Tag: M.W=100-150

Wang, Xuan published the artcileRuthenium-Promoted C-H Activation Reactions between DNA-Conjugated Acrylamide and Aromatic Acids, SDS of cas: 2479-62-1, the publication is Organic Letters (2018), 20(16), 4764-4768, database is CAplus and MEDLINE.

The first example of DNA-compatible C-H activation reaction between DNA-conjugated acrylamides and aromatic acids has been developed. This new transformation enables aromatic acid, previously considered as monofunctional building block, to act like a bifunctional building block for the DNA encoded library synthesis. The general scope of aromatic acid was established for this new on-DNA C-H activation, which paved the way for its application in combinatorial library preparation

Organic Letters published new progress about 2479-62-1. 2479-62-1 belongs to amides-buliding-blocks, auxiliary class Monomers,Acrylamide Monomers, name is N-(2-Amino-2-oxoethyl)acrylamide, and the molecular formula is C6H8O4, SDS of cas: 2479-62-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Tang, Zheng published the artcileAltering elastic-plastic mechanical response of a series of isostructural metal-organic complexes crystals, Quality Control of 1453-82-3, the publication is Science China: Chemistry (2022), 65(4), 710-718, database is CAplus.

The mech. compliant single crystals have attracted massive attention. However, the related reports on the single crystals composed of metal-organic complexes remain scarce. In this study, we synthesized a series of isostructural single crystals of ZnII complexes that manifest mech. bending in response to external stress. In these crystals, the mech. responses can be shifted between elastic bending and plastic bending by the control of the intermol. interactions through a rational structural modification in the substituent group of pyridine ligands. As the mol. reorientation corresponding to ligand variation elongates the interfacial distance between mol. slip planes, and the structural disorder of ligands disperses the interplanar intermol. interactions, the shift from elastic bending to plastic bending of the metal-organic complex-based single crystal was realized. The different mech. responses of single crystals were comprehensively investigated both exptl. and theor.

Science China: Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C4H11NO, Quality Control of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liu, Juan published the artcileInfluence of Monomers’ Structure on the Assembly and Material Property of Pillar[5] arene-Based Supramolecular Polymer Gels, Formula: C6H6N2O, the publication is Chinese Journal of Chemistry (2021), 39(12), 3421-3428, database is CAplus.

Pillar[5]arene-based supramol. polymer gels (SPGs) show broad application prospects. To investigate the influence of the supramol. monomers’ structure on the assembly and properties of corresponding pillar[5]arene-based SPGs, a series of monomers based on different functionalized pillar[5]arene derivatives with various structures were synthesized. There are per-methylated pillar[5]arene (H1), bromobutane-functionalized pillar[5]arene (H2), 4-hydroxybenzaldehyde-functionalized pillar[5]arene (H3), Et thioglycolate-functionalized pillar[5]arene (H4), thioacetylhydrazine-functionalized pillar[5]arene (H5), bola-type bis-pillar[5]arene (H6) and tripodal-type tri-pillar[5]arene (H7). Meanwhile, a neutral tripodal-guest TG was also employed to co-assemble with these pillar[5]arene-based monomers by host-guest interactions. As a result, under the same conditions (10%, DMSO-H2O, w/v, 10 mg·mL-1 = 1%), H1 and H2 cannot assemble into SPGs with TG. Interestingly, mono-p[5] derivatives H3-H5 could assemble into SPGs with TG. More importantly, bis-p[5] H6 and tri-p[5] H7 could assemble into supramol. polymer network gel (SPNG) and supramol. polymer organic framework gel (SOFG) with TG, resp. These gels all show blue aggregation-induced emission (AIE) properties. Among these SPGs, the SPNG shows the best viscoelastic behavior and self-healing properties. The result is attributed to the flexible network structure of SPNGs. In addition, the xerogels of SOFG and SPNG have shown nice adsorption and separation properties for organic dyes in water solution

Chinese Journal of Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Formula: C6H6N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Li, Yin published the artcileTemperature-Dependent Terahertz Spectra of Isonicotinamide in the Form I Studied Using the Quasi-Harmonic Approximation, Related Products of amides-buliding-blocks, the publication is ChemPhysChem (2022), 23(6), e202100849, database is CAplus and MEDLINE.

Anharmonicity of mol. vibrational motions is closely associated with the thermal property of crystals. However, the origin of anharmonicity is still not fully understood. Low-frequency vibrations, which are usually defined in the terahertz (THz) range, show excellent sensitivity to anharmonicity. In this work, anharmonicity of isonicotinamide in the form I was investigated by using temperature-dependent terahertz time-domain spectroscopy and the quasi-harmonic approximation (QHA) approach at PBE-D3 and PBE-MBD levels. Both DFT calculations suggest the variation of π-π stacking conformation dominates in the thermal expansion of the unit cell. Frequency shifts of the modes in THz range obtained by QHA approach are found to be qual. consistent with exptl. observations, demonstrating QHA approach is a useful tool for the interpretation of frequency shifts of modes induced by temperature

ChemPhysChem published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wilde, Felix published the artcileTractable synthesis of multipurpose screening compounds with under-represented molecular features for an open access screening platform, Recommanded Product: 2-Cyano-N-ethylacetamide, the publication is Molecular Diversity (2014), 18(3), 483-495, database is CAplus and MEDLINE.

Abstract: The layout of multipurpose screening libraries must address criteria for the compounds such as novelty, diversity potential, innovative design, and last but not least synthetic tractability. While academic compound collections are often innovative, novel, and highly divers, synthesis of analogs or larger substance quantities is often hampered by complex multistep syntheses with low overall yields. In addition, covalently binding compounds and interaction motifs designed to bind metal ions were discriminated against by the paradigm that these interaction types must almost inevitably lead to toxic effects. We would like to challenge this hypothesis. The lack of such interactions could be a reason for frequent failure in the disclosure of hits for hitherto undruggable target proteins using com. available screening collections. Thus, easily synthesizable screening candidates equipped to bind covalently to nucleophiles or to metalloenzymes by chelation are under-represented in public access screening libraries. Within this work, we present the synthesis and deposition of 88 compounds with five distinct functional classes, each of which features under-represented screening motifs, for example, metal ion complexation, reversible covalent binding, or halogen bonding. The collection includes acetohydrazides, acylhydrazones, propylene glycol ethers, 2-cyanoacetamides, and 2-cyanoacrylamides. The rational for the synthesis of most of the compounds was recently published by our group and is now supplemented by addnl. compounds reported here for the first time. The public access disposition enables academic research groups to collectively expand the druggable space and interdisciplinary collaborate within the scientific field. Graphical Abstract: [Figure not available: see fulltext.].

Molecular Diversity published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C4H11NO, Recommanded Product: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Schroth, W. published the artcileSynthesis of 1,3-thiazinium salts from β-chlorovinyl ketones and thio amide functionalized compounds, Category: amides-buliding-blocks, the publication is Tetrahedron (1982), 38(7), 937-48, database is CAplus.

Thiocarbamoyl compounds reacted with β-chlorovinyl ketones to give 1,3-thiazinium salts via S-ketovinylthioimidium derivatives E.g., condensation reaction of Me₃CCSNH₂ with 4-MeC₆H₄COCH:CHCl in HClO₄ gave the intermediate 4-MeC₆H₄COCH:CHSC(:N⁺H₂)CMe₃ ClO₄^– which underwent acid-catalyzed cyclocondensation reaction to give 72% thiazinium salt I. The thiazinium salts react with nucleophilic reagents preferentially at position 6. E.g., substitution reaction of I with morpholine at -20° gave 94% thiazine II. The scope of the cyclocondensation reaction is discussed.

Tetrahedron published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Schroth, Werner published the artcile1,3-Thiazine syntheses with β-diketones via enol phosphate, Related Products of amides-buliding-blocks, the publication is Synthesis (1983), 827-30, database is CAplus.

RCOCH₂COR (R = Ph; 4-MeOC₆H₄, Me) were successively treated with Na or NaOMe, then (PhO)₂P(O)Cl in C₆H₆ or Et₂O to give 58-75% RCOCH:CROP(O)(OPh)₂ which were cyclized with H₂NC(S)R¹ (R¹ = Ph, Me, CMe₃, SEt, NH₂, NMe₂, morpholino, PhCH:NNH, MeEtC:NNH, 4-MeC₆H₄SO₂NHNH, 4-MeOC₆H₄) in AcOH containing POCl₃, with dropwise addition of 70% HClO₄ to give 39-97% thiazinium perchlorates I.

Synthesis published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhou, Linna published the artcileA Class of 5-Nitro-2-furancarboxylamides with Potent Trypanocidal Activity against Trypanosoma brucei in Vitro, Recommanded Product: 2-Cyano-N-ethylacetamide, the publication is Journal of Medicinal Chemistry (2013), 56(3), 796-806, database is CAplus and MEDLINE.

Recently, the World Health Organization approved the nifurtimox-eflornithine combination therapy for the treatment of human African trypanosomiasis, renewing interest in nitroheterocycle therapies for this and associated diseases. In this study, we have synthesized a series of novel 5-nitro-2-furancarboxylamides that show potent trypanocidal activity, ∼1000-fold more potent than nifurtimox against in vitro Trypanosoma brucei with very low cytotoxicity against human HeLa cells. More importantly, the most potent analog showed very limited cross-resistance to nifurtimox-resistant cells and vice versa. This implies that our novel, relatively easy to synthesize and therefore cheap, 5-nitro-2-furancarboxylamides are targeting a different, but still essential, biochem. process to those targeted by nifurtimox or its metabolites in the parasites. The significant increase in potency (smaller dose probably required) has the potential for greatly reducing unwanted side effects and also reducing the likelihood of drug resistance. Collectively, these findings have important implications for the future therapeutic treatment of African sleeping sickness.

Journal of Medicinal Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C15H24S, Recommanded Product: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rajappa, S. published the artcileA general synthesis of thiazoles. Part 5. Synthesis of 5-acyl-2-dialkylaminothiazoles, Product Details of C5H10N2OS, the publication is Proceedings – Indian Academy of Sciences, Chemical Sciences (1982), 91(5), 445-50, database is CAplus.

The title compounds I [R = morpholino, R¹ = H, R² = Ph, EtO, Me, 4,3-Cl(O₂N)C₆H₄; R = 4-methylpiperazine, R¹ = H, R² = 4-O₂NC₆H₄, 3-O₂NC₆H₄, 4,3-Cl(O₂N)C₆H₄; R = 4-methylpiperazino, R¹ = Me, R² = 3-O₂NC₆H₄] were prepared by cyclization of RCSN:CR¹NMe₂ with R²COCH₂X (X = Cl, Br).

Proceedings – Indian Academy of Sciences, Chemical Sciences published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Laha, Joydev K. published the artcileSynthesis of unsymmetrical urea from aryl- or pyridyl carboxamides and aminopyridines using PhI(OAc)₂via in situ formation of aryl- or pyridyl isocyanates, Recommanded Product: Isonicotinamide, the publication is New Journal of Chemistry (2021), 45(40), 18815-18823, database is CAplus.

A tandem synthesis of unsym. ureas (N-aryl-N’-pyridylurea and N,N’-bipyridylurea) from aryl- or pyridyl carboxamides and aminopyridines via Hofmann rearrangement has been reported. In particular, benzamides, picolinamide, nicotinamide, and isonicotinamide generate reactive intermediate isocyanates, in situ, in the presence of PhI(OAc)₂, which upon further reaction with aminopyridines form urea derivatives As the formation of pyridylisocyanates from their corresponding carboxamides via Hofmann rearrangement remained unexplored previously, attempts have been made to trap the isocyanates. While the three pyridylisocyanates were trapped as their corresponding carbamates, 3-pyridylisocyanate was isolated and characterized. Unlike closely related previous methods reported for urea synthesis, the current method avoids direct use of isocyanates or eliminates the use of toxic phosgene for the in situ generation of isocyanates.

New Journal of Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Recommanded Product: Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics