Tag: M.W=100-150

COA of Formula: C7H5N3O. Zhang, ZG; Dai, SW; Li, L; Jia, CY; Zhang, Y; Li, H in [Zhang, Zhiguang; Dai, Siwei; Li, Ling; Jia, Chenyu; Zhang, Yong] Hebei Univ Sci & Technol, Coll Chem & Pharmaceut Engn, 26 Yuxiang Rd, Shijiazhuang 050018, Hebei, Peoples R China; [Li, Hao] East China Univ Sci & Technol, State Key Lab Bioengn Reactor, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China; [Li, Hao] East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China published Scandium-catalyzed Michael addition of quinazolinones and vinylazaarenes in 2020, Cited 35. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4.

We described a novel scandium-catalyzed selective Michael addition of quinazolinones and vinylazaarenes. The protocol proceeds smoothly to give diverse quinazolinone derivatives in moderate to excellent yields. The high practicality of this protocol was proved by excellent chemo selectivity and broad substrate and functional group compatibility. (C) 2020 Elsevier Ltd. All rights reserved.

COA of Formula: C7H5N3O. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Zhang, ZG; Dai, SW; Li, L; Jia, CY; Zhang, Y; Li, H or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
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Name: Benzo[d][1,2,3]triazin-4(3H)-one. I found the field of Chemistry very interesting. Saw the article Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita published in 2020, Reprint Addresses Xu, XY (corresponding author), East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China.. The CAS is 90-16-4. Through research, I have a further understanding and discovery of Benzo[d][1,2,3]triazin-4(3H)-one.

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol were synthesized and characterized by H-1 NMR, C-13 NMR, F-19 NMR and HRMS. The bioassay results showed that compounds 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-7-methoxybenzo[d][1-3]triazin-4(3H)-one, 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-6-nitrobenzo[d][1-3]triazin-4(3H)-one, 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1-3]triazin-4(3H)-one exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L-1 in vivo. Compound 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1-3]triazin-4(3H)-one showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L-1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further.

About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Chen, XL; Zhou, Z; Li, Z; Xu, XY or concate me.. Name: Benzo[d][1,2,3]triazin-4(3H)-one

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Authors Barak, DS; Mukhopadhyay, S; Dahatonde, DJ; Batra, S in PERGAMON-ELSEVIER SCIENCE LTD published article about CATALYZED DENITROGENATIVE ANNULATION; TERT-BUTYL NITRITE; NEMATOCIDAL ACTIVITIES; SELECTIVE SYNTHESIS; DERIVATIVES; 1,2,3-BENZOTRIAZINE-4-(3H)-ONES; ACID in [Barak, Dinesh S.; Mukhopadhyay, Sushobhan; Dahatonde, Dipak J.; Batra, Sanjay] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Sect 10,Jankipuram Extens,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India; [Batra, Sanjay] CSIR HRDC, Postal Staff Coll Area, Sect 19, Ghaziabad 201002, India in 2019, Cited 39. Category: amides-buliding-blocks. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4

An efficient transformation of 2-aminobenzamides to 1,2,3-benzotriazin-4(3H)-ones in the presence of sodium nitrite (NaNO2) and Iodine (I-2) is described. The reaction is proposed to proceed via formation of nitrosyl halide that induces nitrosylation of the amino group of 2-aminobenzamide leading to diazotization followed by intramolecular cyclization. (C) 2018 Elsevier Ltd. All rights reserved.

Category: amides-buliding-blocks. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Barak, DS; Mukhopadhyay, S; Dahatonde, DJ; Batra, S or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yum, JH; Sugiyama, H; Park, S in [Yum, Ji Hye; Sugiyama, Hiroshi; Park, Soyoung] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kitashirakawa Oiwakecho, Kyoto 6068502, Japan; [Sugiyama, Hiroshi] Kyoto Univ, Inst Integrated Cell Mat Sci iCeMS, Sakyo Ku, Yoshida Ushinomiyacho, Kyoto 6068501, Japan published Modular quadruplex-duplex hybrids as biomolecular scaffolds for asymmetric Michael addition reactions in 2020.0, Cited 45.0. Safety of 2-(4-Aminophenyl)ethanol. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9.

Asymmetric synthesis based on DNA scaffolds has been actively exploited because of the advantages of DNA such as diverse tertiary structures, chemical stability, and easy handling. Since duplex DNA-based hybrid catalysts have demonstrated this remarkable capability, efforts have been made to investigate new biomolecular scaffolds. Herein, we report modular quadruplex-duplex (QD) hybrid DNA catalysts containing bipyridine ligands and hydrogen donor moieties. The conformation, thermal stability, and metal-binding ability of modified QD hybrid DNA were characterized using spectroscopy. The QD hybrid-based DNA catalysts were successfully applied to asymmetric Michael addition reactions (86% conversion and 76% ee). This study describes a new type of DNA hybrid catalyst produced by the construction of a cooperative active site with a Lewis acid and a H-bond donor.

About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Yum, JH; Sugiyama, H; Park, S or concate me.. Safety of 2-(4-Aminophenyl)ethanol

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Computed Properties of C7H5N3O. El Rayes, SM; Ali, IAI; Fathalla, W; Mahmoud, MAA in [El Rayes, Samir M.; Ali, Ibrahim A. I.; Mahmoud, Mostafa A. A.] Suez Canal Univ, Fac Sci, Dept Chem, Ismailia 41529, Egypt; [Fathalla, Walid] Port Said Univ, Fac Engn, Phys & Math Engn Dept, Port Said 42526, Egypt published Synthesis and Biological Activities of Some New Benzotriazinone Derivatives Based on Molecular Docking; Promising HepG2 Liver Carcinoma Inhibitors in 2020, Cited 24. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4.

In one-pot strategy, diazotization of methyl anthranilate 5 followed by addition of amino acid ester hydrochloride, we have prepared methyl-2-(4-oxobenzotriazin-3(4H)-yl)-alkanoates 6a-c. Starting with hydrazides 7a,b, N-alkyl-2-(4-oxobenzotriazin-3(4H)-yl)-alkanamides 9-10(a-h) and methyl-2-(2-(4-oxobenzotriazin-3(4H)-yl)alkanamido)alkanoates 11- 12(a-e) were prepared via azide coupling. Hydrazones 13-15 were prepared via condensation of hydrazides 7a,b with 4-methoxybenzaldehyde, 4-dimethylaminobenzaldehyde, and/or arabinose. Molecular docking was done for synthesized compounds using MOE 2008-10 software. The compounds 9a, 12a, 12c, 13a, 13b, and 14b have the most pronounced strong binding affinities toward the target E. coli Fab-H receptor, whereas compounds 3, 11e, 12e, and 13a have the most pronounced strong binding affinities toward the target vitamin D receptor. The in vitro antibacterial activities of the highest binding affinity docked compounds were tested against E. coli, Staphylococcus aureus, and Salmonella spp. Majority of the tested compounds showed effective positive results against E. coli, while they were almost inactive against Staphylococcus aureus and Salmonella spp. The in vitro cytotoxic activities of the highest binding affinity-docked compounds were tested against the human liver carcinoma cell line (HepG2). Some compounds showed potent cytotoxic activity with low IC50 values, especially for 3 (6.525 mu M) and 13a (10.97 mu M) than that for standard drug doxorubicin (2.06 mu M).

Computed Properties of C7H5N3O. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact El Rayes, SM; Ali, IAI; Fathalla, W; Mahmoud, MAA or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

An article Heteroditopic Macrobicyclic Molecular Vessels for Single Step Aerial Oxidative Transformation of Primary Alcohol Appended Cross Azobenzenes WOS:000649101400054 published article about AROMATIC AZO-COMPOUNDS; PALLADIUM-CATALYZED OXIDATION; HOST-GUEST CHEMISTRY; RECOGNITION; ANILINES; COMPLEXATION; HYDROGEN; BINDING in [Sarkar, Sayan; Sarkar, Piyali; Ghosh, Pradyut] Indian Assoc Cultivat Sci, Sch Chem Sci, Kolkata 700032, India in 2021.0, Cited 101.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9. Safety of 2-(4-Aminophenyl)ethanol

A series of oxy-ether tris-amino heteroditopic macrobicycles (L1-L4) with various cavity dimensions have been synthesized and explored for their Cu(II) catalyzed selective single step aerial oxidative cross-coupling of primary alcohol based anilines with several aromatic amines toward the formation of primary alcohol appended cross azobenzenes (POCABs). The beauty of this transformation is that the easily oxidizable benzyl/primary alcohol group remains unhampered during the course of this oxidation due to the protective oxy-ether pocket of this series of macrobicyclic vessels. Various dimensionalities of the molecular vessels have shown specific size complementary selection for substrates toward efficient syntheses of regioselective POCAB products. To establish the requirement of the three-dimensional cavity based additives, a particular catalytic reaction has been examined in the presence of macrobicycles (L2 and L3) versus macrocycles (MC1 and MC2) and tripodal acyclic (AC1 and AC2) analogous components, respectively. Subsequently, L1-L4 have been extensively utilized toward the syntheses of as many as 44 POCABs and are characterized by different spectroscopic techniques and single crystal X-ray diffraction studies.

About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Sarkar, S; Sarkar, P; Ghosh, P or concate me.. Safety of 2-(4-Aminophenyl)ethanol

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article An Improved Synthesis of the Triethylene Glycol-Substituted 4-(N-Methyl-N-Boc-Amino)Styrylpyridine published in 2020.0. Category: amides-buliding-blocks, Reprint Addresses Hou, WB; Li, YL (corresponding author), Peking Union Med Coll, Inst Radiat Med, Tianjin Key Lab Radiat Med & Mol Nucl Med, Tianjin 300192, Peoples R China.; Hou, WB; Li, YL (corresponding author), Chinese Acad Med Sci, Tianjin 300192, Peoples R China.; Li, YL (corresponding author), Tianjin Univ Tradit Chinese Med, Tianjin 301617, Peoples R China.. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol

An improved five-step synthesis of triethylene glycol-substituted 4-(N-methyl-N-Boc-amino)styrylpyridine (6) is described. Using cost-effective starting materials, the developed synthesis route was synthetic, efficient, and chromatographic purification-free. The key point of the work is the one-pot synthesis of tert-butyl methyl(4-vinylphenyl)carbamate through methylation and elimination in the NaH/THF system. The new synthesis route shows the potential to achieve scaled-up preparation of 6 in the future.

Category: amides-buliding-blocks. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Jia, JH; Wei, HQ; Duan, YQ; Ning, HX; Yu, J; Zhu, Y; Hou, WB; Li, YL or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article NaNO2/I-2 as an alternative reagent for the synthesis of 1,2,3-benzotriazin-4(3H)-ones from 2-aminobenzamides WOS:000456353000009 published article about CATALYZED DENITROGENATIVE ANNULATION; TERT-BUTYL NITRITE; NEMATOCIDAL ACTIVITIES; SELECTIVE SYNTHESIS; DERIVATIVES; 1,2,3-BENZOTRIAZINE-4-(3H)-ONES; ACID in [Barak, Dinesh S.; Mukhopadhyay, Sushobhan; Dahatonde, Dipak J.; Batra, Sanjay] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Sect 10,Jankipuram Extens,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India; [Batra, Sanjay] CSIR HRDC, Postal Staff Coll Area, Sect 19, Ghaziabad 201002, India in 2019, Cited 39. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4. Product Details of 90-16-4

An efficient transformation of 2-aminobenzamides to 1,2,3-benzotriazin-4(3H)-ones in the presence of sodium nitrite (NaNO2) and Iodine (I-2) is described. The reaction is proposed to proceed via formation of nitrosyl halide that induces nitrosylation of the amino group of 2-aminobenzamide leading to diazotization followed by intramolecular cyclization. (C) 2018 Elsevier Ltd. All rights reserved.

Product Details of 90-16-4. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Barak, DS; Mukhopadhyay, S; Dahatonde, DJ; Batra, S or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

SDS of cas: 104-10-9. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Studies towards the development of a PET radiotracer for imaging of the P2Y(1) receptors in the brain: synthesis, F-18-labeling and preliminary biological evaluation published in 2019.0, Reprint Addresses Moldovan, RP (corresponding author), Helmholtz Zentrum Dresden Rossendorf, Inst Radiopharmaceut Canc Res, Permoserstr 15, D-04318 Leipzig, Germany.. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol.

Purine nucleotides such as ATP and ADP are important extracellular signaling molecules in almost all tissues activating various subtypes of purinoreceptors. In the brain, the P2Y(1) receptor (P2Y(1)R) subtype mediates trophic functions like differentiation and proliferation, and modulates fast synaptic transmission, both suggested to be affected in diseases of the central nervous system. Research on P2Y(1)R is limited because suitable brain-penetrating P2Y(1)R-selective tracers are not yet available. Here, we describe the first efforts to develop an F-18-labeled PET tracer based on the structure of the highly affine and selective, non-nucleotidic P2Y(1)R allosteric modulator 1-(2-[2-(tert-butyl)phenoxy]pyridin-3-yl)-3-[4- (trifluoromethoxy)phenyl]urea (7). A small series of fluorinated compounds was developed by systematic modification of the p-(trifluoromethoxy)phenyl, the urea and the 2-pyridyl subunits of the lead compound 7. Additionally, the p-(trifluoromethoxy)phenyl subunit was substituted by carborane, a boron-rich cluster with potential applicability in boron neutron capture therapy (BNCT). By functional assays, the new fluorinated derivative 1-{2-[2-(tert-butyl)phenoxy]pyridin-3-yl}-3-[4-(2-fluoroethyl) phenyl]urea (18) was identified with a high P2Y(1)R antagonistic potency (IC50 = 10 nM). Compound [F-18] 18 was radiosynthesized by using tetra-n-butyl ammonium [F-18]fluoride with high radiochemical purity, radiochemical yield and molar activities. Investigation of brain homogenates using hydrophilic interaction chromatography (HILIC) revealed [F-18]fluoride as major radiometabolite. Although [F-18]18 showed fast in vivo metabolization, the high potency and unique allosteric binding mode makes this class of compounds interesting for further optimizations and investigation of the theranostic potential as PET tracer and BNCT agent. (C) 2019 Elsevier Masson SAS. All rights reserved.

SDS of cas: 104-10-9. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Moldovan, RP; Wenzel, B; Teodoro, R; Neumann, W; Dukic-Stefanovic, S; Kraus, W; Rong, PJ; Deuther-Conrad, W; Hey-Hawkins, E; Krugel, U; Brust, P or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2021.0 J ORG CHEM published article about AROMATIC AZO-COMPOUNDS; PALLADIUM-CATALYZED OXIDATION; HOST-GUEST CHEMISTRY; RECOGNITION; ANILINES; COMPLEXATION; HYDROGEN; BINDING in [Sarkar, Sayan; Sarkar, Piyali; Ghosh, Pradyut] Indian Assoc Cultivat Sci, Sch Chem Sci, Kolkata 700032, India in 2021.0, Cited 101.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9. Product Details of 104-10-9

A series of oxy-ether tris-amino heteroditopic macrobicycles (L1-L4) with various cavity dimensions have been synthesized and explored for their Cu(II) catalyzed selective single step aerial oxidative cross-coupling of primary alcohol based anilines with several aromatic amines toward the formation of primary alcohol appended cross azobenzenes (POCABs). The beauty of this transformation is that the easily oxidizable benzyl/primary alcohol group remains unhampered during the course of this oxidation due to the protective oxy-ether pocket of this series of macrobicyclic vessels. Various dimensionalities of the molecular vessels have shown specific size complementary selection for substrates toward efficient syntheses of regioselective POCAB products. To establish the requirement of the three-dimensional cavity based additives, a particular catalytic reaction has been examined in the presence of macrobicycles (L2 and L3) versus macrocycles (MC1 and MC2) and tripodal acyclic (AC1 and AC2) analogous components, respectively. Subsequently, L1-L4 have been extensively utilized toward the syntheses of as many as 44 POCABs and are characterized by different spectroscopic techniques and single crystal X-ray diffraction studies.

Product Details of 104-10-9. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Sarkar, S; Sarkar, P; Ghosh, P or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics