Tag: M.W=100-150

Karteek, S. Durga published the artcileSynthesis and Docking Study of Novel Pyranocoumarin Derivatives, Recommanded Product: 2-Cyano-N-ethylacetamide, the publication is Russian Journal of Organic Chemistry (2021), 57(2), 272-282, database is CAplus.

A new series of fused tricyclic coumarin derivatives I [R¹ = H, Me, Ph, etc.; R² = H, Me, Et] were designed, synthesized by a simple and convenient method, starting from 4-hydroxycoumarin and virtually screened by mol. docking on the target protein 3FRZ (PDB ID: 3FRZ), a HCV RNA-dependent RNA polymerase, for potency against hepatitis C virus (HCV). Efficient binding to the target protein was found for most of the synthesized compds I.

Russian Journal of Organic Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Recommanded Product: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Reddy, Y. Thirupathi published the artcileSulfamic acid: An efficient, cost-effective, and reusable solid acid catalyst for the synthesis of 1,8-naphthyridines under solvent-free heating and microwave irradiation, COA of Formula: C5H8N2O, the publication is Synthetic Communications (2008), 38(18), 3201-3207, database is CAplus.

An efficient and convenient method is described for the synthesis of 1,8-naphthyridines in excellent yields by condensation of 2-aminonicotinaldehyde with various active methylene compounds in the presence of sulfamate as the catalyst in solvent-free media using both conventional heating and microwave irradiation

Synthetic Communications published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, COA of Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Yadav, Suman published the artcileAerobic oxidation of primary amines to amides catalyzed by an annulated mesoionic carbene (MIC) stabilized Ru complex, Synthetic Route of 1453-82-3, the publication is Catalysis Science & Technology (2021), 11(21), 7018-7028, database is CAplus.

Catalytic aerobic oxidation of primary amines to the amides, using the precatalyst [Ru(COD)(L¹)Br₂] bearing an annulated π-conjugated imidazo[1,2-a][1,8]naphthyridine-based mesoionic carbene ligand L¹, was disclosed. This catalytic protocol was distinguished by its high activity and selectivity, wide substrate scope and modest reaction conditions. A variety of primary amines, RCH₂NH₂ (R = aliphatic, aromatic and heteroaromatic), were converted to the corresponding amides using ambient air as an oxidant in the presence of a sub-stoichiometric amount of KO^tBu in ^tBuOH. A set of control experiments, Hammett relationships, kinetic studies and DFT calculations were undertaken to divulge mechanistic details of the amine oxidation using [Ru(COD)(L¹)Br₂]. The catalytic reaction involveed abstraction of two amine protons and two benzylic hydrogen atoms of the metal-bound primary amine by the oxo and hydroxo ligands, resp. A β-hydride transfer step for the benzylic C-H bond cleavage was not supported by Hammett studies. The nitrile generated by the catalytic oxidation undergoes hydration to afford the amide as the final product.

Catalysis Science & Technology published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C11H15NOS, Synthetic Route of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hartmann, Horst published the artcileHeterocyclic dyes and precursors. XVII. Preparation and characterization of 1,1-disubstituted thioureas, Product Details of C5H10N2OS, the publication is Journal fuer Praktische Chemie (Leipzig) (1973), 315(1), 144-8, database is CAplus.

Reaction of RR1NH with R2CONCS (R2 = EtO or Ph) gave RR1NCSNHCOR2 (I), which were heated in concentrated HCl to give RR1NCSNH2 (II, R = Me, Et. Pr, Bu, PhCH2, or Ph; R1 = Me, Et, Pr, Bu, or PhCH2; RR1N = morpholino, piperidino, or 1-pyrrolidinyl).

Journal fuer Praktische Chemie (Leipzig) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mameli, E. published the artcileAminolysis of ethylxanthogenamide, Related Products of amides-buliding-blocks, the publication is Atti ist. veneto sci., Classe sci. mat. e nat. (1952), 101-2, database is CAplus.

EtOCSNH₂ in H₂O-EtOH in the cold with pyrrolidine at pH 12-13 gave (CH₂)₄NCSNH₂, with piperidine at pH 13 (CH₂)₅NCSNH₂, at pH 11 EtOCSN(CH₂)₅ with morpholine at pH 13, O(C₂H₄)₂NCSNH₂, at pH 11 EtOCSN(C₂H₄)₂O + [O(C₂H₄)₂NC(:NH)NH₂]₂.H₂.

Atti ist. veneto sci., Classe sci. mat. e nat. published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mameli, E. published the artcileAminolysis of ethylxanthogenacetic acid, Formula: C5H10N2OS, the publication is Atti ist. veneto sci., Classe sci. mat. e nat (1952), 99-100, database is CAplus.

EtOCSSCH₂CO₂H gives with pyrrolidine 90% EtOCSN(CH₂)₄, with piperidine 90% EtOCSN(CH₂)₅, with sulfanilamide 70% EtOCSNHC₆H₄SO₂NH₂-p, with diethanolamine 60% EtOCSN(C₂H₄OH)₂. EtOCSSCH₂CO₂H gives with NH₃ mainly EtOCSNH₂ and small quantities of SC(SCH₂CO₂H)₂.

Atti ist. veneto sci., Classe sci. mat. e nat published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Formula: C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Schroth, Werner published the artcileSynthesis and chemical behavior of 6-sec-amino-1,3-thiazine-2-thiones, Quality Control of 14294-10-1, the publication is Monatshefte fuer Chemie (1988), 119(4), 463-76, database is CAplus.

The title compounds I (R = H, Me, OMe, Cl, Br; NR¹R² = pyrrolidino, piperidino, morpholino) have been prepared by ring transformation reactions of the isomeric 2-sec-amino-1,3-thiazine-6-thiones II (NR³R⁴ = NMe₂, pyrrolidino, morpholino) via R²R¹NCSCH:C(C₆H₄R-4)NHCSNR³R⁴ (III) and via cyclocondensation reactions of thiocarboxamides R²R¹NCSCH:C(C₆H₄R-4)NH₂, and R²R¹N⁺:CClCH:C(C₆H₄R-4)OEt BF₄^– obtained from 4-RC₆H₄COCH:CCl₂. The pathways differ specifically in scope and limitations. On the other hand III also react with alkylating agents to give 2,6-di-sec-amino-1,3-thiazinium salts, which are also available via alkylation of I and aminolysis.

Monatshefte fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Quality Control of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Khalaji, Mehrnaz published the artcileVirtual Cocrystal Screening Methods as Tools to Understand the Formation of Pharmaceutical Cocrystals-A Case Study of Linezolid, a Wide-Range Antibacterial Drug, Safety of Isonicotinamide, the publication is Crystal Growth & Design (2021), 21(4), 2301-2314, database is CAplus.

Exptl. mechanochem. screening of cocrystals with linezolid (LIN) resulted in the formation of six new crystal phases, including three neat cocrystals and three cocrystal hydrates, in addition to seven previously described cocrystals. In an attempt to understand the factors governing the formation of these phases, different exptl. conditions of the mechanochem. reactions (polymorphic forms of LIN and presence of different solvents to create liquid-assisted grinding conditions) were tested and the results were compared with the predictions from three commonly used virtual cocrystal screening tools: mol. complementarity, hydrogen bond propensity, and mol. electrostatic potential maps. It is shown that these three methods can be used to help understand a mol.’s preferences to form cocrystals with particular coformers. The influence of mol. conformation on the outcome of the predictions is also evaluated. A comparison between the prediction methods indicates that while considering a set of similar coformers, the approach based on mol. electrostatic potential maps seems to be more consistent with the exptl. results than mol. complementarity and hydrogen bond propensity tools. Instead, these two latter approaches are recommended at the early stages of coformer selection. In addition, intermol. energy contribution (lattice energy) to the total energy of crystal forms of coformers was found to be indicative of the feasibility of cocrystal formation in the case of coformers capable of forming similar supramol. synthons.

Crystal Growth & Design published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Safety of Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Dey, Dhananjay published the artcileCrystal and molecular structure of 2-amino-3-ethylcarbamoyl-4-methyl-5-ethoxycarbonylthiophene, COA of Formula: C5H8N2O, the publication is Crystal Structure Theory and Applications (2012), 1(3), 92-96, 5 pp., database is CAplus.

The crystal and mol. structure of 2-amino-3-ethylcarbamoyl-4-methyl-5-ethoxycarbonylthiophene was determined from single crystal X-ray diffraction data. The primary focus was to investigate the mol. geometry of this compound in the solid state along with the associated intermol. and intramol. hydrogen bonding and related weak interactions present in this mol. This compound crystallized in the monoclinic space group P2₁/c with cell parameters: a = 8.1344(3) Å, b = 13.7392(4) Å, c = 11.4704(4) Å, β = 100.769(2)° , V = 1259.36(7) ų, D = 1.352 g·cm^-3, Z = 4. The mol. geometry was stabilized by intramol. N-H···O=C and C-H···O interactions along with intermol. C-H···N and C-H···O interactions which contribute towards the stability of the crystal packing.

Crystal Structure Theory and Applications published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, COA of Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Jiang, Qihui published the artcileActivation of hydrogen peroxide by graphite supported H₂SO₄-CeO₂ for isoniazid degradation under neutral pH, SDS of cas: 1453-82-3, the publication is Water Science & Technology (2022), 85(7), 2051, database is CAplus.

Graphite felt (GF) supported cerium oxide (CeO₂) composite with sulfation pretreatment (H₂SO₄-CeO₂/GF) was prepared by the impregnation method and employed as the catalyst to activate H₂O₂ for degradation of isoniazid (INH). The obtained samples were characterized by X-ray diffraction (XRD), Fourier transform IR spectroscopy (FTIR), SEM (SEM) and X-ray photoelectron spectrum (XPS). The results showed that H₂SO₄-CeO₂/GF had good properties in activating H₂O₂ for the degradation of INH. The INH removal was about 89.4% in 120 min under the following conditions: H₂O₂ 2.94 mM, H₂SO₄-CeO₂/GF 2.6 g/L, INH 10 mg/L, initial pH at 6.8 and temperature at 25°C. The effects of some reaction parameters, including initial H₂O₂ concentration, initial INH concentration, initial pH value, the catalyst dosage and reaction temperature, on INH degradation were investigated. On the basis of mechanism study and intermediate anal., the possible degradation pathway of INH was proposed. Besides, effective degradation of methyl orange (MO) and norfloxacin (NOF) also confirmed the high activity of H₂SO₄-CeO₂/GF in activation of H₂O₂. The H₂SO₄-CeO₂/GF was relatively stable, showing good application prospects.

Water Science & Technology published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, SDS of cas: 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics