Tag: M.W=100-150

Shukla, J. S. published the artcileSynthesis of some enaminonitriles, HPLC of Formula: 15029-36-4, the publication is Journal of the Indian Chemical Society (1978), 55(3), 281-3, database is CAplus.

Reaction of EtO₂CCH₂CN with RNH₂ gave RNHCOCH₂CN (I; R = Me, Et, PhCH₂, naphthyl, etc.). Treatment of I by CH₂:CHCN gave RNHCOC(CN)(CH₂CH₂CN)₂ (same R). The Thorpe-Ziegler cyclization of the latter gave the title compounds II.

Journal of the Indian Chemical Society published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C18H28B2O4, HPLC of Formula: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Shukla, J. S. published the artcileSome newer cyanoethylated alkyl- and aryl-substituted cyanoacetamides as insecticides. Part III, Recommanded Product: 2-Cyano-N-ethylacetamide, the publication is Journal of the Indian Chemical Society (1976), 53(2), 196-7, database is CAplus.

Cyanoacetamides NCC(CH2CH2CN)2CONHR (I, R = C1-C4 alkyl, PhCH2, 2-MeC6H4, 1- or 2- naphthyl) were prepared by reaction of NCCH2CO2Et with RNH2, followed by cyanoethylation with CH2CHCN in dioxane. Insecticidal test data were given for I and several other cyanoethylated amides.

Journal of the Indian Chemical Society published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C13H15NO6S, Recommanded Product: 2-Cyano-N-ethylacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kamble, Sumit B. published the artcileA single pot organocatalytic diastereoselective synthesis of fluorescent ring fused 2-pyridone decalines via a domino Knoevenagel/Michael/hydro-lactamisation sequence, Formula: C5H8N2O, the publication is Organic Chemistry Frontiers (2021), 8(18), 5032-5039, database is CAplus.

Multifunctional ring fused octahydro 3-CN-2-pyridone I (R = Ph, thiophen-2-yl, 1,3-benzodioxol-5-yl, etc.; R¹ = H, Me, Et) decaline motifs are constructed by a single pot multicomponent, diastereoselective, organocatalytic domino approach. Three consecutive catalytic reaction sequences are presented, wherein L-proline plays a catalytic dual role for Knoevenagel condensation and Michael addition co-operatively with PhCOOH, followed by annulation by hydro-lactamisation. Compounds containing bromine, chlorine, methoxy and methylenedioxy groups showed aggregation-induced fluorescence under long-range UV exposure. The present method is a green synthetic strategy with the following features: high diastereoselectivity (dr > 20), catalytic activity, high yields, cost-effective nature, a simple, mild, and operationally scalable process, and broad substrate scope.

Organic Chemistry Frontiers published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Formula: C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sathunuru, Ramadas published the artcileFacile synthesis of 4H-naphtho[2,3-e] derivatives of 1,3-thiazines and 1,3-selenazines and naphtho[2′,3′:4,5] derivatives of selenolo[2,3-b]pyridines and thieno[2,3-b]pyridines via 2,3- didehydronaphthalene, Product Details of C5H10N2OS, the publication is ARKIVOC (Gainesville, FL, United States) (2004), 51-60, database is CAplus.

Thiaazadienes (2a–e), selenoazadienes (6a–f), Barton selenium esters (8a–e) and Barton sulfur esters (10a–e) react with 2,3-didehydronaphthalene (4) generated from (phenyl)[(3-trimethylsilyl)-2-naphthyl]iodonium triflate (3) at 0°C to give 4H-naphtho[2,3-e]-1,3-thiazines (5a–e), 4H-naphtho[2,3-e]-1,3-selenazines (7a–f), naphtho[2′,3′:4,5]selenolo[2,3-b]pyridines (9a–e) and naphtho[2′,3′:4,5]thieno[2,3-b]pyridines (11a–d). The x-ray and mol. structure of 5e and 7b are reported.

ARKIVOC (Gainesville, FL, United States) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Collins, Jon L. published the artcileN-(2-Benzoylphenyl)-L-tyrosine PPARγ Agonists. 2. Structure-Activity Relationship and Optimization of the Phenyl Alkyl Ether Moiety, Product Details of C5H10N2OS, the publication is Journal of Medicinal Chemistry (1998), 41(25), 5037-5054, database is CAplus and MEDLINE.

We previously reported the identification of (2S)-((2-benzoylphenyl)amino)-3-{4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl}propanoic acid (I) (PPARγ pK_i = 8.94, PPARγ pEC₅₀ = 9.47) as a potent and selective PPARγ agonist. We now report the expanded structure-activity relationship around the Ph alkyl ether moiety by pursuing both a classical medicinal chem. approach and a solid-phase chem. approach for analog synthesis. The solution-phase strategy focused on evaluating the effects of oxazole and Ph ring replacements of the 2-(5-methyl-2-phenyloxazol-4-yl)ethyl side chain of I with several replacements providing potent and selective PPARγ agonists with improved aqueous solubility Specifically, replacement of the Ph ring of the phenyloxazole moiety with a 4-pyridyl group to give (2S)-((2-benzoylphenyl)amino)-3-{4-[2-(5-methyl-2-pyridin-4-yloxazol-4-yl)ethoxy]phenyl}propionic acid (PPARγ pK_i = 8.85, PPARγ pEC₅₀ = 8.74) or a 4-methylpiperazine to give (2S)-((2-benzoylphenyl)amino)-3-(4-{2-[5-methyl-2-(4-methylpiperazin-1-yl)thiazol-4-yl]ethoxy}phenyl)propionic acid (PPARγ pK_i = 8.66, PPARγ pEC₅₀ = 8.89) provided two potent and selective PPARγ agonists with increased solubility in pH 7.4 phosphate buffer and simulated gastric fluid as compared to I. The second strategy took advantage of the speed and ease of parallel solid-phase analog synthesis to generate a more diverse set of Ph alkyl ethers which led to the identification of a number of novel, high-affinity PPARγ ligands (PPARγ pK_i‘s 6.98-8.03). The combined structure-activity data derived from the two strategies provide valuable insight on the requirements for PPARγ binding, functional activity, selectivity, and aqueous solubility

Journal of Medicinal Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Priestley, E. Scott published the artcileDiscovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4, Quality Control of 14294-10-1, the publication is Journal of Medicinal Chemistry (2022), 65(13), 8843-8854, database is CAplus and MEDLINE.

Herein, the optimization of a series of imidazothiadiazole PAR4 antagonists to a first-in-class clin. candidate, BMS-986120 I, and a backup clin. candidate, BMS-986141 II was described. Both compounds demonstrated excellent antithrombotic efficacy and minimal bleeding time prolongation in monkey models relative to the clin. important antiplatelet agent clopidogrel and provide a potential opportunity to improve the standard of care in the treatment of arterial thrombosis.

Journal of Medicinal Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Quality Control of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Tiwari, Dilip published the artcileCopper complexes of imidazole-2-carbaldehyde N(4)-substituted thiosemicarbazones: synthesis, characterization and antimicrobial activity, COA of Formula: C5H10N2OS, the publication is Asian Journal of Chemistry (2016), 28(12), 2793-2797, database is CAplus.

Imidazole-2-carbaldehyde N(4)-pyrrolidinyl, N(4)-piperidinyl, N(4)-morpholinyl and N(4)-piperazinyl thiosemicarbazones and their copper(II) complexes were synthesized. The compounds were characterized by NMR, IR, UV-visible, ESR spectroscopy and ESI mass spectrometry. The stoichiometry, spectroscopic and mass spectrometry data indicates thiosemicarbazone coordination to Cu(II) in neutral form with NNS donors. The coordination spheres of the metal ion are completed by chlorine atoms in approx. square pyramidal geometry. The in vitro antimicrobial properties of the compounds in broth culture exhibited a moderate inhibitory effect on the microbial proliferation. Some copper(II) complexes exhibited a moderate inhibitory activity, better than that of the corresponding free thiosemicarbazone.

Asian Journal of Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C4H7BrO2, COA of Formula: C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Jones, Eleanor C. L. published the artcilePressure-induced superelastic behaviour of isonicotinamide, Application In Synthesis of 1453-82-3, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(89), 11827-11830, database is CAplus and MEDLINE.

Dynamic organic crystals have come to the fore as potential lightweight alternatives to inorganic actuators providing high weight-to-force ratios. We have observed pressure-induced superelastic behavior in Form I of isonicotinamide. The reversible single-crystal to single-crystal transformation exhibited by the system is an important component for functioning actuators. Crucially, our observations have enabled us to propose a mechanism for the mol. movement supported by Pixel energy calculations, that may pave the way for the future design and development of functioning dynamic crystals.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Application In Synthesis of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kleinpeter, E. published the artcileDynamic NMR studies of the restricted rotation at the NC(X) bonding fragment. XV. Influence of the rotational barrier in the NR₂C(X)R¹ bonding fragment by electronic and steric substituent effects, Quality Control of 14294-10-1, the publication is Journal fuer Praktische Chemie (Leipzig) (1982), 324(1), 29-45, database is CAplus.

Rotational barriers (ΔG^⧧) about the partial C-N double bond in R₂NCXR¹ [R₂N = Me₂N, Et₂N, (Me₂CHCH₂)₂N, Bu₂N, 1-pyrrolidinyl, (PhCH₂)₂N, piperidino, morpholino, hexahydro-1-azepinyl; X = O, S, Se; R¹ = NHBz, NH₂, SCH₂CO₂H, SCH₂CH₂CO₂H, CH₂COPh] were determined The electronic and steric effects of R¹ were discussed. The steric demand of R¹ decreased in the following order: NH₂ > carboxyalkylthio > CH₂COPh (enol form) ≫ NHBz.

Journal fuer Praktische Chemie (Leipzig) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Quality Control of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Vivier, Delphine published the artcileDevelopment of the First Two-Pore Domain Potassium Channel TWIK-Related K⁺ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity, Product Details of C5H8N2O, the publication is Journal of Medicinal Chemistry (2017), 60(3), 1076-1088, database is CAplus and MEDLINE.

The TWIK-Related K⁺ channel, TREK-1, has recently emerged as an attractive therapeutic target for the development of a novel class of analgesic drugs, suggesting that activation of TREK-1 could result in pain inhibition. Here the authors report the synthesis of a series of substituted acrylic acids (1-54) based on the previous work with caffeate esters. The analogs were evaluated for their ability to modulate TREK-1 channel by electrophysiol. and for their in vivo antinociceptive activity (acetic acid-induced writhing and hot-plate assays), leading to the identification of a series of novel mols. able to activate TREK-1 and displaying potent antinociceptive activity in vivo. The furyl analog I is the most promising of these series.

Journal of Medicinal Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C13H24INO4, Product Details of C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics