07-8 The title of the article was Flash Vacuum Pyrolysis (FVP) of cis-N-phenyl-hexahydro-2H-benzo[d][1,3]oxazin-2-imine and Thiazin-2-imine Derivatives. And the article contained the following:

Cis-N-phenyl-hexahydro-2H-benzo[d][1,3]oxazin-2-imines and cis-N-phenyl-hexahydro-2H-benzo[d][1,3]thiazin-2-imines I (R = H, Me, PhC2; X = O, S) were prepared and subjected to flash vacuum pyrolysis (FVP). N-H- and N-Me tetrahydrobenzoxazines reacted at lower temperatures than N-H and N-Me tetrahydrobenzothiazines, showing lower thermal stabilities, while the N-benzyl tetrahydrobenzothiazine was less stable than the N-benzyl tetrahydrobenzoxazine. Oxazines and thiazines yielded different products through homolytic fragmentations of the heterocycle moiety, the stability of which increased with the N- substitution. Based on the anal. of the reaction temperatures and the unraveling of the obtained products, it is proposed that any heterocyclic ring-opening reactions (initiated by X3-C4, C8a-N1, or C2-X3 bond rupture) require less energy than the retro-Diels-Alder process (RDA) that yields butadiene. This concerted reaction path is only achieved at temperatures higher than 470°C. Kinetic measurements reveal neg. entropies of activation, which suggest a partially concerted way of reaction or slightly asynchronous fragmentation processes, with higher energy of activation (Ea) values for the N-substituted derivatives compared to the unsubstituted ones. Exptl. results agree with calculations at the DFT level (B3LYP/6-311+G(d,p)) and M06-2X (6-311+G(d,p)) from Gaussian09 software. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Electric Literature of 102-07-8

The Article related to hydrobenzoxazinimine hydrobenzothiazinimine preparation flash vacuum photolysis fragmentation, thermal fragmentation mechanism hydrobenzoxazinimine hydrobenzothiazinimine, calculated transition state structure energy thermal fragmentation hydrobenzoxazinimine hydrobenzothiazinimine, dft method difference calculation transition state structure energy fragmentation and other aspects.Electric Literature of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 31, 1991, Shepard, Kenneth L.; Graham, Samuel L.; Hudcosky, Ronald J.; Michelson, Stuart R.; Scholz, Thomas H.; Schwam, Harvey; Smith, Anthony M.; Sondey, John M.; Strohmaier, Kim M. published an article.Name: 3-Nitro-4-chlorobenzenesulfonamide The title of the article was Topically active carbonic anhydrase inhibitors. 4. [(Hydroxyalkyl)sulfonyl]benzene and [(hydroxyalkyl)sulfonyl]thiophenesulfonamides. And the article contained the following:

For several decades a goal for the treatment of primary open-angle glaucoma has been the development of a topically active carbonic anhydrase inhibitor. (Hydroxyalkyl)sulfonyl-substituted benzene- and thiophenesulfonamides I [R = (CH2)nOH, CH2CH(OH)CH2OH, CH2CH2CMe2OH, etc., n = 2-5; R1 = H, Cl, F, NO2, CO2H, CO2Me, NH2; X = S, SO2] and II [R2 = (CH2)nOH, (CH2)mCO2Me, (CH2)3O2CCH2OMe, (CH2)3O2CCH2CHMe2, (CH2)3NHCH2CHMe2, X = S, SO2, n = 2-4, m = 2, 3] were prepared and examined for carbonic anhydrase inhibitory activity. Thus, condensation of 2-mercaptoethanol with (bromophenylsulfonyl)formamidine III gave I [R = (CH2)2OH, R1 = H, X = S]. These compounds exhibit inhibition of carbonic anhydrase II in the nanomolar range and lower intraocular pressure in the α-chymotrypsinized rabbit model of ocular hypertension after topical instillation. The inhibitory potency could be increased by converting a sulfide to the sulfone. Adding an extra methylene into the 4-substituent of benzene derivatives increases the inhibitory potency slightly more than oxidation of the sulfide. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Name: 3-Nitro-4-chlorobenzenesulfonamide

The Article related to hydroxyalkylsulfonylbenzenesulfonamide preparation carbonic anhydrase inhibitor, hydroxyalkylsulfonylthiophenesulfonamide preparation carbonic anhydrase inhibitor, carbonic anhydrase inhibitor hydroxyalkylsulfonylbenzenesulfonamide hydroxyalkylsulfonylthiophenesulfonamide, glaucoma treatment alkylsulfonylbenzenesulfonamide thiophenesulfonamide and other aspects.Name: 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 26, 1998, Potrzebowski, Marek J.; Michalska, Maria; Koziol, Anna E.; Kazmierski, Slawomir; Lis, Tadeusz; Pluskowski, January; Ciesielski, Wlodzimierz published an article.Related Products of 97-09-6 The title of the article was Structural Implications of C-H···S Contacts in Organophosphorus Compounds. Studies of 1,6-Anhydro-2-O-tosyl-4-S-(5,5-dimethyl-2-thioxa-1,3,2-dioxaphosphorinan-2-yl)-β-D-glucopyranose by X-ray and Solid-State NMR Methods. And the article contained the following:

1,6-Anhydro-2-O-tosyl-4-S-(5,5-dimethyl-2-thioxa-1,3,2-dioxaphosphorinan-2-yl)-β-D-glucopyranose (1, C18H25O8PS3), crystallized from polar and/or nonpolar solvents, forms different modifications in the solid phase. Crystal structures of 1 (obtained from a methanol solution) and its 2-propanol solvate (1a) were established by X-ray structure anal. at low temperature One-component crystal 1 is orthorhombic, space group P212121, with a = 7.483(4) Å, b = 11.156 (6) Å, c = 27.11(2) Å, V = 2263 (2) Å3, Z = 4, and Dc = 1.457 g cm-3. The crystal of 1a is an inclusion structure containing mols. of 1 and 2-propanol in the ratio 1/1; crystals are triclinic, space group P1, with a = 9.637(6) Å, b = 9.709(6) Å, c = 8.865(8) Å, α = 110.27(5)°, β = 106.33(5)°, γ = 108.70(6)°, V = 661.3(8) Å3, Z = 1, and Dc = 1.398 g cm-3. Intermol. hydrogen bonds (O-H···O, C-H···O in 1; O-H···O, O-H···S in 1a) are present along with the C-H···S:P intermol. interactions. The solid-state structures were studied by the NMR spectroscopy. The presence of toluene-d8 in the crystal lattice of inclusion complex was confirmed by 2H NMR spectroscopy. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Related Products of 97-09-6

The Article related to toluene inclusion anhydrotosylthioxadioxaphosphorinanyl glucopyranose crystal structure, propanol solvate anhydrotosylthioxadioxaphosphorinanyl glucopyranose crystal structure, intermol hydrogen bond anhydrotosylthioxadioxaphosphorinanyl glucopyranose nmr, mol crystal structure anhydrotosylthioxadioxaphosphorinanyl glucopyranose and other aspects.Related Products of 97-09-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 24, 2016, Shia, Kak-Shan; Jan, Jiing-Jyh; Tsou, Lun Kelvin; Chen, Chiung-Tong; Chao, Yu-Sheng published a patent.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the patent was Preparation of quinazoline heterocyclic compounds and use thereof to mobilize hematopoietic stem cells and endothelial progenitor cells. And the patent contained the following:

Heterocyclic compounds I [wherein: M = (CH2)m; each of R1 and R2, independently, is H, halogen, NO2, CN, NH2, C1-6-alkyl, C1-6-alkoxy, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, or heteroaryl; or, R1 and R2, together with the two carbon atoms to which they are bonded, are C5-10-cycloalkyl, C3-10-heterocycloalkyl, aryl, or heteroaryl, each of alkyl, alkoxy, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl being optionally substituted;]. [Each of R3 and R4, independently, is NRbRc, Z1 or Z2; in which: each of Rb and Rc, independently, is H or C1-6-alkyl;R5 is H, C1-6-alkyl, C3-10-cycloalkyl, C1-10-heterocycloalkyl, arylalkyl, heteroaryl alkyl, aryl, or heteroaryl; each of alkyl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, aryl, and heteroaryl being optionally substituted;]. [R6 is H, C1-6-alkyl, C1-6-alkoxy, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, or heteroaryl;L1 is heteroaryl, C1-10-heterocycloalkyl, NH, or NRd; in which Rd is C(:O)(CH2)2CHNH2CO2Re; Re being H, C1-6-alkyl, C3-10-cycloalkyl, C3-10-heterocycloalkyl, aryl, or heteroaryl;R7 is H, C1-6-alkyl, C1-6-alkoxy, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, or heteroaryl; each of alkyl, alkoxyl, cycloalkyl,heterocycloalkyl, aryl, and heteroaryl being optionally substituted;]. [M is 1 – 6; n is 1 – 6; each of R8 and R9, independently, is H, C1-6-alkyl, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, or heteroaryl; each of alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl being optionally substituted; L2 is C1-6-alkyl; or L2, together with R8 8or R9 and the nitrogen atom to which they are bonded, is C4-10-heterocycloalkyl or heteroaryl; and,]. [R10 is H, C1-6-alkyl, C1-6-alkoxy, C3-10-cycloalkyl, C1-10-heterocycloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, ester, amide thioamide, or acyl; each of alkyl, alkoxyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aryl alkyl, and heteroaryl alkyl being optionally substituted] are shown herein. Thus, quinazoline II was prepared from 2,4-dichloroquinazoline via amination with tert-Bu 4-aminopiperidine-1-carboxylate; amination with aminotriazle III; and debutoxycarbonylation. The synthesis of II is also desribed. Also disclosed are pharmaceutical compositions containing the heterocyclic compounds and methods of using the heterocyclic compounds to mobilize hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation. Further provided are methods for treating tissue injury, cancer, inflammatory disease, and autoimmune disease with the heterocyclic compounds The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to heterocyclic compound preparation pharmaceutical composition mobilizer hematopoietic stem cells, tissue injury treatment quinazoline pyrimidine compound, cancer treatment quinazoline pyrimidine compound, inflammatory disease treatment quinazoline pyrimidine compound, autoimmune disease treatment quinazoline pyrimidine compound and other aspects.Safety of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 2, 2022, Franchino, Allegra; Marti, Alex; Echavarren, Antonio M. published an article.Electric Literature of 102-07-8 The title of the article was H-Bonded Counterion-Directed Enantioselective Au(I) Catalysis. And the article contained the following:

A new strategy for enantioselective transition-metal catalysis is presented, wherein a H-bond donor placed on the ligand of a cationic complex allows precise positioning of the chiral counteranion responsible for asym. induction. The successful implementation of this paradigm is demonstrated in 5-exo-dig and 6-endo-dig cyclizations of 1,6-enynes, combining an achiral phosphinourea Au(I) chloride complex with a BINOL-derived phosphoramidate Ag(I) salt and thus allowing the 1st general use of chiral anions in Au(I)-catalyzed reactions of challenging alkyne substrates. Experiments with modified complexes and anions, 1H NMR titrations, kinetic data, and studies of solvent and nonlinear effects substantiate the key H-bonding interaction at the heart of the catalytic system. This conceptually novel approach, which lies at the intersection of metal catalysis, H-bond organocatalysis, and asym. counterion-directed catalysis, provides a blueprint for the development of supramolecularly assembled chiral ligands for metal complexes. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Electric Literature of 102-07-8

The Article related to silver binaphtholphosphinate preparation catalyst enyne cyclization crystal structure, crystal structure silver binaphtholphosphinate gold phosphinothiourea complex, mol structure silver binaphtholphosphinate gold phosphinothiourea complex, gold phosphinothiourea complex preparation catalyst enyne cyclization crystal structure and other aspects.Electric Literature of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 28, 2020, Wu, Qiumin; Chen, Jinzhu; Liu, Zhen; Xu, Yisheng published an article.Name: 1,3-Diphenylurea The title of the article was CO Activation Using Nitrogen-Doped Carbon Nanotubes for Reductive Carbonylation of Nitroaromatics to Benzimidazolinone and Phenyl Urea. And the article contained the following:

Carbonylation of nitroaroms. with CO is extensively investigated with efficient but precious group 8-10 metal-based catalysts for the productions of both industrially and academically important chems. such as isocyanates, formamides, carbamates, ureas and several types of heterocyclic compounds Herein, we report that rationally designed nitrogen-doped carbon nanotubes (N-CNTs) exhibit catalytic activity toward CO activation for carbonylation of nitroaroms. to benzimidazolinones and ureas. Under the optimal conditions, N-CNT-promoted intramol. carbonylation of 2-nitroaniline (1a) with CO leads to formation of 1,3-dihydro-2H-benzo[d]imidazol-2-one in 90% yield. Moreover, an intermol. carbonylation of nitrobenzene and aniline with CO in the presence of the N-CNT gives 70% yield of N,N’-diphenylurea. The N-CNT is also applicable to various benzimidazolinones and Ph ureas; moreover, it can be readily reused at least 9 times for the carbonylation. The theor. investigation based on d. functional theory calculations indicates that the graphitic N of the N-CNT plays a crucial step in the 1a reduction with CO. The correlation between the structural defect and catalytic performance of the N-CNT reveals an enhanced catalytic activity of the N-CNT with its increased structural defects. This research thus represents a major breakthrough in CO activation for nitroarom. carbonylation with environmental-friendly, low-cost, and carbon-based catalysts as a potential alternative to expensive and scarce noble-metal-based catalysts. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Name: 1,3-Diphenylurea

The Article related to nitrogen doped carbon nanotube catalyst reductive carbonylation nitroarom aniline, carbon monoxide activation nitrogen doped carbon nanotube, benzimidazolinone ph urea preparation green chem mol modeling, carbon catalysis, carbon monoxide, carbonylation, defect, nitrogen-doped carbon nanotubes and other aspects.Name: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 7, 2016, Toda, Yasunori; Komiyama, Yutaka; Kikuchi, Ayaka; Suga, Hiroyuki published an article.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione The title of the article was Tetraarylphosphonium Salt-Catalyzed Carbon Dioxide Fixation at Atmospheric Pressure for the Synthesis of Cyclic Carbonates. And the article contained the following:

Phosphonium salts exhibit great utility in organic synthesis. However, tetraarylphosphonium salts (TAPS) have found limited use as catalysts. We demonstrate the TAPS-catalyzed carbon dioxide fixation at atm. pressure for the coupling reaction with epoxides. Five-membered cyclic carbonates were obtained, including enantio-enriched carbonates. Mechanistic studies revealed the origin of the behavior of TAPS to be the in situ formation of an active species by TAPS addition to epoxides via halohydrin intermediates. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

The Article related to cyclic carbonate preparation carbon dioxide fixation epoxide atm pressure, tetraarylphosphonium salt preparation catalyst carbon fixation, crystal mol structure hydroxy methylphenyl triphenylphosphonium bromide, carbon dioxide fixation tetraarylphosphonium salt catalyzed epoxide atm pressure and other aspects.Application In Synthesis of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 1, 2015, Wan, Yichao; Wu, Shaolei; Xiao, Guizhi; Liu, Tingting; Hou, Xuben; Chen, Chen; Guan, Peng; Yang, Xinying; Fang, Hao published an article.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide The title of the article was Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors. And the article contained the following:

The B-cell lymphoma-2 (Bcl-2) protein is a promising target for cancer therapy. In the present study, a series of 2-thioxo-4-thiazolidinone derivatives were designed and synthesized as Bcl-2 inhibitors. Most of them possessed decent inhibitory activity for anti-apoptotic Bcl-2 proteins. Among them, compound I has similar growth inhibition towards K562 compared to (R)-Gossypol. In addition, it inhibits the myeloid cell leukemia sequence 1 (Mcl-1) protein with a Ki value of 74 nM. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

The Article related to thioxothiazolidinone derivative preparation preliminary bioactivity bcl2 inhibitor, oxothiazolidinethione derivative preparation preliminary bioactivity bcl2 inhibitor, cancer therapy growth inhibition thioxothiazolidinone derivative, 2-thioxo-4-thiazolidinone, anti-tumor, bcl-2, inhibitors and other aspects.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics