Tag: M.W=150-200

Tong, S; Wang, MX in [Tong, Shuo; Wang, Mei-Xiang] Tsinghua Univ, Dept Chem, MOE Key Lab Bioorgan Phosphorous Chem & Chem Biol, Beijing 100084, Peoples R China published Catalytic Enantioselective Synthesis of 4-Amino-1,2,3,4-tetrahydropyridine Derivatives from Intramolecular Nucleophilic Addition Reaction of Tertiary Enamides in 2019.0, Cited 54.0. Category: amides-buliding-blocks. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A general and efficient method for the synthesis of highly enantiopure 4-amino-1,2,3,4-tetradydropyridine derivatives based on chiral phosphoric acid catalyzed intramolecular nucleophilic addition of tertiary enamides to imines has been developed. We have also demonstrated a substrate engineering strategy to significantly improve the enantioselectivity of asymmetric catalysis

Category: amides-buliding-blocks. About Diphenylmethanamine, If you have any questions, you can contact Tong, S; Wang, MX or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Development of a Large-Scale Route to Glecaprevir: Synthesis of the Macrocycle via Intramolecular Etherification published in 2020.0. HPLC of Formula: C13H13N, Reprint Addresses Cink, RD (corresponding author), AbbVie Inc, Proc Res & Dev, N Chicago, IL 60064 USA.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Glecaprevir was identified as a potent hepatitis C virus (HCV) protease inhibitor, and a large-scale synthesis was required to support the late-stage clinical trials and subsequent commercial launch. The large-scale synthetic route to glecaprevir required the development of completely new synthetic approaches to the two key structural features: the 18-membered macrocycle 3 and the difluoromethyl-substituted cyclopropyl amino acid 4. In this first manuscript, we describe the route development for the macrocycle 3; the second manuscript will describe the development of a new synthetic route to the difluoromethyl-substituted cyclopropyl amino acid 4 and the final assembly of glecaprevir. The large-scale synthetic route to the macrocycle employed a unique intramolecular etherification reaction as the key step in the macrocycle synthesis, avoiding the scalability limitations of the ring-closing metathesis (RCM) reaction of the enabling route. The large-scale synthetic route to the macrocycle was successfully used to produce the amount of glecaprevir required to support the late-stage clinical development.

About Diphenylmethanamine, If you have any questions, you can contact Kallemeyn, JM; Engstrom, KM; Pelc, MJ; Lukin, KA; Morrill, WH; Wei, HJ; Towne, TB; Henle, J; Nere, NK; Welch, DS; Shekhar, S; Ravn, MM; Zhao, G; Fickes, MG; Ding, C; Vinci, JC; Marren, J; Cink, RD or concate me.. HPLC of Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Switchable synthesis of cyclic carbamates by carbon dioxide fixation at atmospheric pressure published in 2021.0. Formula: C13H13N, Reprint Addresses Toda, Y; Suga, H (corresponding author), Shinshu Univ, Fac Engn, Dept Mat Chem, 4-17-1 Wakasato, Nagano 3808553, Japan.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

The base-promoted switchable synthesis of five- and six-membered cyclic carbamates using atmospheric pressure carbon dioxide as the C1 source was developed. The chemoselectivity of products was simply controlled by changing bases and solvents. The reaction proceeds effectively under mild conditions, affording valuable cyclic carbamates. Experimental results and DFT studies revealed the reaction mechanism.

Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Toda, Y; Shishido, M; Aoki, T; Sukegawa, K; Suga, H or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Computed Properties of C13H13N. In 2020 J ORG CHEM published article about N-ACYLIMINIUM IONS; OXIDATIVE DECARBOXYLATION; RADICAL CHEMISTRY; ARYL; DERIVATIVES; ALDEHYDES; ALCOHOLS; KETONES; MILD; HYDROGENATION in [Khan, Shah Nawaz; Zaman, Muhammad Kashif; Li, Ruining; Sun, Zhankui] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China; [Sun, Zhankui] Chinese Acad Sci, Huzhou Res & Industrializat Ctr Technol, Huzhou 313000, Peoples R China in 2020, Cited 49. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A general and practical method for decarboxylative hydroxylation of carboxylic acids was developed through visible light-induced photocatalysis using molecular oxygen as the green oxidant. The addition of NaBH4 to in situ reduce the unstable peroxyl radical intermediate much broadened the substrate scope. Different sp a carbon-bearing carboxylic acids were successfully employed as substrates, including phenylacetic acid-type substrates, as well as aliphatic carboxylic acids. This transformation worked smoothly on primary, secondary, and tertiary carboxylic acids.

Computed Properties of C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Khan, SN; Zaman, MK; Li, RN; Sun, ZK or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

SDS of cas: 91-00-9. Toda, Y; Shishido, M; Aoki, T; Sukegawa, K; Suga, H in [Toda, Yasunori; Shishido, Minoru; Aoki, Tatsuya; Sukegawa, Kimiya; Suga, Hiroyuki] Shinshu Univ, Fac Engn, Dept Mat Chem, 4-17-1 Wakasato, Nagano 3808553, Japan published Switchable synthesis of cyclic carbamates by carbon dioxide fixation at atmospheric pressure in 2021.0, Cited 35.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

The base-promoted switchable synthesis of five- and six-membered cyclic carbamates using atmospheric pressure carbon dioxide as the C1 source was developed. The chemoselectivity of products was simply controlled by changing bases and solvents. The reaction proceeds effectively under mild conditions, affording valuable cyclic carbamates. Experimental results and DFT studies revealed the reaction mechanism.

About Diphenylmethanamine, If you have any questions, you can contact Toda, Y; Shishido, M; Aoki, T; Sukegawa, K; Suga, H or concate me.. SDS of cas: 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about ONE-POT SYNTHESIS; OXIDATIVE CARBONYLATION; EFFICIENT CONVERSION; TRISUBSTITUTED UREAS; BIOLOGICAL-ACTIVITY; CARBOXYLIC-ACIDS; AMINES; FACILE; INHIBITORS; DESIGN, Saw an article supported by the Science and Engineering Research Board (SERB), Department of Science & Technology, New Delhi [EMR/2016/001123]; Council of Scientific & Industrial Research (CSIR), New DelhiCouncil of Scientific & Industrial Research (CSIR) – India; University Grant Commission (UGC), New DelhiUniversity Grants Commission, India. HPLC of Formula: C13H13N. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Singh, AS; Agrahari, AK; Singh, SK; Yadav, MS; Tiwari, VK. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

The good leaving tendency of the benzotriazole moiety has been exploited for the synthesis of symmetric, unsymmetric, N-acyl, and cyclic ureas in good yields from N-acylbenzotriazoles by treating the latter with various amines in the presence of TMSN N in a sealed tube. The salient features of the devised protocol includes the high-yield, mild, metal-free, one-pot reaction conditions, and short reaction time. Furthermore, in many cases, no column chromatography is required for the purification.

About Diphenylmethanamine, If you have any questions, you can contact Singh, AS; Agrahari, AK; Singh, SK; Yadav, MS; Tiwari, VK or concate me.. HPLC of Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2020.0 TETRAHEDRON published article about SULFOXIDE ELECTROPHILIC SULFENYLATION; C-H FUNCTIONALIZATION; SULFONIUM SALTS; ARYL SULFOXIDES; INTRAMOLECULAR SULFENYLATION; ARYLSULFONIUM SALTS; ORTHO-ALLYLATION; GLYCOSYL DONORS; AZULENE; REARRANGEMENT in [Lopez-Alled, Carlos M.; Martin, Frederick J. O.; Chen, Kuan-Yu; James, Tony D.; Lewis, Simon E.] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England; [Lopez-Alled, Carlos M.; James, Tony D.; Wenk, Jannis; Lewis, Simon E.] Univ Bath, Ctr Sustainable Circular Technol, Bath BA2 7AY, Avon, England; [Kociok-Kohn, Gabriele] Univ Bath, Mat & Chem Characterizat MC2, Bath BA2 7AY, Avon, England; [Wenk, Jannis] Univ Bath, Dept Chem Engn, Bath BA2 7AY, Avon, England; [Wenk, Jannis] Univ Bath, Water Innovat & Res Ctr WIRC Bath, Bath BA2 7AY, Avon, England in 2020.0, Cited 149.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. COA of Formula: C13H13N

Azulenes undergo either single or dual SEAr reactions depending on the nature of the sulfur(IV) electrophile employed. These electrophiles are generated in situ from either sulfoxides or sulfides. The resultant cationic or dicationic azulene products can undergo further derivatisation by means of nucleophilic attack at the sulfonium alpha-carbon. In the case of cycloalkyl azulenylsulfonium salts, this leads to ring-opened azulenylsulfide products. (C) 2020 The Authors. Published by Elsevier Ltd.

About Diphenylmethanamine, If you have any questions, you can contact Lopez-Alled, CM; Martin, FJO; Chen, KY; Kociok-Kohn, G; James, TD; Wenk, J; Lewis, SE or concate me.. COA of Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

COA of Formula: C13H13N. Recently I am researching about HYDROGEN; BROMIDES; OLEFINS; ARYL, Saw an article supported by the AbbVieAbbVie; Enanta. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Kallemeyn, JM; Engstrom, KM; Pelc, MJ; Lukin, KA; Morrill, WH; Wei, HJ; Towne, TB; Henle, J; Nere, NK; Welch, DS; Shekhar, S; Ravn, MM; Zhao, G; Fickes, MG; Ding, C; Vinci, JC; Marren, J; Cink, RD. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Glecaprevir was identified as a potent hepatitis C virus (HCV) protease inhibitor, and a large-scale synthesis was required to support the late-stage clinical trials and subsequent commercial launch. The large-scale synthetic route to glecaprevir required the development of completely new synthetic approaches to the two key structural features: the 18-membered macrocycle 3 and the difluoromethyl-substituted cyclopropyl amino acid 4. In this first manuscript, we describe the route development for the macrocycle 3; the second manuscript will describe the development of a new synthetic route to the difluoromethyl-substituted cyclopropyl amino acid 4 and the final assembly of glecaprevir. The large-scale synthetic route to the macrocycle employed a unique intramolecular etherification reaction as the key step in the macrocycle synthesis, avoiding the scalability limitations of the ring-closing metathesis (RCM) reaction of the enabling route. The large-scale synthetic route to the macrocycle was successfully used to produce the amount of glecaprevir required to support the late-stage clinical development.

COA of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Kallemeyn, JM; Engstrom, KM; Pelc, MJ; Lukin, KA; Morrill, WH; Wei, HJ; Towne, TB; Henle, J; Nere, NK; Welch, DS; Shekhar, S; Ravn, MM; Zhao, G; Fickes, MG; Ding, C; Vinci, JC; Marren, J; Cink, RD or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Synthesis and biological evaluation of flavone-8-acrylamide derivatives as potential multi-target-directed anti Alzheimer agents and investigation of binding mechanism with acetylcholinesterase WOS:000475378400053 published article about HUMAN SERUM-ALBUMIN; MOLECULAR-DYNAMICS SIMULATION; MULTIFUNCTIONAL AGENTS; FLAVONOID DERIVATIVES; COUMARIN DERIVATIVES; BETULINIC ACID; DESIGN; INHIBITORS; DISEASE; SERIES in [Shaik, Jeelan Basha; Kandrakonda, Yelamanda Rao; Penumala, Mohan; Zinka, Raveendra Babu; Amooru, Damu Gangaiah] Yogi Vemana Univ, Dept Chem, Kadapa, Andhra Pradesh, India; [Yeggoni, Daniel Pushparaju; Subramanyam, Rajagopal] Univ Hyderabad, Sch Life Sci, Dept Plant Sci, Hyderabad, India; [Kotapati, Kasi Viswanath; Ampasala, Dinakara Rao] Pondicherry Cent Univ, Ctr Bioinformat, Sch Life Sci, Pondicherry, India; [Darla, Mark Manidhar] Sri Venkateswara Univ, Dept Chem, Tirupati, Andhra Pradesh, India in 2019.0, Cited 56.0. HPLC of Formula: C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

In a search for novel multifunctional anti-Alzheimer agents, a congeneric set of seventeen flavone-8-acrylamide derivatives (8a-q) were synthesized and evaluated for their cholinesterase inhibitory, antioxidant, neuroprotective and modulation of A beta aggregation activities. The target compounds showed effective and selective inhibitory activity against the AChE over BuChE. In addition, the target compounds also showed moderate antioxidant activity and strong neuroprotective capacities, and accelerated dosage-dependently the A beta aggregation. Also, we presented here a complete study on the interaction of 8a, 8d, 8e, 8h and 8i with AChE. Through fluorescence emission studies, the binding sites number found to be 1, binding constants were calculated as 2.04 x 10(4), 2.22 x 10(4), 1.18 x 10(4), 9.8 x 10(3) and 3.2 x 10(4) M-1 and free energy change as -5.83, -5.91, -5.51, -5.41 and -6.12 kcal M-1 at 25 degrees C which were well agreed with the computational calculations indicating a strong binding affinity of flavones and AChE. Furthermore, the CD studies revealed that the secondary structure of AChE became partly unfolded upon binding with 8a, 8d, 8e, 8h and 8i.

HPLC of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Shaik, JB; Yeggoni, DP; Kandrakonda, YR; Penumala, M; Zinka, RB; Kotapati, KV; Darla, MM; Ampasala, DR; Subramanyam, R; Amooru, DG or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Toda, Y; Shishido, M; Aoki, T; Sukegawa, K; Suga, H in ROYAL SOC CHEMISTRY published article about ONE-POT SYNTHESIS; SELECTIVE SYNTHESIS; OXAZOLIDINONES; CO2; DERIVATIVES; AMINES; HYDROGEN; IMINES in [Toda, Yasunori; Shishido, Minoru; Aoki, Tatsuya; Sukegawa, Kimiya; Suga, Hiroyuki] Shinshu Univ, Fac Engn, Dept Mat Chem, 4-17-1 Wakasato, Nagano 3808553, Japan in 2021.0, Cited 35.0. Computed Properties of C13H13N. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

The base-promoted switchable synthesis of five- and six-membered cyclic carbamates using atmospheric pressure carbon dioxide as the C1 source was developed. The chemoselectivity of products was simply controlled by changing bases and solvents. The reaction proceeds effectively under mild conditions, affording valuable cyclic carbamates. Experimental results and DFT studies revealed the reaction mechanism.

Computed Properties of C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Toda, Y; Shishido, M; Aoki, T; Sukegawa, K; Suga, H or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics