Tag: M.W=100-150

Product Details of 104-10-9. Lamaa, D; Lin, HP; Bzeih, T; Retailleau, P; Alami, M; Hamze, A in [Lamaa, Diana; Lin, Hsin-Ping; Bzeih, Tourin; Alami, Mouad; Hamze, Abdallah] Univ Paris Saclay, Univ Paris Sud, CNRS, BioCIS,Equipe Labellisee Ligue Canc, F-92290 Chatenay Malabry, France; [Retailleau, Pascal] CNRS, Inst Chim Subst Nat, UPR 2301, F-91198 Gif Sur Yvette, France published TBAB-Catalyzed Csp(3)-N Bond Formation by Coupling Pyridotriazoles with Anilines: A New Route to (2-Pyridyl)alkylamines in 2019.0, Cited 52.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9.

A new metal-free procedure allowing Csp(3)-N bond formation through coupling of pyridotriazoles and weakly nucleophilic anilines has been developed. This sustainable reaction shows high tolerance towards functional groups (ketones, free alcohols) leading to 2-picolylamine derivatives. The key to our success is the use of a catalytic amount of TBAB and water as a co-solvent leading to the formation of pyridylalkylamine derivatives. As this coupling tolerates the presence of Csp(2)-Br bond on both partners of the reaction, we performed a sequential one-pot reaction between functionalized triazolopyridines and anilines followed by a second coupling with N-tosylhydrazones leading to the formation of Csp(3)-N and Csp(2)-Csp(2) bonds.

Product Details of 104-10-9. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Lamaa, D; Lin, HP; Bzeih, T; Retailleau, P; Alami, M; Hamze, A or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2021 GREEN CHEM published article about ALKYNE INSERTION; LIGANDS; ACIDS; ANNULATION; 1,2,3-BENZOTRIAZIN-4(3H)-ONES in [Tang, Guo] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China; Xiamen Univ, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Fujian, Peoples R China in 2021, Cited 54. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4. Application In Synthesis of Benzo[d][1,2,3]triazin-4(3H)-one

Metal-free, visible-light-induced denitrogenative phosphorylation of 1,2,3-benzotriazinones was achieved. With the use of eosin Y as a photoredox catalyst, N,N-diisopropylethylamine as a base, CH3CN-H2O as a solvent and sunlight or a blue LED as a light source, a variety of aryl-phosphonates, aryl-phosphinates, and aryl-phosphine oxides were efficiently prepared. In addition, B(2)pin(2) instead of P-nucleophiles as a radical acceptor was also demonstrated. The key advantages of this newly developed method are the clean reaction profile, use of a low-cost organic-dye catalyst, energy efficiency, broad substrate scope, good to excellent yields and large-scale synthetic applicability. The gram-scale synthesised compounds could be isolated in pure form just upon extraction, followed by re-crystallisation; no tedious chromatographic purification was required.

Application In Synthesis of Benzo[d][1,2,3]triazin-4(3H)-one. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Chen, FS; Hu, SS; Li, SP; Tang, G; Zhao, YF or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2020.0 BIOORGAN MED CHEM published article about TOPOISOMERASE-I INHIBITOR; S-PHASE; DNA; ARREST; CAMPTOTHECIN; DOXORUBICIN; INDUCTION; EFFICIENT; APOPTOSIS; DERIVATIVES in [Ibric, Amra; Battisti, Verena; Deckardt, Sophie; Haller, Anna Veronika; Lee, Calvin; Proetsch, Corinna; Langer, Thierry; Haider, Norbert] Univ Vienna, Dept Pharmaceut Chem, Althanstr 14, A-1090 Vienna, Austria; [Heffeter, Petra; Schueffl, Hemma Henrike; Marian, Brigitte] Med Univ Vienna, Inst Canc Res, Borschkegasse 8a, A-1090 Vienna, Austria; [Heffeter, Petra; Schueffl, Hemma Henrike; Marian, Brigitte] Med Univ Vienna, Comprehens Canc Ctr, Borschkegasse 8a, A-1090 Vienna, Austria in 2020.0, Cited 56.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9. Product Details of 104-10-9

A series of new Luotonin A derivatives with substituents at rings A and E was synthesized, together with some E-ring-unsubstituted derivatives. Subsequently, the compound library was examined in silico for their binding into a previously proposed site in the DNA/topoisomerase I binary complex. Whereas no convincing correlation between docking scores and biological data from in vitro assays could be found, one novel 4,9-diamino Luotonin A derivative had strong antiproliferative activity based on massive G2/M phase arrest. As this biological activity clearly differs from the reference compound Camptothecin, this strongly indicates that at least some Luotonin A derivatives may be potent antiproliferative agents, however with a different mode of action.

Product Details of 104-10-9. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Ibric, A; Battisti, V; Deckardt, S; Haller, AV; Lee, C; Protsch, C; Langer, T; Heffeter, P; Schueffl, HH; Marian, B; Haider, N or concate me.

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Amide – Wikipedia,
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Quality Control of 2-(4-Aminophenyl)ethanol. Recently I am researching about PROLIFERATOR-ACTIVATED RECEPTORS; GAMMA MODULATOR; FATTY-ACIDS; BINDING; IDENTIFICATION, Saw an article supported by the Japan Society for the Promotion of Science [KAKENHI]Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [17K13264]. Published in MDPI in BASEL ,Authors: Utsugi, Y; Kobuchi, H; Kawamura, Y; Atito, ASA; Nagao, M; Isoda, H; Miyamae, Y. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol

Covalent agonists of PPAR cause unique receptor conformational changes and behave as selective PPAR modulators, whereas there are few covalent agonists other than endogenous unsaturated fatty acids metabolites. Previously, we established a cell-based strategy to identify new PPAR ligands and synthesized a new-type of covalent agonist that possesses the hybrid structure of a plant-derived cinnamic acid derivative and GW9662, a covalent antagonist. Herein, we report six analogues that differ in how the two fragments are linked together. Compounds with a simplified linker showed potent agonistic activity with improved EC50 values (less than 5 nM), indicating that close proximity between the two fragments improves binding affinity. When the position of cinnamic acid moiety was placed at 4 carbon of aniline ring, PPAR agonist activity was completely abolished. Docking studies suggested that the activation profile likely depends on interaction with the cavity around helix 3, -sheet, and -loop region in the ligand-binding domain. Furthermore, a cell-based assay revealed that agonist-type compounds activate PPAR transcription in a manner dependent on covalent linkage with the Cys285 residue leading to prolonged transactivation. This activation feature reflects pharmacological benefits of covalent drugs, suggesting that these hybrid compounds may serve as potential leads for a new-class of covalent PPAR ligands.

Quality Control of 2-(4-Aminophenyl)ethanol. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Utsugi, Y; Kobuchi, H; Kawamura, Y; Atito, ASA; Nagao, M; Isoda, H; Miyamae, Y or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about STRESS-MEDIATED APOPTOSIS; THIOREDOXIN REDUCTASE; ARSENIC-BINDING; CELLS; DESIGN; QUANTIFICATION; IDENTIFICATION; FLUOROGENS; CONVERSION; THIOLS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21778028]; Ministry of Science and Technology National Key RD Project [2018YFE0205100]; Natural Science Foundation of Gansu Province [18JR4RA003]; 111 projectMinistry of Education, China – 111 Project. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Hu, GD; Jia, HY; Hou, YN; Han, X; Gan, L; Si, J; Cho, DH; Zhang, H; Fang, JG. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol. Computed Properties of C8H11NO

Vicinal dithiol-containing proteins (VDPs) play an important role in maintaining the structures and functions of proteins mainly through the conversion between dithiols and disulfide bonds. The content of VDPs also reflects the redox status of an organism. To specifically and expediently detect VDPs, we developed a turn-on monoarsenical fluorescent probe (NEP) based on the intramolecular charge transfer mechanism. Naphthalimide was chosen as a fluorophore and linked with the receptor moiety (cyclic dithiarsolane) via carbamate segment. In the presence of VDPs, NEP displays a strong green fluorescence signal produced by the cyclic dithiarsolane cleavage and subsequent intramolecular cyclization to liberate the fluorophore. Furthermore, NEP exhibits high selectivity toward VDPs over other protein thiols and low molecular weight thiols. The favorable properties of NEP enable it readily to detect VDPs in live cells and in vivo. In addition, a remarkable decrease of VDPs in parkinsonism was disclosed for the first time, highlighting that regulating VDPs level has a therapeutic potential for parkinsonism.

Computed Properties of C8H11NO. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Hu, GD; Jia, HY; Hou, YN; Han, X; Gan, L; Si, J; Cho, DH; Zhang, H; Fang, JG or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Iodinated Choline Transport-Targeted Tracers WOS:000603401900045 published article about MAGNETIC-RESONANCE-SPECTROSCOPY; POSITRON-EMISSION-TOMOGRAPHY; PROSTATE-CANCER; RADIATION-DOSIMETRY; LUNG-CANCER; IN-VITRO; METABOLISM; F-18-FLUOROCHOLINE; DIAGNOSIS; CELLS in [Svec, Pavel; Kucka, Jan; Sedlacek, Ondrej; Kolouchova, Kristyna; Groborz, Ondrej; Loukotova, Lenka; Konefal, Rafal L.; Hruby, Martin] CAS, Inst Macromol Chem, Prague 16206 6, Czech Republic; [Svec, Pavel] Charles Univ Prague, Fac Sci, Dept Phys & Macromol Chem, Prague 12843 2, Czech Republic; [Novy, Zbynek; Petrik, Milos; Liskova, Barbora; Medvedikova, Martina; Hajduch, Marian] Palacky Univ Olomouc, Fac Med & Dent, Inst Mol & Translat Med, Olomouc 77900, Czech Republic; [Kuchar, Martin] Univ Chem & Technol, Forens Lab Biol Act Subst, Prague 16000, Czech Republic in 2020, Cited 58. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9. Formula: C8H11NO

We present a novel series of radioiodinated tracers and potential theranostics for diseases accompanied by pathological function of proteins involved in choline transport. Unlike choline analogues labeled with C-11 or F-18 that are currently used in the clinic, the iodinated compounds described herein are applicable in positron emission tomography, single-photon emission computed tomography, and potentially in therapy, depending on the iodine isotope selection. Moreover, favorable half-lives of iodine isotopes result in much less challenging synthesis by isotope exchange reaction. Six of the described compounds were nanomolar ligands, and the best compound possessed an affinity 100-fold greater than that of choline. Biodistribution data of I-125-labeled ligands in human prostate carcinoma bearing (PC-3) mice revealed two compounds with a biodistribution profile superior to that of [F-18]fluorocholine.

Formula: C8H11NO. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Svec, P; Novy, Z; Kucka, J; Petrik, M; Sedlacek, O; Kuchar, M; Liskova, B; Medvedikova, M; Kolouchova, K; Groborz, O; Loukotova, L; Konefal, RL; Hajduch, M; Hruby, M or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocks. Reddy, GS; Snehalatha, AV; Edwin, RK; Hossain, KA; Giliyaru, VB; Hariharapura, RC; Shenoy, GG; Misra, P; Pal, M in [Reddy, Gangireddy Sujeevan; Snehalatha, Ampalam Venkata; Edwin, Rebecca Kristina; Hossain, Kazi Amirul; Misra, Parimal; Pal, Manojit] Dr Reddys Inst Life Sci, Univ Hyderabad Campus, Hyderabad 500046, India; [Reddy, Gangireddy Sujeevan; Giliyaru, Varadaraj Bhat; Hariharapura, Raghu Chandrashekhar; Shenoy, G. Gautham] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal 576104, Karnataka, India published Synthesis of 3-indolylmethyl substituted (pyrazolo/benzo)triazinone derivatives under Pd/Cu-catalysis: Identification of potent inhibitors of chorismate mutase (CM) in 2019, Cited 38. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4.

The chorismate mutase (CM) is considered as an attractive target for the identification of potential antitubercular agents due to its absence in animals but not in bacteria. A series of 3-indolylmethyl substituted pyrazolo-triazinone derivatives were designed and docked into CM in silico as potential inhibitors. These compounds were efficiently synthesized using the Pd/Cu-catalyzed coupling-cyclization in a single pot involving the construction of indole ring. The methodology was later extended to the preparation of corresponding benzo analogs of pyrazolotriazinones i.e. 3-indolylmethyl substituted benzotriazinone derivatives. Several of these novel compounds showed significant inhibition of CM when tested in vitro at 30 mu M. The SAR (Structure-Activity-Relationship) studies suggested that benzotriazinone moiety was more favorable over the pyrazolotriazinone ring. The two best active compounds showed IC50 similar to 0.4-0.9 mu M (better than the reference/known compounds used) and no toxicity till 30 mu M in vitro.

Category: amides-buliding-blocks. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Reddy, GS; Snehalatha, AV; Edwin, RK; Hossain, KA; Giliyaru, VB; Hariharapura, RC; Shenoy, GG; Misra, P; Pal, M or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Biagini, C; Fielden, SDP; Leigh, DA; Schaufelberger, F; Di Stefano, S; Thomas, D in [Biagini, Chiara; Fielden, Stephen D. P.; Leigh, David A.; Schaufelberger, Fredrik; Thomas, Dean] Univ Manchester, Sch Chem, Oxford Rd, Manchester M13 9PL, Lancs, England; [Biagini, Chiara; Di Stefano, Stefano] Univ Roma La Sapienza, Dipartimento Chim, Edificio Cannizzaro VEC,Piazzale Aldo Moro 5, I-00185 Rome, Italy published Dissipative Catalysis with a Molecular Machine in 2019.0, Cited 70.0. HPLC of Formula: C8H11NO. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9.

We report on catalysis by a fuel-induced transient state of a synthetic molecular machine. A [ 2] rotaxane molecular shuttle containing secondary ammonium/amine and thiourea stations is converted between catalytically inactive and active states by pulses of a chemical fuel (trichloroacetic acid), which is itself decomposed by the machine and/or the presence of additional base. The ON-state of the rotaxane catalyzes the reduction of a nitrostyrene by transfer hydrogenation. By varying the amount of fuel added, the lifetime of the rotaxane ON-state can be regulated and temporal control of catalysis achieved. The system can be pulsed with chemical fuel several times in succession, with each pulse activating catalysis for a time period determined by the amount of fuel added. Dissipative catalysis by synthetic molecular machines has implications for the future design of networks that feature communication and signaling between the components.

HPLC of Formula: C8H11NO. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Biagini, C; Fielden, SDP; Leigh, DA; Schaufelberger, F; Di Stefano, S; Thomas, D or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Zhang, XM; Peng, AH; Xie, WD; Wang, M; Zheng, D; Feng, MK in [Zhang, Xiu-Mei; Wang, Mei; Zheng, Dan; Feng, Ming-Kuan] Shandong Drug & Food Vocat Coll, Dept Pharm, Weihai 264210, Peoples R China; [Peng, Ai-Hong; Xie, Wei-Dong] Shandong Univ, Coll Marine Sci, Dept Pharm, Weihai 264209, Peoples R China published Hexokinase II Inhibitory Effect of Secondary Metabolites Derived from a Streptomyces sp. Associated with Mud Dauber Wasp in 2020, Cited 43. Formula: C7H5N3O. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4.

Insect-microbial symbioses have vast biochemical diversity, which is beneficial to produce bioactive secondary metabolites. In this study, chemical examination of a Streptomyces sp. associated with a mud dauber wasp led to the isolation of fourteen compounds. Their structures were determined by spectroscopic methods and comparison with literature data. Among the isolates, compounds 1,2,3-benzotriazin-4(1H)-one and 4-(2-aminoethyl)phenyl acetate were first reported from this species. Bioactivities of the isolated compounds were assayed for the first time against hexokinase II. 4-(2-Aminoethyl)phenyl acetate, germicidin B, phenylacetic acid, isogermicidin A and germicidin C displayed significant inhibitory activity against hexokinase II, with the IC50 values of 5.11, 7.11, 7.15, 8.45 and 8.78 mu M, respectively.

Formula: C7H5N3O. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Zhang, XM; Peng, AH; Xie, WD; Wang, M; Zheng, D; Feng, MK or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

An article 4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents WOS:000646945500004 published article about STAPHYLOCOCCUS-AUREUS MRSA; ACINETOBACTER-BAUMANNII; RESISTANT; ANTIBIOTICS; INFECTIONS; PERSISTERS; INHIBITORS; GROWTH in [Hansa, Raj K. C.; Khan, M. M. K.; Frangie, M. M.; Alam, M. A.] Arkansas State Univ, Coll Sci & Math, Dept Chem & Phys, Jonesboro, AR 72467 USA; [Gilmore, D. F.] Arkansas State Univ, Coll Sci & Math, Dept Biol Sci, Jonesboro, AR 72467 USA; [Shelton, R. S.; Savenka, A., V; Basnakian, A. G.] Univ Arkansas Med Sci, Dept Pharmacol & Toxicol, 4301 W Markham St, Little Rock, AR 72205 USA; [Basnakian, A. G.] Cent Arkansas Vet Healthcare Syst, W 7th St, Little Rock, AR 72205 USA; [Shuttleworth, S. L.; Smeltzer, M. S.] Univ Arkansas Med Sci, Dept Microbiol & Immunol, Dept Orthopaed Surg, Ctr Microbial Pathogenesis & Host Inflammatory Re, 4301 W Markham, Little Rock, AR 72205 USA in 2021.0, Cited 39.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9. Quality Control of 2-(4-Aminophenyl)ethanol

A collection of potent antimicrobials consisting of novel 1,3-bis-benzoic acid and trifluoromethyl phenyl derived pyrazoles has been synthesized and tested for antibacterial activity. The majority of trifluoromethyl phenyl derivatives are highly potent growth inhibitors of Gram-positive bacteria and showed low toxicity to human cultured cells. In particular, two compounds (59 and 74) were selected for additional studies. These compounds are highly effective against Staphylococcus aureus as shown by a low minimum inhibitory concentration (MIC), a bactericidal effect in time-kill assays, moderate inhibition of biofilm formation as well as biofilm destruction, and a bactericidal effect against stationary phase cells representing non-growing persister cells. Multistep resistance assays showed a very low tendency for S. aureus and Enterococcus faecalis to develop resistance through mutation. Additionally, in vivo mouse model studies showed no harmful effects at doses up to 50 mg/kg using 14 blood plasma organ toxicity markers or TUNEL assay in liver and kidney. Investigations into the mode of action by performing macromolecular synthesis inhibition studies showed a broad range of inhibitory effects, suggesting targets that have a global effect on bacterial cell function. Published by Elsevier Masson SAS.

About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Hansa, RKC; Khan, MMK; Frangie, MM; Gilmore, DF; Shelton, RS; Savenka, AV; Basnakian, AG; Shuttleworth, SL; Smeltzer, MS; Alam, MA or concate me.. Quality Control of 2-(4-Aminophenyl)ethanol

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics