Tag: M.W=150-200

Authors Xie, C; Song, JL; Wu, HR; Hu, Y; Liu, HZ; Zhang, ZR; Zhang, P; Chen, BF; Han, BX in AMER CHEMICAL SOC published article about HIGHLY EFFICIENT CATALYST; NITROGEN-COMPOUNDS; PRECIOUS-METAL; PRIMARY AMINES; KETO ACIDS; BIOMASS; HYDROGENATION; AMINATION/CYCLIZATION; HYDRODEOXYGENATION; TRANSFORMATION in [Xie, Chao; Song, Jinliang; Wu, Haoran; Hu, Yue; Liu, Huizhen; Zhang, Zhanrong; Zhang, Pei; Chen, Bingfeng; Han, Buxing] Chinese Acad Sci, Inst Chem, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci,CAS Key Lab Colloid & In, Beijing 100190, Peoples R China; [Xie, Chao; Wu, Haoran; Hu, Yue; Liu, Huizhen; Han, Buxing] Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China in 2019.0, Cited 50.0. Product Details of 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Construction of N-substituted pyrrolidones from biomass-derived levulinic acid (LA) via reductive amination is a highly attractive route for biomass valorization. However, realizing this transformation using H-2 as the hydrogen source under mild conditions is still very challenging. Herein, we designed porous TiO2 nanosheets-supported Pt nanoparticles (Pt/P-TiO2) as the heterogeneous catalyst. The prepared Pt/P-TiO2 was highly efficient for reductive amination of LA to produce various N-substituted pyrrolidones (34 examples) at ambient temperature and H-2 pressure. Meanwhile, Pt/P-TiO2 showed good applicability for reductive amination of levulinic esters, 4-acetylbutyric acid, 2-acetylbenzoic acid, and 2-carboxybenzaldehyde. Systematic studies indicated that the strong acidity of P-TiO2 and the lower electron density of the Pt sites as well as the porous structure resulted in the excellent activity of Pt/P-TiO2.

About Diphenylmethanamine, If you have any questions, you can contact Xie, C; Song, JL; Wu, HR; Hu, Y; Liu, HZ; Zhang, ZR; Zhang, P; Chen, BF; Han, BX or concate me.. Product Details of 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Harrison, D; Boutard, N; Brzozka, K; Bugaj, M; Chmielewski, S; Cierpich, A; Doedens, JR; Fabritius, CHRY; Gabel, CA; Galezowski, M; Kowalczyk, P; Levenets, O; Mroczkowska, M; Palica, K; Porter, RA; Schultz, D; Sowinska, M; Topolnicki, G; Urbanski, P; Woyciechowski, J; Watt, AP in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Harrison, David; Watt, Alan P.] NodThera Ltd, Suite 8,Chesterford Res Pk, Saffron Walden CB10 1XL, Essex, England; [Doedens, John R.; Gabel, Christopher A.] NodThera Inc, 454 N 34th St, Seattle, WA 98103 USA; [Boutard, Nicolas; Brzozka, Krzysztof; Bugaj, Marta; Chmielewski, Stefan; Cierpich, Anna; Fabritius, Charles-Henry R. Y.; Galezowski, Michal; Kowalczyk, Piotr; Levenets, Oleksandr; Mroczkowska, Magdalena; Palica, Katarzyna; Schultz, David; Sowinska, Marta; Topolnicki, Grzegorz; Urbanski, Piotr; Woyciechowski, Jakub] Ryvu Therapeut, Selvita SA, Pk Life Sci,Ul Bobrssynskiego 14, PL-30348 Krakow, Poland; [Porter, Roderick A.] Rod Porter Consultancy, 89 Back St, Baldock SG7 5PG, Herts, England in 2020.0, Cited 25.0. COA of Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

The NLRP3 inflammasome is a component of the innate immune system involved in the production of proinflammatory cytokines. Aberrant activation by a wide range of exogenous and endogenous signals can lead to chronic, low-grade inflammation. It has attracted a great deal of interest as a drug target due to the association with diseases of large unmet medical need such as Alzheimer’s disease, Parkinson’s disease, arthritis, and cancer. To date, no drugs specifically targeting inhibition of the NLRP3 inflammasome have been approved. In this work, we used the known NLRP3 inflammasome inhibitor CP-456,773 (aka CRID3 or MCC 950) as our starting point and undertook a Structure-Activity Relationship (SAR) analysis and subsequent scaffold-hopping exercise. This resulted in the rational design of a series of novel ester-substituted urea compounds that are highly potent and selective NLRP3 inflammasome inhibitors, as exemplified by compounds 44 and 45. It is hypothesized that the ester moiety acts as a highly permeable delivery vehicle and is subsequently hydrolyzed to the carboxylic acid active species by carboxylesterase enzymes. These molecules are greatly differentiated from the state-of-the-art and offer potential in the treatment of NLRP3-driven diseases, particularly where tissue penetration is required.

COA of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Harrison, D; Boutard, N; Brzozka, K; Bugaj, M; Chmielewski, S; Cierpich, A; Doedens, JR; Fabritius, CHRY; Gabel, CA; Galezowski, M; Kowalczyk, P; Levenets, O; Mroczkowska, M; Palica, K; Porter, RA; Schultz, D; Sowinska, M; Topolnicki, G; Urbanski, P; Woyciechowski, J; Watt, AP or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

SDS of cas: 91-00-9. Ahme, S; Perveen, S; Khan, KM; Naz, F; Ali, RA; Ajaz, M; Shah, S in [Ahme, Sumbul; Perveen, Shahnaz] Pakistan Council Sci & Ind Res, Labs Complex, Karachi 75280, Pakistan; [Perveen, Shahnaz; Khan, Khalid Mohammed; Naz, Farzana] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan; [Ali, Rahat Azher] Univ Karachi, Dept Chem, Karachi 75270, Pakistan; [Ajaz, Munazza; Shah, Samreen] Fed Urdu Univ Arts Sci & Technol, Dept Chem, Univ Rd,Gulshan E Iqbal Campus, Karachi, Pakistan; [Khan, Khalid Mohammed] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Clin Pharm, Dammam, Saudi Arabia published Dithiin diisoimides: Synthesis and their antimicrobial studies in 2020.0, Cited 28.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Sixteen derivatives of dithiin diisoimide 2a-2p have been synthesized and screened for antibacterial and antifungal activity. Compounds 2a-2g and 2i-2p are almost same or more active than gentamicine against Acinetobacter. Whereby compound 2,6-didodecyl-1H,5H-pyrrolo[3′,4′,5,6][1,4]dithiino[2,3-c]pyrrole-1,3,5,7(2H,6H)-tetrone (2d) having zone of inhibition 20 mm against Acinetobacter is the most potent among all these compounds and can be used as lead compound for the treatment of Acinetobacter infection.

SDS of cas: 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Ahme, S; Perveen, S; Khan, KM; Naz, F; Ali, RA; Ajaz, M; Shah, S or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Noh, HW; An, Y; Lee, S; Jung, J; Son, SU; Jang, HY in [Noh, Hyeong-Wan; Lee, Seulchan; Jang, Hye-Young] Ajou Univ, Dept Energy Syst Res, Suwon 16499, South Korea; [An, Youngjoon; Jung, Jaehoon] Univ Ulsan, Dept Chem, Ulsan 44610, South Korea; [Son, Seung Uk] Sungkyunkwan Univ, Dept Chem, Suwon 16419, South Korea published Metal-free Carbon Monoxide (CO) Capture and Utilization: Formylation of Amines in 2019.0, Cited 56.0. Application In Synthesis of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

The capture and utilization of CO by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) were performed in the absence of transition-metal complexes. The reaction of TBD with CO afforded TBD-CO adducts, which were converted to formylated TBD (TBD-CHO). TBD-CO adducts may include an interaction of CO with positively charged species based on NMR and IR analysis. In the presence of amines, CO was transferred from TBD-CO to amines, producing formylated amines with good yields. The reaction mechanism involving TBD-CO adducts is presented based on theoretical calculations.

About Diphenylmethanamine, If you have any questions, you can contact Noh, HW; An, Y; Lee, S; Jung, J; Son, SU; Jang, HY or concate me.. Application In Synthesis of Diphenylmethanamine

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Modular click chemistry libraries for functional screens using a diazotizing reagent WOS:000488832500035 published article about DIAZO TRANSFER; IMIDAZOLE-1-SULFONYL AZIDE; DIAZOTRANSFER; CYCLOADDITION; ALKYNES; AMINES; SUFEX; SAFE in [Meng, Genyi; Guo, Taijie; Ma, Tiancheng; Zhang, Jiong; Shen, Yucheng; Sharpless, Karl Barry; Dong, Jiajia] Univ Chinese Acad Sci, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem,Chinese Acad Sci, Shanghai, Peoples R China in 2019, Cited 33. Product Details of 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

Click chemistry is a concept in which modular synthesis is used to rapidly find new molecules with desirable properties(1). Copper(I)-catalysed azide-alkyne cycloaddition (CuAAC) triazole annulation and sulfur(VI) fluoride exchange (SuFEx) catalysis are widely regarded as click reactions(2-4), providing rapid access to their products in yields approaching 100% while being largely orthogonal to other reactions. However, in the case of CuAAC reactions, the availability of azide reagents is limited owing to their potential toxicity and the risk of explosion involved in their preparation. Here we report another reaction to add to the click reaction family: the formation of azides from primary amines, one of the most abundant functional groups(5). The reaction uses just one equivalent of a simple diazotizing species, fluorosulfuryl azide(6-11) (FSO2N3), and enables the preparation of over 1,200 azides on 96-well plates in a safe and practical manner. This reliable transformation is a powerful tool for the CuAAC triazole annulation, the most widely used click reaction at present. This method greatly expands the number of accessible azides and 1,2,3-triazoles and, given the ubiquity of the CuAAC reaction, it should find application in organic synthesis, medicinal chemistry, chemical biology and materials science.

About Diphenylmethanamine, If you have any questions, you can contact Meng, GY; Guo, TJ; Ma, TC; Zhang, J; Shen, YC; Sharpless, KB; Dong, JJ or concate me.. Product Details of 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Mercea, DM; Howlett, MG; Piascik, AD; Scott, DJ; Steven, A; Ashley, AE; Fuchter, MJ in [Mercea, Dan M.; Howlett, Michael G.; Piascik, Adam D.; Scott, Daniel J.; Ashley, Andrew E.; Fuchter, Matthew J.] Imperial Coll London, Mol Sci Res Hub, Dept Chem, White City Campus,Wood Lane, London W12 0BZ, England; [Steven, Alan] AstraZeneca PT&D, Charter Way, Macclesfield SK10 2NA, Cheshire, England published Enantioselective reduction of N-alkyl ketimines with frustrated Lewis pair catalysis using chiral borenium ions in 2019.0, Cited 54.0. HPLC of Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Enantioselective reduction of ketimines was demonstrated using chiral N-heterocyclic carbene (NHC)-stabilised borenium ions in frustrated Lewis pair catalysis. High levels of enantioselectivity were achieved for substrates featuring secondary N-alkyl substituents. Comparative reactivity and mechanistic studies identify key determinants required to achieve useful enantioselectivity and represent a step forward in the further development of enantioselective FLP methodologies.

HPLC of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Mercea, DM; Howlett, MG; Piascik, AD; Scott, DJ; Steven, A; Ashley, AE; Fuchter, MJ or concate me.

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Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Synthesis of deuterium-labeled DL-threo-thiamphenicol WOS:000528146700001 published article about STEREOSELECTIVE-SYNTHESIS; (-)-CHLORAMPHENICOL in [Zhang, Meihui; Zhang, Lizhi; Xu, Liying; Dong, Jinhua] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, 85 Hongliu Rd, Benxi 117004, Liaoning, Peoples R China; [Wang, Wei; Yan, Tingchang] Shandong Huijing Biopharmaceut Technol Co Ltd, Zibo 255000, Shandong, Peoples R China in 2020.0, Cited 12.0. SDS of cas: 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A convenient and inexpensive approach for the synthesis of deuterium-labeled thiamphenicol was described. DL-threo-Thiamphenicol-methyl-d(3) was prepared with high chemical purity and isotopic enrichment via a six-step process starting from 4-bromobenzaldehyde and DMSO-d(6) by employing microwave-assisted copper-mediated methylthiolation and modified Wulff’s asymmetric aziridination.

SDS of cas: 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Zhang, MH; Zhang, LZ; Wang, W; Yan, TC; Xu, LY; Dong, JH or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Chithanna, S; Vyasamudri, S; Yang, DY in AMER CHEMICAL SOC published article about SOLID-PHASE SYNTHESIS; DDE; STRATEGY; ACIDS; FMOC; BOC in [Chithanna, Sivanna; Vyasamudri, Sameer; Yang, Ding-Yah] Tunghai Univ, Dept Chem, Taichung 40704, Taiwan in 2020.0, Cited 42.0. Quality Control of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A simple protocol for the protection of amines was realized through a base-catalyzed one-pot reaction of dimedone, beta-nitroalkene, and amine. Employing this strategy, a variety of amines/amino acids were protected in excellent yields. These acid/base stable protected amines can be deprotected by either ethylene diamine or hydrazine hydrate under mild conditions. The practical application of this orthogonal protecting group was demonstrated by the synthesis of cyclic peptide melanotan II via SPPS.

Quality Control of Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Chithanna, S; Vyasamudri, S; Yang, DY or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recommanded Product: Diphenylmethanamine. In 2021.0 CHEMMEDCHEM published article about CORONAVIRUS PAPAIN-LIKE; RESPIRATORY SYNDROME CORONAVIRUS; PNEUMONIA in [Welker, Armin; Sotriffer, Christoph] Justus Maximilians Univ Wurzburg, Inst Pharm & Food Chem, D-97074 Wurzburg, Germany; [Kersten, Christian; Zimmer, Collin; Mueller, Patrick; Zimmermann, Robert; Hammerschmidt, Stefan; Maus, Hannah; Schirmeister, Tanja] Johannes Gutenberg Univ Mainz, Inst Pharmaceut & Biomed Sci, Staudingerweg 5, D-55128 Mainz, Germany; [Mueller, Christin; Madhugiri, Ramakanth; Ziebuhr, John] Justus Liebig Univ Giessen, Inst Med Virol, Schubertstr 81, D-35392 Giessen, Germany in 2021.0, Cited 29.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Inhibition of coronavirus (CoV)-encoded papain-like cysteine proteases (PLpro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure-activity relationships (SAR) of the noncovalent active-site directed inhibitor (R)-5-amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl) benzamide (2 b), which is known to bind into the S3 and S4 pockets of the SARS-CoV PLpro. Moreover, we report the discovery of isoindolines as a new class of potent PL(pro)inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS-CoV-2 replication in cell culture suggesting that, due to the high structural similarities of the target proteases, inhibitors identified against SARS-CoV PL(pro)are valuable starting points for the development of new pan-coronaviral inhibitors.

Recommanded Product: Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Welker, A; Kersten, C; Muller, C; Madhugiri, R; Zimmer, C; Muller, P; Zimmermann, R; Hammerschmidt, S; Maus, H; Ziebuhr, J; Sotriffer, C; Schirmeister, T or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Uniform Cu/chitosan beads as a green and reusable catalyst for facile synthesis of imines via oxidative coupling reaction WOS:000540547000064 published article about HETEROGENEOUS CATALYST; METAL-FREE; FUNCTIONALIZED-CHITOSAN; EFFICIENT CATALYST; AEROBIC OXIDATION; COPPER CATALYST; PRIMARY AMINES; BENZYLAMINES; COMPLEXES; AMBIENT in [Chutimasakul, Threeraphat; Nakhonpanom, Pakamon Na; Tirdtrakool, Warinda; Intanin, Apichai; Bunchuay, Thanthapatra; Chantiwas, Rattikan; Tantirungrotechai, Jonggol] Mahidol Univ, Fac Sci, Ctr Excellence Innovat Chem, Dept Chem, Bangkok 10400, Thailand in 2020.0, Cited 52.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Computed Properties of C13H13N

A nonprecious metal and biopolymer-based catalyst, Cu/chitosan beads, has been successfully prepared by using a software-controlled flow system. Uniform, spherical Cu/chitosan beads can be obtained with diameters in millimeter-scale and narrow size distribution (0.78 +/- 0.04 mm). The size and morphology of the Cu/chitosan beads are reproducible due to high precision of the flow rate. In addition, the application of the Cu/chitosan beads as a green and reusable catalyst has been demonstrated using a convenient and efficient protocol for the direct synthesis of imines via the oxidative self- and cross-coupling of amines (24 examples) with moderate to excellent yields. Importantly, the beads are stable and could be reused more than ten times without loss of the catalytic performance. Furthermore, because of the bead morphology, the Cu/chitosan catalyst has greatly simplified recycling and workup procedures.

About Diphenylmethanamine, If you have any questions, you can contact Chutimasakul, T; Nakhonpanom, PN; Tirdtrakool, W; Intanin, A; Bunchuay, T; Chantiwas, R; Tantirungrotechai, J or concate me.. Computed Properties of C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics