Tag: M.W=100-150

Arya, V. P. published the artcilePsychoactive agents: part VIII. Isothiazoles: part VIII. Synthesis and biological activity of 4-(2-amino-4-thiazolyl)isothiazoles, Product Details of C5H10N2OS, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1978), 16B(5), 402-4, database is CAplus.

RR¹NH (NRR¹ = morpholino, hexahydro-1-azepinyl, octahydro-1-azocinyl, 3-azabicyclo[3.2.2]nonan-3-yl, 4-(4-fluorophenyl)piperazin-1-yl) were treated with tert-BuNCS to give RR¹NCSNHCMe₃, which ws debutylated to give RR¹NCSNH₂. This and R²CSNH² (R² = NH₂, NHMe, NHBu, NHCH₂CH:CH₂, NHCH₂Ph, etc.) were cyclized with I (R³ = H, Me, Et) to give the corresponding II. Among II, 4-(2-amino-4-thiazolyl)-3,5-dimethylisothiazole showed the highest analgesic activity and 4-(2-amino-4-thiazolyl)-3-methylisothiazole had the highest antiinflammatory activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Chavan, Sunil S. published the artcileIonic liquid-catalyzed 4,6-disubstituted-3-cyano-2-pyridone synthesis under solvent-free conditions, Safety of 2-Cyano-N-ethylacetamide, the publication is Catalysis Letters (2011), 141(11), 1693-1697, database is CAplus.

A green protocol for the synthesis of 4,6-disubstituted-3-cyano-2-pyridones from cyanoacetamides and 1,3-dicarbonyl compounds or chalcones using guanidine-based ionic liquid as catalyst was developed. In solvent-free conditions at 30 °, 1,1,3,3-tetramethylguanidine lactate had the highest catalytic activity among the ionic liquids including 1,1,3,3-tetramethylguanidine acetate, 1,1,3,3-tetramethylguanidine propionate, 1,1,3,3-tetramethylguanidine n-butyrate, and 1,1,3,3-tetramethylguanidine trifluoroacetate. The catalyst was recovered and recycled several times without significant loss of catalytic activity.

Catalysis Letters published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Safety of 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Henry, Ronald A. published the artcileMiscellaneous derivatives of morpholine, Product Details of C5H10N2OS, the publication is Journal of the American Chemical Society (1950), 2806, database is CAplus.

Molar proportions of Ph₂NCOCl and morpholine (I) reacted directly. The mixture heated with H₂O and NaHCO₃ precipitated diphenylcarbamyl morpholide, m. 110-11° (from EtOH). I with RNCS gave the following thioureas: Ph, m. 130.5°; o-tolyl, m. 144.5-5.5°; p-tolyl, m. 151-1.5°; allyl, m. 56-7°. I in EtOH refluxed with picryl chloride gave 90% 4-picrylmorpholine (II), m. 147.5-8.5°, resolidified, and m. at 166-6.5° (from EtOH). II with (NH₄)₂S gave 4-picramylmorpholine, decompose 256° (from EtOH). A solution of I.HCl and KCNS evaporated to dryness, then extracted with absolute EtOH, gave (4-morpholinyl)thiocarbonamide, m. 111.5-12.5°. [O(CH₂.CH₂)₂NCS]₂S₂ (III) and KCN in 40% EtOH refluxed 30 min., then diluted with 50 ml. H₂O, precipitated [O(CH₂.CH₂)₂NCS]₂S, m. 126-6.5° (from EtOH). III and I heated at 120° for 4 hrs., then extracted with H₂O gave [O(CH₂.CH₂)₂N]₂CS.H₂O, m. 89.5-90° (from H₂O).

Journal of the American Chemical Society published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

O’Callaghan, C. N. published the artcileAnticancer agents XIII. Synthesis and antitumor activity of 2-iminochromene derivatives, SDS of cas: 15029-36-4, the publication is Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science (1979), 79B(6), 87-98, database is CAplus.

Iminochromenes I (R = H, 6-OMe, 7-OMe, 6-NO₂, 6,8-Br₂, 8-OEt, 8-OMe; R¹ = H, alkyl, hydroxyalkyl, NHCSNHMe, optionally substituted Ph, anilino, acylamino, morpholino) were prepared by condensing salicylaldehydes with NCCH₂CONHR¹. II (R² = OMe, OEt, OPr, R³ = H; R² = H, R³ = OMe, OEt, OPr) were obtained by condensing salicylaldehydes with 1-cyanoacetyl-3,5-dimethylpyrazole. I, II, and related compounds had antitumor activity. Thus, I (R = 6-OMe, R¹ = H) gave a mean survival time 131% of controls as 108 mg/kg in P 388 lymphocytic leukemia-infected mice.

Proceedings of the Royal Irish Academy, Section B: Biological, Geological and Chemical Science published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, SDS of cas: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Charnley, Adam K. published the artcileCrystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity, Name: Morpholine-4-carbothioamide, the publication is Bioorganic & Medicinal Chemistry (2015), 23(21), 7000-7006, database is CAplus and MEDLINE.

Receptor interacting protein 2 (RIP2) is an intracellular kinase and key signaling partner for the pattern recognition receptors NOD1 and NOD2 (nucleotide-binding oligomerization domain-containing proteins 1 and 2). As such, RIP2 represents an attractive target to probe the role of these pathways in disease. In an effort to design potent and selective inhibitors of RIP2 we established a crystallog. system and determined the structure of the RIP2 kinase domain in an apo form and also in complex with multiple inhibitors, including AMP-PCP (β,γ-methyleneadenosine 5′-triphosphate, a non-hydrolyzable ATP mimic) and structurally diverse ATP competitive chemotypes identified via a high-throughput screening campaign. These structures represent the first set of diverse RIP2-inhibitor co-crystal structures and demonstrate that the protein possesses the ability to adopt multiple DFG-in as well as DFG-out and C-helix out conformations. These structures reveal key protein-inhibitor structural insights and serve as the foundation for establishing a robust structure-based drug design effort to identify both potent and highly selective inhibitors of RIP2 kinase.

Bioorganic & Medicinal Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Name: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Chisca, Diana published the artcileFour Cu(II) coordination polymers with biocompatible isonicotinamide and picolinate ligands in interplay with anionic and neutral linkers, Application of Isonicotinamide, the publication is Inorganic Chemistry Communications (2021), 108864, database is CAplus.

Four Cu(II)-based neutral coordination polymers, 1D {[Cu(isonia)₂(adi)(dmf)].0.5H₂adi}_n (1), 2D {[Cu(isonia)₂(adi)](H₂O.H₂adi)}_n (2), 1D {[Cu(pic)(CH₃COO)(bpe)].H₂O}_n (3), and 2D [Cu₂(pic)₂(CH₃COO)₂(bpy)]_n (4) with biocompatible mols.: isonicotinamide (isonia), pyridine-2-carboxylic (picolinic, Hpic) and adipic (H₂adi) acids and 1,2-bis(4-pyridyl)-ethane (bpe) and 4,4′-bipyridine (bpy) as neutral linkers are reported. The polymer extension in 1 and 2 is reached via bidentate bridging adi anions with isonia ligands as single 1 and double 2 pillars. 1D and 2D coordination arrays are associated in elegant 3D H-bonded networks via interplay of robust amide(isonia)…amide(isonia) homosynthon and NH…O(COO^–) side interactions. In 3 the pic residue coordinates in a chelate mode and forms the five-membered [Cu(pic)] corner fragment. The structure expansion occurs via bidentate-bridging bpe neutral linker registered in a coordination wire as different conformers thus providing long (Cu-bpe)₆ crystallog. unique chain fragment. Oppositely, in 4 the pic residue acts in a bidentate chelate bridging mode and gives rise to the 2D coordination array. The bpy trapping between each two Cu(II) atoms, does not participate in further structure extension. The decisive impact of amido-group of isonia ligand in structure rigidification and retention of protic H₂adi and water guest mols. is demonstrated. The gradual decrease of guest’s capacity correlates with an increased liphophilicity of 3 and 4 comparing with 1 and 2.

Inorganic Chemistry Communications published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Application of Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhang, YaHan published the artcileA hyperbranched polymer-based water-resistant adhesive: Durable underwater adhesion and primer for anchoring anti-fouling hydrogel coating, Safety of N-(2-Amino-2-oxoethyl)acrylamide, the publication is Science China: Technological Sciences (2022), 65(1), 201-213, database is CAplus.

Direct deployment of gluing and achieving durable robust adhesion in water is challenging due to difficulty in repelling interface water. This work reports a novel hyperbranched polymer-based water-resistant adhesive (HBPBA) based on Michael addition reaction of multi-vinyl monomers with dopamine and 3-aminophenylboronic acid. Upon encountering water, the HBPBA forms coacervates whose hydrophobic chains aggregate to displace interface water, and meanwhile the catechols exposing outwards contribute to underwater adhesion. The HBPBA can strongly glue diverse substrates including PTFE, PE, PET, ceramic, Ti and stainless steel. The HBPBA can maintain stable adhesion in different environments, such as tap water, simulated sea water, PBS, and a wide range of pH solutions (pH 2 to 10) for 3 mo, supposedly due to the complexation of catechol with boronic acid. Intriguingly, HBPBA film can be bonded to the titanium surface as a primer, which firmly anchors the antifouling PNAGA-PCBAA hydrogel coating through copolymerization of remaining double bonds in HBPBA and NAGA plus CBAA. The PNAGA-PCBAA hydrogel-modified titanium is biocompatible and shows outstanding antifouling ability both in vitro and in vivo. This work proposes a new strategy for creating underwater deployable and water-resistant adhesives that may find promising applications in engineering and biomedical fields.

Science China: Technological Sciences published new progress about 2479-62-1. 2479-62-1 belongs to amides-buliding-blocks, auxiliary class Monomers,Acrylamide Monomers, name is N-(2-Amino-2-oxoethyl)acrylamide, and the molecular formula is C13H18N2, Safety of N-(2-Amino-2-oxoethyl)acrylamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Nechaev, Ilya V. published the artcileThree-Component Reaction of 3,3-Difluorocyclopropenes, s-Tetrazines, and (benzo) Pyridines, Related Products of amides-buliding-blocks, the publication is Journal of Organic Chemistry (2021), 86(1), 1037-1052, database is CAplus and MEDLINE.

A new three-component reaction leading to 1-α-(pyridyl-2-[1,2,4]triazolyl)-2-alkyl-ethanones has been discovered while studying the reactivity of monosubstituted 3,3-difluorocyclopropenes in an inverse electronic demand Diels-Alder (IEDDA) cycloaddition-cycloreversion sequence with s-tetrazines. The reaction involving the above-mentioned reactants and (benzo)pyridine as a third component results in a complex transformation proceeding in mild conditions in a stoichiometric ratio of reactants and has high functional group tolerance (phenols, amides, ethers, carboxylic acids, ketones, and acrylic esters). As a result, simple pyridines are selectively functionalized at the α-position in good isolated yields. The reaction mechanism includes a rare azaphilic [4 + 2]-cycloaddition step between s-tetrazine and intermediate 1-hydroxyindolizine, suggested after byproduct identification and tracked with a deuterium label. To date, it is only the third known example of skewed azaphilic cycloaddition of tetrazine. The reaction is truly three-component and cannot be effectively performed stepwise.

Journal of Organic Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hussain, Muhammad Asif published the artcileAn efficient hydration of nitriles with ruthenium-supported heterogeneous catalyst in water under moderate conditions, HPLC of Formula: 1453-82-3, the publication is Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) (2021), 187-195, database is CAplus.

A facile eco-friendly heterogeneous catalytic system has been developed for amide synthesis that further utilized in pharmaceutical and organic chem. The Ru/MnO₂ catalyst has shown outstanding and unprecedented activity for a wide range of aliphatic and benzylic nitriles in green solvent water at 60°C. The system has also exhibited a remarkable tolerance for selective hydration of heteroatom (e.g. nitrogen, oxygen and sulfur atoms) containing nitriles. Pharmaceutically important nicotinamides and pyrazinamide has been synthesized by hydration of the heteroat. nitriles with appreciable yields and selectivities. Moreover, the Ru/MnO₂ catalyst has employed water as a benign solvent, with more than 30,000 TONs and reusability five times after isolation from the reaction mixture by centrifugation and easy workup that established a path for green environmental and technol. acceptable protocol.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, HPLC of Formula: 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Song, Liangliang published the artcilePyridine-Enabled C-N Bond Activation for the Rapid Construction of Amides and 4-Pyridylglyoxamides by Cooperative Palladium/Copper Catalysis, Safety of Isonicotinamide, the publication is Journal of Organic Chemistry (2020), 85(12), 8045-8054, database is CAplus and MEDLINE.

A pyridine-enabled C-N bond activation of peptidomimetics employing cooperative palladium/copper catalysis in water is developed. Diverse amides and 4-pyridylglyoxamides are simultaneously synthesized through two steps from com. available materials in a rapid, environmentally friendly, and high atom-economical manner.

Journal of Organic Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C19H34ClN, Safety of Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics