Tag: M.W=150-200

Recently I am researching about ONE-POT SYNTHESIS; CONJUGATED DIENES; HYDROGENATION; COMPLEXES; ELIMINATION; ALKYLATION; PORPHYRIN; LIGAND; SITE, Saw an article supported by the China Scholarship Council (CSC)China Scholarship Council; Technical University of Denmark; Independent Research Fund Denmark-Technology and Production Sciences. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Miao, YL; Samuelsen, SV; Madsen, R. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Safety of Diphenylmethanamine

Vanadium(IV) tetraphenylporphyrin dichloride and chromium(III) tetraphenylporphyrin chloride have been developed as catalysts for the acceptorless dehydrogenation of alcohols. The catalysts have been applied to the direct synthesis of imines in overall good yields from a variety of alcohols and amines. The transformations are proposed to proceed by metal-ligand bifunctional pathways with an outer-sphere transfer of two hydrogen atoms from the alcohol to the metal porphyrin complexes. The results show that vanadium and chromium catalysts can also be employed for the dehydrogenation of alcohols with the release of hydrogen gas, and they may represent valuable alternatives to other catalysts based on Earth-abundant metals.

Safety of Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Miao, YL; Samuelsen, SV; Madsen, R or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Name: Diphenylmethanamine. In 2020.0 BIOL PHARM BULL published article about POTENT; MICROSOMES; BENZOFURAN; DIMERS in [Yamaguchi, Yuki; Nishizono, Naozumi; Oda, Kazuaki] Hlth Sci Univ Hokkaido, Sch Pharmaceut Sci, Ishikari, Hokkaido 0610293, Japan in 2020.0, Cited 27.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Aromatase inhibitors are effective for the treatment of diseases such as breast cancer, which has led to an increase in their demand. However, only a limited number of aromatase inhibitor drugs are currently being marketed. In addition, considering the important aspect of drug resistance, the development of newer drug types is required. We have been developing inhibitors with backbone structures that differ from existing aromatase inhibitors. In this regard, we previously reported that diethylaminocoumarin dimers and thiazolyl coumarin derivatives possess strong aromatase inhibiting capabilities. In this study, we further examined the structure activity relationships of coumarin derivatives synthesized from thiazolyl coumarin derivatives and their aromatase inhibiting capabilities. Consequently, amide coumarin N-benzhydry1-7-(diethylamino)2-oxo-2H-chromene-3-carboxamide (IC50 values 4.5 mu M) is inhibitor of aromatase. This inhibitor was found to be comparable aromatase inhibitory activity to the 1st generation aromatase inhibitor aminoglutethimide (3.2 mu M). Substitution of the amide group on the amide coumarin derivative affects the aromatase inhibiting activity. Our findings suggest that the structure of each substituent changes the orientation of the compound in the active site of aromatase, thus creating a difference in their activities.

Name: Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Yamaguchi, Y; Nishizono, N; Oda, K or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2020.0 EUR J MED CHEM published article about THERMAL SHIFT ASSAYS; CYCLOPHILIN-A; REPLICATION; INFECTION; PROTEIN; ROLES; INHIBITION; DISCOVERY; POTENT; CELLS in [Wang, Lei; Vernekar, Sanjeev Kumar V.; Do, Ha T.; Sahani, Rajkumar Lalji; Xie, Jiashu; Wang, Zhengqiang] Univ Minnesota, Coll Pharm, Ctr Drug Design, Minneapolis, MN 55455 USA; [Casey, Mary C.] Univ Missouri, Christopher S Bond Life Sci Ctr, Dept Mol Microbiol & Immunol, Sch Med, Columbia, MO 65211 USA; [Kirby, Karen A.; Du, Haijuan; Zhang, Huanchun; Tedbury, Philip R.; Sarafianos, Stefan G.] Emory Univ, Dept Pediat, Lab Biochem Pharmacol, Sch Med, Atlanta, GA 30322 USA; [Hachiya, Atsuko] Natl Hosp Org, Clin Res Ctr, Nagoya Med Ctr, Nagoya, Aichi 4600001, Japan; [Wang, Lei] Dalian Univ Technol, Sch Chem Engn, Dept Pharm, Dalian 116024, Peoples R China in 2020.0, Cited 51.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Formula: C13H13N

The capsid protein (CA) of HIV-1 plays essential roles in multiple steps of the viral replication cycle by assembling into functional capsid core, controlling the kinetics of uncoating and nuclear entry, and interacting with various host factors. Targeting CA represents an attractive yet underexplored antiviral approach. Of all known CA-targeting small molecule chemotypes, the peptidomimetic PF74 is particularly interesting because it binds to the same pocket used by a few important host factors, resulting in highly desirable antiviral phenotypes. However, further development of PF74 entails understanding its pharmacophore and mitigating its poor metabolic stability. We report herein the design, synthesis, and evaluation of a large number of PF74 analogs aiming to provide a comprehensive chemical profiling of PF74 and advance the understanding on its detailed binding mechanism and pharmacophore. The analogs, containing structural variations mainly in the aniline domain and/or the indole domain, were assayed for their effect on stability of CA hexamers, antiviral activity, and cytotoxicity. Selected analogs were also tested for metabolic stability in liver microsomes, alone or in the presence of a CYP3A inhibitor. Collectively, our studies identified important pharmacophore elements and revealed additional binding features of PF74, which could aid in future design of improved ligands to better probe the molecular basis of CA-host factor interactions, design strategies to disrupt them, and ultimately identify viable CA-targeting antiviral leads. (C) 2020 Elsevier Masson SAS. All rights reserved.

Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Wang, L; Casey, MC; Vernekar, SKV; Do, HT; Sahani, RL; Kirby, KA; Du, HJ; Hachiya, A; Zhang, HC; Tedbury, PR; Xie, JS; Sarafianos, SG; Wang, ZQ or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

COA of Formula: C13H13N. Recently I am researching about ASYMMETRIC-SYNTHESIS; HYDROPHOSPHONYLATION; AMINALIZATION; IMINES; ACID, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51373067]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Liu, YX; Wang, JD; Wei, ZL; Cao, JG; Liang, DP; Lin, YJ; Duan, HF. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

N,N’-Acetals are sensitive compounds, and the challenging asymmetric synthesis of acyclic N,N’-acetals by the general addition of amines to ketimines has never been reported so far. In this study, highly enantioselective addition of aryl amines to isatin-derived ketimines catalyzed by chiral urea derived from quinine was developed. A series of new acyclic N,N’-acetals were constructed by this protocol in high to excellent yields (78-99%) and high to excellent enantioselectivities (76-96% ee).

COA of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Liu, YX; Wang, JD; Wei, ZL; Cao, JG; Liang, DP; Lin, YJ; Duan, HF or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Harrison, D; Boutard, N; Brzozka, K; Bugaj, M; Chmielewski, S; Cierpich, A; Doedens, JR; Fabritius, CHRY; Gabel, CA; Galezowski, M; Kowalczyk, P; Levenets, O; Mroczkowska, M; Palica, K; Porter, RA; Schultz, D; Sowinska, M; Topolnicki, G; Urbanski, P; Woyciechowski, J; Watt, AP in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Harrison, David; Watt, Alan P.] NodThera Ltd, Suite 8,Chesterford Res Pk, Saffron Walden CB10 1XL, Essex, England; [Doedens, John R.; Gabel, Christopher A.] NodThera Inc, 454 N 34th St, Seattle, WA 98103 USA; [Boutard, Nicolas; Brzozka, Krzysztof; Bugaj, Marta; Chmielewski, Stefan; Cierpich, Anna; Fabritius, Charles-Henry R. Y.; Galezowski, Michal; Kowalczyk, Piotr; Levenets, Oleksandr; Mroczkowska, Magdalena; Palica, Katarzyna; Schultz, David; Sowinska, Marta; Topolnicki, Grzegorz; Urbanski, Piotr; Woyciechowski, Jakub] Ryvu Therapeut, Selvita SA, Pk Life Sci,Ul Bobrssynskiego 14, PL-30348 Krakow, Poland; [Porter, Roderick A.] Rod Porter Consultancy, 89 Back St, Baldock SG7 5PG, Herts, England in 2020.0, Cited 25.0. Recommanded Product: 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

The NLRP3 inflammasome is a component of the innate immune system involved in the production of proinflammatory cytokines. Aberrant activation by a wide range of exogenous and endogenous signals can lead to chronic, low-grade inflammation. It has attracted a great deal of interest as a drug target due to the association with diseases of large unmet medical need such as Alzheimer’s disease, Parkinson’s disease, arthritis, and cancer. To date, no drugs specifically targeting inhibition of the NLRP3 inflammasome have been approved. In this work, we used the known NLRP3 inflammasome inhibitor CP-456,773 (aka CRID3 or MCC 950) as our starting point and undertook a Structure-Activity Relationship (SAR) analysis and subsequent scaffold-hopping exercise. This resulted in the rational design of a series of novel ester-substituted urea compounds that are highly potent and selective NLRP3 inflammasome inhibitors, as exemplified by compounds 44 and 45. It is hypothesized that the ester moiety acts as a highly permeable delivery vehicle and is subsequently hydrolyzed to the carboxylic acid active species by carboxylesterase enzymes. These molecules are greatly differentiated from the state-of-the-art and offer potential in the treatment of NLRP3-driven diseases, particularly where tissue penetration is required.

About Diphenylmethanamine, If you have any questions, you can contact Harrison, D; Boutard, N; Brzozka, K; Bugaj, M; Chmielewski, S; Cierpich, A; Doedens, JR; Fabritius, CHRY; Gabel, CA; Galezowski, M; Kowalczyk, P; Levenets, O; Mroczkowska, M; Palica, K; Porter, RA; Schultz, D; Sowinska, M; Topolnicki, G; Urbanski, P; Woyciechowski, J; Watt, AP or concate me.. Recommanded Product: 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Xie, C; Song, JL; Wu, HR; Hu, Y; Liu, HZ; Zhang, ZR; Zhang, P; Chen, BF; Han, BX in [Xie, Chao; Song, Jinliang; Wu, Haoran; Hu, Yue; Liu, Huizhen; Zhang, Zhanrong; Zhang, Pei; Chen, Bingfeng; Han, Buxing] Chinese Acad Sci, Inst Chem, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci,CAS Key Lab Colloid & In, Beijing 100190, Peoples R China; [Xie, Chao; Wu, Haoran; Hu, Yue; Liu, Huizhen; Han, Buxing] Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China published Ambient Reductive Amination of Levulinic Acid to Pyrrolidones over Pt Nanocatalysts on Porous TiO2 Nanosheets in 2019.0, Cited 50.0. Quality Control of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Construction of N-substituted pyrrolidones from biomass-derived levulinic acid (LA) via reductive amination is a highly attractive route for biomass valorization. However, realizing this transformation using H-2 as the hydrogen source under mild conditions is still very challenging. Herein, we designed porous TiO2 nanosheets-supported Pt nanoparticles (Pt/P-TiO2) as the heterogeneous catalyst. The prepared Pt/P-TiO2 was highly efficient for reductive amination of LA to produce various N-substituted pyrrolidones (34 examples) at ambient temperature and H-2 pressure. Meanwhile, Pt/P-TiO2 showed good applicability for reductive amination of levulinic esters, 4-acetylbutyric acid, 2-acetylbenzoic acid, and 2-carboxybenzaldehyde. Systematic studies indicated that the strong acidity of P-TiO2 and the lower electron density of the Pt sites as well as the porous structure resulted in the excellent activity of Pt/P-TiO2.

About Diphenylmethanamine, If you have any questions, you can contact Xie, C; Song, JL; Wu, HR; Hu, Y; Liu, HZ; Zhang, ZR; Zhang, P; Chen, BF; Han, BX or concate me.. Quality Control of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Deal;Structure-Activity Relationships of Benzamides and Isoindolines Designed as SARS-CoV Protease Inhibitors Effective against SARS-CoV-2 published in 2021.0. Recommanded Product: 91-00-9, Reprint Addresses Schirmeister, T (corresponding author), Johannes Gutenberg Univ Mainz, Inst Pharmaceut & Biomed Sci, Staudingerweg 5, D-55128 Mainz, Germany.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Inhibition of coronavirus (CoV)-encoded papain-like cysteine proteases (PLpro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure-activity relationships (SAR) of the noncovalent active-site directed inhibitor (R)-5-amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl) benzamide (2 b), which is known to bind into the S3 and S4 pockets of the SARS-CoV PLpro. Moreover, we report the discovery of isoindolines as a new class of potent PL(pro)inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS-CoV-2 replication in cell culture suggesting that, due to the high structural similarities of the target proteases, inhibitors identified against SARS-CoV PL(pro)are valuable starting points for the development of new pan-coronaviral inhibitors.

Recommanded Product: 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Welker, A; Kersten, C; Muller, C; Madhugiri, R; Zimmer, C; Muller, P; Zimmermann, R; Hammerschmidt, S; Maus, H; Ziebuhr, J; Sotriffer, C; Schirmeister, T or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about FORMYLMETHYL-SUBSTITUTED ENAMIDES; HIGHLY EFFICIENT; BRONSTED ACID; DIASTEREOSELECTIVE SYNTHESIS; BETA-HYDROXY; CYCLOADDITION; BIOTRANSFORMATIONS; PIPERIDINES; CYCLIZATION; PYRIDINES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21320102002, 91427301]. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Tong, S; Wang, MX. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. COA of Formula: C13H13N

A general and efficient method for the synthesis of highly enantiopure 4-amino-1,2,3,4-tetradydropyridine derivatives based on chiral phosphoric acid catalyzed intramolecular nucleophilic addition of tertiary enamides to imines has been developed. We have also demonstrated a substrate engineering strategy to significantly improve the enantioselectivity of asymmetric catalysis

COA of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Tong, S; Wang, MX or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2020.0 SYNTHETIC COMMUN published article about KABACHNIK-FIELDS REACTION; DOT-H DISTANCES; DERIVATIVES; SOLVENT; BONDS; ACIDS; DFT in [Hudson, Harry R.] London Metropolitan Univ, Fac Life Sci & Comp, London, England; [Tajti, Adam; Balint, Erika; Czugler, Matyas; Keglevich, Gyorgy] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1521 Budapest, Hungary; [Karaghiosoff, Konstantin] Ludwig Maximilians Univ Munchen, Dept Chem, Munich, Germany in 2020.0, Cited 38.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. COA of Formula: C13H13N

A series of N-benzhydryl protected alpha-aminophosphonates with alpha-phenyl, alpha-(1-naphtyl), alpha-(9-anthryl) or alpha-(1-pyrenyl) substituents was synthesized by the Kabachnik-Fields condensation of diphenylmethylamine (benzhydrylamine), the corresponding aryl aldehyde and a dialkyl phosphite under MW irradiation. X-ray studies performed at low temperatures for a few of these alpha-aminophosphonates confirmed the presence of unusually short intramolecular C-alpha-H delta+ center dot center dot center dot H delta+-C-peri contacts. [GRAPHICS] .

COA of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Hudson, HR; Tajti, A; Balint, E; Czugler, M; Karaghiosoff, K; Keglevich, G or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Selective Synthesis of Secondary Amines from Nitriles by a User-Friendly Cobalt Catalyst WOS:000483835300004 published article about TRANSFER HYDROGENATION; AROMATIC NITRILES; MILD; COMPLEXES; INDOLES; IMINES; (DE)HYDROGENATION; ALKYNYLATION; ALKYLATION; ALDEHYDES in Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [Sharma, Dipesh M.; Punji, Benudhar] NCL, CSIR, Div Chem Engn, Organometall Synth & Catalysis Grp, Pune 411008, Maharashtra, India; [Sharma, Dipesh M.; Punji, Benudhar] NCL, CSIR, Acad Sci & Innovat Res AcSIR, Pune 411008, Maharashtra, India in 2019.0, Cited 57.0. SDS of cas: 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Selective hydrogenation/reductive amination of nitriles to secondary amines catalyzed by an inexpensive and user-friendly cobalt complex, (Xantphos)CoCl2, is reported. The use of (Xantphos)CoCl2 and ammonia borane (NH3-BH3) combination affords the selective reduction of nitriles to symmetrical secondary amines, whereas the employment of (Xantphos)CoCl2 and dimethylamine borane (Me2NH-BH3) along with external amines produce unsymmetrical secondary amines and tertiary amines. The general applicability of this methodology is demonstrated by the synthesis of 43 symmetrical and unsymmetrical secondary and tertiary amines bearing diverse functionalities.

About Diphenylmethanamine, If you have any questions, you can contact Sharma, DM; Punji, B or concate me.. SDS of cas: 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics