Tag: M.W=100-200

In an article, author is Chen, Siming, once mentioned the application of 536-90-3, Name is 3-Methoxyaniline, molecular formula is C7H9NO, molecular weight is 123.16, MDL number is MFCD00007783, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, Name: 3-Methoxyaniline.

The reactivity of cyclic tertiary sulfamidates derived from alpha-methylisoserine strongly depends on the substitution at the C and N termini. These substrates are one of the very few examples able to undergo nucleophilic ring opening at a quaternary carbon with complete inversion of the configuration, as demonstrated both experimentally and computationally. When the sulfonamide is unprotected, the characteristic ring-opening reaction is completely silenced, which explains that the majority of the ring-opening reactions reported in the literature invoke N alkyl or N-carbonyl-protected sulfamidates. Accumulation of negative charge at the NSO3 moiety in the transition state, especially when the sulfonamide NH is deprotonated, drastically raises the activation barrier for the nucleophilic attack. On the other hand, ester groups at the carboxylic position favor ring opening, whereas amides allow competition between the substitution and elimination pathways. Using pyridine as a nucleophilic probe, we have demonstrated both experimentally and computationally that a proper selection of the substitution scheme can enhance the synthetic scope of alpha-methylisoserine-derived sulfamidates, switching off and on the nucleophilic ring-opening in a controlled manner. This is particularly convenient for hybrid alpha/beta-peptide synthesis, as demonstrated recently by our group.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

92-50-2, Name is 2-(Ethyl(phenyl)amino)ethanol, molecular formula is C10H15NO, HPLC of Formula: https://www.ambeed.com/products/92-50-2.html, belongs to amides-buliding-blocks compound, is a common compound. In a patnet, author is Yeasmin, Sabina, once mentioned the new application about 92-50-2.

To investigate the synergistic coordination ability of a polytorsional-amide ligand to construct new coordination polymers (CPs), N,N’-bis(4-methylpyridin-4-yl)-1,4-naphthalenediamide (L) was selected as the main ligand. Ni2+ and Cu2+ with electrochemical activity and different carboxylates [2-nitrobenzoic acid (2-HNBA), 4-nitrobenzoic acid (4-HNBA), p-toluic acid (HPTA), 1,2-benzenedicarboxylic acid (1,2-H2BDC), pimelic acid (H2PIM), 1,3-phenylenediacetic acid (H(2)PDA), o-methylsalicylic acid (HOMSA), propanedioic acid (H2PRO) and azelaic acid (H(2)AZE)] have been selected, and ten new CPs were obtained: [Ni(L)(2)(2-NBA)(2)] (1), [Ni(L)(4-NBA)(2)(H2O)(2)] (2), [Ni(L)(PTA)(2)(H2O)(2)] (3), [Ni(L)(1,2-BDC)(H2O)(3)]center dot H2O (4), [Ni(L) (PDA)]center dot 0.5H(2)O (5), [Ni(L)(PIM)]center dot 0.5H(2)O (6), [Cu(L)(4-NBA)(2)] (7), [Cu(L)(OMSA)2(H2O)] (8), [Cu(L)(PRO) (H2O)]center dot 3H(2)O (9) and [Cu(L)(AZE)(H2O)] (10). The ten CPs were structurally determined through single-crystal X-ray diffraction analyses, PXRD and IR spectra. 1, 5, 6 and 10 are the 4-connected 2D networks. 2 and 3 are similar racemic chains. 4 and 7 are 1D helical structures. 8 is a zigzag chain and 9 is a U type chain. The effects of the twist degrees of the amide ligands and the coordination features of the carboxylates/metal ions on the structures and properties of the target CPs were investigated. 1-10 modified carbon paste electrodes (n-CPEs) display a quasi-reversible oxidation-reduction process at the surface of the n-CPE. Representative CPs (2, 5, 7 and 10) show good electrochemical sensing properties for ascorbic acid (AA) and chloramphenicol (CAP).

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 56-84-8, Name is H-Asp-OH, formurla is C4H7NO4. In a document, author is Nair, Akshay M., introducing its new discovery. Application In Synthesis of H-Asp-OH.

In this study, through introducing a new functional group into the structure, the performance and efficiency of MOFs as a sensor for heavy metal cations have been improved. It was observed that the N1,N3-di(pyridine-4-yl) malonamide ligand (-NH-CO-CH2-CO-NH-)(S), one of the pillar linkers, has not directly entered into the structure of the synthesized MOFs. To solve this issue, three new structures based on copper metal-organic frameworks and amide-functionalized pillar ligands (-NH-CO-), TMU-46, 47 and 48 have been synthesized under hydrothermal conditions. An exciting aspect of the acylamide pillar ligands is their efficient detection ability of Hg2+ (mercury ion) in the presence of other heavy metal cations such as Cd2+ (cadmium), Cu2+ (copper), and Cr3+ (chromium). Due to their chelating effect on heavy metal cations, we hypothesized that decoration of the MOF wall with both malonamide and acylamide struts would promote their Lewis basic properties, and improve the removal capacity of heavy metal ions. A new linker, containing suitable functional group malonamide (S) to enhance Hg2+ cation sensing, was successfully exchanged and the produced material was labeled TMU-46S, TMU-47S and TMU-48S. Designing dual-functionalized MOFs is our design-for-purpose approach for the decoration of MOF walls by suitable functional groups resulting in high removal capacity and sensitivity of heavy metal ions. To the best of our knowledge, this is the first report of a mixed amide-malonamide based MOF which provides a proper coordination site to coordinate strongly to Hg2+ ions, along with 714 mg g(-1) maximum adsorption capacity and 186 087 M-1Ksv. Generally, we attributed the impressive Hg2+ sensing of TMU-48S to synergistic effects of both hydrophilic chelating malonamide and acylamide functional groups. Hence, the results represent an effective strategy in designing and developing multi-functional MOF-based materials and their application in removal processes and environmental protection efforts.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 3184-13-2, Name is H-Orn-OH Hydrochloride, molecular formula is , belongs to amides-buliding-blocks compound. In a document, author is Abrams, Geoffrey D., SDS of cas: 3184-13-2.

The unique electronic reactivity of imidates has been recently exploited for the syntheses of diverse classes of N-heterocycles via C-N annulation reactions under acid/base/metal-catalyzed/radical-mediated reaction conditions. As opposed to amides, the imidate functionality provides both electrophilic and nucleophilic centers and eventually enhances its versatility as an organic synthon. In general, imidate motifs act as the soft nucleophiles that coordinate with transition metals to form stable 5-membered metallacycles to activate the proximal C-H bonds followed by annulation reactions to afford the desired N-heterocycles. The imidate precursor also generates in situ nitrogen radicals under suitable conditions to form C-N bonds via 1,5-HAT. This review highlights the recent application of imidates as building blocks for the synthesis of saturated and un-saturated N-heterocycles like oxazolines, oxazines, quinazolines, isoquinolines, imidazoles, and triazoles among others. Different reaction conditions, coupling partners, and imidate substrates reported in the literature have been addressed herein for the nitrogen-containing mono-, bi- and tricyclic ring systems.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3184-13-2, in my other articles. SDS of cas: 3184-13-2.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 997-55-7, Name is Ac-Asp-OH, molecular formula is C6H9NO5, belongs to amides-buliding-blocks compound, is a common compound. In a patnet, author is Yilmaz, Bahar, once mentioned the new application about 997-55-7, Computed Properties of https://www.ambeed.com/products/997-55-7.html.

Four Ala-Ala dipeptides with a semi-perfluoroalkyl chain were synthesized. The intermolecular hydrogen bonding among amide groups and carboxyl groups as well as the hydrophobic association of semi-perfluoroalkyl chains drove the self-assembly of dipeptides. Homochiral dipeptides were able to self-assemble into coiled nanoribbons in a mixed solvent of DMSO/H2O (5/5, v/v), while entangled twisted nanofibers formed for heterochiral ones in a mixed solvent of DMSO/H2O (4/6, v/v). The handedness of self-assemblies and the stacking chirality of phenylene groups were controlled by the chirality of the alanine residue at the C-terminal. The vibration circular dichroism investigation indicated that the helicity of the semi-perfluoroalkyl chain was controlled by the handedness of dipeptide self-assemblies. The X-ray diffraction study showed that homochiral and heterochiral dipeptides underwent distinct molecular packing during the self-assembly. Our results clearly demonstrated that, through supramolecular self-assembly, the chirality transferred from the amino acid building block to the self-assemblies and eventually to the semi-perfluoroalkyl chain.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 997-55-7. The above is the message from the blog manager. Computed Properties of https://www.ambeed.com/products/997-55-7.html.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 71776-70-0, Name is 4-Methylpentan-2-amine hydrochloride, SMILES is NC(C)CC(C)C.[H]Cl, in an article , author is Hashim, Nur Athirah, once mentioned of 71776-70-0, Recommanded Product: 71776-70-0.

Herein, the impact of alkyl bridge length is unraveled on the self-assembly of N-annulated perylenetetracarboxamides 1-4 that cooperatively form supramolecular polymers. Spectroscopic studies in different solvents as media for the self-assembly demonstrate the impact that the length of the bridge separating the two amide groups of compounds 1-4 exerts on the supramolecular polymerization process: i) in MCH/Tol (8/2), compounds 1-3 exhibit a consecutive process that, however, it is not operative for 4; ii) the presence of three methylene units in 2, which can induce a parallel distribution of the amide groups, notably decreases the stability of the corresponding aggregates in Tol; iii) increasing the spacer length accelerates the conversion of the metastable, intramolecularly H-bonded monomeric species, which prevents to develop seeded supramolecular polymerizations; iv) the presence of a spacer with five methylene units in 4 hinders the formation of the corresponding 10-membered pseudo-cycle; and v) only the higher relative stability of the inactivated monomeric species of 1 enables pathway complexity, with a kinetically controlled self-assembly to yield nanoparticles and a thermodynamically controlled supramolecular polymerization to achieve fibrillar structures. The results presented herein expand the knowledge on the structure/property relationship for self-assembling units to provide pathway complexity and to bias the kinetics and stability of the supramolecular aggregates.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 103-89-9, Name is 4′-Methylacetanilide, molecular formula is C9H11NO. In an article, author is Chen, Yang,once mentioned of 103-89-9, COA of Formula: https://www.ambeed.com/products/103-89-9.html.

Solvatochromic shifts of local vibrational probes report on the strength of the surrounding electric fields and the probe’s hydrogen bonding status. Stretching vibrational mode of the ester carbonyl group is a popular solvatochromic reporter used in the studies of peptides and proteins. Small molecules, used to calibrate the response of the vibrational probes, sometimes involve Fermi resonances (FRs) induced by inter-molecular interactions. In the present work, we focus on the scenario where FR does not appear in the infrared spectrum of the ester carbonyl stretching mode in aprotic solvents; however, it is intensified when a hydrogen bond with the reporter is established. When two molecules form hydrogen bonds to the same carbonyl oxygen atom, FR leads to strong hybridization of the involved modes and splitting of the absorption peak. Spectral overlap between the Fermi doublets associated with singly and doubly hydrogen-bonded carbonyl groups significantly complicates quantifying different hydrogen-bonded conformations. We employed a combination of linear and third-order (2DIR) infrared spectroscopy with chemometrics analysis to reveal the individual line shapes and to estimate the occupations of the hydrogen-bonded conformations in methyl acetate, a model small molecule. We identified a hydrogen-bond-induced FR in complexes of methyl acetate with alcohols and water and found that FR is lifted in larger molecules used for control experiments-cholesteryl stearate and methyl cyanoacetate. Applying this methodology to analyze acetonitrile-water solutions revealed that when dissolved in neat water, methyl acetate occupies a single hydrogen-bonding conformation, which is in contrast to the conclusions of previous studies. Our approach can be generally used when FRs prevent direct quantification of the hydrogen bonding status of the vibrational probe. Published by AIP Publishing.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In an article, author is Mastropierro, Pasquale, once mentioned the application of 71776-70-0, Recommanded Product: 71776-70-0, Name is 4-Methylpentan-2-amine hydrochloride, molecular formula is C6H16ClN, molecular weight is 137.6509, MDL number is MFCD11101418, category is amides-buliding-blocks. Now introduce a scientific discovery about this category.

An essential part of molecular scaffolds of organosilver(I) catalysing reactions of C-H bond activation and C-X (X = C or O) bond formation of polysubstituted benzoic acids in polar medium represent biphenyls, 6H-benzo-[c]-chromene[6]-one, chromeno[5,4,3-cde] chromene-5,10-dione, and 4,10-dioxa-pyrene-5,9-diones. A second strand of catalytic activity is in promoting synthesis of substituted quanterphenyls. This paper is a an extend of the systematic examining of catalytic activity of Ag-I-containing intermediates of substituted benzoic acids, gaining insights by synthesis of oligomers, studying benzene-1,2,4-tricarboxylic acid (124BA) and benzene-1,3,5-tricarboxylic acid (135BA). Arguably, the optimization of the latter reactions need further effort in order to achieve the standard characteristics allowing their effective implementation as routine routs in the field of organic synthesis. The purpose of this part of the research is mass spectrometric (MS) quantitative kinetic and thermodynamic treatment of collision induced dissociation (CID) reactions comparing experimental reaction kinetics and energetics with quantum chemical modelling of MS fragment processes. Analyses – experimental and theoretical include deuterium labelled oligomers as the most useful technique studying MS reaction mechanisms. More specifically we treat eight substituted quaterphenyls both experimentally and theoretically along with a set of one hundred twenty 3D molecular models of MS fragment species. Importantly, the detail understanding of the molecular mechanistic aspects of the reactions causing for obtaining of high functionalized oligomers allows an efficient optimization of synthetic roads studying polyfunctional derivatives. This knowledge is the kay to understanding why the obtaining of the oligomer derivatives depends on the positional isomerism of the starting reagents as clearly evidenced in this study. In this context the study is relevant to the fields of organometallic synthesis and catalysis as well as the polymers’ chemistry. (C) 2017 Elsevier B. V. All rights reserved.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Mehra, Manish Kumar, once mentioned the application of 34381-71-0, Name is (S)-(-)-1-Methyl-2-pyrrolidinemethanol, molecular formula is C6H13NO, molecular weight is 115.1735, MDL number is MFCD00011727, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, HPLC of Formula: https://www.ambeed.com/products/34381-71-0.html.

A potentiometric sensor based on carbon paste electrode impregnated concurrently with molecularly imprinted polymer (MIP) and multi-walled carbon nanotubes (MWCNTs) was fabricated and used to measure stavudine (STV), currently applied as a drug in the treatment of human immuno-deficiency virus (HIV) infection. To synthesize the MIP, methacrylic acid (or acryl amide) and ethylene glycol dimethacrylate were utilized as functional monomer and cross-linker, respectively. The kind of the functional monomer had decisive influence on the response of the MIP-based electrode to target molecule of STV. MWCNTs had positive effect on both sensitivity and detection range of the electrode. The electrode response behavior (Nernstian behavior) was shown to be affected by homoconjugation of STV molecules in the imprinting process. The proposed sensor exhibited Nernstian slope of 27.9 mV per decade for stavudine over a wide concentration range of 1.0 x 10(-6) to 1.0 x 10(-1) mol L-1, with a detection limit of 5.0 x 10(-7) mol L-1. The sensor was used for STV determination in pharmaceutical samples.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 600-21-5, Name is H-N-Me-DL-Ala-OH, formurla is C4H9NO2. In a document, author is Mukhopadhyay, Dwaipayan, introducing its new discovery. COA of Formula: https://www.ambeed.com/products/600-21-5.html.

PurposeChemical exchange saturation transfer (CEST) MRI has shown promise in tissue characterization in diseases like stroke and tumor. However, in vivo CEST imaging such as amide proton transfer (APT) MRI is challenging because of concomitant factors such as direct water saturation, macromolecular magnetization transfer, and nuclear overhauser effect (NOE), which lead to a complex contrast in the commonly used asymmetry analysis (MTRasym). Here, we propose a direct saturation-corrected CEST (DISC-CEST) analysis for simplified decoupling and quantification of in vivo CEST effects. MethodsCEST MRI and relaxation measurements were carried out on a classical 2-pool creatine-gel CEST phantom and normal rat brains (N=6) and a rat model of glioma (N=8) at 4.7T. The proposed DISC-CEST quantification was carried out and compared with conventional MTRasym and the original three-offset method. ResultsWe demonstrated that the DISC-CEST contrast in the phantom had much stronger correlation with MTRasym than the three-offset method, which showed substantial underestimation. In normal rat brains, the DISC-CEST approach revealed significantly stronger APT effect in gray matter and higher NOE effect in white matter. Furthermore, the APT and NOE maps derived from DISC-CEST showed significantly higher APT effect in the tumors than contralateral normal tissue but no apparent difference in NOE. ConclusionThe proposed DISC-CEST method, by correction of nonlinear direct water saturation effect, serves as a promising alternative to both the commonly used MTRasym and the simplistic three-offset analyses. It provides simple yet reliable in vivo CEST quantification such as APT and NOE mapping in brain tumor, which is promising for clinical translation. Magn Reson Med 78:2307-2314, 2017. (c) 2017 International Society for Magnetic Resonance in Medicine.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics