Tag: M.W=100-150

Kashani, Saeed K. published the artcileExploring Homogeneous Conditions for Mild Buchwald-Hartwig Amination in Batch and Flow, Quality Control of 1453-82-3, the publication is Organic Process Research & Development (2020), 24(10), 1948-1954, database is CAplus.

The use of high throughput experimentation to identify a number of conditions that enable Buchwald-Hartwig reactions to be carried out using readily available ligands (e.g. XantPhos) with DBU as a soluble, functional group tolerant, homogeneous base was described. Application of this system to diverse aminations in batch and flow were demonstrated, as was the translation of this technique to performing continuous Mizoroki-Heck and Sonogashira coupling reactions.

Organic Process Research & Development published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Quality Control of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Chen, Wei published the artcileSyntheses of 3,4-dihydro-4-oxopyrimido[4,5-b]quinolines, Quality Control of 15029-36-4, the publication is Gaodeng Xuexiao Huaxue Xuebao (1990), 11(5), 532-3, database is CAplus.

Pyrimidoquinolines I (R = H, alkyl, PHCH₂, Ph; R¹, R² = H, H; R¹R² = methylenedioxy) were prepared in 81-94% yield by heating aminoquinolinecarboxamides II with HCONH₂ at 160-170°.

Gaodeng Xuexiao Huaxue Xuebao published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Quality Control of 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Uhlemann, Erhard published the artcileSynthesis of 1,1-disubstituted 3-thiobenzoylthioureas, COA of Formula: C5H10N2OS, the publication is Zeitschrift fuer Chemie (1981), 21(11), 413-14, database is CAplus.

The title thioureas were prepared by acylation of PhCSNH₂ with dialkyl(thio)carbamoyl chlorides in pyridine in the presence of Ni(OAc)₂ (isolated as the Ni chelates), thiobenzoylation of thioureas with PhCS₂CH₂CO₂H in MeCN containing KOH, or treating dialkyl(thio)carbamoyl isothiocyanates with PhMgBr in Et₂O.

Zeitschrift fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C8H8ClN5, COA of Formula: C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Adrian, Rafael A. published the artcileBis(isonicotinamide-κN)silver(I) trifluoromethanesulfonate acetonitrile disolvate, Application In Synthesis of 1453-82-3, the publication is IUCrData (2021), 6(10), x211073, database is CAplus.

The central AgI atom of the title salt, [Ag(INAM)₂](CF₃SO₃)·2CH₃CN, where INAM is isonicotinamide (C₆H₆N₂O), is twofold coordinated by the pyridine N atoms of two isonicotinamide ligands creating a slightly distorted linear mol. geometry. The formation of polymeric chains {[Ag(INAM)₂]⁺}_n, held together by discrete hydrogen bonds through the amide group of the INAM ligand leaves voids for non-coordinating acetonitrile mols. that interact the silver metal center via regium bonds.

IUCrData published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Application In Synthesis of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kumar, Arvind published the artcileKetene dithioacetals. Part 12. Synthesis and reactions of α-oxoketene dithioacetals derived from heterocyclic ketones, Safety of 2-Cyano-N-ethylacetamide, the publication is Journal of Chemical Research, Synopses (1979), 268-9, database is CAplus.

Ten title dithioacetals I [R²R³ = C(SMe)₂](R = H, Me; R¹ = H, Me, OMe; X = O, S, NSO₂C₆H₄Me-4; n = 1, 2) were prepared (51-75%) from the corresponding benzopyranones I (R² = R³ = H) by treatment with CS₂ in the presence of NaOCMe₃ followed by methylation. I [R = R¹ = H, R²R³ = C(SMe)₂, X = S, n = 1] (II) reacted with NH₂NH₂ in EtOH in the presence and absence of morpholine to give 48% benzothiopyranopyrazole III (R = NHNH₂) and 87% III (R = SMe), resp. II reacted with H₂NC(:NH)NH₂ to give 30% benzothiopyranopyrimidine IV (R = OMe) and 9% IV (R = H) and with NCCH₂CONHR (R = H, Me, Et) in the presence of NaOCHMe₂ to give 76% benzothiopyranopyridone V and 69-74% benzothiopyranonaphthyridinedione VI (R = Me, Et), resp.

Journal of Chemical Research, Synopses published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Safety of 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kasak, Peter published the artcileNicotinamide-based supergelator self-assembling via asymmetric hydrogen bonding NH···OC and H···Br^– pattern for reusable, moldable and self-healable nontoxic fuel gels, Formula: C6H6N2O, the publication is Journal of Colloid and Interface Science (2021), 182-190, database is CAplus and MEDLINE.

Development of highly efficient low-mol. weight gelators (LMWGs) for safe energy storage materials is of great demand. Energy storage materials as fuel gels are often achieved by construction of hybrid organic frameworks capable of multiple noncovalent interactions in self-assembly, which allow tuning required properties at the mol. level by altering individual building blocks of the LMWG. However, LMWGs have limited rechargeable capability due to their chem. instability. We designed, synthesized and characterized a novel, bio-inspired chiral gemini amphiphile derivative 1 containing N-hexadecyl aliphatic tails from quaternized nicotinamide-based segment and bromide anion showing supergelation ability in water, alcs., aprotic polar and aromatic solvents, with critical gel concentrations as low as 0.1 and 0.035 wt% in isopropanol and water, resp. Nanostructural architecture of the network depended on the solvent used and showed variations in size and shape of 1D nanofibers. Supergelation is attributed to a unique asym. NH···OC, H···Br- hydrogen bonding pattern between H-2 hydrogens from nicotinamide-based segment, amide functional groups from chiral trans-cyclohexane-1,2-diamide-based segment and bromide ions, supporting the intermol. amide-amide interactions appearing across one strand of the self-assembly. Gels formed from 1 exhibit high stiffness, self-healing, moldable and colorable properties. In addition, isopropanol gels of 1 are attractive as reusable, shape-persistent non-toxic fuels maintaining the chem. structure with gelation efficiency for at least five consecutive burning cycles.

Journal of Colloid and Interface Science published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Formula: C6H6N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Yang, Hongxing published the artcilePigmentiphaga sp. strain D-2 uses a novel amidase to initiate the catabolism of the neonicotinoid insecticide acetamiprid, Formula: C6H6N2O, the publication is Applied and Environmental Microbiology (2020), 86(6), e02425-19, database is CAplus and MEDLINE.

Acetamiprid, a chloronicotinyl neonicotinoid insecticide, is among the most commonly used insecticides worldwide, and its environmental fate has caused considerable concern. The compound 1-(6-chloropyridin-3-yl)-N-methylmethanamine (IM 1-4) has been reported to be the main intermediate during acetamiprid catabolism in microorganisms, honeybees, and spinach. However, the mol. mechanism underlying the hydrolysis of acetamiprid to IM 1-4 has not yet been elucidated. In this study, a novel amidase (AceAB) that initially hydrolyzes the C-N bond of acetamiprid to generate IM 1-4 was purified and characterized from the acetamiprid-degrading strain Pigmentiphaga sp. strain D-2. Based on peptide profiling of the purified AceAB and the draft genome sequence of strain D-2, aceA (372 bp) and aceB (2,295 bp), encoding the α and β subunits of AceAB, resp., were cloned and found to be necessary for acetamiprid hydrolysis in strain D-2. The characteristics of AceAB were also systematically investigated. Though AceA and AceB showed 35% to 56% identity to the α and β subunits of the N,N-dimethylformamidase from Paracoccus aminophilus, AceAB was specific for the hydrolysis of acetamiprid and showed no activities to N,N-dimethylformamide or its structural analogs.

Applied and Environmental Microbiology published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C22H32O2, Formula: C6H6N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kong, Lingbin published the artcileMulti-component solvent-free cascade reaction of 2-cyanoacetamides: regioselective synthesis of pyridin-2-ones bearing quaternary centers, COA of Formula: C5H8N2O, the publication is Green Chemistry (2020), 22(1), 256-264, database is CAplus.

A novel protocol has been constructed for the synthesis of four types of pyridin-2-ones via solvent-free cascade reactions of 2-cyanoacetamides, various ketones, and acetone via multicomponent reactions to prepare target compounds with good to excellent yields. As a result, functionalized pyridin-2-ones bearing quaternary centers, specifically, spiropyridin-2-ones, were generated by piperidine under solvent-free conditions. Also, a double bond has been introduced into the target compounds through aryl substituted 2-cyanoacetamides under the same conditions. The advantages of this approach include no solvents, simple and practical operation (multi-component one-pot), high yields (up to 95%), and a product with potential biol. activity.

Green Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, COA of Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wu, Mei published the artcileDIPEA-induced activation of OH^– for the synthesis of amides via photocatalysis, Product Details of C6H6N2O, the publication is RSC Advances (2022), 12(23), 14724-14728, database is CAplus and MEDLINE.

Herein, an efficient light-mediated strategy for the synthesis of amides in which a weak organic base acts as a reductant to induce the formation of OH- from water under metal-free conditions was reported. A mechanistic study revealed that the generation of an N,N-diisopropylethylamine (DIPEA) radical via single electron transfer (SET), with the assistance of photocatalyst, that increased the nucleophilicity of the water mols. with respect to the cyanides was essential. Moreover, the removal rate of nitrile in wastewater can be as high as 83%, indicating that this strategy had excellent potential for nitrile degradation

RSC Advances published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C10H18BNO2, Product Details of C6H6N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wen, Xiaoting published the artcileHydration of Nitriles Enabled by PNP-manganese Pincer Catalyst, Recommanded Product: Isonicotinamide, the publication is Asian Journal of Organic Chemistry (2022), 11(4), e202100781, database is CAplus.

A general and practical methodol. for the hydration of nitriles to primary amides enabled by manganese catalyst was presented. The described protocol showed broad substrate scope with good functional group tolerance, including a wide range of (hetero)aromatic and aliphatic nitriles, thus afforded the corresponding amides RC(O)NH₂ [R = c-hexyl, Ph, 2-furyl., etc.] in good to excellent isolated yields under mild conditions. Preliminary mechanistic studies indicated that metal-ligand cooperation (MLC) mode was involved in this catalytic process.

Asian Journal of Organic Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C8H11NO, Recommanded Product: Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics