Tag: M.W=100-150

He, Peipei published the artcileHeterogeneous manganese-oxide-catalyzed successive cleavage and functionalization of alcohols to access amides and nitriles, Computed Properties of 1453-82-3, the publication is Chem (2022), 8(7), 1906-1927, database is CAplus.

Herein, a novel and efficient protocol that enables the direct synthesis of amides via heterogeneous manganese-oxide-catalyzed successive cleavage and amidation of C-C bonds in alcs was reported. A wide range of primary and secondary alcs., 1,2-diols, and even β-O-4 and β-1 lignin model compounds can undergo C-C bond cleavage smoothly to deliver one- or multiple-carbon shorter amides. Moreover, a slight modification of reaction conditions allows for the cleavage and cyanation of alcs. to access sterically hindered nitriles. Detailed characterizations and d. functional theory (DFT) calculations indicate that high sp. surface area, abundant oxygen vacancies, and moderate acid sites contribute to the high catalytic performance of the manganese oxides.

Chem published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Computed Properties of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Grols, Jan Roland published the artcileMechanochemical co-crystallization: Insights and predictions, Application In Synthesis of 1453-82-3, the publication is Computers & Chemical Engineering (2021), 107416, database is CAplus.

Mechanochem. integrates mech. and chem. phenomena to spawn new modes of reactivity, faster reaction kinetics and the discovery of novel materials, in a solvent-free and environmental manner. This simple, yet efficient technique has become a well-established screening technique to discover pharmaceutical co-crystals – components that incorporate a secondary crystalline structure into the lattice of an active pharmaceutical ingredient (API) to improve its physicochem. properties. Today, predicting the reactivity of solid-state materials under mechanochem. conditions remains a major challenge. Here, we explore various machine learning algorithms and identified XGBoost ideal to accurately predict mechanochem. co-crystallization The model was trained using 1000 co-crystallization events and 2083 chem. descriptors, revealing fundamental insights about mechanochem. The model was implemented to screen secondary crystalline structures against a model API, yielding three new mechanochem.-formed co-crystals. This predictive model will accelerate the discovery of novel pharmaceuticals while its insights aid at developing a more sustainable chem. industry.

Computers & Chemical Engineering published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Application In Synthesis of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Murugesan, Kathiravan published the artcileA General Catalyst Based on Cobalt Core-Shell Nanoparticles for the Hydrogenation of N-Heteroarenes Including Pyridines, HPLC of Formula: 1453-82-3, the publication is Angewandte Chemie, International Edition (2020), 59(40), 17408-17412, database is CAplus and MEDLINE.

Herein, we report the synthesis of specific silica-supported Co/Co₃O₄ core-shell based nanoparticles prepared by template synthesis of cobalt-pyromellitic acid on silica and subsequent pyrolysis. The optimal catalyst material allows for general and selective hydrogenation of pyridines, quinolines, and other heteroarenes including acridine, phenanthroline, naphthyridine, quinoxaline, imidazo[1,2-a]pyridine, and indole under comparably mild reaction conditions. In addition, recycling of these Co nanoparticles and their ability for dehydrogenation catalysis are showcased.

Angewandte Chemie, International Edition published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, HPLC of Formula: 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Yusov, A. S. published the artcileSynthesis and Analgesic and Anti-Inflammatory Activities of (3,3-Dipropyl-6,7-Dimethoxy-3,4-Dihydroisoquinolin-1(2H)-Ylidene)-Acetamide Hydrochlorides, SDS of cas: 15029-36-4, the publication is Pharmaceutical Chemistry Journal (2019), 53(1), 35-39, database is CAplus.

Cyclocondensation of 4-(3,4-dimethoxybenzyl)heptan-4-ol with N-substituted cyanoacetamide was used to synthesize (3,3-dipropyl-6,7-dimethoxy-3,4-dihydroisoquinolin-2(2H)-ylidene)acetamides. The hydrochlorides of the resulting enaminoamides exist in the imino form. All hydrochlorides displayed analgesic effects in the hotplate test at the level of sodium metamizole, and the most active were the amide with the N-substituted 2-(3,4-dimethyoxyphenyl)ethyl radical, which had greater levels of analgesic activity than metamizole and nimesulide. Many of the resulting amides displayed anti-inflammatory effects in a carragheenan model which were comparable in magnitude to those of sodium metamizole.

Pharmaceutical Chemistry Journal published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C23H43NP2, SDS of cas: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Palmer, James T. published the artcileDesign and synthesis of tri-ring P₃ benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K, HPLC of Formula: 14294-10-1, the publication is Journal of Medicinal Chemistry (2005), 48(24), 7520-7534, database is CAplus and MEDLINE.

A series of achiral aminoacetonitriles, bearing tri-ring benzamide moieties and an aminocyclohexanecarboxylate residue was prepared This combination of binding elements resulted in sub-250 pM, reversible, selective, and orally bioavailable cathepsin K inhibitors. Lead compounds displayed single digit nanomolar inhibition in vitro (of rabbit osteoclast-mediated degradation of bovine bone). The best compound in this series, I (CRA-013783/L-006235), was orally bioavailable in rats, with a terminal half-life of over 3 h. I was dosed orally in ovariectomized rhesus monkeys once per day for 7 days. Collagen breakdown products were reduced by up to 76% dose-dependently. Plasma concentrations of I above the bone resorption IC₅₀ after 24 h indicated a correlation between functional cellular and in vivo assays. Inhibition of collagen breakdown by cathepsin K inhibitors suggests this mechanism of action may be useful in osteoporosis and other indications involving bone resorption.

Journal of Medicinal Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, HPLC of Formula: 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Clout, Alexander E. published the artcileMechanistic In Situ and Ex Situ Studies of Phase Transformations in Molecular Co-Crystals, Synthetic Route of 1453-82-3, the publication is Chemistry – A European Journal (2020), 26(64), 14645-14653, database is CAplus and MEDLINE.

Co-crystallization is widely explored as a route to improve the phys. properties of pharmaceutical active ingredients, but little is known about the fundamental mechanisms of the process. Herein, we apply a hyphenated differential scanning calorimetry-X-ray diffraction technique to mimic the com. hot melt extrusion process, and explore the heat-induced synthesis of a series of new co-crystals containing isonicotinamide. These comprise a 1:1 co-crystal with 4-hydroxybenzoic acid, 2:1 and 1:2 systems with 4-hydroxyphenylacetic acid and a 1:1 crystal with 3,4-dihydroxyphenylactic acid. The formation of co-crystals during heating is complex mechanistically. In addition to co-crystallization, conversions between polymorphs of the co-former starting materials and co-crystal products are also observed A subsequent study exploring the use of inkjet printing and milling to generate co-crystals revealed that the synthetic approach has a major effect on the co-crystal species and polymorphs produced.

Chemistry – A European Journal published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Synthetic Route of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Tambe, Suparna published the artcileStructure-performance relationships of phenyl cinnamic acid derivatives as MALDI-MS matrices for sulfatide detection, Related Products of amides-buliding-blocks, the publication is Analytical and Bioanalytical Chemistry (2017), 409(6), 1569-1580, database is CAplus and MEDLINE.

A key aspect for the further development of matrix-assisted laser desorption ionization (MALDI)-mass spectrometry (MS) is a better understanding of the working principles of MALDI matrixes. To address this issue, a chem. compound library of 59 structurally related cinnamic acid derivatives was synthesized. Potential MALDI matrixes were evaluated with sulfatides, a class of anionic lipids which are abundant in complex brain lipid mixtures For each matrix relative mean S/N ratios of sulfatides were determined against 9-aminoacridine as a reference matrix using neg. ion mass spectrometry with 355 and 337 nm laser systems. The comparison of matrix features with their corresponding relative mean S/N ratios for sulfatide detection identified correlations between matrix substitution patterns, their chem. functionality, and their MALDI-MS performance. Crystal structures of six selected matrixes provided structural insight in hydrogen bond interactions in the solid state. Principal component anal. allowed the addnl. identification of correlation trends between structural and phys. matrix properties like number of exchangeable protons at the head group, MW, logP, UV-Vis, and sulfatide detection sensitivity.

Analytical and Bioanalytical Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C7H5I2NO3, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics