Tag: M.W=150-200

Pal, Manojit published the artcileSynthesis and cyclooxygenase-2 (COX-2) inhibiting properties of 1,5-diarylpyrazoles possessing N-substitution on the sulfonamide (-SO₂NH₂) moiety, HPLC of Formula: 489-17-8, the publication is Letters in Drug Design & Discovery (2005), 2(4), 329-340, database is CAplus.

A number of novel 1,5-diarylpyrazoles possessing N-substitution on the sulfonamide (SO₂NH₂) moiety were synthesized and tested for COX-1/COX-2 inhibition in vitro. Many of these 1,1-dioxo-2,3-dihydrobenzo[d]isothiazolyl substituted 1,5-diarylpyrazoles, where the SO₂NH₂ group was a part of the fused ring, showed COX inhibitory activity. Few of them were identified as selective COX-2 inhibitors. A structure-activity relationship study within the series are discussed. Compounds prepared for this study included derivatives of 5-[3-(difluoromethyl)-5-[2-fluoro-4-(methylthio)phenyl]-1H-pyrazol-1-yl]-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide and 5-[5-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2,3-dihydro-1,2-benzisothiazole dioxide (i.e., cyclic benzenesulfonamide analogs).

Letters in Drug Design & Discovery published new progress about 489-17-8. 489-17-8 belongs to amides-buliding-blocks, auxiliary class Fluoride,Sulfamide,Amine,Benzene, name is 4-Fluoro-2-methylbenzenesulfonamide, and the molecular formula is C7H8FNO2S, HPLC of Formula: 489-17-8.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Pal, Manojit published the artcileSynthesis of fused sulfonamide (1,1-dioxoisothiazole)-substituted 1,5-diarylpyrazoles as cyclooxygenase inhibitors, Related Products of amides-buliding-blocks, the publication is Journal of the Indian Chemical Society (2003), 80(12), 1095-1101, database is CAplus.

First synthesis of novel 1,1-dioxo-2,3-dihydrobenzo[d]isothiazolyl substituted arylpyrazoles, e.g., I, has been accomplished via oxidative cyclization of 4-fluoro-2-Me benzenesulfonamide followed by the treatment with hydrazine and then with 1,3-dicarbonyl compounds A number of 1,5-diarylpyrazoles were synthesized in good yields and some of them were of potential biol. interest. In studies evaluating cyclooxygenase inhibiting activity, I was found to be more than 100 fold selective in COX-2 inhibition over COX-1.

Journal of the Indian Chemical Society published new progress about 489-17-8. 489-17-8 belongs to amides-buliding-blocks, auxiliary class Fluoride,Sulfamide,Amine,Benzene, name is 4-Fluoro-2-methylbenzenesulfonamide, and the molecular formula is C7H8FNO2S, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bossi, R. published the artcileAnalysis of polar pesticides in rainwater in Denmark by liquid chromatography-tandem mass spectrometry, Recommanded Product: 2,4-Dichlorobenzamide, the publication is Journal of Chromatography A (2002), 957(1), 27-36, database is CAplus and MEDLINE.

A new LC-MS-MS method for anal. of rainwater was developed and validated for 53 pesticides, degradation products of pesticides and selected nitrophenols. The method was used to monitor the concentration of pesticides in rainwater at one location near Roskilde, Denmark from Feb. 2000 to August 2000. Sampling was done in periods of up to 4 wk using a cooled wet-only sampler. H₂O samples were extracted by solid-phase extraction on Oasis HLB columns. The anal. of the extracts was performed by LC-MS-MS with electrospray ionization. All samples were analyzed in neg. and in pos. ionization mode, resp. for acidic and neutral compounds All analyses were done in the selected reaction monitoring mode to obtain a better signal-to-noise ratio. The method was validated for the following parameters: recovery, detection limit, uncertainty and linearity. Atrazine, terbuthylazine, isoproturon, mechlorprop and (2-methyl-4-chlorophenoxy)acetic acid were measured at concentrations >0.100 μg/l, mainly during the period of agricultural use. Nitrophenols were measured at high concentrations all year with peaks in the cold season (Feb.-Mar.).

Journal of Chromatography A published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Recommanded Product: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liu, Bin published the artcileMechanistic Investigation on Oxidative Degradation of ROS-Responsive Thioacetal/Thioketal Moieties and Their Implications, Product Details of C4H6F3NOS, the publication is Cell Reports Physical Science (2020), 1(12), 100271, database is CAplus.

In this work, through a series of structure-property relationship studies such as Hammett correlation, a mechanism of the oxidative cleavage of thioacetals and thioketals, where the thiolate components were converted to the corresponding disulfide product along with the formation of the resp. aldehydes and ketones, is proposed. The mechanism involves thioether oxidation that leads to the formation of a thionium intermediate, hydrolysis of which leads to the aldehyde/ketone product. In addition, a preliminary demonstration of the utility of such an understanding, as it offers the sequential release of two distinct small mols. caged in a substrate using two contradictory stimuli, viz. oxidative and reductive conditions, is presented.

Cell Reports Physical Science published new progress about 1869-45-0. 1869-45-0 belongs to amides-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is 2,2,2-Trifluoro-N-(2-mercaptoethyl)acetamide, and the molecular formula is C4H6F3NOS, Product Details of C4H6F3NOS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Wan, Wei-Lin published the artcilePhotosynthesis-inspired H₂ generation using a chlorophyll-loaded liposomal nanoplatform to detect and scavenge excess ROS, Computed Properties of 1869-45-0, the publication is Nature Communications (2020), 11(1), 534, database is CAplus and MEDLINE.

A disturbance of reactive oxygen species (ROS) homeostasis may cause the pathogenesis of many diseases. Inspired by natural photosynthesis, this work proposes a photo-driven H₂-evolving liposomal nanoplatform (Lip NP) that comprises an upconversion nanoparticle (UCNP) that is conjugated with gold nanoparticles (AuNPs) via a ROS-responsive linker, which is encapsulated inside the liposomal system in which the lipid bilayer embeds chlorophyll a (Chla). The UCNP functions as a transducer, converting NIR light into upconversion luminescence for simultaneous imaging and therapy in situ. Functioning as light-harvesting antennas, AuNPs are used to detect the local concentration of ROS for FRET biosensing, while the Chla activates the photosynthesis of H₂ gas to scavenge local excess ROS. The results thus obtained indicate the potential of using the Lip NPs in the anal. of biol. tissues, restoring their ROS homeostasis, possibly preventing the initiation and progression of diseases.

Nature Communications published new progress about 1869-45-0. 1869-45-0 belongs to amides-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is 2,2,2-Trifluoro-N-(2-mercaptoethyl)acetamide, and the molecular formula is C12H15NO4, Computed Properties of 1869-45-0.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Medina, Jesus R. published the artcileCell-Based Drug Discovery: Identification and Optimization of Small Molecules that Reduce c-MYC Protein Levels in Cells, Quality Control of 475216-25-2, the publication is Journal of Medicinal Chemistry (2021), 64(21), 16056-16087, database is CAplus and MEDLINE.

Elevated expression of the c-MYC oncogene is one of the most common abnormalities in human cancers. Unfortunately, efforts to identify pharmacol. inhibitors that directly target MYC have not yet yielded a drug-like mol. due to the lack of any known small mol. binding pocket in the protein, which could be exploited to disrupt MYC function. We have recently described a strategy to target MYC indirectly, where a screening effort designed to identify compounds that can rapidly decrease endogenous c-MYC protein levels in a MYC-amplified cell line led to the discovery of a compound series that phenocopies c-MYC knockdown by siRNA. Herein, we describe our medicinal chem. program that led to the discovery of potent, orally bioavailable c-MYC-reducing compounds The development of a min. pharmacophore model based on empirical structure activity relationship as well as the property-based approach used to modulate pharmacokinetics properties will be highlighted.

Journal of Medicinal Chemistry published new progress about 475216-25-2. 475216-25-2 belongs to amides-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Amine,Benzene,Amide,Benzene Compounds, name is 4-Fluoro-N-methyl-3-nitrobenzamide, and the molecular formula is C8H7FN2O3, Quality Control of 475216-25-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Walczynski, K. published the artcileHistamine H₁ receptor ligands. Part I. Novel thiazol-4-ylethanamine derivatives: synthesis and in vitro pharmacology, Recommanded Product: 3-Methoxybenzothioamide, the publication is Farmaco (1999), 54(8), 533-541, database is CAplus and MEDLINE.

A series of 2-substituted thiazol-4-ylethanamines have been synthesized and tested for their histaminergic H₁-receptor activities. The compounds with 2-Ph substitution, regardless of the different physicochem. properties of the meta-substituents at the Ph ring, showed weak H₁-agonistic activity with pD₂ values ranging from 4.35 to 5.36. When the Ph group was replaced by a benzyl group, the resulting compounds all exhibited weak H₁-antagonistic activity (pA₂: 4.14-4.82).

Farmaco published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C10H9NO4S, Recommanded Product: 3-Methoxybenzothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Orr, David published the artcileSingle-Step Microwave-Mediated Syntheses of Oxazoles and Thiazoles from 3-Oxetanone: A Synthetic and Computational Study, Recommanded Product: 3-Methoxybenzothioamide, the publication is Chemistry – A European Journal (2013), 19(29), 9655-9662, database is CAplus and MEDLINE.

The direct microwave-mediated condensation between 3-oxetanone and primary amides and thioamides has delivered moderate to good yields of (hydroxymethyl)oxazoles and (hydroxymethyl)thiazoles. The reactions use a sustainable solvent and only require short reaction times. These are highly competitive methods for the construction of two classes of valuable heteroarenes, which bear a useful locus for further elaboration. Electronic structure calculations have shown that the order of events involves chalcogen atom attack at sp³ carbon and alkyl-oxygen cleavage. The critical role of acid catalysis was shown clearly, and the importance of acid strength was demonstrated. The calculated barriers were also fully consistent with the observed order of thioamide and amide reactivity. Spontaneous ring opening involves a modest degree of C-O cleavage, moderating the extent of strain relief. On the acid-catalyzed pathway, C-O cleavage is less extensive still, but proton transfer to the nucleofuge is well advanced with the carboxylic acid catalysts, and essentially complete with methanesulfonic acid.

Chemistry – A European Journal published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, Recommanded Product: 3-Methoxybenzothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bianchini, Gianluca published the artcileDiscovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through pK_a and LogD Modulation, Name: 3-Methoxybenzothioamide, the publication is Journal of Medicinal Chemistry (2021), 64(22), 16820-16837, database is CAplus and MEDLINE.

Transient receptor potential melastatin 8 (TRPM8) is crucially involved in pain modulation and perception, and TRPM8 antagonists have been proposed as potential therapeutic approaches for pain treatment. Previously, we developed two TRPM8 antagonists and proposed them as drug candidates for topical and systemic pain treatment. Here, we describe the design and synthesis of these two TRPM8 antagonists (27 (I) and 45 (II)) and the rational approach of modulation/replacement of bioisosteric chem. groups, which allowed us to identify a combination of narrow ranges of pK_a and LogD values that were crucial to ultimately optimize their potency and metabolic stability. Following the same approach, we then pursued the development of new TRPM8 antagonists suitable for the topical treatment of ocular painful conditions and identified two new compounds (51 (III) and 59 (IV)), N-alkoxy amide derivatives, that can permeate across ocular tissue and reduce the behavioral responses induced by the topical ocular menthol challenge in vivo.

Journal of Medicinal Chemistry published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, Name: 3-Methoxybenzothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Horley, D. published the artcileThe infrared spectra of some titanium(IV) complexes with primary diamines, Recommanded Product: 2,4-Dichlorobenzamide, the publication is Canadian Journal of Chemistry (1965), 43(12), 3201-5, database is CAplus.

A series of Ti(IV) halide-diamine complexes was prepared and their ir spectra measured in the solid state, 300-4000 cm.^-1 The configuration of the ligand and extent of aminolysis of the Ti-halide bond are discussed in relation to the spectra. Some assignments are proposed in the 300-600-cm.^-1 region for the ethylenediamine complexes.

Canadian Journal of Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Recommanded Product: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics