Tag: M.W=100-150

An article A Highly Selective Palladium-Catalyzed Aerobic Oxidative Aniline-Aniline Cross-Coupling Reaction WOS:000487577200019 published article about BOND FORMATION; DERIVATIVES; ARYLATION; BINAM; BIPHENOLS; PHENOLS in [Matsumoto, Kenji; Takeda, Satoshi; Hirokane, Tsukasa; Yoshida, Masahiro] Tokushima Bunri Univ, Fac Pharmaceut Sci, 180 Nishihama Boji, Yamashiro, Tokushima 7708514, Japan in 2019.0, Cited 58.0. SDS of cas: 104-10-9. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

The first catalytic oxidative aniline-aniline cross-coupling reaction using oxygen as the terminal oxidant is reported. Anilines possessing a pyrrolidino group can be preferentially oxidized under mild aerobic conditions and reacted with other anilines to afford a variety of nonsymmetrical 2-aminobiphenyls with high selectivities. A heterogeneous palladium catalyst is used for the dehydrogenative cross-coupling of anilines with structurally diverse arenes. This reaction does not require stoichiometric oxidants and is an economical and environmentally friendly method.

Welcome to talk about 104-10-9, If you have any questions, you can contact Matsumoto, K; Takeda, S; Hirokane, T; Yoshida, M or send Email.. SDS of cas: 104-10-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2021 GREEN CHEM published article about ALKYNE INSERTION; LIGANDS; ACIDS; ANNULATION; 1,2,3-BENZOTRIAZIN-4(3H)-ONES in [Tang, Guo] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China; Xiamen Univ, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Fujian, Peoples R China in 2021, Cited 54. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4. Name: Benzo[d][1,2,3]triazin-4(3H)-one

Metal-free, visible-light-induced denitrogenative phosphorylation of 1,2,3-benzotriazinones was achieved. With the use of eosin Y as a photoredox catalyst, N,N-diisopropylethylamine as a base, CH3CN-H2O as a solvent and sunlight or a blue LED as a light source, a variety of aryl-phosphonates, aryl-phosphinates, and aryl-phosphine oxides were efficiently prepared. In addition, B(2)pin(2) instead of P-nucleophiles as a radical acceptor was also demonstrated. The key advantages of this newly developed method are the clean reaction profile, use of a low-cost organic-dye catalyst, energy efficiency, broad substrate scope, good to excellent yields and large-scale synthetic applicability. The gram-scale synthesised compounds could be isolated in pure form just upon extraction, followed by re-crystallisation; no tedious chromatographic purification was required.

Name: Benzo[d][1,2,3]triazin-4(3H)-one. Bye, fridends, I hope you can learn more about C7H5N3O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

An article Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives containing benzo[d][1,2,3]thiadiazole against Meloidogyne incognita WOS:000554890700005 published article about SYSTEMIC ACQUIRED-RESISTANCE; ROTYLENCHULUS-RENIFORMIS; ELICITORS; NEMATICIDES; EFFICACY; TOMATO; PLANTS; SPP. in [Zhang, Ruifeng; Wang, Gaolei; Chen, Xiulei; Li, Zhong; Xu, Xiaoyong] East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China; [Guo, Wei] China Crop Protect Ind Assoc, Beijing 100723, Peoples R China in 2020, Cited 28. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4. Name: Benzo[d][1,2,3]triazin-4(3H)-one

Based on the characteristic of benzo[d][1,2,3]thiadiazole to induce the systemic acquired resistance and improve the immunity of plants, benzo[d][1,2,3]thiadiazole was introduced into 1,2,3-benzotriazin-4-one, thirty-one novel 1,2,3-benzotriazin-4-one derivatives containing benzo[d][1,2,3]thiadiazole were designed and synthesized. Nematicidal activity showed that most of the synthesized compounds exhibited great inhibitory activity in vivo against Meloidogyne incognita at 20 mg/L. Among 31 tested compounds, A2 and A3 showed an excellent nematicidal activity with the inhibition rate of 50.4% and 53.1% at the concentration of 1.0 mg/L, respectively. The influence of substituent type and position was investigated. The relationship between structure and activity was also preliminary analyzed.

Welcome to talk about 90-16-4, If you have any questions, you can contact Zhang, RF; Guo, W; Wang, GL; Chen, XL; Li, Z; Xu, XY or send Email.. Name: Benzo[d][1,2,3]triazin-4(3H)-one

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

An article Selective N-monomethylation of primary anilines with the controllable installation of N-CH2D, N-CHD2, and N-CD3 units WOS:000546177200004 published article about GENERAL CATALYTIC METHYLATION; CARBON-DIOXIDE; AROMATIC-AMINES; BORROWING HYDROGEN; DIMETHYL CARBONATE; REDUCTIVE METHYLATION; DEUTERATED DRUGS; COMPLEX BEARING; FORMIC-ACID; METHANOL in [Meng, Jing; Wang, Zhijuan] Nanjing Nch Univ, Sch Chem & Mol Engn, Inst Adv Synth, Nanjing 211816, Peoples R China; [Xia, Hui-Min; Xu, Ai-Qing; Wang, Yi-Feng; Zhang, Feng-Lian] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China; [Xia, Hui-Min; Xu, Ai-Qing; Wang, Yi-Feng; Zhang, Feng-Lian] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China in 2020.0, Cited 81.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9. Recommanded Product: 2-(4-Aminophenyl)ethanol

The selective N-monomethylation of primary anilines was realized by the use of the Me3N-BH3/N,N-dimethylformamide (DMF) system as the methyl source. This method also allows for the controllable introduction of N-CH2D, N-CHD2, and N-CD3 units with high levels of deuterium incorporation using Me3N-BH3/d(7)-DMF, Me3N-BD3/DMF and Me3N-BD3/d(7)-DMF systems, respectively.

Welcome to talk about 104-10-9, If you have any questions, you can contact Meng, J; Xia, HM; Xu, AQ; Wang, YF; Wang, ZJ; Zhang, FL or send Email.. Recommanded Product: 2-(4-Aminophenyl)ethanol

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Safety of Benzo[d][1,2,3]triazin-4(3H)-one. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis of 3-indolylmethyl substituted (pyrazolo/benzo)triazinone derivatives under Pd/Cu-catalysis: Identification of potent inhibitors of chorismate mutase (CM) published in 2019, Reprint Addresses Pal, M (corresponding author), Dr Reddys Inst Life Sci, Univ Hyderabad Campus, Hyderabad 500046, India.. The CAS is 90-16-4. Through research, I have a further understanding and discovery of Benzo[d][1,2,3]triazin-4(3H)-one.

The chorismate mutase (CM) is considered as an attractive target for the identification of potential antitubercular agents due to its absence in animals but not in bacteria. A series of 3-indolylmethyl substituted pyrazolo-triazinone derivatives were designed and docked into CM in silico as potential inhibitors. These compounds were efficiently synthesized using the Pd/Cu-catalyzed coupling-cyclization in a single pot involving the construction of indole ring. The methodology was later extended to the preparation of corresponding benzo analogs of pyrazolotriazinones i.e. 3-indolylmethyl substituted benzotriazinone derivatives. Several of these novel compounds showed significant inhibition of CM when tested in vitro at 30 mu M. The SAR (Structure-Activity-Relationship) studies suggested that benzotriazinone moiety was more favorable over the pyrazolotriazinone ring. The two best active compounds showed IC50 similar to 0.4-0.9 mu M (better than the reference/known compounds used) and no toxicity till 30 mu M in vitro.

Welcome to talk about 90-16-4, If you have any questions, you can contact Reddy, GS; Snehalatha, AV; Edwin, RK; Hossain, KA; Giliyaru, VB; Hariharapura, RC; Shenoy, GG; Misra, P; Pal, M or send Email.. Safety of Benzo[d][1,2,3]triazin-4(3H)-one

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Quality Control of 2-(4-Aminophenyl)ethanol. Bhupathiraju, NVSDK; Younes, A; Cao, MH; Ali, J; Cicek, HT; Tully, KM; Ponnala, S; Babich, JW; Deri, MA; Lewis, JS; Francesconi, LC; Drain, CM in [Bhupathiraju, N. V. S. Dinesh K.; Younes, Ali; Cao, Minhua; Ali, Jafar; Cicek, Huseyin T.; Francesconi, Lynn C.; Drain, Charles Michael] CUNY Hunter Coll, Dept Chem, New York, NY 10065 USA; [Tully, Kathryn M.; Lewis, Jason S.] Weill Cornell Med, Dept Pharmacol, New York, NY 10065 USA; [Tully, Kathryn M.; Lewis, Jason S.] Mem Sloan Kettering Canc Ctr, Dept Radiol, Program Pharmacol, New York, NY 10065 USA; [Tully, Kathryn M.; Lewis, Jason S.] Mem Sloan Kettering Canc Ctr, Radiochem & Mol Imaging Probes Core, New York, NY 10065 USA; [Ponnala, Shashikanth; Babich, John W.] Weill Cornell Med, Radiophamaceut Sci, New York, NY USA; [Ponnala, Shashikanth; Babich, John W.] Weill Cornell Med, Dept Radiol, New York, NY USA; [Deri, Melissa A.] CUNY, Lehman Coll, Bronx, NY 10468 USA; [Deri, Melissa A.; Francesconi, Lynn C.; Drain, Charles Michael] CUNY, Grad Ctr, Chem Program, New York, NY 10016 USA published Improved synthesis of the bifunctional chelator p-SCN-Bn-HOPO in 2019.0, Cited 14.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9.

The bifunctional ligand p-SCN-Bn-HOPO, which has four 1,2-hydroxypyridinone groups on a spermine backbone with an isothiocyanate linker, has been shown to be an efficient and stable chelator for Zr(iv) and, more importantly, the radioisotope Zr-89 for use in radiolabeling antibodies for positron emission tomography (PET) imaging. Previous studies of Zr-89-HOPO-trastuzumab in mice showed low background, good tumor to organ contrast, and very low bone uptake which show p-SCN-Bn-HOPO to be an important next-generation bifunctional chelator for radioimmunoPET imaging with Zr-89. However, the reported synthesis of p-SCN-Bn-HOPO involves nine steps and multiple HPLC purifications with an overall yield of about 1.4%. Herein we report an improved and efficient synthesis of p-SCN-Bn-HOPO in four steps with 14.3% overall yield which will improve its availability for further biological studies and wider application in PET imaging. The new synthetic route also allows variation in linker length and chemistries which may be helpful in modifying in vivo clearance behaviors of future agents.

Welcome to talk about 104-10-9, If you have any questions, you can contact Bhupathiraju, NVSDK; Younes, A; Cao, MH; Ali, J; Cicek, HT; Tully, KM; Ponnala, S; Babich, JW; Deri, MA; Lewis, JS; Francesconi, LC; Drain, CM or send Email.. Quality Control of 2-(4-Aminophenyl)ethanol

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Synthesis of 3-indolylmethyl substituted (pyrazolo/benzo)triazinone derivatives under Pd/Cu-catalysis: Identification of potent inhibitors of chorismate mutase (CM) WOS:000487812000051 published article about 1,2,3-BENZOTRIAZIN-4-ONE DERIVATIVES; NEMATOCIDAL ACTIVITIES; INDOLES; 1-ALKYNES; RV1885C; 2-HETEROARYL; DOCKING; PROTEIN; 2-ARYL in [Reddy, Gangireddy Sujeevan; Snehalatha, Ampalam Venkata; Edwin, Rebecca Kristina; Hossain, Kazi Amirul; Misra, Parimal; Pal, Manojit] Dr Reddys Inst Life Sci, Univ Hyderabad Campus, Hyderabad 500046, India; [Reddy, Gangireddy Sujeevan; Giliyaru, Varadaraj Bhat; Hariharapura, Raghu Chandrashekhar; Shenoy, G. Gautham] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal 576104, Karnataka, India in 2019, Cited 38. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4. Recommanded Product: Benzo[d][1,2,3]triazin-4(3H)-one

The chorismate mutase (CM) is considered as an attractive target for the identification of potential antitubercular agents due to its absence in animals but not in bacteria. A series of 3-indolylmethyl substituted pyrazolo-triazinone derivatives were designed and docked into CM in silico as potential inhibitors. These compounds were efficiently synthesized using the Pd/Cu-catalyzed coupling-cyclization in a single pot involving the construction of indole ring. The methodology was later extended to the preparation of corresponding benzo analogs of pyrazolotriazinones i.e. 3-indolylmethyl substituted benzotriazinone derivatives. Several of these novel compounds showed significant inhibition of CM when tested in vitro at 30 mu M. The SAR (Structure-Activity-Relationship) studies suggested that benzotriazinone moiety was more favorable over the pyrazolotriazinone ring. The two best active compounds showed IC50 similar to 0.4-0.9 mu M (better than the reference/known compounds used) and no toxicity till 30 mu M in vitro.

Welcome to talk about 90-16-4, If you have any questions, you can contact Reddy, GS; Snehalatha, AV; Edwin, RK; Hossain, KA; Giliyaru, VB; Hariharapura, RC; Shenoy, GG; Misra, P; Pal, M or send Email.. Recommanded Product: Benzo[d][1,2,3]triazin-4(3H)-one

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

An article Hexokinase II Inhibitory Effect of Secondary Metabolites Derived from a Streptomyces sp. Associated with Mud Dauber Wasp WOS:000538917100001 published article about BACTERIAL SYMBIONTS; GLYCOLYSIS; CANCER; GERMINATION; ANSAMYCIN; PROVIDE in [Zhang, Xiu-Mei; Wang, Mei; Zheng, Dan; Feng, Ming-Kuan] Shandong Drug & Food Vocat Coll, Dept Pharm, Weihai 264210, Peoples R China; [Peng, Ai-Hong; Xie, Wei-Dong] Shandong Univ, Coll Marine Sci, Dept Pharm, Weihai 264209, Peoples R China in 2020, Cited 43. Recommanded Product: Benzo[d][1,2,3]triazin-4(3H)-one. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4

Insect-microbial symbioses have vast biochemical diversity, which is beneficial to produce bioactive secondary metabolites. In this study, chemical examination of a Streptomyces sp. associated with a mud dauber wasp led to the isolation of fourteen compounds. Their structures were determined by spectroscopic methods and comparison with literature data. Among the isolates, compounds 1,2,3-benzotriazin-4(1H)-one and 4-(2-aminoethyl)phenyl acetate were first reported from this species. Bioactivities of the isolated compounds were assayed for the first time against hexokinase II. 4-(2-Aminoethyl)phenyl acetate, germicidin B, phenylacetic acid, isogermicidin A and germicidin C displayed significant inhibitory activity against hexokinase II, with the IC50 values of 5.11, 7.11, 7.15, 8.45 and 8.78 mu M, respectively.

Recommanded Product: Benzo[d][1,2,3]triazin-4(3H)-one. Bye, fridends, I hope you can learn more about C7H5N3O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recently I am researching about BIOLOGICAL-ACTIVITIES; MANNICH-BASES; DESIGN; ANTIFUNGAL; FLUORINE; PRODUCT; ANALOGS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21672061]; National Key Research Program of China [2017YFD0200505, 2018YFD0200105]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [222201718004]. Category: amides-buliding-blocks. Published in ELSEVIER SCIENCE INC in NEW YORK ,Authors: Chen, XL; Jia, HW; Li, Z; Xu, XY. The CAS is 90-16-4. Through research, I have a further understanding and discovery of Benzo[d][1,2,3]triazin-4(3H)-one

To explore new skeleton with nematicidal activity, a series of novel 1,2,3-benzotriazin-4-one derivatives containing piperazine as linker were synthesized and varied fragments were also introduced to increase structure diversity of the new skeleton. Their inhibitory activities in vivo were evaluated against Meloidogyne incognita. The newly prepared compounds A6, A8, A21, A28 and A38 exhibited more than 50% inhibition at the concentration of 20 mg/L. Especially compound A6 displayed 71.4% inhibition against Meloidogyne incognita at the concentration of 20 mg/L. The nematicidal activities varied significantly depending on the types and positions of the substituents, which provided guidance for further structure modification. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Category: amides-buliding-blocks. Welcome to talk about 90-16-4, If you have any questions, you can contact Chen, XL; Jia, HW; Li, Z; Xu, XY or send Email.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, XM; Peng, AH; Xie, WD; Wang, M; Zheng, D; Feng, MK in [Zhang, Xiu-Mei; Wang, Mei; Zheng, Dan; Feng, Ming-Kuan] Shandong Drug & Food Vocat Coll, Dept Pharm, Weihai 264210, Peoples R China; [Peng, Ai-Hong; Xie, Wei-Dong] Shandong Univ, Coll Marine Sci, Dept Pharm, Weihai 264209, Peoples R China published Hexokinase II Inhibitory Effect of Secondary Metabolites Derived from a Streptomyces sp. Associated with Mud Dauber Wasp in 2020, Cited 43. Name: Benzo[d][1,2,3]triazin-4(3H)-one. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4.

Insect-microbial symbioses have vast biochemical diversity, which is beneficial to produce bioactive secondary metabolites. In this study, chemical examination of a Streptomyces sp. associated with a mud dauber wasp led to the isolation of fourteen compounds. Their structures were determined by spectroscopic methods and comparison with literature data. Among the isolates, compounds 1,2,3-benzotriazin-4(1H)-one and 4-(2-aminoethyl)phenyl acetate were first reported from this species. Bioactivities of the isolated compounds were assayed for the first time against hexokinase II. 4-(2-Aminoethyl)phenyl acetate, germicidin B, phenylacetic acid, isogermicidin A and germicidin C displayed significant inhibitory activity against hexokinase II, with the IC50 values of 5.11, 7.11, 7.15, 8.45 and 8.78 mu M, respectively.

Name: Benzo[d][1,2,3]triazin-4(3H)-one. Welcome to talk about 90-16-4, If you have any questions, you can contact Zhang, XM; Peng, AH; Xie, WD; Wang, M; Zheng, D; Feng, MK or send Email.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics