Tag: M.W=100-200

Adding a certain compound to certain chemical reactions, such as: 98-64-6, name is 4-Chlorobenzenesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 98-64-6, HPLC of Formula: C6H6ClNO2S

General procedure: To a round-bottom flask (500 mL) that contained a solution of aryl sulfonamide (6 mmol), 4-dimethyaminopyridine (DMAP, 13 mmol), and 1-[3-(dimethyamino)-propyl]-3-ethylcarbodiimide hydrochloride (EDCI, 13 mmol) in CH2Cl2 (150 mL) was added the synthesized cinnamic acid (6 mmol) at room temperature. The resulting mixture was stirred at room temperature for 12 h, then cooled to 5 °C, and acidified to pH 1 with addition of HCl aqueous solution (10percent), which was followed by extraction with CH2Cl2/MeOH (9:1, 3 .x. 100 mL). The combined organic layers were washed with H2O and brine, dried over Na2SO4, and concentrated in vacuo. The residue was subjected to silica gel chromatography or crystallization if necessary to afford the compounds (9a-16e) (Scheme 1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chlorobenzenesulfonamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Luo, Yin; Qiu, Ke-Ming; Lu, Xiang; Liu, Kai; Fu, Jie; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 19; 16; (2011); p. 4730 – 4738;,
Amide – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 6274-22-2, name is 4-Amino-N-methylbenzamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6274-22-2, name: 4-Amino-N-methylbenzamide

Thiophosgene (1.13 ml, 1.1 eq) is added dropwise to a solution cooled down to 0 C., of 4-amino-N-methylbenzamide (2 g, 1 eq) and triethylamine (5.6 ml, 3 eq) in tetrahydofuran (260 ml). The mixture is stirred for 30 minutes at 0 C. then the cold bath is removed and stirring is continued for another 30 minutes. Water (100 ml) and diethyl ether (250 ml) are added to the mixture. After decantation and extractions, the organic phases are combined, washed with salt water, dried over Na2SO4 then concentrated under reduced pressure at 40 C. The solid obtained is recrystallized from a dichloromethane/petroleum ether mixture (2.2 g; 86% yield). NMR (1H, 400 MHz, DMSO-d6): delta 2.77 (d, 3H), 7.51 (AB, 2H), 7.88 (AB, 2H), 8.52 (m, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Amino-N-methylbenzamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Poitout, Lydie; Brault, Valerie; Sackur, Carole; Roubert, Pierre; Plas, Pascale; US2006/173036; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Related Products of 6973-09-7, A common heterocyclic compound, 6973-09-7, name is 5-Amino-2-methylbenzenesulfonamide, molecular formula is C7H10N2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred suspension of the product of Intermediate Example 4 (1.1 g, 3.7 mmol) in 10 mL of THF, was added 5-amino-2-methylbenzenesulfonamide (0.70 g, 3.8 mmol, 1.0 equiv) at room temperature. The reaction mixture was heated at reflux for 3 h, then 4 M HCI in 1 ,4-dioxane (18 muL, 0.072 mmol) was added in one portion. After 5 h, the suspension was cooled to room temperature, and filtered. The resulting solid was washed with 16 mL of THF and dried in the air to yield 1.6 g (92%) of 5-({4- [(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl}amino)-2-methylbenzene sulfonamide monohydrochloride as a light yellow solid.

The synthetic route of 6973-09-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/64753; (2007); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 2895-21-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2895-21-8, name is N-Isopropyl-2-chloroacetamide, This compound has unique chemical properties. The synthetic route is as follows.

A solution of 4-{[6-(3-chlorophenyl)-4-oxo-4,5-dihydropyrazolo[1 ,5-a]pyrazin-2-yl]oxy}butyl acetate (0.25 g, P23) and potassium carbonate (0.18 g) in dry acetonitrile (6 ml.) 2-chloro- N-(1-methylethyl)acetamide (0.1 g) was added and the reaction was stirred at 8O0C on. After cooling the mixture was diluted with AcOEt and washed with chilly water and brine. The organic phase was dried, filtered and the solvent evaporated under vacuum. The crude was dissolved in THF (20 ml_), lithium hydroxyde (5 ml_, 0.5 M solution in water) was added and the mixture was stirred at RT for 2h. Solvent was removed under reduced pressure; the residue was taken up with AcOEt and washed with water. The organic phase was dried, filtered and evaporated under vacuum to give a mixture of the title compounds (0.21 g) that was used in next step without further purification.MS ( m/z): 433 [MH]+.

The chemical industry reduces the impact on the environment during synthesis N-Isopropyl-2-chloroacetamide. I believe this compound will play a more active role in future production and life.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/130232; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 7150-72-3, The chemical industry reduces the impact on the environment during synthesis 7150-72-3, name is tert-Butyl vinylcarbamate, I believe this compound will play a more active role in future production and life.

General procedure: A 25 mL round bottom flask or 20 mL glass vial with a stir bar was charged with thiol (1.2 mmol) and enecarbamate or enamide (1.0 mmol) followed by the addition of water (5 mL, 0.2M). The reactions were stirred vigorously at room temperature for 18 hours. The aqueous reaction was extracted with EtOAc (3 x 20 mL). The organic layers were collected and dried with Na2SO4, filtered and the solvent evaporated to provide the crude product. The crude product was purified by column chromatography using hexanes/EtOAc in an increasing polarity up to 1:1 mixture. The fractions containing the desired product were concentrated to provide the desired thioethers.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl vinylcarbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Barman, Eliezer; Hourezadeh; Lim, Daniel; Tetrahedron Letters; vol. 60; 34; (2019);,
Amide – Wikipedia,
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Let’s face it, organic chemistry can seem difficult to learn, Recommanded Product: 70-47-3, Especially from a beginner’s point of view. Like 70-47-3, Name is H-Asn-OH, molecular formula is amides-buliding-blocks, belongs to amides-buliding-blocks compound. In a document, author is Bisht, Ranjana, introducing its new discovery.

Solid-liquid equilibria for the binary systems of acetophenone and {N-methylformamide, or N,N-dimethylformamide, or N,N-dimethylacetamide, or N-methyl-2-pyrrolidone} were determined by the cloudpoint and DSC techniques. For the same systems, excess enthalpies were measured at 293.15 K and 308.15 K by the titration calorimetry. Both types of data were correlated by the Redlich-Kister equation. The description of the solid-liquid equilibria incorporated measured excess enthalpies. The results of the prediction performed by the modified UNIFAC model were compared with the experimental data. The observed trends and differences between systems were discussed. (C) 2019 Elsevier B.V. All rights reserved.

If you are hungry for even more, make sure to check my other article about 70-47-3, Recommanded Product: 70-47-3.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In an article, author is Raja, K., once mentioned the application of 104-63-2, Name is 2-(Benzylamino)ethanol, molecular formula is C9H13NO, molecular weight is 151.21, MDL number is MFCD00002840, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, HPLC of Formula: https://www.ambeed.com/products/104-63-2.html.

In this study, we report first time in India on the morphology, ultra-architectural pattern of the chorion in the egg and egg hair (setae). Further, physico-chemical characterizations of egg hairs (setae) were studied in the new invasive pest, fall armyworm, Spodoptera frugiperda. The egg is dome shaped with flattened base and curves upward to a broadly rounded point at the apex. HR-SEM micrographs revealed the surface ultrastructure of eggs chorion and shows structural elements of a marked rosette of petals surround the micropyle followed by micropylar rosette region around the micropyle plate. There was a small single micropylar opening along with 9 micropylar rosette cells and 13 micropylar rosette zones present near to the micropylar pit. In the egg the first order ribs were absent, but around 58-60 numbers of second order ribs were present. All the ventral and lateral cells of the eggs are connected by 19-22 cross striae and not forming a grid pattern, but joints with the longitudinal ribs at several of angles and totally 1,277-1,495 convex cells present at the egg’s surface. The physico-chemical characteristics of egg hairs were studied using Fourier transform infrared (FT-IR) and thermogravimetric analysis (TGA) analysis. TGA results show that three weight losses occurred at 142, 418, and 880 degrees C, respectively. FT-IR confirms the presence of amides, sulfoxide, and nitro compounds in egg hairs (setae).

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 1492-24-6, Name is H-Abu-OH, molecular formula is C4H9NO2. In an article, author is Shcherbina, L.,once mentioned of 1492-24-6, HPLC of Formula: https://www.ambeed.com/products/1492-24-6.html.

The ability of the 2-substituted aniline motif to serve as a scaffold for designing potential LuxR-regulated quorum sensing (QS) modulators has been investigated, using docking experiments and biological evaluation of a series of 15 specially synthesized compounds. Aniline, 2-acetyl-aniline and 2-nitroaniline were considered, as well as their N-acylated derivatives. Docking experiments showed that the 2-substituted aniline motif fits within the LuxR binding site at the place of the lactone moiety of AHL, and the biological evaluation revealed QS antagonisitic activity for several compounds, validating the hypothesis that this scaffold acts on QS. Structure activity relationships are discussed regarding interactions with the key residues of the LuxR binding site, showing significant variations in the H-bonding pattern.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 104-63-2, Name is 2-(Benzylamino)ethanol, SMILES is OCCNCC1=CC=CC=C1, in an article , author is Zhang, Zexin, once mentioned of 104-63-2, Recommanded Product: 104-63-2.

Self-assembled diphenylalanine (FF) nanostructures have recently been demonstrated to be interesting materials for antibacterial and anticancer applications. These applications, among others, seek to take advantage of the high-order and resulting appealing physical properties of FF nanostructures by modifying the peptide in some way to achieve specific functionality. To rationally design modifications to the dipeptide that allow for this behavior, the driving forces of FF self-assembly must be understood. Molecular simulations have been utilized to assess these properties but have yielded conflicting conclusions due to inconsistencies in models chosen as well as the lack of quantitative analyses on the specific driving forces. Here, we present an all-atom explicit solvent molecular dynamics-based study on different length scales of FF aggregation. We utilize a free energy decomposition analysis as well as a dimer cluster analysis to identify the initial aggregation driving force to be FF intermolecular electrostatics, whereas solvent-mediated forces drive crystal growth. These data are consistent with the hypothesis that all hydrophobic dipeptides will have a similar initial aggregation mechanism until a critical aggregate size is reached, at which point crystallization occurs and subsequent crystal growth is dominated by solvent-mediated forces. We demonstrate that this proposed mechanism is testable by infrared spectroscopy focusing on the blueshift of the amide I peak as well as the ordering of the carboxylate peak.

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Amide – Wikipedia,
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Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Mu, Youbing, once mentioned the application of 148-18-5, Name is Sodium diethylcarbamodithioate, molecular formula is C5H10NNaS2, molecular weight is 171.2594, MDL number is MFCD00041028, category is amides-buliding-blocks. Now introduce a scientific discovery about this category, COA of Formula: https://www.ambeed.com/products/148-18-5.html.

This article presents the synthesis of a series of amides, based on the interaction of several 3-aminospirohydantoins with nalidixic acid. The target compounds were characterized by physicochemical parameters, IR, H-1 and C-13 NMR spectral data. The antimicrobial activity of the products obtained was determined against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, Gram-negative bacteria Escherichia coli, Pseudomonas aeruginosa and Salmonella abony, the yeasts Candida albicans and Saccharomyces cerevisiae and the molds Penicillium chrysogenum and Aspergillus niger. The relationship between structure and biological activity of the products obtained was discussed. It was found that the most effective compounds are tetralin (5f) and indane (5g) derivatives, which exhibit a pronounced antimicrobial activity against both tested Gram-positive and Gram-negative bacteria.

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics