Tag: M.W=100-150

Singh, Harjit published the artcileSynthesis of heterocyclic compounds via enamines. Part 8. Acid-catalyzed transformations in 4,4,6-trimethyl-1,4-dihydropyrimidine-2(3H)-thione derivatives and related compounds, Formula: C5H10N2OS, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1980), 1013-18, database is CAplus.

The N-substituted trimethylpyrimidinethiones I (R = alkyl, alkenyl, Ph) were converted into the corresponding N-substituted 1,3-thiazines II and/or thioureas by heating in 11M HCl at 100-10°. However at 95-100°, Dimroth rearrangement products, e.g. the N-substituted thiazines III (R = alkyl, alkenyl, Ph), were formed. Thus, I (R = Me) (IV) in 11M HCl at 100-10° for 4 h gave 90% methylthiourea. IV in 11M HCl at 95-100° for 2.5 h gave 98% III (R = Me).

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C18H34N4O5S, Formula: C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Singh, Harjit published the artcileSynthesis of heterocyclics via enamines. II. Reactions of cyclohex-1-enyl -aniline, -morpholine, and -piperidine with 1,1-dimethyl-3-oxobutyl isothiocyanate, Synthetic Route of 14294-10-1, the publication is Australian Journal of Chemistry (1975), 28(1), 143-9, database is CAplus.

The condensation of cyclohex-1-enylaniline with 1,1-dimethyl-3-oxobutyl isothiocyanate (I) gave mainly 1,5-benzodiazocine-6(1H)-thione II with some pyrimidine-2-thione III as the minor product. Similar condensations of I with cyclohex-1-enylmorpholine and cyclohex-1-enylpiperidine formed the 1-thiocarbamoyl derivatives through β-elimination of the intermediate IV (X = O, CH2).

Australian Journal of Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C10H16Br3N, Synthetic Route of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Ramesh, Pattipati published the artcileDesign, synthesis and biological evaluation of some novel 3-substituted acrylamide quinoline derivatives, Safety of 2-Cyano-N-ethylacetamide, the publication is International Journal of ChemTech Research (2017), 10(3), 259-270, database is CAplus.

A new series of (2,8-dichloroquinolin-3-yl)acrylamide derivatives I (R¹ = Me, c-Pr, Ph, etc.; R² = H; -R¹R²– = -(CH₂)₄-, -(CH₂)O(CH₂)-) were designed by incorporating simple chem. methods. Here different N-substituted cyanoacetamide derivatives were used as the pharmacophore entities to link with the parent quinoline moiety. Antimicrobial activity of synthesized compounds was screened, which has revealed that the few of the compounds were more potent than the corresponding standard drugs.

International Journal of ChemTech Research published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Safety of 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhang, Zhichao published the artcileNovel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach, HPLC of Formula: 15029-36-4, the publication is European Journal of Medicinal Chemistry (2013), 141-149, database is CAplus and MEDLINE.

Based on a known nanomolar Bcl-2 homol. domain 3 (BH3) mimetic 3-thiomorpholin-8-oxo-8H-acenaphtho[1,2-b] pyrrole-9-carbonitrile (I, MW: 331), we applied a fragment-based approach to obtain BH3 mimetics with improved affinity and improved solubility in a water-ethanol (9:1) cosolvent. After the deconstruction of I, we obtained fragment cyanoacetamide (II), which was determined to be a ligand efficiency (LE) hot part. After a rational optimization through fragment evolution beginning with fragment II, a smaller Mcl-1 inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (III, MW: 288) with a 6-fold increase in affinity compared to I was obtained, as predicted by our optimization curve and identified by Mcl-1 protein NMR (NMR).

European Journal of Medicinal Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C9H7NO2, HPLC of Formula: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Shen, Jincheng published the artcileIntegrated metabolomic and transcriptomic analysis reveals factors underlying differences in fruit quality between Fragaria nilgerrensis and Fragaria pentaphylla, COA of Formula: C6H6N2O, the publication is Journal of the Science of Food and Agriculture (2022), 102(8), 3287-3296, database is CAplus and MEDLINE.

Strawberries have become one of the most popular fruits because of their unique flavor and high nutritional value. Fruit quality and price are the most important criteria that determine consumer acceptability. Fragaria nilgerrensis and Fragaria pentaphylla are two wild Asian diploid strawberry species that differ in fruit color, taste, and aroma. To understand the mol. mechanisms involved in the formation of high-quality strawberry fruit, we integrated transcriptomics and metabolomics research methods to compare the metabolic and biosynthetic mechanisms of the two Fragaria species. F. nilgerrensis fruit has higher amino acid and lipid contents and a higher sugar-to-acid ratio than F. pentaphylla fruit does, underlying their superior nutritional value, aroma, firmness, and taste. Compared with F. nilgerrensis fruit, F. pentaphylla fruit contained more flavonoids, indicating its enhanced color and health benefits. In addition, candidate structural genes that regulate the biosynthesis of flavonoids, amino acids, and glycerophospholipids in the two strawberry fruit were screened. The differences in aroma, firmness, and taste between F. nilgerrensis fruit and F. pentaphylla fruit are probably due to differences in their amino acid and lipid contents, as well as the difference in their sugar-to-acid ratios. Eight key structural genes that may play important roles in the biosynthesis of amino acids, lipids, and flavonoids were identified. 2021 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C15H14BNO4S, COA of Formula: C6H6N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Devani, M. B. published the artcileSynthesis and pharmacological properties of some 4-amino-5-substituted thiazole-2(3H)-thiones and thiazolo(4,5-d)pyrimidin-7(6H)-one-2(3H)-thiones, Recommanded Product: 2-Cyano-N-ethylacetamide, the publication is Arzneimittel-Forschung (1977), 27(9), 1652-5, database is CAplus and MEDLINE.

Twenty-six aminothiazolethiones I (R = Et, benzyl, allyl, Ph, tolyl, etc.; R1 = NH2, NHMe, piperidino, morpholino, PhNHNH) were prepared in 40-90% yield by reaction of RNCS with NCCH2CONHR1. Eleven thiazolopyrimidinones II (R = benzyl, tolyl, Ph, Me, Et, R2 = H, Me, Et, Ph, anilino) were prepared in 55-70% yield by reaction of the appropriate I with HC(OEt)2 in Ac2O. I and II were screened for antimicrobial and pharmacol. activities. Maximum antiinflammatory activity was found in I (R = o-tolyl, R1 = morpholino); at 200 mg/kg its activity was almost equal to phenylbutazone at 100 mg/kg. I (R = allyl, R1 = PhNHNH) was the most active antimicrobial of the series. I (R = benzyl, R1 = NH2) was the most potent analgesic.

Arzneimittel-Forschung published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Recommanded Product: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Devani, M. B. published the artcileSynthesis of 2-aminothiophenes and thieno[2,3-d]pyrimidines, Safety of 2-Cyano-N-ethylacetamide, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1976), 14B(5), 357-60, database is CAplus.

The thienopyrimidinones I [R = Me, R1 = CO2Et, R2 = H; RR1 = (CH2)4, R2 = Ph] were prepared by treating the aminothiophenes II (R = CO2Et, CONHPh) with HCONH2 or (EtO)3CH, whereas cyclization of II [R = Me, R1 = EtO2C, R3 = cyano; RR1 = (CH2)4, R3 = cyano] with HCONH2 gave the corresponding aminothienopyrimidines III. Furthermore, the spiro[benzothienopyrimidine-2,1′-cyclohexane] IV was prepared by cyclization of NCCH2CONHNHPh with cyclohexanone in the presence of S. IV had antiinflammatory and anticonvulsant activities and II had only antiinflammatory activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Safety of 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zigeuner, G. published the artcileHeterocycles, part 51. Syntheses of 4-dialkylamino-5,6-dihydro-2(1H)-pyridinethiones and 4-alkylamino or 4-arylamino compounds, Related Products of amides-buliding-blocks, the publication is Monatshefte fuer Chemie (1976), 107(6), 1361-7, database is CAplus.

(Dialkylamino)dihydro-2(1H)-pyridinethiones I (R = Me or R2 = CH2CH2OCH2CH2) were prepared by heating the heterocycles II (X = NH, S) with dialkylformamides or by the reaction of secondary amines with thiazinthiones III (R1 = OH, morpholino), with MeCOCH2CMe2NHCSNR2 or with MeCOCH2CMe2N:C:S. A general method for the preparation of I is the reaction of R2NH.HNCS, R2NCSNH2, or dialkylammonium chlorides and KCNS with MeCOCH:CHMe or MeCOCH2CH2OH.

Monatshefte fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C7H16Cl2Si, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Shreykar, Milind R. published the artcileResonance induced proton transfer leading to NIR emission in coumarin thiazole hybrid dyes: Synthesis and DFT insights, Application of Morpholine-4-carbothioamide, the publication is Tetrahedron Letters (2016), 57(37), 4174-4177, database is CAplus.

Two novel coumarin thiazole hybrid dyes (E)-2-(3-(2-(4-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-morpholinothiazol-5-yl)vinyl)-5,5-dimethylcyclohex-2-en-1-ylidene)malononitrile (CSI) and (E)-2-(3-(2-(4-(4-methoxy-2-oxo-2H-chromen-3-yl)-2-morpholinothiazol-5-yl)vinyl)-5,5-dimethylcyclohex-2-en-1-ylidene)malononitrile (MeOCSI) were synthesized. CSI exhibits near IR emission with large Stokes shift. The dye CSI shows resonance induced excited state intramol. proton transfer (RI-ESIPT). DFT and TD-DFT calculations clearly support and define the finding.

Tetrahedron Letters published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C3H3Br2ClO, Application of Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Tayade, Rajratna P. published the artcileNovel Thiazole Based Styryl Dyes with Benzimidazole Unit – Synthesis, Photophysical and TD-DFT Studies, COA of Formula: C5H10N2OS, the publication is Journal of Fluorescence (2017), 27(1), 167-180, database is CAplus and MEDLINE.

Three new Y-shaped styryl dyes were designed and synthesized from thiazole carbaldehyde with different active methylene compounds as acceptor moieties. All the dyes were characterized by IR, ¹HNMR, MS/LCMS/HRMS. Spectroscopic properties and non-linear optical properties styryl derivatives were analyzed and the effect of change in solvent polarity on their absorption and emissive properties has been investigated. The dye with (1-phenylethylidene) propanedinitrile unit shows red shift absorption/emission profile among all the dyes. D. Functional Theory and Time Dependent-D. Functional Theory computations have been used for comparative study with the exptl. data and also to understand the structural, mol., electronic and photophys. parameters of the styryl dyes. The computational method was also employed to investigate the nonlinear optical properties of the styryl dyes in different organic solvent. The unsubstituted benzimidazolyl thiazole styryl dyes possess good non-linear optical properties.

Journal of Fluorescence published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C6H12O2, COA of Formula: C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics