Tag: M.W=100-150

Tayade, Rajratna P. published the artcileSynthesis of Novel Thiazole Based Carbaldehyde as Potential Sensor for Fluoride Anion and their Spectroscopic Properties, Safety of Morpholine-4-carbothioamide, the publication is Journal of Fluorescence (2017), 27(3), 1117-1128, database is CAplus and MEDLINE.

A novel thiazole based carbaldehyde bearing benzimidazole fluorophore as the receptor unit for F^– anion was prepared by multistep synthesis. D. functional theory was used to understand the structural and electronic properties of the receptor. The anion sensing activities of receptor I were studied for various anions in acetonitrile solvent. The receptor showed fluorescence enhancement in the presence of fluoride anion due to intramol. charge transfer (ICT) mechanism. No significant changes were observed upon addition of less basic anions such as OAc^–, Cl^–, Br^–, I^–, HSO₄^–. After the interaction of fluoride anion with the receptor I leads to an 88 nm red shift in emission maxima. [TBA]OH and ¹H NMR titration experiments indicated that deprotonation of N-H in the benzimidazole due to interaction with fluoride anions.

Journal of Fluorescence published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C10H10O2, Safety of Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Thorat, Kishor G. published the artcilePyrrole-thiazole based push-pull chromophores: An experimental and theoretical approach to structural, spectroscopic and NLO properties of the novel styryl dyes, Quality Control of 14294-10-1, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2017), 1-17, database is CAplus.

Novel push-pull fluorophores constituted by two donors (substituted pyrrole and morpholine) linked to acceptor through thiazole electron spacer have been synthesized. The fluorophores are investigated for linear and non-linear optical properties by UV-VIS absorption and fluorescence spectroscopies, and by means of TD-DFT (B3LYP/6-31G(d)) method, with the aim of elucidating the ability of the morpholine/pyrrole-donor-thiazole-spacer based D-π-A fluorophores as organic NLO materials. The bond length alternation and generalized Mulliken-Hush (GMH) anal. is performed to understand the involvement of the donor in effective transfer of the charge to acceptor. Values of first-order hyperpolarizabilities (β_CT or β₀), obtained by the solvatochromic method (Lippert Mataga model), and the transition dipole moments (μ_eg) used to characterize and evaluate the non-linear optical performances of the D-π-A fluorophores in various microenvironments. The D-π-A fluorophores possess good values of β_CT or β₀ in different organic solvents and hold high thermal stabilities therefore can be used as potential organic NLO materials.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C12H17NS2, Quality Control of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Moutaoukil, Zakaria published the artcileN-Alkylation of organonitrogen compounds catalyzed by methylene-linked bis-NHC half-sandwich ruthenium complexes, Synthetic Route of 1453-82-3, the publication is Organic & Biomolecular Chemistry (2022), 20(4), 831-839, database is CAplus and MEDLINE.

An efficient ruthenium-catalyzed N-alkylation of amines, amides and sulfonamides was developed employing novel pentamethylcyclopentadienylruthenium(II) complexes bearing the methylene linked bis(NHC) ligand bis(3-methylimidazol-2-ylidene)methane. The acetonitrile complex I was proved to be particularly effective with a broad range of substrates with low catalyst loading (0.1-2.5 mol%) and high functional group tolerance under mild conditions. A total of 52 N-alkylated organonitrogen compounds including biol. relevant scaffolds were synthesized from (hetero)aromatic and aliphatic amines, amides and sulfonamides using alcs. or diols as alkylating agents in up to 99% isolated yield, even on gram-scale reactions. In the case of sulfonamides, it was the first example of N-alkylation employing a transition-metal complex bearing NHC ligands.

Organic & Biomolecular Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Synthetic Route of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liu, Fangyao published the artcileAtom transfer radical polymerization as a tool for making poly(N-acryloylglycinamide) with molar mass independent UCST-type transitions in water and electrolytes, Category: amides-buliding-blocks, the publication is Polymer Chemistry (2013), 4(10), 3123-3131, database is CAplus.

Atom transfer radical polymerization (ATRP) of N-acryloylglycinamide has been used as a tool to make poly(NAGA) showing UCST-type phase transitions in water and electrolytes independent of molar mass and end-groups. We hypothesized that similarity in the structure of polymer chain ends with the repeat unit of poly(NAGA) could help in eliminating the effect of molar mass dependence of the cloud point especially in the low molar mass region. The monomer-like end-groups were introduced by choosing an appropriate initiator for ATRP like chloropropionamide (CPA). The catalyst system CuCl/CuCl₂ and tris[2-(dimethylamino)ethyl]-amine (Me₆TREN) as a ligand provided controlled polymerization of NAGA in DMSO at 45° with UCST-type transitions retained in water and electrolytes without being influenced by chain ends/M mass and high concentration of salts like NaCl and Na₂SO₄.

Polymer Chemistry published new progress about 2479-62-1. 2479-62-1 belongs to amides-buliding-blocks, auxiliary class Monomers,Acrylamide Monomers, name is N-(2-Amino-2-oxoethyl)acrylamide, and the molecular formula is C5H8N2O2, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liu, Fangyao published the artcileA Non-ionic Thermophilic Hydrogel with Positive Thermosensitivity in Water and Electrolyte Solution, Formula: C5H8N2O2, the publication is Macromolecular Chemistry and Physics (2014), 215(15), 1466-1472, database is CAplus.

The first example of a chem. crosslinked synthetic non-ionic hydrogel showing reversible pos. swelling behavior in pure water as well as electrolyte solution is highlighted. Homopolymeric hydrogels are synthesized from N-acryloylglycinamide with N,N’-methylenbis(acrylamide) as a chem. crosslinker via free radical polymerization in DMSO. The swelling-ratio dependency of the hydrogels upon temperature as well as on the amounts of crosslinker from 1 to 4.8 mol% is studied. With 1 mol% crosslinker, the hydrogel is able to take up over three times water of its weight at 37 °C in pure water and phosphate-buffered saline. All the samples show almost 100% of reversibility for at least 6 d up to 37 °C irresp. of the amount of the crosslinker, making them promising candidates for biomedical applications. The sample with a higher amount of crosslinker, i.e., 4.8 mol% is even stable for over 6 d at 70 °C.

Macromolecular Chemistry and Physics published new progress about 2479-62-1. 2479-62-1 belongs to amides-buliding-blocks, auxiliary class Monomers,Acrylamide Monomers, name is N-(2-Amino-2-oxoethyl)acrylamide, and the molecular formula is C5H8N2O2, Formula: C5H8N2O2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liu, Fangyao published the artcileControlled radical polymerization of N-acryloylglycinamide and UCST-type phase transition of the polymers, Name: N-(2-Amino-2-oxoethyl)acrylamide, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2012), 50(23), 4920-4928, database is CAplus.

N-Acryloylglycinamide was polymerized via the reversible addition fragmentation transfer process without sacrificing its key property, the upper critical solution temperature in water. This could be achieved by choosing an appropriate nonionic initiator [2,2′-azobis(4-methoxy-2.4-dimethyl valeronitrile) (V-70)] and nonionic chain-transfer agent (cyanomethyl dodecyl trithiocarbonate). A good molar mass control was accomplished as proved by the linear increase of molar mass with conversion, a chain extension experiment, and low dispersity. The influence of molar mass, polymer end groups, or salt concentration on the cloud point was analyzed by turbidimetry. Polymer end groups exerted a distinct effect on the cloud points, whereas the influence increased with decreasing molar masses. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 2479-62-1. 2479-62-1 belongs to amides-buliding-blocks, auxiliary class Monomers,Acrylamide Monomers, name is N-(2-Amino-2-oxoethyl)acrylamide, and the molecular formula is C5H8N2O2, Name: N-(2-Amino-2-oxoethyl)acrylamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kempf, Dale J. published the artcileDiscovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy, HPLC of Formula: 14294-10-1, the publication is Journal of Medicinal Chemistry (1998), 41(4), 602-617, database is CAplus and MEDLINE.

The structure-activity studies leading to the potent and clin. efficacious HIV protease inhibitor ritonavir are described. Beginning with the moderately potent and orally bioavailable inhibitor A-80987, systematic investigation of peripheral (P3 and P2′) heterocyclic groups designed to decrease the rate of hepatic metabolism provided analogs with improved pharmacokinetic properties after oral dosing in rats. Replacement of pyridyl groups with thiazoles provided increased chem. stability toward oxidation while maintaining sufficient aqueous solubility for oral absorption. Optimization of hydrophobic interactions with the HIV protease active site produced ritonavir, with excellent in vitro potency (EC₅₀ = 0.02 μM) and high and sustained plasma concentrations after oral administration in 4 species. Details of the discovery and preclin. development of ritonavir are described.

Journal of Medicinal Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, HPLC of Formula: 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Shoair, Abdel Ghany F. published the artcileElectrochemical and catalytic properties of oxo-ruthenate(VI) in aqueous alkaline medium, HPLC of Formula: 1453-82-3, the publication is International Journal of Electrochemical Science (2021), 16(5), 210545, database is CAplus.

The complex K₂[Ru^(III)Cl₅(H₂O)] has been prepared and characterized by different spectroscopic techniques (IR and UV-VIS). The electrochem. properties of this complex were investigated at different pH′s using Robinson buffer solutions The cyclic voltammograms exhibited three redox different oxidation and potential peaks due to generation of Ru(III), Ru(IV), Ru(V) and Ru(VI) ions. The catalytic activity of K₂[Ru^(III)Cl₅(H₂O)] towards the hydration of some aromatic and three heterocyclic nitriles to their corresponding amides was investigated with excess of three co-oxidants K₂S₂O₈, NaOCl and KBrO₃. A number of factors have been investigated and the best yields were obtained with K₂S₂O₈ as a co-oxidant in a 1.0 M KOH at 80 °C. Both spectroscopic and electrochem. techniques were used to establish the nature of active species in this catalytic reaction and the active catalyst was found to be K₂[Ru^(VI)O₃(OH)₂], as well as to explain the possible reaction mechanism. The suggested mechanism included the coordination of nitrile to ruthenium center followed by liberation of the corresponding amide and the active complex again.

International Journal of Electrochemical Science published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C9H5ClO2, HPLC of Formula: 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kalita, Gauravjyoti D. published the artcileBimetallic Au-Pd nanoparticles supported on silica with a tunable core@shell structure: enhanced catalytic activity of Pd(core)-Au(shell) over Au(core)-Pd(shell), Recommanded Product: Isonicotinamide, the publication is Nanoscale Advances (2021), 3(18), 5399-5416, database is CAplus.

A facile ligand-assisted approach of synthesizing bimetallic Au-Pd nanoparticles supported on silica with a tunable core@shell structure is presented. Maneuvering the addition sequence of metal salts, both Aucore-Pdshell (Au@Pd-SiO₂) and Pdcore-Aushell (Pd@Au-SiO₂) nanoparticles were synthesized. The structures and compositions of the core-shell materials were confirmed by probe-corrected HRTEM, TEM-EDX mapping, EDS line scanning, XPS, PXRD, BET, FE-SEM-EDX and ICP anal. The synergistic potentials of the core-shell materials were evaluated for two important reactions viz. hydrogenation of nitroarenes to anilines and hydration of nitriles to amides. In fact, in both the reactions, the Au-Pd materials exhibited superior performance over monometallic Au or Pd counterparts. Notably, among the two bimetallic materials, the one with Pd_core-Au_shell structure displayed superior activity over the Au_core-Pd_shell structure which could be attributed to the higher stability and uniform Au-Pd bimetallic interfaces in the former compared to the latter. Apart from enhanced synergism, high chemoselectivity in hydrogenation, wide functional group tolerance, high recyclability, etc. are other advantages of our system. A kinetic study has also been performed for the nitrile hydration reaction which demonstrates first order kinetics. Evaluation of rate constants along with a brief investigation on the Hammett parameters has also been presented.

Nanoscale Advances published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Recommanded Product: Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Telore, Rahul D. published the artcilePush-pull fluorophores with viscosity dependent and aggregation induced emissions insensitive to polarity, Product Details of C5H10N2OS, the publication is Dyes and Pigments (2015), 359-367, database is CAplus.

A series of push-pull chromophoric extended styryls from 5,5′-(9-ethyl-9H-carbazole-3,6-diyl)bis(2-morpholinothiazole-4-carbaldehyde) were synthesized by Knoevenagal condensation reaction with active methylene compounds The intermediate carbaldehyde was synthesized from carbazole through multistep reactions. The intramol. charge transfer of synthesized highly conjugated sym. D-π-A (D-donor, A-acceptor) extended styryls with rigid structure have been investigated by means of photophys. properties. The photophys. properties like absorption, emission and quantum yield of styryl derivatives were evaluated in various solvents of different polarities. All these synthesized extended styryls have exhibited aggregation induced emission with enhanced fluorescence intensity. This series of compounds can also be used as fluorescence mol. rotors for viscosity sensing. The sensitivity of viscosity towards UV absorption as well as fluorescence emission has also been investigated.

Dyes and Pigments published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10O, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics