Tag: M.W=100-150

Xue, Xuan published the artcileUpper critical solution temperature thermo-responsive polymer brushes and a mechanism for controlled cell attachment, COA of Formula: C5H8N2O2, the publication is Journal of Materials Chemistry B: Materials for Biology and Medicine (2017), 5(25), 4926-4933, database is CAplus and MEDLINE.

We report the synthesis of thermo-responsive polymer brushes with Upper Critical Solution Temperature (UCST)-type behavior on glass to provide a new means to control cell attachment. Thermoresponsive poly(N-acryloyl glycinamide)-stat-poly(N-phenylacrylamide) (PNAGAm-PNPhAm) brushes with three different monomer ratios were synthesized to give tunable phase transition temperatures (T_p) in solution Surface energies of surface-grafted brushes of these polymers at 25, 32, 37 and 50 °C were calculated from contact angle measurements and at. force microscopy (AFM) studies confirmed that these polymers were highly extended at temperatures close to T_p in physiol.-relevant media. Importantly, NIH-3T3 cells were attached on the collapsed PNAGAm-PNPhAm brush surface at 30 °C after 20 h incubation, while release of cells from the extended brushes was observed within 2 h after the culture temperature was switched to 37 °C. Furthermore, the changes in cell attachment followed changes in the Lewis base component of surface energy. The results indicate that, in contrast to the established paradigm of enhanced cell attachment to surfaces where polymers are above a Lower Critical Solution Temperature (LCST), these novel substrates enable detachment of cells from surfaces at temperatures above a UCST. In turn these responsive materials open new avenues for the use of polymer-modified surfaces to control cell attachment for applications in cell manufacture and regenerative medicine.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about 2479-62-1. 2479-62-1 belongs to amides-buliding-blocks, auxiliary class Monomers,Acrylamide Monomers, name is N-(2-Amino-2-oxoethyl)acrylamide, and the molecular formula is C7H13NO2, COA of Formula: C5H8N2O2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rowbottom, Martin W. published the artcileSynthesis and structure-activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5, Formula: C5H10N2OS, the publication is Bioorganic & Medicinal Chemistry Letters (2004), 14(19), 4967-4973, database is CAplus and MEDLINE.

The synthesis of a series of (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils, e.g., I, containing a substituted thiophene or thiazole at C-5 is described. SAR around C-5 of the uracil led to the discovery that a 2-thienyl or (2-phenyl)thiazol-4-yl group is required for optimal receptor binding. The best compound from the series had a binding affinity of 2 nM (K_i) for the human GnRH receptor. A convenient preparation of N-1-(2,6-difluorobenzyl)-6-methyluracil is also described.

Bioorganic & Medicinal Chemistry Letters published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Formula: C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Oba, Yasuhiro published the artcileIdentifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites, Category: amides-buliding-blocks, the publication is Nature Communications (2022), 13(1), 2008, database is CAplus and MEDLINE.

The lack of pyrimidine diversity in meteorites remains a mystery since prebiotic chem. models and laboratory experiments have predicted that these compounds can also be produced from chem. precursors found in meteorites. Here we report the detection of nucleobases in three carbonaceous meteorites using state-of-the-art anal. techniques optimized for small-scale quantification of nucleobases down to the range of parts per trillion (ppt). In addition to previously detected purine nucleobases in meteorites such as guanine and adenine, we identify various pyrimidine nucleobases such as cytosine, uracil, and thymine, and their structural isomers such as isocytosine, imidazole-4-carboxylic acid, and 6-methyluracil, resp. Given the similarity in the mol. distribution of pyrimidines in meteorites and those in photon-processed interstellar ice analogs, some of these derivatives could have been generated by photochem. reactions prevailing in the interstellar medium and later incorporated into asteroids during solar system formation. This study demonstrates that a diversity of meteoritic nucleobases could serve as building blocks of DNA and RNA on the early Earth.

Nature Communications published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Nagasaki, Yo-hei published the artcileDehydration of Amides to Nitriles over Heterogeneous Silica-Supported Molybdenum Oxide Catalyst, SDS of cas: 1453-82-3, the publication is ChemCatChem (2022), 14(9), e202101846, database is CAplus.

Silica-supported molybdenum oxide (MoO_x/SiO₂) with 4.8 wt% Mo (0.5 mmol g^-1) was an effective and reusable heterogeneous catalyst for dehydration of 2-furamide to 2-furonitrile (96% yield). The catalyst was applicable to the dehydration of various amides including heteroaromatic, aromatic and alkyl amides, providing the corresponding nitriles in high yields (87-97%). Based on the results of catalyst characterizations (XRD, TEM, UV-vis, Raman) and activity tests, MoO_x species are highly dispersed over SiO₂, and heptamolybdate anion ([Mo₇O₂₄]^6-) and isolated dioxo ((O=)₂MoO₂) were mainly formed on the SiO₂ support of the optimal MoO_x/SiO₂ catalyst. The strong Bronsted acid sites (Mo-OH-Si site) can be formed from the MoOx species and the adjacent silanol group, and the acid-base pair site (Mo(=O)OHSi site) of the strong Bronsted acid site (MoOH-Sisite) and base site (Mo=O) over MoO_x/SiO₂ catalyst could be themain active site for the dehydration of amides.

ChemCatChem published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, SDS of cas: 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Meng, Yuanyuan published the artcilePreparation, characterization, and pharmacokinetics of rivaroxaban cocrystals with enhanced in vitro and in vivo properties in beagle dogs, HPLC of Formula: 1453-82-3, the publication is International Journal of Pharmaceutics: X (2022), 100119, database is CAplus and MEDLINE.

Rivaroxaban (RIV) is a direct Factor Xa inhibitor anticoagulant, but the oral bioavailability of RIV is estimated to be only 60% due to its poor solubility The aim of the present study was to improve the solubility and bioavailability of RIV. Five cocrystals-p-hydroxybenzoic acid (HBA), 2,4-dihydroxybenzoic acid (DBA), nicotinamide (NA), isonicotinamide (IA), and succinic acid (SA)-were used as cofomers and were successfully obtained and characterized by powder X-ray diffraction, thermal anal., and Fourier transform IR spectra. RIV-DBA and RIV-HBA cocrystals showed obvious improvements in solubility, dissolution (under sink conditions), and intrinsic dissolution rates vs. RIV. Moreover, the dissolution of RIV-HBA, RIV-DBA, and RIV-SA cocrystals under non-sink conditions showed obvious “spring and parachute” patterns. The in vitro permeability levels in a Caco-2 cell model of RIV-DBA and RIV-IA cocrystals were significantly improved vs. RIV. Pharmacokinetic studies in beagle dogs showed that RIV-DBA and RIV-HBA cocrystals had higher bioavailability than RIV. The enhancements in solubility and bioavailability indicate the potential of RIV cocrystals as a better candidate for the treatment of thrombosis vs. RIV.

International Journal of Pharmaceutics: X published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, HPLC of Formula: 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liu, Wenbo published the artcileCu₂O-Catalyzed Conversion of Benzyl Alcohols Into Aromatic Nitriles via the Complete Cleavage of the C≡N Triple Bond in the Cyanide Anion, Product Details of C6H6N2O, the publication is Chemistry – An Asian Journal (2021), 16(21), 3509-3513, database is CAplus and MEDLINE.

Nitrogen transfer from cyanide anion to an aldehyde is emerging as a promising method for the synthesis of aromatic nitriles. However, this method still suffers from a disadvantage that a use of stoichiometric Cu(II) or Cu(I) salts is required to enable the reaction. As authors report herein, overcame this drawback and developed a catalytic method for nitrogen transfer from cyanide anion to an alc. via the complete cleavage of the C≡N triple bond using phen/Cu₂O as the catalyst. The present condition allowed a series of benzyl alcs. to be smoothly converted into aromatic nitriles in moderate to high yields. In addition, the present method could be extended to the conversion of cinnamic alc. to 3-phenylacrylonitrile.

Chemistry – An Asian Journal published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Product Details of C6H6N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Lundrigan, Travis published the artcileNickel-Catalyzed N-Arylation of Amides with (Hetero)aryl Electrophiles by Using a DBU/NaTFA Dual-Base System, SDS of cas: 1453-82-3, the publication is Synlett (2021), 32(16), 1665-1669, database is CAplus.

The first nickel-catalyzed N-arylation of amides with (hetero)aryl (pseudo)halides employing an organic amine base is described. By using a bis(cyclooctadienyl)nickel/8-[2-(dicyclohexylphosphinyl)phenyl]-1,3,5,7-tetramethyl-2,4,6-trioxa-8-phosphaadamantane catalyst mixture in combination with DBU/NaTFA as a dual-base system, a diversity of (hetero)aryl chloride, bromide, tosylate, and mesylate electrophiles were successfully cross-coupled with structurally diverse primary amides, as well as a selection of secondary amide, lactam, and oxazolidone nucleophiles.

Synlett published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, SDS of cas: 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

McCall, J. M. published the artcileNew approach to triaminopyrimidine N-oxides, HPLC of Formula: 15029-36-4, the publication is Journal of Organic Chemistry (1975), 40(22), 3304-6, database is CAplus and MEDLINE.

2,4,Diamino-6-(substituted amino)pyrimidine 3-oxides (I, R = H, R2 = Me, Et, Bu, n-C10H21, cyclohexyl; R = R1 = Bu, cyclohexyl; NRR1 = piperidine, 1-pyrrolidinyl) are prepared from amides NCCH2CONRR1 which are O-methylated to NCCH:C(OMe)NRR2, the products reacted with H2NCN to give NCCH2C(NRR1):NCN, and these treated in situ with NH2OH to give I. The sequential generation of the heterocycle from smaller fragments unequivocally establishes the position of the amine and N-oxide functionalities and allows ready variation of the 6-amino substituent. The three-step process proceeds in good yield and is easily performed.

Journal of Organic Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, HPLC of Formula: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Matsuda, Takehisa published the artcileSynthesis of Multifunctional, Nonionic Vinyl Polymers and Their ¹³C Spin-Lattice Relaxation Times in Deuterium Oxide Solutions, Synthetic Route of 2479-62-1, the publication is Macromolecules (1996), 29(16), 5375-5383, database is CAplus.

A study was conducted to design very hydrophilic vinyl polymers. Various nonionic, water-soluble polymers with hydroxyl or primary amide groups in their side chains were prepared by radical polymerization of corresponding monomers or by polymer reactions to modify side chains derivatized in poly(vinyl ethers). The functional groups interconnecting a hydrophobic main chain and a side chain included ether, secondary and tertiary amide, and ester groups. The number of hydroxyl groups incorporated in the side chains per monomer unit ranged from one to nine, and that of primary amide groups ranged from one to three. The spin-lattice relaxation times (T₁) of individual carbon atoms were measured in deuterium oxide (D₂O) by an inversion-recovery Fourier transform method as an indicator of chain or group mobility. As for the effect of interconnecting groups on the mobilities of main and side chains, these increased in the following order: ether > ester and tertiary amide > secondary amide. Considerably reduced T₁ values were found with increasing number of hydroxyl groups in the side chains. The addition of lithium bromide to D₂O solutions substantially increased T₁ values for hydroxyl group-derivatized polymers, indicating that intramol. hydrogen bonds responsible for reduced T₁ values are broken to enhance chain or group mobility. On the other hand, minimal effect of lithium bromide addition was found for ether- or primary amide-derivatized polymers. These results suggest that, when an ether group is incorporated as an interconnecting group into a vinyl polymer and primary amide groups are well distributed at the terminal ends of the side chains, such a polymer could have high chain and group mobility, which may impart high hydrophilicity. The mol. structure-mobility relationship was discussed in terms of T₁ values. It is suggested that a combination of factors, such as the structure of interconnecting group, the structure of hydrophilic group, intra- and interpendant-group interactions, hydrogen bonding, and steric factors, all contribute to T₁ values.

Macromolecules published new progress about 2479-62-1. 2479-62-1 belongs to amides-buliding-blocks, auxiliary class Monomers,Acrylamide Monomers, name is N-(2-Amino-2-oxoethyl)acrylamide, and the molecular formula is C5H8N2O2, Synthetic Route of 2479-62-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hirai, Kentaro published the artcileStudies on heterocyclic cation systems. XI. Syntheses of 2-disubstituted-amino-4-arylthiazol-5-ylalkanoic acids, COA of Formula: C5H10N2OS, the publication is Chemical & Pharmaceutical Bulletin (1977), 25(9), 2292-9, database is CAplus.

2-Disubstituted-amino-4-arylthiazol-5-ylalkanoic acids I (R = piperidino, morpholino, MeNH, BzNH, p-ClC₆H₄CONH, R¹ = H, Me; R² = Ph, 2-thienyl, p-ClC₆H₄, p-BrC₆H₄) were prepared Thus, dehydration of S-(α-benzoyl-β-ethoxycarbonyl)ethyl 1-piperidinethiocarbonate in the presence of aqueous HClO₄-Ac₂O yielded 4-ethoxycarbonylmethyl-5-phenyl-2-piperidino-1,3-oxathiolium perchlorate, which underwent nucleophilic reaction with NH₃ and the 5-ethoxycarbonylmethyl-4-phenyl-2-piperidinothiazole hydrolyzed to give I (R = piperidino, R¹ = H, R² = Ph). I were also synthesized by the classical Hantzsch method. I were evaluated as antiinflammatory agents on carrageenin induced abscess in rats.

Chemical & Pharmaceutical Bulletin published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, COA of Formula: C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics