Tag: M.W=100-200

Related Products of 2675-89-0,Some common heterocyclic compound, 2675-89-0, name is 2-Chloro-N,N-dimethylacetamide, molecular formula is C4H8ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Under molecular oxygen atmosphere, to a mixture of Pd(OAc)2 (1.3 mg, 0.006 mmol) and bpy (0.9 mg, 0.006 mmol), toluene (2.0 mL) was added. Then aniline (0.2 mmol), amide (2.0 mmol), PivOH (40.9 mg, 0.4 mmol), and BF3Et2O (42.6 mg, 0.3 mmol) were added to the mixture. The mixture was heated to 120 C and it stirred at 120 C for 24 h. After completion, the mixture was cooled to room temperature and diluted with ethyl acetate. Washed withaq NaHCO3, water, and aq NaCl. Dried over MgSO4 and filtered. Aftere vaporation of the solvent, the residue was purified by preparative thin-layer chromatography on silica gel with PE/EtOAc (1/1) as aneluent to give the product 3.

The synthetic route of 2675-89-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gu, Da-Wei; Guo, Xun-Xiang; Tetrahedron; vol. 71; 48; (2015); p. 9117 – 9122;,
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Application of 154350-29-5,Some common heterocyclic compound, 154350-29-5, name is Cyclopropanesulfonamide, molecular formula is C3H7NO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of (22E)-3-oxo-4,6,22-cholatrien-24-oic acid (2.00 g, 5.43 mmol) in CH2CI2(40 mL) was added EDCI (1.69 g, 10.9 mmol) and DMAP (1.33 g, 10.9 mmol).Cyclopropane sulfonamide (1.97 g, 16.3 mmol) was added and the reaction was stirred at room temperature for 22 h. Water (25 mL) was added and the layers were separated. The aqueous layer was extracted with CH2CI2 (2 x 25 mL) and the combined organics were washed with 2 M aq HCI (20 mL), 10percent aq. NaCI (10 mL), dried over sodium sulfate andconcentrated under reduced pressure. The residue was purified by column chromatography on silica gel (0-10percent acetone in toluene) to give the desired product (1.68 g, 66percent) asan off-white solid. OH (400 MHz, CDCI3); 8.90 (1H, s, NH), 6.95 (1H, dd, J15.5,9.0, 023-OH), 6.11 (2H, brs, 06-OH and 07-OH), 5.86 (1H, dd, J15.5, 0.5, 022-OH), 5.68 (1H, s, 04-OH), 3.00 (1H, dddd, J 12.8, 9.5, 8.1, 4.8, SO2OH), 2.64 (1H, ddd, J 18.1, 14.4,5.4, O2OHaHb), 2.51-2.41 (1H, m, 02-OHaHb), 2.40-2.28 (1H, m), 2.25-2.15 (1H, m), 2.09-1.96 (2H, m), 1.85-1.64 (3H, m), 1.63-1.52 (1H, m), 1.51-1.17 (9H, m), 1.17-1.07 (5H, m),1.12 (3H, s, 019-OH3), 0.80 (3H, s, 018-OH3); 00 (100 MHz, 0D013); 200.0, 164.2, 164.1,155.5, 141.3, 127.9, 123.6, 119.4,54.7, 53.2, 50.6, 43.8, 39.8, 39.3, 37.8, 36.1, 33.9, 33.9,31.5, 28.1, 23.7, 20.6, 19.1, 16.3, 12.2, 6.3, 6.3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Cyclopropanesulfonamide, its application will become more common.

Reference:
Patent; NZP UK LIMITED; WEYMOUTH-WILSON, Alexander Charles; KOMSTA, Zofia; WALLIS, Laura; EVANS, Timothy; (139 pag.)WO2017/199036; (2017); A1;,
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Electric Literature of 640-61-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 640-61-9, name is N,4-Dimethylbenzenesulfonamide, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a resealable Schlenk tube was added Fe3O4SiO2-P-AuOTf (66 mg, 0.025 mmol). The reaction tubewas evacuated and back-filled with argon and this evacuation/back-fillprocedure was repeated one additional time. Alkynylcyclopropane(0.5 mmol), sulfonamide (0.6 mmol) and DCE (5 mL) were then addedunder a stream of argon. The reaction tube was quickly sealed and thecontents were stirred while heating in an oil bath at 100 C for 24 h. After thereaction mixture was cooled to room temperature, the supported goldcatalyst was magnetically separated and the reaction mixture wasconcentrated under vacuum and then purified by flash chromatography(petroleum ether/ethyl acetate = 7:1) to afford the corresponding product.The recovered gold catalyst was washed with DCE (2 2 mL), air-dried andused directly for the next run.

The chemical industry reduces the impact on the environment during synthesis N,4-Dimethylbenzenesulfonamide. I believe this compound will play a more active role in future production and life.

Reference:
Article; Yi, Feiyan; Huang, Bin; Nie, Quan; Cai, Mingzhong; Tetrahedron Letters; vol. 57; 39; (2016); p. 4405 – 4410;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13304-62-6, name is N-Benzylacrylamide, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 13304-62-6

A mixture of 11-iodo-7,12-dihydropyrido[2?,3?:2,3]azepino[4,5-b]indol-6(5H)-one (11 b, 200mg, 0.530mmol), N-benzylacrylamide (95mg, 0.59mmol), triethylamine (101mg, 1.00mmol, 0.14mL), and Pd(OAc)2 (7mg, 0.03mmol) in DMF (3 mL) was heated for 40 min to 100 C in a sealed microwave reaction vial by means of a mono mode microwave device (100 W, 150 PSI, CEM Discover, CEM GmbH, Kamp-Lintfort, Germany). After cooling to room temperature the mixture was filtered through a charcoal frit. Upon addition of ethyl acetate (220 mL) to the filtrate a precipitate formed, which was filtered off and was washed on the frit with n-hexane (320 mL). In the combined washing layers more precipitate formed, which was also filtered off. The combined precipitates were crystallized from ethanol to yield a brown solid (49.0 mg, 22.7%); dec. starting at 226 C; IR (KBr): 3423 (NH), 2918 (CH aliphat.), 1655 (C=O), 1441, 1350 cm-1; 1H NMR (400 MHz, DMSO-d6): delta = 11.95 (s, 1H), 10.38 (s, 1H), 8.64 (t, 1H, 3JH,H = 6.0 Hz), 8.44 (dd, 1H, 3JH,H = 4.7 Hz, 4JH,H = 1.7 Hz), 8.36 (dd, 1H, 3JH,H = 7.9Hz, 4JH,H = 1.8 Hz), 8.23 (d, 1H, 3JH,H = 15.5 Hz), 7.95 (s, 1H), 7.75 (dd, 1H, 3JH,H= 7.8 Hz, 4JH,H = 0.9 Hz), 7.59 – 7.45 (m, 1H), 7.44 – 7.30 (m, 4H), 7.32 – 7.20 (m, 1H), 7.22 – 7.09 (m, 1H), 6.86 (d, 1H, 3JH,H = 15.6 Hz), 4.46 (d, 2H, 3JH,H = 5.9Hz), 3.63 (s, 2H); 13C NMR (100.6 MHz, DMSO-d6): delta = 171.4, 165.2, 162.3, 147.7, 139.4, 136.6, 131.2, 127.4, 117.6, 108.4 (quat C); 147.6, 136.3, 134.5, 128.3 (2C), 127.4 (2C), 126.8, 122.1, 119.5, 119.5, 119.3, 119.0 (tert C); 42.3, 35.7 (sec C); C25H20N4O2 (408.45); MS (EI): m/z = 408 ([M]+, 95), 301 (52), 274 ([C17H12N3O]+, 21), 259 (100); HRMS (EI): m/z ([M]+) calcd. 408.15808, found 408.15883; HPLC: 96.8% at 254 nm, 97.1% at 280 nm, tN = 6.4 min, tM = 1.09 min (ACN/H2O; 40:60), max = 269, 338 nm.

According to the analysis of related databases, 13304-62-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Maiwald, Franziska; Benitez, Diego; Charquero, Diego; Dar, Mahin Abad; Erdmann, Hanna; Preu, Lutz; Koch, Oliver; Hoelscher, Christoph; Loaec, Nadege; Meijer, Laurent; Comini, Marcelo A.; Kunick, Conrad; European Journal of Medicinal Chemistry; vol. 83; (2014); p. 274 – 283;,
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Reference of 49805-30-3,Some common heterocyclic compound, 49805-30-3, name is 2-Azabicyclo[2.2.1]hept-5-en-3-one, molecular formula is C6H7NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1.6. Preparation of a (+-)-1-amino-4-(hydroxymethyl)-2-cyclopentene in an alcohol/ether mixture A 10 ml round-bottom flask was charged under at inert-gas atmosphere with 0.5 g (4.6 mmol) of (+-)-2-azabicyclo[2.2.1]hept-5-en-3-one and 0.59 g (18.4 mmol) of methanol in 7.5 ml of dioxane (abs.). 0.21 g (9.2 mmol) of lithium borohydride were added, and the mixture was heated for 4 h at 60 C. The mixture was then cooled to 5 C. using an ice/waterbath, and about 10 ml of semi-concentrated HCl was carefully added to the reaction mixture (vigorous reaction, gas evolution), as a result of which a yellowish clear solution formed. This solution was analyzed directly by a quantitative ion-chromatographic method It contained 0.60 mmol (13.1%) of (+-)-2-azabicyclo[2.2.1]hept-5-en-3-one (determined as HCl salt of the corresponding amino acid, which is the acidic hydrolysis product of (+-)-2-azabicyclo-[2.2.1]hept-5-en-3-one) and 3.06 mmol of product, corresponding to a yield of 66.8%, aminoalcohol

The synthetic route of 49805-30-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Lonza AG; US2002/10360; (2002); A1;,
Amide – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 115643-59-9, name is 2-Amino-6-fluorobenzamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 2-Amino-6-fluorobenzamide

Step 1 To a solution of 2-amino-6-fluorobenzamide (3.80 g, 24.7 mmol) and triethylamine (2.99 g, 29.6 mmol) in THF (50 mL) was added dropwise ethyl chloroglyoxylate (3.70 g, 27.1 mmol) under ice-cooling, and the mixture was stirred at room temperature for 3 hr. The mixture was partitioned between ethyl acetate and water, and the organic layer was washed with saturated brine, dried over sodium sulfate, and concentrated under reduced pressure. The residue was suspended in ethanol, and the insoluble material was collected by filtration to give ethyl ((2-(aminocarbonyl)-3-fluorophenyl)amino)(oxo)acetate as a white powder (4.95 g, 79%).

The synthetic route of 115643-59-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1953148; (2008); A1;,
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Synthetic Route of 14719-21-2, The chemical industry reduces the impact on the environment during synthesis 14719-21-2, name is 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide, I believe this compound will play a more active role in future production and life.

The mixture of compound 3 (500 mg, 1.18 mmol), Pd (PPh3)4 (145 mg,0.12 mmol, 0.1 eq), CuI (44.5 mg, 0.25 mmol, 0.2 eq), N-(2-propynyl)-2,2,2-trifluoroacetamide (1.07 g,7.08 mmol, 6.0 eq) and triethylamine (0.5 mL, 3.54 mmol, 3.0 eq) in DMF (20 mL) was stirred at roomtemperature overnight. Upon completion of the reaction as monitored by TLC, the mixture wasconcentrated under reduced pressure. The residue was purified by flash chromatography on a silicagel column to provided 310 mg of product 17 as a white solid in 60% yield with an HPLC purity of95%. Rf = 0.40 (dichloromethane-methanol = 10:1). 1H NMR (DMSO-d6, 400 MHz) 10.16 (s, 1H, NH),7.03 (s, 2H, NH2), 5.95 (d, 1H, J = 4.2 Hz, 10-H), 5.36 (d, 1H, J = 6.0 Hz, 20-OH), 5.10 (d, J = 4.2 Hz, 1H,30-OH), 4.74 (t, J = 5.6 Hz, 1H, 50-OH), 4.44-4.55 (m, 1H, 20-H), 4.07-4.17 (m, 1H, 30-H), 3.96 (s, 3H,CH3), 3.76-3.88 (m, 1H, 40-H), 3.37-3.56 (m, 2H, CH2). ESI-MS m/z: 447.1 [M + H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ren, Hang; An, Haoyun; Tao, Jingchao; Molecules; vol. 24; 5; (2019);,
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Reference of 108723-79-1, These common heterocyclic compound, 108723-79-1, name is 2-Amino-N,N-diethylacetamide hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred mixture of 2-amino-N,N-diethylacetamide hydrochloride (64.0 mg, 0.38 mmol) and triethylamine (77.7 mg, 0.77 mmol) in i-PrOH (3 mL) was added 4-chloro-5-[2-methyl-6-(trifluoromethyl)pyridin-4-yl]-6-phenylpyrimidin-2-amine (140.1 mg, 0.38 mmol) at room temperature. After stirring for 16 h at 110 C, the reaction mixture was cooled and concentrated. The residue was purified by Prep-HPLC to afford 2-((2- amino-5-(2-methyl-6-(trifluoromethyl)pyridin-4-yl)-6-phenylpyrimidin-4-yl)amino)-N,N- diethylacetamide (61 mg, 34.6%) as an off-white solid. ES-MS (m/z) [M+l]+ = 459.1.

The synthetic route of 108723-79-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NIKANG THERAPEUTICS, INC.; LOU, Yan; FU, Jiping; HE, Yigang; (0 pag.)WO2020/14332; (2020); A1;,
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Reference of 89226-13-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89226-13-1, name is tert-Butyl (2-amino-2-thioxoethyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

a 2-(N-t-butoxycarbonylamino)methyl-5-formylthiazole To 33 ml of a DMF solution containing 5.5 g (purity 65%) of chloromalondialdehyde, 4.7 g of calcium carbonate, 4.8 g of sodium bromide and 5.8 g of (N-t-butoxycarbonyl)aminoacetothioamide were added, and the mixture was then stirred at 60 C. for 11 hours. Then, the solvent was evaporated under reduced pressure, and the resulting residue was dissolved in 300 ml of ethyl acetate. The solution was washed twice with an aqueous saturated sodium bicarbonate solution and once with a 10% saline solution, dried over anhydrous sodium sulfate and then filtered, and the solvent was evaporated under reduced pressure. The resulting residue was purified by a silica gel column chromatograph to obtain 4.57 mg of 2-(N-t-butoxycarbonylamino)methyl-5-formylthiazole. NMR (CDCl3) delta: 1.48 (9H, s), 4.66 (2H, d, J=6.2 Hz), 5.33 (1H, br.s), 8.32 (1H, s), 10.00 (1H, s)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (2-amino-2-thioxoethyl)carbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Meiji Seika Kabushiki Kaisha; US5990101; (1999); A;,
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Related Products of 63920-73-0, A common heterocyclic compound, 63920-73-0, name is 2-Amino-4,6-dimethoxybenzamide, molecular formula is C9H12N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-Amino-4,6-dimethoxy-benzamide (1.06 g, 5.4 mmol), 3,5-dimethyl-4-hydroxybenzaldehyde (0.810 g, 5.4 mmol), K2CO3 (0.747 g, 5.4 mmol) and I2 (1.645 g, 6.5 mmol) were mixed in DMF (20 mL) and the reaction mixture was heated at 80 C. for 12 h. It was cooled to room temperature and poured into crushed ice. The solid was collected and purified by column chromatography to give 2-(4-hydroxy-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (0.9 g, 51%) as a white solid. Selected data: MP 291-293 C

The synthetic route of 63920-73-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter Ronald; US2013/281397; (2013); A1;,
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