Tag: M.W=100-200

In an article, author is Miyamura, Hiroyuki, once mentioned the application of 56-86-0, Name is H-Glu-OH, molecular formula is C5H9NO4, molecular weight is 147.1293, MDL number is MFCD00002634, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, Quality Control of H-Glu-OH.

This paper investigates the correlation between fatigue performance and static tensile behavior of fiber reinforced rubber materials and presents change of fiber reinforced effect during fatigue process. A rough aramid fiber (AF) surface, which is helpful for combining AF and rubber matrix, was achieved by etching AF in NaOH/CH3CH2OH solution via the hydrolysis of amide bonds on the fiber. Then, the treated fiber was coated with an epoxy-functionalized silane (gamma-propyltrimethoxysilane, KH560) and was used to prepare AF/carbon black/styrene-butadiene rubber (AF/CB/SBR) composites. The results showed that the interfacial adhesion between the complex-modified AF and the rubber matrix was further enhanced and the mechanical properties of the composite were further improved compared with those of the composite which was prepared by unhydrolyzed AF coated with KH560. The hysteresis reinforcing effect of the fiber was found after 30,000 cycles of strain-controlled fatigue, and the reinforcing effect of AF was reduced with increasing average fatigue strain. Moreover, the relative debonding energy (RDE) was calculated to evaluate the reinforcing effect of the fiber, and the RDE value sharply decreased after 30,000 cycles of strain-controlled fatigue. When the AF was treated with the NaOH/CH3CH2OH solution and then coated with KH560, the rubber composite had a high RDE value, and the fatigue life of the composite under the stress-control condition was increased approximately 4 times. The results from the characterization of the fracture appearance after 30,000 cycles of fatigue showed that the composite with the complex-modified AF could maintain better interface bonding during the fatigue process.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 56-86-0, Quality Control of H-Glu-OH.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Synthetic Route of 56-86-0, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 56-86-0, Name is H-Glu-OH, SMILES is O=C(O)[C@@H](N)CCC(O)=O, belongs to amides-buliding-blocks compound. In a article, author is Patil, Chandrashekhar K., introduce new discover of the category.

A visible-light-mediated late-stage aminocarbonylation of unactivated alkyl iodides with stoichiometric amounts of carbon monoxide is presented. The method provides a mild, one-step route to [carbonyl-C-13/14] alkyl amides, thereby reducing radioactive waste, and handling of radioactive materials. Easily accessible and low-cost equipment and a palladium catalyst were successfully used for the synthesis of a wide range of alkyl amides.

Synthetic Route of 56-86-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 56-86-0.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Electric Literature of 62-57-7, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 62-57-7, Name is H-Aib-OH, SMILES is CC(C(O)=O)(C)N, belongs to amides-buliding-blocks compound. In a article, author is Ray, Ritwika, introduce new discover of the category.

A catalytic amount of an iron salt and bipyridine ligand in the presence of an organozinc base activates the ortho C-H bond of a carboxamide, and the following reaction with an alkene such as ethylene gas (1 atm), styrene derivatives, and vinylsilane or vinylboron derivatives via carbometalation gives a putative alkylzinc intermediate. This intermediate can be further reacted with electrophiles such as deuterium oxide or allyl bromide. When monosubstituted alkenes are used as a substrate, the linear alkyl product is selectively obtained. The monoalkylated product is exclusively obtained, and dialkylation does not proceed.

Electric Literature of 62-57-7, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 62-57-7.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Synthetic Route of 112257-19-9, The chemical industry reduces the impact on the environment during synthesis 112257-19-9, name is tert-Butyl methyl(2-(methylamino)ethyl)carbamate, I believe this compound will play a more active role in future production and life.

A mixture of 3-iodo- l-(oxan-2-yl)-lH-pyrazole-4-carbaldehyde (21.5 g, 70.24 mmol, 1.00 equiv), iert-butyl N-methyl-N-(2-(methylamino)ethyl)carbamate (20 g, 106.23 mmol, 1.51 equiv) and NaBH(OAc)3 (29.8 g, 137.98 mmol, 1.96 equiv) in dichloroethane (300 mL) was stirred for 1 h at room temperature. The reaction was diluted with 300 mL of dichloromethane and then washed with 3×300 mL of brine. The organic layer was dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was purified on a silica gel column eluted with 0-7percent methanol in dichloromethane to give 31 g (92percent) of tert- butyl (2-(((3-iodo- l-(tetrahydro-2H-pyran-2-yl)- lH-pyrazol-4- yl)methyl)(methyl)amino)ethyl)(methyl)carbamate as a yellow oil. 1H-NMR (300 MHz, CDC13): delta 7.62 (s, 1H), 5.34-5.30 (m, 1H), 4.06-4.02 (m, 1H), 3.68-3.62 (m, 1H), 3.42-3.38 (m, 4H), 2.85 (s, 4H), 2.62-2.53 (m, 2H), 2.47-2.46 (m, 2H), 2.13-1.97 (m, 3H), 1.74- 1.69 (m, 3H), 1.46 (s, 9H) ppm. LCMS (method A, ESI): RT = 1.17 min, m/z = 479.0 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl methyl(2-(methylamino)ethyl)carbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; EPIZYME, INC.; CHESWORTH, Richard; MITCHELL, Lorna, Helen; CAMPBELL, John, Emmerson; REITER, Lawrence, Alan; SWINGER, Kerren, Kalai; (387 pag.)WO2016/44626; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2895-21-8 as follows. HPLC of Formula: C5H10ClNO

General procedure: The corresponding CH-acid 1a-f (25 mmol) was dissolved in a solution of potassium hydroxide (1.4 g, 25 mmol) in ethanol (50 ml) at 10 C. In several cases after addition of 1 a precipitate was formed, which did not have an effect on the reaction conditions or the final product. After stirring for 1 min carbon disulfide (1.5 ml, 25 mmol) was added to the resulting solution, and the reaction mixture was stirred for 20 min. Water (10-15 ml) was added to the mixture to dissolve the resulting precipitate. Subsequently, ester 4 (3.4 ml, 25 mmol) in ethanol (20 ml) was added to the reaction mixture dropwise for 1 h, which was quenched with potassium hydroxide solution (2.8 g, 50 mmol) in ethanol (100 ml), after stirring for 10 min. The resulting reaction mixture was refluxed for 2.5 h. After cooling to room temperature, the solution was quenched with concentrated HBr (2.8 ml, 25 mmol), stirred for 30 min, and divided into five equal portions. Each portion was then reacted with the corresponding alkylhalide 8a-t (5 mmol) under refluxing conditions for 1 min. After cooling the reaction to room temperature, the resulting precipitate was filtered off and rinsed on the filter to give pure thieno[3,2-b]pyridines 9a-af in 58-88% yield.

According to the analysis of related databases, 2895-21-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zubarev, Andrey A.; Shestopalov, Anatoliy M.; Larionova, Natalia A.; Rodinovskaya, Lyudmila A.; Shestopalov, Alexander A.; Tetrahedron; vol. 69; 46; (2013); p. 9648 – 9655;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 83922-54-7, These common heterocyclic compound, 83922-54-7, name is 4-(Methylsulfonamido)benzaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of [INTERMEDIATE] 11 (0.0088 mol) [AND N- (4-FONNYLPHENYL)-] [METHANESULFONAMIDE] (0.012 mol) in [ETOH] (20ml) was stirred and refluxed for 3 hours, then brought to room temperature. The precipitate was filtered off and dried. Yielding: 2.34g of intermediate 30 (75%).

The synthetic route of 83922-54-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2004/7498; (2004); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24243-71-8 as follows. COA of Formula: C3H9NO2S

In DMSO were dissolved 2,3-dichloroquinoxaline (5.00 g, 25.1 mmol) and propane-1-sulfonamide (3.09 g, 25.1mmol). Potassium carbonate (3.47 g, 25.1 mmol) was added and the mixture was stirred at 150C for 1 hour. A 1%aqueous acetic acid solution was added to the mixture and the mixture was stirred at room temperature for 3 hours. Theprecipitated solid was separated by filtration and the obtained solid was washed with water. The separated solid wasthen purified by slurrying in diisopropyl ether to give compound AA (6.01 g, 84% yield).

According to the analysis of related databases, 24243-71-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kyowa Hakko Kirin Co., Ltd.; KANAI, Toshimi; UCHIDA, Kenji; HONMA, Masakazu; FUKUDA, Yuichi; (51 pag.)EP2781517; (2014); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 125414-41-7, A common heterocyclic compound, 125414-41-7, name is tert-Butyl (1,3-dihydroxypropan-2-yl)carbamate, molecular formula is C8H17NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation K Acetic acid 3-acetoxy-2-tert-butoxycarbonylamino-propyl ester (2-Hydroxy-1-hydroxymethyl-ethyl)-carbamic acid tert-butyl ester (5.0 g, 26.1 mmol) was dissolved in pyridine (50 ml) and acetic anhydride (50 ml) was added. The solution was stirred at ambient temperature for 24 h when TLC showed no starting material remained. The solvent was evaporated and the residue dissolved in ethyl acetate (120 ml) and washed with dilute hydrochloric acid (3*50 ml), sodium bicarbonate solution (50 ml), brine, dried over magnesium sulphate, filtered and evaporated to give a colourless oil (7.2 g, 99% yield). The structure was confirmed by 1H NMR (300 MHz, CDCl3): 1.42 (s, 9H), 2.05 (s, 6H), 4.00-4.20 (m, 4H), 4.76-4.88 (m, 1H).

The synthetic route of 125414-41-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Morrison-Iverson, Veronique; Wynn, Duncan George; US2010/233097; (2010); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19047-31-5, name is 2-Chloro-N-cyclopropylacetamide, This compound has unique chemical properties. The synthetic route is as follows., name: 2-Chloro-N-cyclopropylacetamide

General procedure: The appropriate 1,2,4-triazole-3-thiol (45-69, 1 equiv), 2-chloro-acetamide (70a-m, 1.1 equiv), Cs2CO3 (1.1 equiv) and NaI (0.05 equiv) were stirred in dry MeCN at 50C, and reaction progress was monitored by UPLC/MS. Then water was added, and the final compounds 3-42 were purified by washing the precipitated powder or by flash chromatography (Scheme 1).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 19047-31-5.

Reference:
Article; Roberti, Marinella; Schipani, Fabrizio; Bagnolini, Greta; Milano, Domenico; Giacomini, Elisa; Falchi, Federico; Balboni, Andrea; Manerba, Marcella; Farabegoli, Fulvia; De Franco, Francesca; Robertson, Janet; Minucci, Saverio; Pallavicini, Isabella; Di Stefano, Giuseppina; Girotto, Stefania; Pellicciari, Roberto; Cavalli, Andrea; European Journal of Medicinal Chemistry; vol. 165; (2019); p. 80 – 92;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 6973-09-7,Some common heterocyclic compound, 6973-09-7, name is 5-Amino-2-methylbenzenesulfonamide, molecular formula is C7H10N2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 5-amino-2-methylbenzenesulfonamide (14.4 mg, 0.077 mmol) and compound 13a (20 mg, 0.077 mmol) in 1-butanol (1.5 mL) was subjected to ultrasonic reaction at 200 ° C for 30 minutes. The reaction vial was cooled to room temperature and the solvent was evaporated under vacuum. The crude product was purified by flash column chromatography (MeOH: DCM = 1: 20) to give compound MKP101 (20.1 mg, 0.0492 mmol, 63.9percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-2-methylbenzenesulfonamide, its application will become more common.

Reference:
Patent; CHUNG ANG University industry Academic Cooperation Foundation; Min, Kyung-Hoon; (30 pag.)KR2016/147170; (2016); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics