Tag: M.W=100-200

Related Products of 536-90-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 536-90-3, Name is 3-Methoxyaniline, SMILES is NC1=CC=CC(OC)=C1, belongs to amides-buliding-blocks compound. In a article, author is Hock, Andreas, introduce new discover of the category.

The adipokine, apelin has many biological functions but its activity is curtailed by rapid plasma degradation. Fatty acid derived apelin analogues represent a new and exciting avenue for the treatment of obesity-diabetes. This study explores four novel fatty acid modified apelin-13 analogues, namely, (Lys(8)GluPAL)apelin-13 amide, pGlu(Lys(8)GluPAL)apelin-13 amide, Lys(8)GluPAL(Tyr(13))apelin-13 and Lys(8)GluPAL(Val(73))apelin-13. Fatty acid modification extended the half-life of native apelin-13 to >24 h in vitro. pGlu(Lys(8)GluPAL)apelin-13 amide was the most potent insulinotropic analogue in BRIN-BD11 cells and isolated islets with maximal stimulatory effects of up to 2.7-fold (p < .001). (Lys(8)GluPAL) apelin-13 amide (1.9-fold) and Lys(8)GluPAL(Tyr(13))apelin-13 (1.7-fold) were less effective, whereas Lys(8)GluPAL(Val(13))apelin-13 had an inhibitory effect on insulin secretion. Similarly, pGlu(Lys(8)GluPAL) apelin-13 amide was most potent in increasing beta-cell intracellular Ca2+ concentrations (1.8-fold, p < .001) and increasing glucose uptake in 3T3-L1 adipocytes (2.3-fold, p < .01). Persistent biological action was observed with both pGlu(Lys(8)GluPAL)apelin-13 amide and (Lys(8)GluPAL)apelin-13 amide significantly reducing blood glucose (39-43%, p < .01) and enhancing insulin secretion (43-56%, p < .001) during glucose tolerance tests in diet-induced obese mice. pGlu(Lys8GluPAL)apelin-13 amide and (Lys(8)GluPAL)apelin-13 amide also inhibited feeding (28-40%, p < .001), whereas Lys(8)GluPAL(Val(13)) apelin-13 increased food intake (8%, p < .05) in mice. These data indicate that novel enzymatically stable analogues of apelin-13 may be suitable for future development as therapeutic agents for obesity-diabetes. (C) 2017 Elsevier Inc. All rights reserved. Related Products of 536-90-3, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 536-90-3.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 73-32-5, Name is H-Ile-OH, molecular formula is C6H13NO2. In an article, author is Zhang, Chunling,once mentioned of 73-32-5, Safety of H-Ile-OH.

In the current work, we present the use of two free-base and two zinc-metallated porphyrin-ruthenium(II) polypyridine dyads, along with two reference porphyrin derivatives, as sensitizers in both nand p-type DSSCs and DSPECs. Two of the dyads contain the well-known Ru(bpy)(3) unit (HOOC-DMP-Ru(bpy)(3) and HOOC-(Zn)DMPRu(bpy)(3)), while in the other two terpyridine-Ru(Cl)-bypiridine was used (HOOC-DMP-tpy-Ru and HOOC-(Zn) DMP-tpy-Ru). In all systems, the amide-bonding motif was utilized for the connection of the counterparts comprising each dyad. Photophysical investigation of the reported systems indicated sufficient electronic interactions for the dyads in their excited states (emission measurements). The photovoltaic measurements revealed that the presence of the ruthenium complex improves the overall performance of the dyads with the most efficient dyad being HOOC-(Zn)DMP-tpy-Ru in both nand p-type DSSCs. Consequently, HOOC-(Zn)DMPtpy-Ru was used to fabricate nand p-DSPECs towards the oxidation of methoxy-benzyl alcohol and the reduction of CO2, respectively.

Interested yet? Keep reading other articles of 73-32-5, you can contact me at any time and look forward to more communication. Safety of H-Ile-OH.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 1492-24-6, Name is H-Abu-OH, molecular formula is , belongs to amides-buliding-blocks compound. In a document, author is Stone, Nicole L., Formula: https://www.ambeed.com/products/1492-24-6.html.

Soluble epoxide hydrolase (sEH) is an alpha/beta hydrolase fold protein and widely distributed in numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively maintain endogenous epoxyeicosatrienoic acids (EETs) levels and reduce dihydroxyeicosatrienoic acids (DHETs) levels, resulting in therapeutic potentials for cardiovascular, central nervous system, and metabolic diseases. Therefore, since the beginning of this century, the development of sEH inhibitors is a hot research topic. A variety of potent sEH inhibitors have been developed by chemical synthesis or isolated from natural sources. In this review, we mainly summarized the interconnected aspects of sEH with cardiovascular, central nervous system, and metabolic diseases and then focus on representative inhibitors, which would provide some useful guidance for the future development of potential sEH inhibitors.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1492-24-6, in my other articles. Formula: https://www.ambeed.com/products/1492-24-6.html.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, HPLC of Formula: https://www.ambeed.com/products/70161-44-3.html, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 70161-44-3, Name is Sodium 2-((hydroxymethyl)amino)acetate, molecular formula is C3H6NNaO3. In an article, author is Chakraborty, Madhurima,once mentioned of 70161-44-3.

A new AuNPs-based thermosensitive nanoreactor (SiO2@PMBA@Au@PNIPAM) was designed and prepared by stabilizing AuNPs in the layer of poly(N,N’-methylenebisacrylamide) (PMBA) and subsequent wrapping with the temperature-sensitive poly(N-isopropylacrylamide) (PNIPAM) layer. The new nanoreactor exhibited high dispersibility and stability in aqueous solution and effectively prevented the aggregation of AuNPs caused by the phase transformation of PNIPAM. The XPS and ATR-FTIR results indicated that AuNPs could be well stabilized by PMBA due to the electron transfer between the N atoms of amide groups in the PMBA and Au atoms of AuNPs. The catalytic activity and thermoresponsive property of the new nanoreactor were invested by the reduction of the environmental pollutant, 4-nitrophenol (4-NP), with NaBH4 as a reductant. It exhibited a higher catalytic activity at 20 degrees C and 30 degrees C (below LCST of PNIPAM), but an inhibited catalytic activity at 40 degrees C (above LCST of PNIPAM). The PNIPAM layer played a switching role in controlling the catalytic rate by altering the reaction temperature. In addition, this nanoreactor showed an easily recyclable property due to the existence of a silica core and also preserved a rather high catalytic efficiency after 16 times of recycling.

If you’re interested in learning more about 70161-44-3. The above is the message from the blog manager. HPLC of Formula: https://www.ambeed.com/products/70161-44-3.html.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 15761-38-3, Name is Boc-Ala-OH, molecular formula is C8H15NO4. In an article, author is Lazareva, Nataliya F.,once mentioned of 15761-38-3, Application In Synthesis of Boc-Ala-OH.

Selective methyl labeling is an extremely powerful approach to study the structure, dynamics and function of biomolecules by NMR. Despite spectacular progress in the field, such studies remain rather limited in number. One of the main obstacles remains the assignment of the methyl resonances, which is labor intensive and error prone. Typically, NOESY crosspeak patterns are manually correlated to the available crystal structure or an in silico template model of the protein. Here, we propose methyl assignment by graphing inference construct, an exhaustive search algorithm with no peak network definition requirement. In order to overcome the combinatorial problem, the exhaustive search is performed locally, i.e. for a small number of methyls connected through-space according to experimental 3D methyl NOESY data. The local network approach drastically reduces the search space. Only the best local assignments are combined to provide the final output. Assignments that match the data with comparable scores are made available to the user for cross-validation by additional experiments such as methyl-amide NOEs. Several NMR datasets for proteins in the 25-50 kDa range were used during development and for performance evaluation against the manually assigned data. We show that the algorithm is robust, reliable and greatly speeds up the methyl assignment task.

Interested yet? Keep reading other articles of 15761-38-3, you can contact me at any time and look forward to more communication. Application In Synthesis of Boc-Ala-OH.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 2491-20-5, Name is H-Ala-OMe.HCl, SMILES is N[C@@H](C)C(OC)=O.[H]Cl, in an article , author is Lone, Abdullah, once mentioned of 2491-20-5, Recommanded Product: 2491-20-5.

Gel structure formation and gel properties of low-methoxyl pectin (LMP) and low-methoxyl amidated pectin (LMAP) with similar degree of methoxylation have been investigated by oscillatory rheological measurements. The gelling process was examined in a sugar-acid environment matching the conditions in jams and jellies. Factors studied included cooling rate, calcium content and pH. Parameters derived from the rheological measurements comprised the gel point, structuring velocity, initial and critical structuring temperature, average structuring developing rate and loss factor (tan delta(end)). The influence of the cooling rate on the gelling process of LMP was moderate and the influence on the final gel properties was significant, tandend decreased with increasing cooling rate. The calcium content significantly affected the structuring process of LMAP and the final gel properties. At high calcium content, the gelling process started at a higher temperature but the resulting gels were less strong. The pH had a significant but partly opposite effect on the gelation of LMP as well as LMAP. The differences in gelation behavior between LMP and LMAP can be explained by the lower number of available blocks of free carboxyl groups in LMAP as well as by the formation of additional hydrogen bonds through the amide groups. (C) 2017 Elsevier Ltd. All rights reserved.

Interested yet? Read on for other articles about 2491-20-5, you can contact me at any time and look forward to more communication. Recommanded Product: 2491-20-5.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 2835-81-6, Name is H-DL-Abu-OH, molecular formula is C4H9NO2. In an article, author is Dasgupta, Medhanjali,once mentioned of 2835-81-6, Name: H-DL-Abu-OH.

Chlamydia trachomatis is a global health burden due to its prevalence as a sexually transmitted disease and as the causative agent of the eye infection trachoma. We recently discovered 3-amido thiazolino 2-pyridones which attenuated C. trachomatis infectivity without affecting host cell or commensal bacteria viability. We present here the synthesis and evaluation of nonhydrolyzable amide isosteres based on this class, leading to highly potent 1,2,3-triazole based infectivity inhibitors (EC50 <= 20 nM). Interested yet? Keep reading other articles of 2835-81-6, you can contact me at any time and look forward to more communication. Name: H-DL-Abu-OH.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In an article, author is Tsuge, Akihiko, once mentioned the application of 33208-99-0, Product Details of 33208-99-0, Name is H-Ala-NH2.HCl, molecular formula is C3H9ClN2O, molecular weight is 124.57, MDL number is MFCD00066145, category is amides-buliding-blocks. Now introduce a scientific discovery about this category.

Harvesting energy from biogas is a potential way to retard the depletion of fossil fuels and fight against global warming simultaneously. Membrane technology holds great promise to achieve cost-effective biogas upgrading, along with advantages of low energy consumption and environmental friendliness, which leads to extensive exploration in fabricating CO2 membranes with high separation performance. In this study, mixed matrix membranes are fabricated by incorporating exfoliation-free layered double hydroxides laminates intercalated with amino acids (Phe with hydrophobic side chains and Glu with hydrophilic side chains) into a low-cost commercial Pebax (poly (amide-b-ethylene oxide)) polymer. Both amino and carboxyl groups can facilitate the transport of CO2 through quadrupole moment interaction, enlarged interlayer spacing and reversible reaction. Particularly, MMM containing 5 wt% AA-LDH exhibits an optimal permeability of 790 Barrer and a promising CO2/CH4 selectivity of 31, which is 64.6% and 83.9% higher than the pristine Pebax membrane, respectively. The distinct advantages in terms of facile fabrication and processability confer the LDH-based membrane with great potential for large-scale CO2 capture and separation.

If you are interested in 33208-99-0, you can contact me at any time and look forward to more communication. Product Details of 33208-99-0.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 600-21-5, Name is H-N-Me-DL-Ala-OH, molecular formula is C4H9NO2. In an article, author is Cai, Jianfeng,once mentioned of 600-21-5, HPLC of Formula: https://www.ambeed.com/products/600-21-5.html.

We describe here the first enantioselective oxidative heterocoupling of enolates. Our strategy relies on the memory of chirality concept and allows the stereocontrolled formation of quaternary centres on -amino acid derivatives with an enantiomeric excess of up to 94%.

Interested yet? Keep reading other articles of 600-21-5, you can contact me at any time and look forward to more communication. HPLC of Formula: https://www.ambeed.com/products/600-21-5.html.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 3184-13-2, Name is H-Orn-OH Hydrochloride, SMILES is N[C@@H](CCCN)C(O)=O.[H]Cl, in an article , author is Chen, Ye, once mentioned of 3184-13-2, Quality Control of H-Orn-OH Hydrochloride.

A liquid chromatographic chiral stationary phase, which contains two N-CH3 amide connecting groups, based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid was first applied to the resolution of methoxyphenamine (2-methoxy-Nmethylamphetamine, a beta-adrenergic receptor agonist used as a bronchodilator). The resolution of methoxyphenamine on the chiral stationary phase containing two NCH3 amide connecting groups was quite successful with the separation factor (alpha) of 1.42 and resolution (RS) of 4.22 compared with those (a of 1.09 and RS of 1.55) on the chiral stationary phase containing two N-H amide connecting groups. In addition, the chiral stationary phase containing two N-CH3 amide connecting groups was applied to the resolution of methoxyphenamine analogues. From the comparison of the resolution results of methoxyphenamine with those of methoxyphenamine analogues on the chiral stationary phase containing two N-CH3 amide connecting groups, the Nmethyl group and the 2-methoxyphenyl group of methoxyphenamine were elucidated to be the structurally essential parts for the resolution on the chiral stationary phase.

Interested yet? Read on for other articles about 3184-13-2, you can contact me at any time and look forward to more communication. Quality Control of H-Orn-OH Hydrochloride.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics