Tag: M.W=100-200

Reference of 63920-73-0, The chemical industry reduces the impact on the environment during synthesis 63920-73-0, name is 2-Amino-4,6-dimethoxybenzamide, I believe this compound will play a more active role in future production and life.

To a solution of 2-amino-4,6-dimethoxy-benzamide (7.50 g, 38.2 mmol) and 3-(2-hydroxy-ethoxy)-5-methoxy-benzaldehyde (7.50 g, 38.2 mmol) in N,N-dimethylacetamide (30 mL) was added NaHSO3 (58.5 wt %, 4.37 g, 42.0 mmol) and p-TSA (0.72 g, 3.8 mmol). The reaction mixture was heated to 115-120 C. for 16 hours, and then cooled to room temperature. N,N-dimethylacetamide was removed under reduced pressure, the residue was diluted with water (50 mL), and the solid was filtered, collected, and mixed with ether (50 mL), then filtered and dried under vacuum, to give 2-[3-(2-hydroxy-ethoxy)-5-methoxy-phenyl]-5,7-dimethoxy-3H-quinazolin-4-one as a white solid. Yield: 10 g (70%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-4,6-dimethoxybenzamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Resverlogix Corp.; Hansen, Henrik C.; (96 pag.)US9238640; (2016); B2;,
Amide – Wikipedia,
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Synthetic Route of 1268810-09-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1268810-09-8, name is tert-Butyl (1-ethynylcyclopropyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

tert-Butyl (1-ethynylcyclopropyl )carbamate (200.0 mg, 1.104 mmol) was treated with azidotrimethyl silane (508.6 mg, 4.414 mmol, 4 equiv.) in the presence of copper iodide (21.0 mg, 0.11 mmol) in N,N-dimethylformamide (1 mL) and methanol (1 mL) and stirred at 110 C for 2 h. After cooling, purification by prep HPLC gave fert-butyl (1-(1H-1,2,3- triazol-4-yl)cyclopropyl)carbamate. LCMS-ESI+ (m/z): [M+H] + calculated for C10H17N4O2: 225.1 ; found: 225.1 .

The synthetic route of tert-Butyl (1-ethynylcyclopropyl)carbamate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GILEAD SCIENCES, INC.; GUTIERREZ, David A.; KOBAYASHI, Tetsuya; LAZERWITH, Scott E.; LEE, Rick A.; MORGANELLI, Philip A.; PYUN, Hyung-Jung; (0 pag.)WO2019/165374; (2019); A1;,
Amide – Wikipedia,
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Application of 4141-08-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4141-08-6, name is 2-Amino-N-methylbenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Dissolve 2-amino-N-methylbenzamide (1.26g, 8.4mmol) and 2,4-dichloro-5-methylpyrimidine (0.93ml, 8mmol) in anhydrous DMF (6ml) under ice bath 60% NaH (0.38g, 9.6mmol) was added and stirred at room temperature for 24h. After the end, water was added dropwise to terminate the reaction, extracted with dichloromethane, washed with saturated brine, dried over anhydrous sodium sulfate, and separated and purified by silica gel column (eluted with ethyl acetate / petroleum ether) to obtain 0.88 g of yellow solid with a yield of 40%.

The synthetic route of 2-Amino-N-methylbenzamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beijing Xibo Pharmaceutical Co., Ltd.; Yin Yuxin; Su Yue; (37 pag.)CN111072571; (2020); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 121492-06-6, name: N-Boc-(2-Aminoethyl)-N-methylamine

EXAMPLE H-l 4 Example H-14 N-ethyl-N-(2-((4-(2-hvdroxypropan-2-yl)pyrinudin-2-yl)(methyl)aniino)ethyl)-2- isopropoxynicotinamide Step 1 : tert-butyl (2-(((benzyloxy)carbonyl)amino)ethyl)(methyl)carbamate (H-7) To a solution of tert-butyl (2-aminoethyl) (methyl)carbamate (5.0 g, 28.7 mmol) in THF (100 mL) was added NaHC03 (12.1 g, 143.5 mmol) at 0 C. The resulting mixture was stirred at the same temperature for 15 min. Cbz-Cl (5.9 g, 34.4 mmol) was added dropwise. The mixture was stirred at RT overnight, then filtered and the filtrate was concentrated in vacuo. The residue was purified by combiflash (10% EtOAc in petroleum ether) to give the title compound H-7. LRMS m/z (M+H) 309.1found, 309.4 required.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Boc-(2-Aminoethyl)-N-methylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KIM, Ronald; KUDUK, Scott, D.; LIVERTON, Nigel; ZHUO, Gang; (116 pag.)WO2016/100161; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 21744-84-3,Some common heterocyclic compound, 21744-84-3, name is 4-Methyl-2H-1,4-Benzoxazin-3-one, molecular formula is C9H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a cooled solution of 2H-1,4-benzoxazin-3(4H)-one (11.93 g, 80 mmol) in N,N-dimethylformamide (120 ml) was added sodium hydride (60% dispersion in mineral oil, 3.2 g, 80 mmol) in portions between 0 C. and 5 C. (1 h).The mixture was stirred 1 h at 0 C. To the cooled mixture was added ethyl iodide (13.7 g, 88 mmol) dropwise. The ice bath was removed and the mixture was stirred at r.t. for 17 h. The mixture was poured on water and extracted twice with AcOEt. The organic layers were washed with brine and water, dried (MgSO4) and concentrated. The crude product was purified by column chromatography (silica gel, heptane/AcOEt 9:1) to give the title compound (13.3 g) as colorless oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Methyl-2H-1,4-Benzoxazin-3-one, its application will become more common.

Reference:
Patent; Hunziker, Daniel; Lerner, Christian; Mueller, Werner; Sander, Ulrike Obst; Pflieger, Philippe; Waldmeier, Pius; US2010/249124; (2010); A1;,
Amide – Wikipedia,
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These common heterocyclic compound, 366-49-4, name is 2-Acetamido-4-fluorotoluene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-Acetamido-4-fluorotoluene

To a stirred solution of DMF (3 mL) at 00C was added phosphorus oxychloride (12 mL, 126 mmol) over 30 minutes, keeping the internal temperature below 7C. N-(5- Fluoro-2-methylphenyl)acetamide (2 g, 12 mmol) was added to the solution and heated to 85C overnight. The reaction was cooled to room temperature and added dropwise to water (50 mL). The precipitate was collected by filtration, washed with water and dried in the vacuum oven to give the title compound (274 mg, 10%) as a yellow solid. 5H (CDCl3) 10.58 (s, IH), 9.01 (s, IH), 7.60-7.70 (m, IH), 7.15-7.25 (m, IH), 2.75 (s, 3H).

The synthetic route of 2-Acetamido-4-fluorotoluene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UCB PHARMA S.A.; WO2009/81105; (2009); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 122334-37-6,Some common heterocyclic compound, 122334-37-6, name is 4-Chloro-N-methoxy-N-methylbenzamide, molecular formula is C9H10ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Ethyl magnesium bromide (3.0 M in diethyl ether, 21.5 mL, 64.4 mmol) was added via syringe over a few minutes to a clear colorless solution of 5-bromo-1-methyl-1H-imidazole (10.4 g, 64.4 mmol) in THF (100 mL) under a nitrogen atmosphere in an ice bath. A white precipitate formed during the addition. The mixture was removed from the ice bath and was stirred for 20 minutes, then was again cooled in an ice bath before addition of 4-chloro-N-methoxy-N-methylbenzamide (10.7 g, 53.6 mmol, Intermediate 43: step a). The resulting white suspension was stirred overnight at room temperature. The reaction was quenched by addition of saturated aqueous NH4Cl and diluted with water. The mixture was partially concentrated to remove THF and was diluted with DCM. The mixture was acidified to pH 1 with 1 N aqueous HCl, then neutralized with saturated aqueous NaHCO3. The phases were separated and the aqueous phase was further extracted with DCM. The organic extracts were washed with water, then were dried (Na2SO4), filtered, and concentrated, affording a white solid. The crude product was triturated with a mixture of EtOAc:heptanes (1:1, 150 mL). The precipitated solid was collected by vacuum filtration, washing with heptanes, to afford the title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Chloro-N-methoxy-N-methylbenzamide, its application will become more common.

Reference:
Patent; Janssen Pharmaceutica NV; Leonard, Kristi A.; Barbay, Kent; Edwards, James P.; Kreutter, Kevin D.; Kummer, David A.; Maharoof, Umar; Nishimura, Rachel; Urbanski, Maud; Venkatesan, Hariharan; Wang, Aihua; Wolin, Ronald L.; Woods, Craig R.; Fourie, Anne; Xue, Xiaohua; Cummings, Maxwell D.; Jones, William Moore; Goldberg, Steven; US2015/105366; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 112257-19-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 112257-19-9, name is tert-Butyl methyl(2-(methylamino)ethyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of 3-(4-isopropoxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carbaldehyde (3.0 g, 9.54 mmol, 1.00 equiv) and tert-butyl N-methyl-N-[2-(methylamino)ethyl]carbamate (2.2 g, 11.69 mmol, 1.22 equiv) in 1,2-dichloroethane (30 mL) at room temperature was added NaBH(OAc)3 (4.1 g, 19.34 mmol, 2.03 equiv) in portions. The resulting solution was stirred at room temperature overnight and then diluted with 300 mL of dichloromethane. The resulting mixture was washed with 3*100 mL of brine. The organic layer was dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was purified on a silica gel column eluted with 1-3percent MeOH in CH2Cl2 to give 4.0 g (86percent) of tert-butyl 2-(((3-(4-isopropoxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)methyl)(methyl)amino)ethyl)(methyl)carbamate as a yellow oil. LCMS (method D, ESI): RT=1.76 min, m/z=487.0 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl methyl(2-(methylamino)ethyl)carbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; EPIZYME, INC.; CHESWORTH, RICHARD; MITCHELL, LORNA HELEN; SHAPIRO, GIDEON; BORIACK-SJODIN, PAULA ANN; MORADEI, OSCAR MIGUEL; JIN, LEI; DUNCAN, KENNETH W.; US2014/323537; (2014); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 67279-23-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67279-23-6, name is 2,3,5,6,7,8-Hexahydrophthalazine-1,4-dione, This compound has unique chemical properties. The synthetic route is as follows.

Step 2: Preparation of 1,4-dichloro-5,6,7,8-tetrahydrophthalazine (compound 1c) The compound 1b (1 g, 6.02 mmol) was dissolved into phosphorus oxychloride (8 ml). The air in the system was replaced 3 times with nitrogen gas. The system was warmed up to a temperature of 110 C. and stirred for 3 h. The reaction was stopped and then naturally cooled. The reaction solution was slowly dripped into ice water. The mixture was adjusted to pH 10 with a 1N sodium hydroxide aqueous solution and extracted 3 times with ethyl acetate. Organic phases were combined, and the organic phase was washed with saturated brine and concentrated to dry, to obtain a compound 1c (1.1 g).

The chemical industry reduces the impact on the environment during synthesis 2,3,5,6,7,8-Hexahydrophthalazine-1,4-dione. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Terns, Inc.; YU, Shanghai; LI, Ben; (28 pag.)US2020/190064; (2020); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2675-89-0, name is 2-Chloro-N,N-dimethylacetamide, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C4H8ClNO

7-(5-Methoxy-l//^-indol-3-yl)-l-methyl-6 osyl-l,6-dihydropyrazolo[3,4-J]pyrrolo[2,3-ft]pyridine (0.100 g, 0.212 mmol; Preparation No.P.1.1) and 60 wt% NaH (0.009 g, 0.212 mmol) were suspended in DMF (3 mL). After about 10 min, 2-chloro-A^,A^-dimethylacetamide (0.052 g, 0.424 mmol, Pfaltz-Bauer) was added and mixture was stirred at rt. After about 1 h additional 60 wt% NaH (0.005 g, 0.212 mmol) was added and the mixture was heated to about 40 C for about 16 h. The mixture was concentrated in vacuo and purified on a 4 g silica column eluting with EtOAc to provide 2-(5-methoxy-3-(l-methyl-6-tosyl-l,6-dihydropyrazolo[3,4-dJpyrrolo[2,3-bJpyridin-7- yl)-lH-indol-l-yl)-N,N-dimethylacetamide (0.097 g, 82%): LC/MS (Table 2, Method c) Rt = 1.46 min; MS m/z 557 (M+H)+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2675-89-0.

Reference:
Patent; ABBOTT LABORATORIES; WISHART, Neil; ARGIRIADI, Maria A.; BREINLINGER, Eric C.; CALDERWOOD, David J.; ERICSSON, Anna M.; FIAMENGO, Bryan A.; FRANK, Kristine E.; FRIEDMAN, Michael; GEORGE, Dawn M.; GOEDKEN, Eric R.; JOSEPHSOHN, Nathan S.; LI, Biqin C.; MORYTKO, Michael J.; MULLEN, Kelly D.; SOMAL, Gagandeep; STEWART, Kent D.; VOSS, Jeffrey W.; WALLACE, Grier A.; WANG, Lu; WOLLER, Kevin R.; WO2011/68899; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics