Tag: M.W=100-150

Demchenko, Anatoly published the artcileSynthesis and biological activity of new [1,3]Thiazolo[4,5-d]pyridazin-4(5H)-ones, Product Details of C5H10N2OS, the publication is Scientia Pharmaceutica (2016), 84(2), 255-268, database is CAplus and MEDLINE.

A series of novel 2-(N-pyrrolidino, N-piperidino or N-morpholino)-7-phenyl- (α-furoyl or α-thienyl)-[1,3]thiazolo[4,5-d]pyridazinones 10a-c, 14-16a,b was synthesized in 78-87% yields via the reaction of Me 5-benzoyl(α-furoyl or α-thienyl)-2-aminosubstituted-thiazol-4-carboxylates 9a-c, 13a-e with hydrazine. These new compounds have been tested for their in vivo analgesic and anti-inflammatory activities. All compounds have been characterized by 1H- NMR, 13C-NMR spectroscopy, and liquid chromatog.-mass spectrometry.

Scientia Pharmaceutica published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Puzari, Amlan published the artcileBinuclear Pd(II) complexes with multidentate Schiff base ligands: synthesis, catalysis, and antibacterial properties, Synthetic Route of 1453-82-3, the publication is Monatshefte fuer Chemie (2022), 153(5-6), 435-442, database is CAplus.

Abstract: Three new binuclear palladium(II) complexes with multidentate Schiff base ligands were synthesized and characterized by FTIR, UV-visible, ¹H-NMR, ESI-MS, and CHN anal. The complexes were successfully applied as catalysts for hydration of nitriles to amides. Using one of the complexes, a wide range of aryl/heteroaryl nitriles were efficiently converted to corresponding amides in moderate-to-excellent yields with low catalyst loading (0.8 mol%). In addition, the complexes were also tested for antibacterial activity against two gram-pos. and two gram-neg. bacteria using Kirby Bauer’s disk diffusion method. However, to the authors’ surprise, among the three complexes, only one complex showed growth inhibitory effect against gram-pos. bacteria, Bacillus subtilis, for which min. inhibitory concentration (MIC) is 30μg cm^-3.

Monatshefte fuer Chemie published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Synthetic Route of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rahman, Taskia published the artcileActivated Mont K10-Carbon supported Fe₂O₃: A versatile catalyst for hydration of nitriles to amides and reduction of nitro compounds to amines in aqueous media, Application In Synthesis of 1453-82-3, the publication is Journal of Chemical Sciences (Berlin, Germany) (2021), 133(1), 27, database is CAplus.

The iron oxide was successfully supported on activated clay/carbon through an exptl. viable protocol for both hydration of nitriles RCN (R = Ph, pyridin-4-yl, 4-bromophenyl, etc.) to RC(O)NH₂ to amides and reduction of nitro compounds R¹NO₂ (R¹ = Ph, 3-nitrophenyl, 2-trifluoromethyl-4-nitrophenyl, etc.) to amines R¹NH₂. The as-prepared catalyst has been extensively characterized by XPS, SEM-EDX, TEM, TGA, BET surface area measurements and powd. X-ray diffraction (PXRD). A wide variety of substrates could be converted to the desired products with good to excellent yields by using water as a green solvent for both the reactions. The catalyst was recyclable and reusable up to six consecutive cycles without compromising its catalytic proficiency.

Journal of Chemical Sciences (Berlin, Germany) published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Application In Synthesis of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hwang, Jimin published the artcileMulticomponent Petasis Reaction for the Synthesis of Functionalized 2-Aminothiophenes and Thienodiazepines, Name: 2-Cyano-N-ethylacetamide, the publication is ACS Combinatorial Science (2020), 22(10), 495-499, database is CAplus and MEDLINE.

Multicomponent Petasis reaction has been widely applied for the synthesis of functionalized amine building blocks and biol. active compounds Employing primary aromatic amines that are not typical reactive substrates contributes to expand the application scope of the Petasis reaction. In this study, we demonstrated the synthesis of functionalized 2-aminothiophenes using Gewald-reaction-derived 2-aminothiophenes as the amine substrates, whose low reactivity in the Petasis reaction was overcome using hexafluoro-2-propanol as the solvent in a mild condition. The obtained Petasis products are amenable for further transformations owing to the presence of multiple functional handles. A following intramol. cyclization of selected Petasis products afforded substituted tricyclic heterocycles that incorporate a pharmaceutically interesting thienodiazepine moiety.

ACS Combinatorial Science published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Name: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Brulet, Jeffrey W. published the artcileLiganding Functional Tyrosine Sites on Proteins Using Sulfur-Triazole Exchange Chemistry, Name: Isonicotinamide, the publication is Journal of the American Chemical Society (2020), 142(18), 8270-8280, database is CAplus and MEDLINE.

Tuning reactivity of sulfur electrophiles is key for advancing click chem. and chem. probe discovery. To date, activation of the sulfur electrophile for protein modification has been ascribed principally to stabilization of a fluoride leaving group (LG) in covalent reactions of sulfonyl fluorides and arylfluorosulfates. We recently introduced sulfur-triazole exchange (SuTEx) chem. to demonstrate the triazole as an effective LG for activating nucleophilic substitution reactions on tyrosine sites of proteins. Here, we probed tunability of SuTEx for fragment-based ligand discovery by modifying the adduct group (AG) and LG with functional groups of differing electron-donating and -withdrawing properties. We discovered the sulfur electrophile is highly sensitive to the position of modification (AG vs. LG), which enabled both coarse and fine adjustments in solution and proteome activity. We applied these reactivity principles to identify a large fraction of tyrosine sites (~30%) on proteins (~44%) that can be liganded across >1500 probe-modified sites quantified by chem. proteomics. Our proteomic studies identified noncatalytic tyrosine and phosphotyrosine sites that can be liganded by SuTEx fragments with site specificity in lysates and live cells to disrupt protein function. Collectively, we describe SuTEx as a versatile covalent chem. with broad applications for chem. proteomics and protein ligand discovery.

Journal of the American Chemical Society published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Name: Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Merzoug, Amina published the artcileMolecular docking study of the acetylcholinesterase inhibition, Category: amides-buliding-blocks, the publication is Current Issues in Pharmacy and Medical Sciences (2021), 34(1), 20-27, database is CAplus.

While Alzheimer disease is the most common form of dementia, acetylcholinesterase is an interesting therapeutic target for the development of new anti-Alzheimer’s disease drugs. In order to discover potential compounds inhibiting this protein target, a mol. docking study of a similar collection of 1-[[2,4-bis[(E)hydroxyiminomethyl] pyridin-1-ium-1-yl]methoxymethyl] pyridin-1-ium-4-carboxamide (HLO) inhibitor from ZINC database using FlexX program was realized. Before performing the mol. docking, FlexX was validated by Root mean square deviation test to determine the reproducibility of the docking program. The strategy undertaken in this study permitted us to propose products 4-[[2-[(Z)-N’-hydroxycarbamimidoyl]-4-pyridyl]methylamino] benzamide and N-[(E)-[1-(4-nitrophenyl)pyrrol-2-yl]methylene amino]isonicotinamide as potential new inhibitors of humane acetylcholinesterase. The two proposed products may act as strong anti-Alzheimer leads compounds

Current Issues in Pharmacy and Medical Sciences published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Soukup, Ondrej published the artcileThe wide-spectrum antimicrobial effect of novel N-alkyl monoquaternary ammonium salts and their mixtures; the QSAR study against bacteria, SDS of cas: 1453-82-3, the publication is European Journal of Medicinal Chemistry (2020), 112584, database is CAplus and MEDLINE.

In this study we have prepared 43 novel N-alkyl monoquaternary ammonium salts including 7 N,N-dialkyl monoquaternary ammonium salts differing bearing alkyl chain either of 12, 14 or 16 carbons. Together with 15 already published QASs we have studied the antimicrobial efficacy of all water-soluble compounds together with standard benzalkonium salts against Gram-pos. (G+) and Gram-neg. (G-) bacteria, anaerobic spore-forming Cl. difficile, yeasts, filamentous fungi and enveloped Varicella zoster virus (VZV). To address the mechanism of action, lipophilicity seems to be a key parameter which determines antimicrobial efficacy, however, exceptions are likely to occur and therefore QSAR anal. on the efficacy against G+ and G- bacteria was applied. We showed that antibacterial activity is higher when the mol. is larger, more lipophilic, less polar, and contains fewer oxygen atoms, fewer Me groups bound to heteroatoms or fewer hydrogen atoms bound to polarized carbon atoms. In addition, from an application point of view, we have formulated mixtures, on the basis of obtained efficiency of individual compounds, in order to receive wide-spectrum agent. All formulated mixtures completely eradicated tested G+ and G- strains, including the multidrug-resistant P. aeruginosa as well as in case of yeasts. Finally, 3 out of 4 formulated mixtures were safer than reference com. agent based on benzalkonium salts only in the skin irritation test using reconstructed human epidermidis.

European Journal of Medicinal Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C8H7N3, SDS of cas: 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Pandey, Pragati published the artcileHydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex, HPLC of Formula: 1453-82-3, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(73), 9204-9207, database is CAplus and MEDLINE.

A terminal [Ni-OH] complex 1, supported by triflamide-functionalized NHC ligands, catalyzes the hydrosilylative reduction of a range of primary amides into primary amines in good to excellent yields under base-free conditions with key functional group tolerance. Catalyst 1 is also effective for the reduction of a variety of tertiary and secondary amides. In contrast to literature reports, the reactivity of 1 towards amide reduction follows an inverse trend, i.e., 1° amide > 3° amide > 2° amide. The reaction does not follow a usual dehydration pathway.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, HPLC of Formula: 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Seidelmann, O. published the artcileCyclic voltammetric studies on N,N-disubstituted N’-ferrocenoylthioureas and their transition metal complexes, Recommanded Product: Morpholine-4-carbothioamide, the publication is Polyhedron (1998), 17(10), 1601-1610, database is CAplus.

The Fe(II)/Fe(III) redox potentials of N,N-disubstituted N’-ferrocenoylthioureas and the resp. ferrocene-1,1′-dicarbonic acid di-N,N-dialkyl-thioureids are shifted cathodically by complexation of Ni(II), Cu(II), Co(III), Mn(II), Pt(II) and Pd(II). The extent of the shift is more pronounced in the latter ligand class and reaches values up to -0.32 V. The N,N-disubstituted N’-ferrocenoylthioureas exhibit two redox processes in dichloromethane. A mechanistic scheme is proposed. Ferrocene-1,1′-dicarbonic acid di-N,N-dialkyl-thioureids decompose after oxidation in dichloromethane. In contrast, complexes of both ligand types contain quasireversibly oxidizable ferrocene subunits.

Polyhedron published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C17H20ClN3, Recommanded Product: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Naik, Kuverji Gosai published the artcileCondensation of cyanoacetic ester with some aryl- and alkyl-amines. Preparation of some aryl- and alkyl-substituted cyano-acetamides, Formula: C5H8N2O, the publication is Quarterly Journal of the Indian Chemical Society (1927), 547-51, database is CAplus.

Cyano- aceto-toluidide, m. 125°, m-toluidide, m. 132°, α-naphthylamide, m. 175°, β-naphthylamide, m. 174°, vic-m-xylidide, m. 107°, methylamide, m. 101° and ethylamide, m. 74°, are prepared for the first time. The methods of preparation vary with the basic strength of the amines. In the preparation of the substituted amides of the aromatic acids, Whiteley’s method, as modified by Naik (C. A. 15, 2072) was used. Cyanoacetanilide, m. 198-9° is prepared by refluxing CNCH₂CO₂Et with redistilled NH₂ at 160-70° for 6 hrs. p-Toluidide, similarly prepared, substituting p-MeC₆H₄NH₂ for PhNH₂, m. 180°. Benzylamide, m. 120°.

Quarterly Journal of the Indian Chemical Society published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics