Tag: M.W=150-200

Sanz Sharley, Daniel D. published the artcileA selective hydration of nitriles catalyzed by a Pd(OAc)₂-based system in water, SDS of cas: 2447-79-2, the publication is Tetrahedron Letters (2017), 58(43), 4090-4093, database is CAplus.

In situ formation of a [Pd(OAc)₂bipy] (bipy = 2,2′-bipyridyl) complex in water selectively catalyzes the hydration of a wide range of organonitriles at 70°. Catalyst loadings of 5 mol% afford primary amide products RC(O)NH₂ (R = Et, n-Pr, C₆H₅, etc.) in excellent yields in the absence of hydration-promoting additives such as oximes and hydroxylamines.

Tetrahedron Letters published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, SDS of cas: 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Yam, Vivian Wing-Wah published the artcileSynthesis, photophysics, ion-binding studies, and structural characterization of organometallic rhenium(I) crown complexes, Recommanded Product: N,N-Diethylisonicotinamide, the publication is Organometallics (1995), 14(9), 4034-6, database is CAplus.

Re(I) complexes [Re(L)(CO)₃Cl] (1, L = I; 2, L = N-(2-pyridinylmethylene)phenylamine) and [Re(phen)(CO)₃(L’)]PF₆ (3, L’ = II; 4, L’ = 4-(N,N-diethylformamido)pyridine) were synthesized and their photophys. and cation binding properties studied. The x-ray crystal structure of 3 also was determined All the complexes exhibited long-lived intense yellow-green to orange-red emission upon visible light excitation both in the solid state and in fluid solutions at 298 K.

Organometallics published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C9H21NO3, Recommanded Product: N,N-Diethylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhang, Lijun published the artcileCannizzaro-Type Disproportionation of Aromatic Aldehydes to Amides and Alcohols by Using Either a Stoichiometric Amount or a Catalytic Amount of Lanthanide Compounds, Recommanded Product: 2,4-Dichlorobenzamide, the publication is Journal of Organic Chemistry (2006), 71(8), 3149-3153, database is CAplus and MEDLINE.

Aromatic aldehydes can be directly converted to the corresponding amides and alcs. in good to excellent yields by treatment with LiN(SiMe₃)₂ in the presence of catalytic lanthanide chlorides LnCl₃ or with a stoichiometric amount of lanthanide amides [(Me₃Si)₂N]₃Ln(μ-Cl)Li(THF)₃ at ambient temperature. The effects of solvents, substituents on the Ph ring, and lanthanide metals on the reaction have been examined The mechanism of the disproportionation reaction was proposed based on the exptl. results.

Journal of Organic Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C5H10O2S, Recommanded Product: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Ma, Liang published the artcileSynthesis, Activity, and Docking Study of Novel Phenylthiazole-Carboxamido Acid Derivatives as FFA2 Agonists, Quality Control of 2447-79-2, the publication is Chemical Biology & Drug Design (2016), 88(1), 26-37, database is CAplus and MEDLINE.

Free fatty acid receptor 2 (FFA2), also known as GPR43, is activated by short-chain fatty acids (SCFAs) that are mainly produced by the gut microbiota through the fermentation of undigested carbohydrates and dietary fibers. FFA2 currently appears to be a potential target in the management of obesity, diabetes, inflammatory diseases, and cancer. In the study, a series of novel phenylthiazole-carboxamido acid derivatives has been synthesized and evaluated as potential orthosteric FFA2 ligands for the study of structure-activity relationships. Compound 6e was found to exhibit the twofold potent agonistic activity in the stable hFFA2-transfected CHO-K1 cells (EC₅₀ = 23.1 μm) as that of pos. control propionate (EC₅₀ = 43.3 μm). We also reported the results of mutagenesis studies based on the crystal structure of hFFA1 bound to TAK-875 at 2.3 Å resolution to identify important residues for orthosteric agonist 6e inducing FFA2 activation.

Chemical Biology & Drug Design published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Quality Control of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

He, Haifeng published the artcileSynthesis, antitumor activity and mechanism of action of novel 1,3-thiazole derivatives containing hydrazide-hydrazone and carboxamide moiety, SDS of cas: 2447-79-2, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(14), 3263-3270, database is CAplus and MEDLINE.

A series of novel 2,4,5-trisubstituted 1,3-thiazole derivatives containing hydrazide-hydrazine and carboxamide moieties including 46 compounds T were synthesized, and evaluated for their antitumor activity in vitro against a panel of five human cancer cell lines. Eighteen title compounds T displayed higher inhibitory activity than that of 5-Fu against MCF-7, HepG2, BGC-823, Hela, and A549 cell lines. Especially, I, II, and III exhibit best cytotoxic activities with IC₅₀ values of 2.21 μg/mL, 1.67 μg/mL, and 1.11 μg/mL, against MCF-7, BCG-823, and HepG2 cell lines, resp. These results suggested that the combination of 1,3-thiazole, hydrazide-hydrazone, and carboxamide moieties was favorable to cytotoxicity activity. Furthermore, the flow cytometry anal. revealed that compounds I and III could induce apoptosis in HepG2 cells, and it was confirmed III led the induction of cell apoptosis by S cell-cycle arrest.

Bioorganic & Medicinal Chemistry Letters published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, SDS of cas: 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Boschelli, Diane H. published the artcileSynthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles, HPLC of Formula: 2447-79-2, the publication is Journal of Medicinal Chemistry (2001), 44(5), 822-833, database is CAplus and MEDLINE.

Screening of a directed compound library in a yeast-based assay identified 4-[(2,4-dichlorophenyl)amino]-6,7-dimethoxy-3-quinolinecarbonitrile (I) as a Src inhibitor. An enzymic assay established that I was an ATP-competitive inhibitor of the kinase activity of Src. We present here SAR data for I which shows that the aniline group at C-4, the carbonitrile group at C-3, and the alkoxy groups at C-6 and C-7 of the quinoline are crucial for optimal activity. Increasing the size of the C-2 substituent of the aniline at C-4 of I from chloro to bromo to iodo resulted in a corresponding increase in Src inhibition. Furthermore, replacement of the 7-methoxy group of I with various 3-heteroalkylaminopropoxy groups provided increased inhibition of both Src enzymic and cellular activity. Compound II, which contains a 3-morpholinopropoxy group, had an IC₅₀ of 3.8 nM in the Src enzymic assay and an IC₅₀ of 940 nM for the inhibition of Src-dependent cell proliferation.

Journal of Medicinal Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, HPLC of Formula: 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhang, Zeshuai published the artcileSelective N-Monovinylation of Primary Aromatic Amides Using Calcium Carbide as an Alkyne Source, Application In Synthesis of 2447-79-2, the publication is ChemistrySelect (2022), 7(26), e202201463, database is CAplus.

An efficient method for the selective N-monovinylation of primary aromatic amides using calcium carbide as an alkyne source was described. A series of N-vinylbenzamides (enamides) RC(O)NHCH=CH₂ [R = Ph, 2-MeC₆H₄, 4-ClMeC₆H₄, etc.] were readily synthesized by this strategy. The salient features for this protocol were the use of inexpensive, easy-to-handle solid alkyne source, high chemoselectivity, transition metal catalyst-free, good functional group tolerance, and simple work-up procedures. These reactions was also be extended to the gram-scale level.

ChemistrySelect published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C27H39ClN2, Application In Synthesis of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Klabunde, Thomas published the artcileAcyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes, Computed Properties of 2447-79-2, the publication is Journal of Medicinal Chemistry (2005), 48(20), 6178-6193, database is CAplus and MEDLINE.

Using a focused screening approach, acyl ureas have been discovered as a new class of inhibitors of human liver glycogen phosphorylase (hlGPa). The x-ray structure of screening hit 1 (IC₅₀ = 2 μM) in a complex with rabbit muscle glycogen phosphorylase b reveals that 1 binds at the AMP site, the main allosteric effector site of the dimeric enzyme. A first cycle of chem. optimization supported by x-ray structural data yielded derivative 21, which inhibited hlGPa with an IC₅₀ of 23±1 nM, but showed only moderate cellular activity in isolated rat hepatocytes (IC₅₀ = 6.2 μM). Further optimization was guided by (i) a 3D pharmacophore model that was derived from a training set of 24 compounds and revealed the key chem. features for the biol. activity and (ii) the 1.9 Å crystal structure of 21 in complex with hlGPa. A second set of compounds was synthesized and led to 42 with improved cellular activity (hlGPa IC₅₀ = 53±1 nM; hepatocyte IC₅₀ = 380 nM). Administration of 42 to anesthetized Wistar rats caused a significant reduction of the glucagon-induced hyperglycemic peak. These findings are consistent with the inhibition of hepatic glycogenolysis and support the use of acyl ureas for the treatment of type 2 diabetes.

Journal of Medicinal Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Computed Properties of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Ovchinnikova, N. S. published the artcileMass-spectroscopic study of fluoroalkylated and fluoroacylated alkylamines, ethylenediamines and propylenediamines, Product Details of C6H10F3NO, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1986), 827-32, database is CAplus.

The mass spectra of RCONEt₂ (R = CF₃, C₆F₁₃), R¹CONHCH₂CH₂NHCOR (R¹ = CF₃, C₈F₁₇), C₈F₁₇CONHCH₂CH₂NH₂, CF₃CONHCH₂CH(CF₃)NHCOCF₃, R²XNHCH₂CHMeNH₂ (R² = CF₃, C₃F₇, C₆F₁₃, C₈F₁₇; X = CO, CH₂), and R²XNH(CH₂)₃NMe₂ (same R², X) were analyzed. The structure of the amine affected the spectra more strongly than the size of the fluorinated radical.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Product Details of C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Premkumar, Muniyappan published the artcileHalf-sandwich Ruthenium(II) Schiff base complexes: Synthesis, characterization and effective catalysts for one-pot conversion of aldehydes to amides, SDS of cas: 2447-79-2, the publication is Journal of Organometallic Chemistry (2019), 120964, database is CAplus.

Five new Schiff base ligands and conformationally rigid half-sandwich organo ruthenium(II) Schiff base complexes (1–5) with the general formula [Ru(η⁶-p-cymene)(Cl)(L_1-5)] (where, L = mono anionic Schiff base ligands) have been synthesized from the reaction of [{(η⁶-p-cymene)RuCl}₂(μ-Cl)₂] with a bidentate Schiff bases ligands. These ruthenium(II) Schiff base complexes were fully characterized by elemental anal., FT-IR, UV-Vis, ¹H & ¹³C NMR and mass spectroscopy studies. In chloroform solution, all the metal complexes exhibit characteristic metal to ligand charge transfer bands (MLCT) and emission bands in the visible region. The crystal structure of the complexes [Ru(η⁶-p-cymene)(Cl)(L₁)] (1) and [Ru(η⁶-p-cymene)(Cl)(L₃)] (3) were determined by single crystal x-ray crystallog. The complexes exhibited good catalytic activity for aldehydes to amides by one-pot conversion process in the presence of NaHCO₃/NH₂OH·HCl.

Journal of Organometallic Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, SDS of cas: 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics