Tag: M.W=100-200

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5004-88-6 as follows. Computed Properties of C9H12N2O3

General procedure: A mixture of 2-chlorobenzoic acid (1b) (0.61 g, 3.92 mmol) and thionyl chloride (1 mL) was heated for 2 h. The excess of thionyl chloride was recovered under reduced pressure and the residue so obtained was dissolved in dry dioxane (1 mL). The solution was then dropwise added to mixture of 2-amino-4,5-dimethoxybenzamide (2) (0.7 g, 3.57 mmol) and TEA (1.2 mL, 8.92 mmol) in dry dioxane (2 mL) at 10 C. The reaction mixture was stirred at rt for another 1 h and quenched into cold water (50 mL). The precipitate formed was filtered, washed with water and dried to obtain compound 3b (0.85 g, 71%).

According to the analysis of related databases, 5004-88-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yadav, Mange R.; Grande, Fedora; Chouhan, Bishram S.; Naik, Prashant P.; Giridhar, Rajani; Garofalo, Antonio; Neamati, Nouri; European Journal of Medicinal Chemistry; vol. 48; (2012); p. 231 – 243;,
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Synthetic Route of 5511-18-2, The chemical industry reduces the impact on the environment during synthesis 5511-18-2, name is Adamantane-1-carboxamide, I believe this compound will play a more active role in future production and life.

A solution of adamantanecarboxamide (1 mmol) in THF (4 mL) was treated with LiAIH4 (4 mmol) at 0 C and stirred under a N2 atmosphere whilst warming to room temperature. After 2 h, the reaction was heated at reflux for 16 h and then cooled on ice. Chilled H20 (150 pL) was added dropwise, with vigorous stirring, and then followed by aqueous sodium hydroxide (15% wiv, 150 pL) and additional water (0.5 mL). The solution was left stirring at room temperature until effervescence had ceased and the grey powder had turned white (30 min). The solution was dried (MgS04) and then filtered. The precipitate was washed with additional dichloromethane (2 x 4 mL). The filtrates in each case were combined. Purification was carried out as follows

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Adamantane-1-carboxamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE UNIVERSITY OF SYDNEY; KASSIOU, Michael; FIGTREE, Gemma; O’BRIEN-BROWN, James; WILKINSON, Shane; HANSEN, Thomas; (64 pag.)WO2020/37350; (2020); A1;,
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Electric Literature of 37045-73-1,Some common heterocyclic compound, 37045-73-1, name is 3-(Methylsulfonamido)aniline, molecular formula is C7H10N2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The solution of cyanuryl chloride (1 mmol, 1 equiv.) in THF (20 ml) was stirred,cooled to -10 C, and aniline (1 mmol, 1 equiv.) in THF (6 ml) and DIEA (3.6 mmol, 1.2equiv.) was added dropwise. The mixture was stirred at this temperature for 0.5-2 h. Uponcompletion, monitored by TLC, another aniline (1 mmol, 1 equiv.) was added. The mixturewas stirred under room temperature for 2-12 h. After the solvent was removed under reducedpressure the resulting solid was collected by filtration, dried and crystallised or purified bysilica gel column chromatography to get the desired product as a white solid.

The synthetic route of 37045-73-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Dao, Pascal; Jarray, Rafika; Le Coq, Johanne; Lietha, Daniel; Loukaci, Ali; Lepelletier, Yves; Hadj-Slimane, Reda; Garbay, Christiane; Raynaud, Francoise; Chen, Huixiong; Bioorganic and Medicinal Chemistry Letters; vol. 23; 16; (2013); p. 4552 – 4556;,
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Electric Literature of 774-67-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 774-67-4, name is 4-Amino-N-isopropylbenzamide, This compound has unique chemical properties. The synthetic route is as follows.

(14) methyl 3-(Z)-[1-{4-[isopropyl-carbamoyl]-phenylamino}-1-phenyl-methylidene]-2-indolinone-6-carboxylate Prepared from 1-acetyl-3-(1-ethoxy-1-phenylmethylene)-6-methoxycarbonyl-2-indolinone and 4-amino-N-isopropyl-benzamide. Yield: 0.18 g (46% of theoretical), Melting point: 273-274 C.

The chemical industry reduces the impact on the environment during synthesis 4-Amino-N-isopropylbenzamide. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Roth, Gerald Juergen; Heckel, Armin; Lehmann-Lintz, Thorsten; Kley, Joerg; Hilberg, Frank; Van Meel, Jacobus; US2003/92756; (2003); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 148017-28-1, name is tert-Butyl sulfamoylcarbamate, This compound has unique chemical properties. The synthetic route is as follows., category: amides-buliding-blocks

Step b: fert-Butyl (aminosulf onyl) f r(3aR,4R<6R,6aR)-6-(6-chloro-9H-purin-9-yl)- 2,2-dimethyltetrahydrofuror3,4-rfiri31dioxol-4-yl1memyl)carbamate; [0237] (2R/3R,4S,5R)-2-(6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (6.352g, 0.01944mol), N-Boc-sulfamide (5.717g, 0.02913mol) and triphenylphosphine (6.119g, 0.02333mol) were dissolved in ethyl acetate (20OmL) under nitrogen and diisopropyl azodicarboxylate (5.742mL, 0.02916mol) was added dropwise. The solution was stirred for 2h, and then concentrated in vacuo. The residue was purified by flash chromatography (Hex/EtOAc 25% to 65%) to afford 5.46Og of product as a white solid and 1.4Og of product with triphenylphosphine oxide impurity. This second batch was purified by flash chromatography (Hex/EtOAc 20% to 60%). The product was obtained as a white solid (6.16Og, 63%).[0238] LCMS: R.t. 1.66 min ES+ 505 (formic acid). Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 148017-28-1. Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; WO2006/84281; (2006); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75175-77-8, name is 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 75175-77-8

General procedure: N,N-Dimethylenaminones 1 (1.0 mmol), amines 2 (0.5mmol), PEG-400 (5 mL), oxone (1.2 eq) and trifluoroacetic acid (TFA) (0.2 mL) were charged into a 25 mL round-bottom flask, and the mixture was stirred at 120 oC for 20 min until the N,N-dimethyl enaminones1 were completely consumed. The mixture was cooled to room temperature,neutralized with a saturated solution of Na2CO3 to pH 8-9, and then EtOAc (30 mL ¡Á 2) were added. The organic phase was washed with water (20 mL), dried over Na2SO4, concentrated and purified by flash column chromatography to afford 1,4-DHPs 3 in a 50-72% yield.

According to the analysis of related databases, 75175-77-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yu, Fu-Chao; Zhou, Bei; Xu, Hui; Chang, Kwen-Jen; Shen, Yuehai; Tetrahedron Letters; vol. 56; 6; (2015); p. 837 – 841;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2564-07-0, name is 2-Chloro-N-(2,3-dimethylphenyl)acetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C10H12ClNO

EXAMPLE 17B 2-[4-(3-cyano-2-pyridinyl)-1-piperazinyl]-N-(2,3-dimethylphenyl)acetamide The procedure described in Example 8 was followed, substituting the product from Example 17A for N-chloroacetyl-3-nitroaniline, to provide the title compound (32% yield as a white solid. mp 124-126 C.; 1H NMR (300 MHz, DMSO-d6) delta2.12 (s, 3H), 2.26 (s, 3H), 2.72 (m, 4H), 3.21(s, 2H), 3.69 (m, 4H), 6.94 (dd, 11H, J=7.8, 4.8 Hz), 6.99 (br d, 1H, J=7.4 Hz), 7.07 (dd, 1H, J=7.4, 7.4 Hz), 7.45 (br d, 1H, J=7.8 Hz), 8.08 (dd, 1H, J=7.8, 2.0 Hz), 8.42 (dd, 1H, 4.8, 2.1 Hz), 9.42 (br s, 1H); MS (DCI/NH3) m/e 350 (M+H)+; Anal. calcd for C20H23N5O.0.10 H2O: C, 68.39; H, 6.66; N, 19.94. Found: C, 68.74; H, 6.58; N, 19.56.

The synthetic route of 2564-07-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bhatia, Pramila A.; Daanen, Jerome F.; Hakeem, Ahmed A.; Kolasa, Teodozyj; Matulenko, Mark A.; Mortell, Kathleen H.; Patel, Meena V.; Stewart, Andrew O.; Wang, Xueqing; Xia, Zhiren; Zhang, Henry Q.; US2004/29887; (2004); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 102-93-2, name is 3-Phenylpropanamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 3-Phenylpropanamide

General procedure: Following the adapted procedure reported by Huang et al. [40], to a round-bottom flaskcharged with a solution of derivatized L-Proline in water (volume to make a 0.8 M solution ofsubstrate) at r.t., CuSO4.5H2O (1 equiv.), AgNO3 (0.15 equiv.) and NH4S2O8 (1.5 equiv.) were addedand the reaction was stirred for 30 min at r.t. Then, the reaction was heated to 60 C and Amberlyst15 (15% weight of substrate) and the corresponding nucleophile (1.1 equiv.) were added and thereaction was stirred for 16-18 h. After that the reaction mixture was diluted with MeOH and filteredunder a celite pad (washed with water and MeOH several times). The filtrate was evaporated untildryness and purified by using RP18 column chromatography. The collected fractions were analyzedby UV-vis and combined according to the obtained UV-spectra to afford the desired product.

The synthetic route of 102-93-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rippel, Rafael; Pinheiro, Luis; Lopes, Monica; Lourenco, Ana; Ferreira, Luisa M.; Branco, Paula S.; Molecules; vol. 25; 4; (2020);,
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Some common heterocyclic compound, 122334-37-6, name is 4-Chloro-N-methoxy-N-methylbenzamide, molecular formula is C9H10ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: amides-buliding-blocks

Ethyl magnesium bromide (3.0 M in diethyl ether, 21.5 mL, 64.4 mmol) was added via syringe over a few minutes to a clear colorless solution of 5-bromo-1-methyl-1H-imidazole (10.4 g, 64.4 mmol) in THF (100 mL) under a nitrogen atmosphere in an ice bath. A white precipitate formed during the addition. The mixture was removed from the ice bath and was stirred for 20 minutes, then was again cooled in an ice bath before addition of 4-chloro-N-methoxy-N-methylbenzamide (10.7 g, 53.6 mmol, Intermediate 22: step a). The resulting white suspension was stirred overnight at room temperature. The reaction was quenched by addition of saturated aqueous NH4Cl and diluted with water. The mixture was partially concentrated to remove THF and was diluted with DCM. The mixture was acidified to pH 1 with 1 N aqueous HCl, then neutralized with saturated aqueous NaHCO3. The phases were separated and the aqueous phase was further extracted with DCM. The organic extracts were washed with water, then were dried (Na2SO4), filtered, and concentrated, affording a white solid. The crude product was triturated with a mixture of EtOAc:heptanes (1:1, 150 mL). The precipitated solid was collected by vacuum filtration, washing with heptanes, to afford the title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 122334-37-6, its application will become more common.

Reference:
Patent; JOHNSON & JOHNSON; LEONARD, KRISTI A.; BARBAY, KENT; EDWARDS, JAMES P.; KREUTTER, KEVIN D.; KUMMER, DAVID A.; MAHAROOF, UMAR; NISHIMURA, RACHEL; URBANSKI, MAUD; VENKATESAN, HARIHARAN; WANG, AIHUA; WOLIN, RONALD L.; WOODS, CRAIG R.; FOURIE, ANNE; XUE, XIAOHUA; CUMMINGS, MAXWELL D.; MCCLURE, KELLY; TANIS, VIRGINIA; US2015/111870; (2015); A1;,
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Electric Literature of 98-64-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 98-64-6, name is 4-Chlorobenzenesulfonamide, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 2.2 General procedure: 4-methyl-N-phenylbenzenesulfonamide (3a) A 25 mL oven-dried reaction vessel was charged with Pd(TFA)2 (2.3 mg, 0.01 mmol), 1,10-phenanthroline (3.6 mg, 0.02 mmol), p-toluene sulfonamide (1a, 34.2 mg, 0.2 mmol), cyclohexanone (2a, 32 muL, 0.3 mmol). The reaction vessel was flushed with oxygen three times and then sealed. Toluene (0.7 mL) was added by syringe and the resulting solution was stirred at 140 ¡ãC for 40 h. After cooling to room temperature, the volatiles were removed under vacuum and the residue was purified by column chromatography (silica gel, petroleum ether/ethyl acetate = 4:1) to give the corresponding product 3a (39.9 mg) as white solid in 81percent yield.

The chemical industry reduces the impact on the environment during synthesis 4-Chlorobenzenesulfonamide. I believe this compound will play a more active role in future production and life.

Reference:
Article; Cao, Xiangxiang; Bai, Yang; Xie, Yanjun; Deng, Guo-Jun; Journal of Molecular Catalysis A: Chemical; vol. 383-384; (2014); p. 94 – 100;,
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