Tag: M.W=100-150

An article NaNO2/I-2 as an alternative reagent for the synthesis of 1,2,3-benzotriazin-4(3H)-ones from 2-aminobenzamides WOS:000456353000009 published article about CATALYZED DENITROGENATIVE ANNULATION; TERT-BUTYL NITRITE; NEMATOCIDAL ACTIVITIES; SELECTIVE SYNTHESIS; DERIVATIVES; 1,2,3-BENZOTRIAZINE-4-(3H)-ONES; ACID in [Barak, Dinesh S.; Mukhopadhyay, Sushobhan; Dahatonde, Dipak J.; Batra, Sanjay] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Sect 10,Jankipuram Extens,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India; [Batra, Sanjay] CSIR HRDC, Postal Staff Coll Area, Sect 19, Ghaziabad 201002, India in 2019, Cited 39. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4. Application In Synthesis of Benzo[d][1,2,3]triazin-4(3H)-one

An efficient transformation of 2-aminobenzamides to 1,2,3-benzotriazin-4(3H)-ones in the presence of sodium nitrite (NaNO2) and Iodine (I-2) is described. The reaction is proposed to proceed via formation of nitrosyl halide that induces nitrosylation of the amino group of 2-aminobenzamide leading to diazotization followed by intramolecular cyclization. (C) 2018 Elsevier Ltd. All rights reserved.

Application In Synthesis of Benzo[d][1,2,3]triazin-4(3H)-one. Bye, fridends, I hope you can learn more about C7H5N3O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives containing benzo[d][1,2,3]thiadiazole against Meloidogyne incognita published in 2020. Quality Control of Benzo[d][1,2,3]triazin-4(3H)-one, Reprint Addresses Xu, XY (corresponding author), East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China.. The CAS is 90-16-4. Through research, I have a further understanding and discovery of Benzo[d][1,2,3]triazin-4(3H)-one

Based on the characteristic of benzo[d][1,2,3]thiadiazole to induce the systemic acquired resistance and improve the immunity of plants, benzo[d][1,2,3]thiadiazole was introduced into 1,2,3-benzotriazin-4-one, thirty-one novel 1,2,3-benzotriazin-4-one derivatives containing benzo[d][1,2,3]thiadiazole were designed and synthesized. Nematicidal activity showed that most of the synthesized compounds exhibited great inhibitory activity in vivo against Meloidogyne incognita at 20 mg/L. Among 31 tested compounds, A2 and A3 showed an excellent nematicidal activity with the inhibition rate of 50.4% and 53.1% at the concentration of 1.0 mg/L, respectively. The influence of substituent type and position was investigated. The relationship between structure and activity was also preliminary analyzed.

Bye, fridends, I hope you can learn more about C7H5N3O, If you have any questions, you can browse other blog as well. See you lster.. Quality Control of Benzo[d][1,2,3]triazin-4(3H)-one

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

An article A Highly Selective Palladium-Catalyzed Aerobic Oxidative Aniline-Aniline Cross-Coupling Reaction WOS:000487577200019 published article about BOND FORMATION; DERIVATIVES; ARYLATION; BINAM; BIPHENOLS; PHENOLS in [Matsumoto, Kenji; Takeda, Satoshi; Hirokane, Tsukasa; Yoshida, Masahiro] Tokushima Bunri Univ, Fac Pharmaceut Sci, 180 Nishihama Boji, Yamashiro, Tokushima 7708514, Japan in 2019.0, Cited 58.0. Safety of 2-(4-Aminophenyl)ethanol. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

The first catalytic oxidative aniline-aniline cross-coupling reaction using oxygen as the terminal oxidant is reported. Anilines possessing a pyrrolidino group can be preferentially oxidized under mild aerobic conditions and reacted with other anilines to afford a variety of nonsymmetrical 2-aminobiphenyls with high selectivities. A heterogeneous palladium catalyst is used for the dehydrogenative cross-coupling of anilines with structurally diverse arenes. This reaction does not require stoichiometric oxidants and is an economical and environmentally friendly method.

Welcome to talk about 104-10-9, If you have any questions, you can contact Matsumoto, K; Takeda, S; Hirokane, T; Yoshida, M or send Email.. Safety of 2-(4-Aminophenyl)ethanol

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Application In Synthesis of Benzo[d][1,2,3]triazin-4(3H)-one. Zhang, XM; Peng, AH; Xie, WD; Wang, M; Zheng, D; Feng, MK in [Zhang, Xiu-Mei; Wang, Mei; Zheng, Dan; Feng, Ming-Kuan] Shandong Drug & Food Vocat Coll, Dept Pharm, Weihai 264210, Peoples R China; [Peng, Ai-Hong; Xie, Wei-Dong] Shandong Univ, Coll Marine Sci, Dept Pharm, Weihai 264209, Peoples R China published Hexokinase II Inhibitory Effect of Secondary Metabolites Derived from a Streptomyces sp. Associated with Mud Dauber Wasp in 2020, Cited 43. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4.

Insect-microbial symbioses have vast biochemical diversity, which is beneficial to produce bioactive secondary metabolites. In this study, chemical examination of a Streptomyces sp. associated with a mud dauber wasp led to the isolation of fourteen compounds. Their structures were determined by spectroscopic methods and comparison with literature data. Among the isolates, compounds 1,2,3-benzotriazin-4(1H)-one and 4-(2-aminoethyl)phenyl acetate were first reported from this species. Bioactivities of the isolated compounds were assayed for the first time against hexokinase II. 4-(2-Aminoethyl)phenyl acetate, germicidin B, phenylacetic acid, isogermicidin A and germicidin C displayed significant inhibitory activity against hexokinase II, with the IC50 values of 5.11, 7.11, 7.15, 8.45 and 8.78 mu M, respectively.

Application In Synthesis of Benzo[d][1,2,3]triazin-4(3H)-one. Bye, fridends, I hope you can learn more about C7H5N3O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Computed Properties of C8H11NO. Authors Lee, JW; Jung, S; Jo, J; Han, GH; Lee, DM; Oh, J; Hwang, HJ; Choi, D; Kim, SW; Lee, JH; Yang, C; Baik, JM in ROYAL SOC CHEMISTRY published article about in [Lee, Jae Won; Lee, Dong-Min; Kim, Sang-Woo; Baik, Jeong Min] Sungkyunkwan Univ SKKU, Sch Adv Mat Sci & Engn, Suwon 16419, South Korea; [Jung, Sungwoo; Oh, Jiyeon; Yang, Changduk] Ulsan Natl Inst Sci & Technol UNIST, Low Dimens Carbon Mat Ctr, Perovtron Res Ctr, Dept Energy Engn,Sch Energy & Chem Engn, Ulsan 44919, South Korea; [Jo, Jinhyeong; Lee, Jun Hee] Ulsan Natl Inst Sci & Technol UNIST, Sch Energy & Chem Engn, Ulsan 44919, South Korea; [Han, Gi Hyeon] Ulsan Natl Inst Sci & Technol UNIST, Sch Mat Sci & Engn, Ulsan 44919, South Korea; [Hwang, Hee Jae; Choi, Dukhyun] Kyung Hee Univ, Dept Mech Engn, Yongin 17104, South Korea in 2021.0, Cited 76.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

In this paper, we report on a new dielectric, a C-60-containing block polyimide (PI-b-C-60). This was realized by introducing C-60 as pendent groups into a polymer backbone. When this dielectric was used in a non-contact mode triboelectric nanogenerator (TENG), it achieved high output power and reliable operation. Compared with perfluoroalkoxy alkane film-based TENGs, the TENG based on PI-b-C-60 generated 4.3 times higher output power and a superior charge density of over 300 mu C m(-2) with a 3 times slower charge decay rate. These results are most likely due to the excellent charge-retention characteristics induced by the most negative electrostatic potential of C-60 within the backbone, and these characteristics were confirmed by surface potential measurements. Furthermore, in the course of our work, two non-contact mode applications, a keyless electronic door lock system and a speed sensor with a tone wheel for a car, were developed. Without an ion injection process being needed, very sensitive and reliable operations of the speed sensor were successfully demonstrated, even under very humid conditions (similar to 99% RH).

Computed Properties of C8H11NO. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Lee, JW; Jung, S; Jo, J; Han, GH; Lee, DM; Oh, J; Hwang, HJ; Choi, D; Kim, SW; Lee, JH; Yang, C; Baik, JM or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Name: Benzo[d][1,2,3]triazin-4(3H)-one. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Hexokinase II Inhibitory Effect of Secondary Metabolites Derived from a Streptomyces sp. Associated with Mud Dauber Wasp published in 2020, Reprint Addresses Zhang, XM (corresponding author), Shandong Drug & Food Vocat Coll, Dept Pharm, Weihai 264210, Peoples R China.. The CAS is 90-16-4. Through research, I have a further understanding and discovery of Benzo[d][1,2,3]triazin-4(3H)-one.

Insect-microbial symbioses have vast biochemical diversity, which is beneficial to produce bioactive secondary metabolites. In this study, chemical examination of a Streptomyces sp. associated with a mud dauber wasp led to the isolation of fourteen compounds. Their structures were determined by spectroscopic methods and comparison with literature data. Among the isolates, compounds 1,2,3-benzotriazin-4(1H)-one and 4-(2-aminoethyl)phenyl acetate were first reported from this species. Bioactivities of the isolated compounds were assayed for the first time against hexokinase II. 4-(2-Aminoethyl)phenyl acetate, germicidin B, phenylacetic acid, isogermicidin A and germicidin C displayed significant inhibitory activity against hexokinase II, with the IC50 values of 5.11, 7.11, 7.15, 8.45 and 8.78 mu M, respectively.

Name: Benzo[d][1,2,3]triazin-4(3H)-one. Bye, fridends, I hope you can learn more about C7H5N3O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recently I am researching about PHARMACOLOGICAL EVALUATION; LIGANDS; GROWTH, Saw an article supported by the Science & Technology Development Fund in Egypt STDF Project [22909]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: El Rayes, SM; Ali, IAI; Fathalla, W; Mahmoud, MAA. The CAS is 90-16-4. Through research, I have a further understanding and discovery of Benzo[d][1,2,3]triazin-4(3H)-one. HPLC of Formula: C7H5N3O

In one-pot strategy, diazotization of methyl anthranilate 5 followed by addition of amino acid ester hydrochloride, we have prepared methyl-2-(4-oxobenzotriazin-3(4H)-yl)-alkanoates 6a-c. Starting with hydrazides 7a,b, N-alkyl-2-(4-oxobenzotriazin-3(4H)-yl)-alkanamides 9-10(a-h) and methyl-2-(2-(4-oxobenzotriazin-3(4H)-yl)alkanamido)alkanoates 11- 12(a-e) were prepared via azide coupling. Hydrazones 13-15 were prepared via condensation of hydrazides 7a,b with 4-methoxybenzaldehyde, 4-dimethylaminobenzaldehyde, and/or arabinose. Molecular docking was done for synthesized compounds using MOE 2008-10 software. The compounds 9a, 12a, 12c, 13a, 13b, and 14b have the most pronounced strong binding affinities toward the target E. coli Fab-H receptor, whereas compounds 3, 11e, 12e, and 13a have the most pronounced strong binding affinities toward the target vitamin D receptor. The in vitro antibacterial activities of the highest binding affinity docked compounds were tested against E. coli, Staphylococcus aureus, and Salmonella spp. Majority of the tested compounds showed effective positive results against E. coli, while they were almost inactive against Staphylococcus aureus and Salmonella spp. The in vitro cytotoxic activities of the highest binding affinity-docked compounds were tested against the human liver carcinoma cell line (HepG2). Some compounds showed potent cytotoxic activity with low IC50 values, especially for 3 (6.525 mu M) and 13a (10.97 mu M) than that for standard drug doxorubicin (2.06 mu M).

HPLC of Formula: C7H5N3O. Welcome to talk about 90-16-4, If you have any questions, you can contact El Rayes, SM; Ali, IAI; Fathalla, W; Mahmoud, MAA or send Email.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Authors El Rayes, SM; Ali, IAI; Fathalla, W; Mahmoud, MAA in AMER CHEMICAL SOC published article about PHARMACOLOGICAL EVALUATION; LIGANDS; GROWTH in [El Rayes, Samir M.; Ali, Ibrahim A. I.; Mahmoud, Mostafa A. A.] Suez Canal Univ, Fac Sci, Dept Chem, Ismailia 41529, Egypt; [Fathalla, Walid] Port Said Univ, Fac Engn, Phys & Math Engn Dept, Port Said 42526, Egypt in 2020, Cited 24. Computed Properties of C7H5N3O. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4

In one-pot strategy, diazotization of methyl anthranilate 5 followed by addition of amino acid ester hydrochloride, we have prepared methyl-2-(4-oxobenzotriazin-3(4H)-yl)-alkanoates 6a-c. Starting with hydrazides 7a,b, N-alkyl-2-(4-oxobenzotriazin-3(4H)-yl)-alkanamides 9-10(a-h) and methyl-2-(2-(4-oxobenzotriazin-3(4H)-yl)alkanamido)alkanoates 11- 12(a-e) were prepared via azide coupling. Hydrazones 13-15 were prepared via condensation of hydrazides 7a,b with 4-methoxybenzaldehyde, 4-dimethylaminobenzaldehyde, and/or arabinose. Molecular docking was done for synthesized compounds using MOE 2008-10 software. The compounds 9a, 12a, 12c, 13a, 13b, and 14b have the most pronounced strong binding affinities toward the target E. coli Fab-H receptor, whereas compounds 3, 11e, 12e, and 13a have the most pronounced strong binding affinities toward the target vitamin D receptor. The in vitro antibacterial activities of the highest binding affinity docked compounds were tested against E. coli, Staphylococcus aureus, and Salmonella spp. Majority of the tested compounds showed effective positive results against E. coli, while they were almost inactive against Staphylococcus aureus and Salmonella spp. The in vitro cytotoxic activities of the highest binding affinity-docked compounds were tested against the human liver carcinoma cell line (HepG2). Some compounds showed potent cytotoxic activity with low IC50 values, especially for 3 (6.525 mu M) and 13a (10.97 mu M) than that for standard drug doxorubicin (2.06 mu M).

Computed Properties of C7H5N3O. Bye, fridends, I hope you can learn more about C7H5N3O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocks. In 2019.0 J MED CHEM published article about CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; CAMP-SPECIFIC PHOSPHODIESTERASE; LONG-TERM-MEMORY; PROTEIN-KINASE; MOLECULAR-MECHANISMS; ADENYLYL-CYCLASE; STRUCTURAL BASIS; AMP PRODUCTION; KNOCKOUT MICE; DROSOPHILA in [Gurney, Mark E.; Nugent, Richard A.; Mo, Xuesheng; Sindac, Janice A.] Tetra Discovery Partners Inc, 38 Fulton St West, Grand Rapids, MI 49503 USA; [Hagen, Timothy J.] Northern Illinois Univ, Dept Chem & Biochem, 1425 West Lincoln Highway, De Kalb, IL 60115 USA; [Fox, David, III] Beryllium Discovery Corp, 7869 NE Day Rd West, Bainbridge Isl, WA 98110 USA; [O’Donnell, James M.; Zhang, Chong; Xu, Ying] SUNY Buffalo, Dept Pharmaceut Sci, Sch Pharm & Pharmaceut Sci, Buffalo, NY 14214 USA; [Zhang, Han-Ting] West Virginia Univ, Hlth Sci Ctr, Rockefeller Neurosci Inst, Dept Behav Med & Psychiat, 1 Med Ctr Dr, Morgantown, WV 26506 USA; [Zhang, Han-Ting] West Virginia Univ, Hlth Sci Ctr, Rockefeller Neurosci Inst, Dept Physiol Pharmacol & Neurosci, 1 Med Ctr Dr, Morgantown, WV 26506 USA; [Groppi, Vincent E.] Univ Michigan, Michigan Drug Discovery, Life Sci Inst, 210 Washtenaw Ave, Ann Arbor, MI 48103 USA; [Bailie, Marc] INDS Inc, 6111 Jackson Rd,Suite 100, Ann Arbor, MI 48103 USA; [White, Ronald E.] White Global Pharma Consultants, 31 Kinglet Dr, South Cranbury, NJ 08512 USA; [Romero, Donna L.] Pharma Vat Consulting LLC, 1201 Turnberry Ridge Court, Chesterfield, MO 63005 USA; [Vellekoop, A. Samuel; Walker, Joel R.; Surman, Matthew D.; Zhu, Lei; Campbell, Robert F.] Albany Mol Res Inc, 21 Corp Circle, Albany, NY 12203 USA; [Fox, David, III] UCB Pharma, 7869 NE Day Rd West, Bainbridge Isl, WA 98110 USA; [Zhang, Chong] Janssen China R&D, 65 Guiqing Rd,Bldg A,Floor 6, Shanghai 200233, Peoples R China; [Campbell, Robert F.] Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA in 2019.0, Cited 81.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9.

Novel pyridine- and pyrimidine-based allosteric inhibitors are reported that achieve PDE4D subtype selectivity through recognition of a single amino acid difference on a key regulatory domain, known as UCR2, that opens and closes over the catalytic site for cAMP hydrolysis. The design and optimization of lead compounds was based on iterative analysis of X-ray crystal structures combined with metabolite identification. Selectivity for the activated, dimeric form of PDE4D provided potent memory enhancing effects in a mouse model of novel object recognition with improved tolerability and reduced vascular toxicity over earlier PDE4 inhibitors that lack subtype selectivity. The lead compound, 28 (BPN14770), has entered midstage, human phase 2 clinical trials for the treatment of Fragile X Syndrome.

Welcome to talk about 104-10-9, If you have any questions, you can contact Gurney, ME; Nugent, RA; Mo, XS; Sindac, JA; Hagen, TJ; Fox, D; O’Donnell, JM; Zhang, C; Xu, Y; Zhang, HT; Groppi, VE; Bailie, M; White, RE; Romero, DL; Vellekoop, AS; Walker, JR; Surman, MD; Zhu, L; Campbell, RF or send Email.. Category: amides-buliding-blocks

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Matsumoto, K; Takeda, S; Hirokane, T; Yoshida, M in AMER CHEMICAL SOC published article about BOND FORMATION; DERIVATIVES; ARYLATION; BINAM; BIPHENOLS; PHENOLS in [Matsumoto, Kenji; Takeda, Satoshi; Hirokane, Tsukasa; Yoshida, Masahiro] Tokushima Bunri Univ, Fac Pharmaceut Sci, 180 Nishihama Boji, Yamashiro, Tokushima 7708514, Japan in 2019.0, Cited 58.0. Application In Synthesis of 2-(4-Aminophenyl)ethanol. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

The first catalytic oxidative aniline-aniline cross-coupling reaction using oxygen as the terminal oxidant is reported. Anilines possessing a pyrrolidino group can be preferentially oxidized under mild aerobic conditions and reacted with other anilines to afford a variety of nonsymmetrical 2-aminobiphenyls with high selectivities. A heterogeneous palladium catalyst is used for the dehydrogenative cross-coupling of anilines with structurally diverse arenes. This reaction does not require stoichiometric oxidants and is an economical and environmentally friendly method.

Application In Synthesis of 2-(4-Aminophenyl)ethanol. Welcome to talk about 104-10-9, If you have any questions, you can contact Matsumoto, K; Takeda, S; Hirokane, T; Yoshida, M or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics