Tag: M.W=100-150

Jiang, Jiaxuan published the artcileThe isonicotinamide cocrystal promotes inhibitory effects of naringenin on nonalcoholic fatty liver disease in mice, Application of Isonicotinamide, the publication is Journal of Drug Delivery Science and Technology (2020), 101874, database is CAplus.

Cocrystal formation can increase the solubility and dissolution rate of the poorly water-soluble drugs, thus enhancing their oral absorption and bioavailability. Our previous study demonstrates that a high dose (100 mg/kg) of naringenin (NGN) has a prominent inhibitory effect on nonalcoholic fatty liver disease (NAFLD) in mice. However, NGN is poorly soluble in water and has low oral bioavailability, which greatly limit its application. To increase solubility and dissolution rate of NGN, the naringenin-isonicotinamide cocrystal (NGN-INT) was prepared by solvent volatilization method. Compared to an equal dose (50 mg/kg) of the NGN crude drug, the NGN-INT significantly increased in vitro release rate as well as in vivo gastrointestinal absorption of NGN and thus more significantly alleviated liver deposition of triglycerides (TG) of the NAFLD mice induced by a methionine choline deficient (MCD) diet.

Journal of Drug Delivery Science and Technology published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Application of Isonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhang, Xing published the artcileHPMC improves protective effects of naringenin and isonicotinamide co-crystals against abdominal aortic aneurysm, Quality Control of 1453-82-3, the publication is Cardiovascular Drugs and Therapy, database is CAplus and MEDLINE.

Abdominal aortic aneurysm (AAA) rupture is one of the most common causes of mortality in cardiovascular diseases, but currently there is no approved drug for AAA treatment or prevention in the clinic. Naringenin (NGN) has been reported to have anti-AAA effects. However, water solubility and in vivo absorption of NGN are not satisfactory, which leads to its low bioavailability, thus affecting its pharmacol. effects. In this project, the improving effects of isonicotinamide (INT) co-crystal and hydroxy Pr Me cellulose (HPMC) or polyvinyl pyrrolidone (PVP) on the solubility, in vivo absorption, and anti-AAA effects of NGN were evaluated. In the current study, co-crystals of naringenin-isonicotinamide (NGN-INT) were prepared, and effects of PVP or HPMC on precipitation rate, supersaturation, and bioavailability of NGN were explored. In addition, with or without HPMC supply, the effects of NGN-INT co-crystal on anti-AAA efficacy of NGN were investigated on an elastase-induced AAA mouse model, and the results were compared with the efficacy of the NGN crude drug. Our results demonstrate that NGN-INT formulation, compared to the NGN crude drug, enhanced the dissolution rate of NGN and significantly increased C_max and AUC_(0-∞) of NGN by 18 times and 1.97 times, resp. Addition of PVP or HPMC in NGN-INT co-crystal further increased bioavailability of NGN in NGN-INT. The in vivo pharmacodynamic study showed that NGN-INT with HPMC significantly improved the inhibitory effects of NGN against AAA. NGN-INT significantly improved the absorption and aortic protective effects of NGN. The supersaturation-prolonging effect of HPMC further enhanced bioavailability and anti-AAA effects of NGN-INT.

Cardiovascular Drugs and Therapy published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C4H10OS, Quality Control of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sekar, Nagaiyan published the artcileSynthesis of novel styryl derivatives from 4-chloro-2-(morpholin-4-yl)-1,3-thiazole-5-carbaldehyde, study of their photophysical properties and TD-DFT computations, Synthetic Route of 14294-10-1, the publication is Journal of Luminescence (2014), 8-18, database is CAplus.

Novel fluorescent styryl push-pull compounds having electron donating thiazole unit were synthesized by condensing 4-chloro-2-(morpholin-4-yl)-1,3-thiazole-5-carbaldehyde with active methylene compounds via classical Knoevenagel condensation. The synthesized styryl mols. were characterized by spectral anal. Photophys. properties of these styryl derivatives were analyzed and the effect of change in solvent polarity and viscosity on their absorptive and emissive properties has been investigated. D. functional theory (DFT) and time dependent-d. functional theory (TD-DFT) computations have been used to understand the structural, mol., electronic and photophys. parameters of push-pull dyes. Bakhshiev and Kawski-Chamma-Viallet correlations were used to calculate the ratio of ground to excited state dipole moment of the synthesized novel styryl compounds

Journal of Luminescence published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C4H6O3, Synthetic Route of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Djerassi, Carl published the artcileOptical rotatory dispersion studies. XLIII. Absolute configurational assignment of α-substituted carboxylic acids by anomalous rotatory dispersion of their acylthiourea derivatives, Recommanded Product: Morpholine-4-carbothioamide, the publication is Journal of the American Chemical Society (1960), 5755-6, database is CAplus.

cf. CA 54, 7574h; 55, 7476f. In order to show anomalous rotatory dispersion, carboxylic acids must be converted to derivatives containing a chromophore. The acyl thioureas, RCONHCSNR’₂, were suitable, especially when NR’₂ = morpholino; they showed pos. Cotton effects when R belonged to the L series, neg. when R was D. In a typical preparation, the acid chloride from 120 mg. dehydroabietic acid and excess SOCl₂ was refluxed 1 hr. with 44 mg. KSCN in 4 cc. Me₂CO. Morpholine (0.6 cc.) was added, heating continued 10 min., and the mixture kept overnight. Removal of solvent, addition of H₂O and dilute acid, and extraction with Et₂O yielded 86% dehydroabietyl morpholinothiocarbamide, m. 102-4° (hexane), λ (MeOH) 282 and 340 mμ, log ε 4.16 and 2.41. This derivative showed a pos. Cotton effect, while that of acetoxypodocarpic acid showed a neg. one; the 2 substances differed stereochem. only in configuration at the center adjacent to the CO₂H.

Journal of the American Chemical Society published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Recommanded Product: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Herder, Martin published the artcileSwitching with orthogonal stimuli: electrochemical ring-closure and photochemical ring-opening of bis(thiazolyl)maleimides, Application of Morpholine-4-carbothioamide, the publication is Chemical Science (2013), 4(3), 1028-1040, database is CAplus.

The photochem. as well as electrochem. of novel donor-acceptor bis(morpholinothiazolyl)-maleimides has been investigated. Proper substitution of these diarylethene-type mol. switches leads to the unique situation in which their ring-closure can only be accomplished electrochem., while ring-opening can only be achieved photochem. Hence, these switches operate with orthogonal stimuli, i.e. redox potential and light, resp. The switch system could be optimized by introducing trifluoromethyl groups at the reactive carbon atoms in order to avoid byproduct formation during oxidative ring closure. Both photochem. and electrochem. pathways were investigated for methylated, trifluoromethylated, and nonsym. bis(morpholinothiazolyl)maleimides as well as the bis(morpholinothiazolyl)cyclopentene reference compound With the aid of the nonsym. “mixed” derivative, the mechanism of electrochem. driven ring closure could be elucidated and seems to proceed via a dicationic intermediate generated by two-fold oxidation All exptl. work has been complemented by d. functional theory that provides detailed insights into the thermodn. of the ring-open and closed forms, the nature of their excited states, and the reactivity of their neutral as well as ionized species in different electronic configurations. The particular diarylethene systems described herein could serve in multifunctional (logic) devices operated by different stimuli (inputs) and may pave the way to converting light into elec. energy via photoinduced “pumping” of redox-active meta-stable states.

Chemical Science published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Application of Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Batenko, N. G. published the artcileSynthesis of 2,5-bis(2-aminothiazol-5-yl)-3,6-dichloro-1,4-benzoquinones, Application In Synthesis of 14294-10-1, the publication is Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) (2000), 36(6), 733-737, database is CAplus.

A series of 2-(2-aminothiazol-5-yl)-3,6-dichloro-5-diethylaminoethenyl-1,4-benzoquinones was synthesized from 2-(2-aminothiazol-5-yl)-3,5,6-trichloro-1,4-benzoquinones using acetaldehyde and diethylamine in toluene solution Refluxing these compounds with substituted thioureas in acetonitrile in the presence of hydrochloric acid gives the corresponding 2,5-bis(2-aminothiazol-5-yl)-3,6-dichlorohydroquinones which can be oxidized to the target products with ferric chloride in aqueous DMF.

Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Application In Synthesis of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Semichenko, E. S. published the artcileZeolites in the synthesis of 1-alkyl-2-oxonicotinonitriles, Product Details of C5H8N2O, the publication is Russian Journal of Organic Chemistry (2005), 41(2), 313-314, database is CAplus.

Cyclocondensation of acetylacetone with cyanoacetamide or N-alkylcyanoacetamides (alkyl = Me, Et) in the presence of NaA zeolite afforded 4,6-dimethyl-2-oxonicotinonitrile or 1-alkyl-4,6-dimethyl-2-oxonicotinonitriles, resp. The condensation of 3-hydroxyiminopenta-2,4-dione with cyanoacetamide in the same manner furnished 4,6-dimethyl-5-nitroso-2-oxonicotinonitrile.

Russian Journal of Organic Chemistry published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C13H10O2, Product Details of C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Doshi, Hiren published the artcile6-Tosyl-4,5,6,7-Tetrahydrothieno[2,3-c]Pyridine-3-Carboxamide Analogues: Synthesis, Characterization, MO Calculation, and Antibacterial Activity, Category: amides-buliding-blocks, the publication is Applied Biochemistry and Biotechnology (2015), 175(3), 1700-1709, database is CAplus and MEDLINE.

A series of 6-tosyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide I (R¹ = H, OH; R² = R³ = H, Cl, OCH₃; R⁴ = H, Cl, OCH₃, OH) analogs are synthesized. These are tested for their antibacterial activity against Bacillus subtilis (abbreviated as BS), Staphylococcus aureus (abbreviated as SA), and Escherichia coli (abbreviated as EC). The synthesized compounds are able to inhibit the growth of the SA and EC. None of the compounds are effective against BS. All valence MO (abbreviated as MO) calculations with PM⁶ have been carried out for the mols. for which bioactivity data are available. Ciprofloxacin is taken as the standard antibiotics to compare activity with the mols. synthesized. It has been attempted to correlate the activity of the mols. with their electronic structure.

Applied Biochemistry and Biotechnology published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Dash, Sibananda G. published the artcileComputational Screening of Multicomponent Solid Forms of 2-Aryl-Propionate Class of NSAID, Zaltoprofen, and Their Experimental Validation, Computed Properties of 1453-82-3, the publication is Crystal Growth & Design (2021), 21(1), 449-461, database is CAplus.

A rational coformer screening methodol. was adopted to identify new multicomponent solid preformulations of the 2-aryl propionate class of nonsteroidal anti-inflammatory drugs. The coformer screening was performed using a modified mol. electrostatic potential based site-pair interaction energy computations used in conjunction with the free energy of cocrystal formation calculations to attain better predictability. The computational results were validated against the available exptl. data and used for optimizing the cocrystal screening methodol. for the drug zaltoprofen. A new polymorph and three new cocrystal forms of zaltoprofen were reported in the study, which exhibits up to four times enhancement in the drug solubility than that of the marketed form. We also report one new salt and two new cocrystals of (+)-ibuprofen, a drug from the same 2-aryl propionate family. In hindsight, we propose incorporating secondary heteromeric interactions formed by homo/heterodimer in the calculations of site-pair interaction energy differences for improving the predictability of the mol. electrostatic potential (MESP) based screening. A combined coformer screening strategy utilizing an MESP site-pair interaction energy and the free energy of cocrystal formation calculations helped to develop several novel multicomponent solids of zaltoprofen.

Crystal Growth & Design published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Computed Properties of 1453-82-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Unterhalt, B. published the artcileNitramines; IX. Acylnitramines, SDS of cas: 15029-36-4, the publication is Synthesis (1976), 241-2, database is CAplus.

Acylnitramines RCONMeNO2 (R = Me, Ph, PhCH2, 4-O2NC6H4, etc.) were prepared in 39-64% yield by the reaction of O2NNNaMe with RCOCl in anhydrous MeCN containing K2CO3. RCONR1NO2 [R = H, Me, NCCH2, O2NC6H4, (O2N)2C6H3, etc.; R1 = Me, Et) were prepared in 36-96% yield by the nitration of RCONHR1 with N2O5 in anhydrous HCCl3 at -60°.

Synthesis published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C27H39ClN2, SDS of cas: 15029-36-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics