Tag: M.W=150-200

Recently I am researching about ENANTIOSELECTIVE SYNTHESIS; HIGHLY EFFICIENT; LACTAM SYNTHESIS; AMIDES; ACIDS; POLYMERIZATION; HYDROGENATION; HETEROCYCLES; SUBSTITUTION; CAPURAMYCIN, Saw an article supported by the CERCA Program/Generalitat de Catalunya, ICREA; Spanish MINECO [CTQ-2014-60419-R]; AGAURAgencia de Gestio D’Ajuts Universitaris de Recerca Agaur (AGAUR) [2017-SGR-232]; Chinese Research Council (CSC) [2016-06200061, 2019-06870036]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Xie, JN; Li, XT; Kleij, AW. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Application In Synthesis of Diphenylmethanamine

A stereoselective amination/cyclization cascade process has been developed that allows for the preparation of a series of unsaturated and substituted caprolactam derivatives in good yields. This conceptually novel protocol takes advantage of the easy access and modular character of vinyl gamma-lactones that can be prepared from simple precursors. Activation of the lactone substrate in the presence of a suitable Pd precursor and newly developed phosphoramidite ligand offers a stereocontrolled ring-opening/allylic amination manifold under ambient conditions. The intermediate (E)-configured epsilon-amino acid can be cyclized using a suitable dehydrating agent in an efficient one-pot, two-step sequence. This overall highly chemo-, stereo- and regio-selective transformation streamlines the production of a wide variety of modifiable and valuable caprolactam building blocks in an operationally attractive way.

About Diphenylmethanamine, If you have any questions, you can contact Xie, JN; Li, XT; Kleij, AW or concate me.. Application In Synthesis of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

HPLC of Formula: C13H13N. In 2019.0 BIOORG CHEM published article about HUMAN SERUM-ALBUMIN; MOLECULAR-DYNAMICS SIMULATION; MULTIFUNCTIONAL AGENTS; FLAVONOID DERIVATIVES; COUMARIN DERIVATIVES; BETULINIC ACID; DESIGN; INHIBITORS; DISEASE; SERIES in [Shaik, Jeelan Basha; Kandrakonda, Yelamanda Rao; Penumala, Mohan; Zinka, Raveendra Babu; Amooru, Damu Gangaiah] Yogi Vemana Univ, Dept Chem, Kadapa, Andhra Pradesh, India; [Yeggoni, Daniel Pushparaju; Subramanyam, Rajagopal] Univ Hyderabad, Sch Life Sci, Dept Plant Sci, Hyderabad, India; [Kotapati, Kasi Viswanath; Ampasala, Dinakara Rao] Pondicherry Cent Univ, Ctr Bioinformat, Sch Life Sci, Pondicherry, India; [Darla, Mark Manidhar] Sri Venkateswara Univ, Dept Chem, Tirupati, Andhra Pradesh, India in 2019.0, Cited 56.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

In a search for novel multifunctional anti-Alzheimer agents, a congeneric set of seventeen flavone-8-acrylamide derivatives (8a-q) were synthesized and evaluated for their cholinesterase inhibitory, antioxidant, neuroprotective and modulation of A beta aggregation activities. The target compounds showed effective and selective inhibitory activity against the AChE over BuChE. In addition, the target compounds also showed moderate antioxidant activity and strong neuroprotective capacities, and accelerated dosage-dependently the A beta aggregation. Also, we presented here a complete study on the interaction of 8a, 8d, 8e, 8h and 8i with AChE. Through fluorescence emission studies, the binding sites number found to be 1, binding constants were calculated as 2.04 x 10(4), 2.22 x 10(4), 1.18 x 10(4), 9.8 x 10(3) and 3.2 x 10(4) M-1 and free energy change as -5.83, -5.91, -5.51, -5.41 and -6.12 kcal M-1 at 25 degrees C which were well agreed with the computational calculations indicating a strong binding affinity of flavones and AChE. Furthermore, the CD studies revealed that the secondary structure of AChE became partly unfolded upon binding with 8a, 8d, 8e, 8h and 8i.

HPLC of Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Shaik, JB; Yeggoni, DP; Kandrakonda, YR; Penumala, M; Zinka, RB; Kotapati, KV; Darla, MM; Ampasala, DR; Subramanyam, R; Amooru, DG or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recommanded Product: Diphenylmethanamine. In 2020.0 ANGEW CHEM INT EDIT published article about CARBONYL-COMPOUNDS; DEOXYGENATION; ALCOHOLS; HYDROGENOLYSIS; 1,2-DIOLS; AMINES; HYDROSILYLATION; ACTIVATION; CONVERSION; MECHANISM in [Fang, Huaquan; Oestreich, Martin] Tech Univ Berlin, Inst Chem, Str 17 Juni 115, D-10623 Berlin, Germany in 2020.0, Cited 52.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

The strong boron Lewis acid tris(pentafluorophenyl)borane B(C6F5)(3) is known to catalyze the dehydrogenative coupling of certain amines and hydrosilanes at elevated temperatures. At higher temperature, the dehydrogenation pathway competes with cleavage of the C-N bond and defunctionalization is obtained. This can be turned into a useful methodology for the transition-metal-free reductive deamination of a broad range of amines as well as heterocumulenes such as an isocyanate and an isothiocyanate.

About Diphenylmethanamine, If you have any questions, you can contact Fang, HQ; Oestreich, M or concate me.. Recommanded Product: Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about CARBON-CARBON BOND; C-C; TRIPLE BOND; METAL-FREE; CATALYZED NITROGENATION; CYCLIC AMINES; ACTIVATION; ALKYNES; FUNCTIONALIZATION; OXYGENATION, Saw an article supported by the NSF of ChinaNational Natural Science Foundation of China (NSFC) [21706058, 21878072, 21573065]; NSF of Hunan Province [2016JJ1007, 2018JJ3031]. Product Details of 91-00-9. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: He, JH; Dong, J; Su, LB; Wu, SF; Liu, LX; Yin, SF; Zhou, YB. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

A selective functionalization of C-C.C bonds toward N-C=O bonds is realized by an n-Bu4NI-catalyzed reaction of 3-methylindoles with primary amines using TBHP as the unique oxidant. The systematic process involves oxygenation, nitrogenation, ring-opening, and recyclization, affording a broad range of quinazolinones in good to excellent yields.

About Diphenylmethanamine, If you have any questions, you can contact He, JH; Dong, J; Su, LB; Wu, SF; Liu, LX; Yin, SF; Zhou, YB or concate me.. Product Details of 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2020.0 J RADIOANAL NUCL CH published article about STEREOSELECTIVE-SYNTHESIS; (-)-CHLORAMPHENICOL in [Zhang, Meihui; Zhang, Lizhi; Xu, Liying; Dong, Jinhua] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, 85 Hongliu Rd, Benxi 117004, Liaoning, Peoples R China; [Wang, Wei; Yan, Tingchang] Shandong Huijing Biopharmaceut Technol Co Ltd, Zibo 255000, Shandong, Peoples R China in 2020.0, Cited 12.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Quality Control of Diphenylmethanamine

A convenient and inexpensive approach for the synthesis of deuterium-labeled thiamphenicol was described. DL-threo-Thiamphenicol-methyl-d(3) was prepared with high chemical purity and isotopic enrichment via a six-step process starting from 4-bromobenzaldehyde and DMSO-d(6) by employing microwave-assisted copper-mediated methylthiolation and modified Wulff’s asymmetric aziridination.

Quality Control of Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Zhang, MH; Zhang, LZ; Wang, W; Yan, TC; Xu, LY; Dong, JH or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Asymmetric Hydrogenation of Dibenzo[c,e]azepine Derivatives with Chiral Cationic Ruthenium Diamine Catalysts WOS:000476957200035 published article about HIGHLY ENANTIOSELECTIVE HYDROGENATION; REDUCTIVE AMINATION; CYCLIC AMINES; IMINES; BENZODIAZEPINONES; KETONES; ACCESS; ROUTE; SCOPE in [Chen, Fei; Fan, Qing-Hua] Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China; Univ Chinese Acad Sci, Beijing 100190, Peoples R China in 2019.0, Cited 59.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Name: Diphenylmethanamine

An efficient Ru-catalyzed asymmetric hydrogenation of dibenzo[c,e]azepines is reported. A series of seven-membered cyclic amines were obtained with moderate to excellent enantioselectivity. The catalyst counteranion played an important role in achieving high-level chiral induction. Moreover, a one-pot synthesis of chiral 6,7-dihydro-5H-dibenz[c,e]azepines via two-step reductive amination was also developed.

Name: Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Zhang, SS; Chen, F; He, YM; Fan, QH or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about TRANSFER HYDROGENATION; SUBSTITUENT CONSTANTS; SUSTAINABLE SYNTHESIS; AMINES; LIGAND; KETONES; IRON; EPOXIDATION; ALKYLATION; EFFICIENT, Saw an article supported by the Technical University of Denmark. Recommanded Product: 91-00-9. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Samuelsen, S; Santilli, C; Ahlquist, MSG; Madsen, R. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

The first example of a manganese(III) catalyst for the acceptorless dehydrogenation of alcohols is presented. N,N’-Bis(salicylidene)-1,2-cyclohexanediaminomanganese(III) chloride (2) has been shown to catalyze the direct synthesis of imines from a variety of alcohols and amines with the liberation of hydrogen gas. The mechanism has been investigated experimentally with labelled substrates and theoretically with DFT calculations. The results indicate a metal-ligand bifunctional pathway in which both imine groups in the salen ligand are first reduced to form a manganese(III) amido complex as the catalytically active species. Dehydrogenation of the alcohol then takes place by a stepwise outer-sphere hydrogen transfer generating a manganese(III) salan hydride from which hydrogen gas is released.

Recommanded Product: 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Samuelsen, S; Santilli, C; Ahlquist, MSG; Madsen, R or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2019.0 J MED CHEM published article about DIHYDROFOLATE-REDUCTASE; THYMIDYLATE SYNTHASE; BINDING MODES; LEISHMANIA; IDENTIFICATION; ASSAY; DERIVATIVES; VALIDATION; SOLUBILITY; RESISTANCE in [Linciano, Pasquale; Luciani, Rosaria; Sesenna, Antony; Quotadamo, Antonio; Costantino, Luca; Costi, Maria Paola] Univ Modena & Reggio Emilia, Dipartimento Sci Vita, Via Campi 103, I-41125 Modena, Italy; [Pozzi, Cecilia; dello Iacono, Lucia; di Pisa, Flavio; Landi, Giacomo; Bonucci, Alessio; Mangani, Stefano] Univ Siena, Dipartimento Biotecnol Chim & Farm, Via Aldo Moro 2, I-53100 Siena, Italy; [Gul, Sheraz; Kuzikov, Maria; Ellinger, Bernhard; Witt, Gesa] Fraunhofer Inst Mol Biol & Appl Ecol Screening Po, D-22525 Hamburg, Germany; [Santarem, Nuno; Baptista, Catarina] Inst Mol & Cell Biol, P-4150180 Porto, Portugal; [Santarem, Nuno; Baptista, Catarina] Univ Porto, Inst Invest & Inovacao Saude, P-4150180 Porto, Portugal; [Franco, Caio; Moraes, Carolina B.] CNPEM, Lab Nacl Biociencias LNBio, BR-13083100 Campinas, SP, Brazil; [Mueller, Wolfgang; Wittig, Ulrike] HITS, Sci Databases & Visualizat Grp, D-69118 Heidelberg, Germany; [Wittig, Ulrike] HITS, Mol & Cellular Modeling Grp, D-69118 Heidelberg, Germany; [Franco, Caio; Moraes, Carolina B.] Univ Sao Paulo, Dept Microbiol, Inst Biomed Sci, BR-05508900 Sao Paulo, SP, Brazil in 2019.0, Cited 57.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Name: Diphenylmethanamine

2-Amino-benzo[d]thiazole was identified as a new scaffold for the development of improved pteridine reductase-1 (PTR1) inhibitors and anti-trypanosomatidic agents. Molecular docking and crystallography guided the design and synthesis of 42 new benzothiazoles. The compounds were assessed for Trypanosoma brucei and Leishmania major PTR1 inhibition and in vitro activity against T. brucei and amastigote Leishmania infantum. We identified several 2-amino-benzo[d]thiazoles with improved enzymatic activity (TbPTR1 IC50 = 0.35 mu M; LmPTR1 IC50 = 1.9 mu M) and low mu M antiparasitic activity against T. brucei. The ten most active compounds against TbPTR1 were able to potentiate the antiparasitic activity of methotrexate when evaluated in combination against T. brucei, with a potentiating index between 1.2 and 2.7. The compound library was profiled for early ADME toxicity, and 2-amino-N-benzylbenzo[d]thiazole-6-carboxamide (4c) was finally identified as a novel potent, safe, and selective anti-trypanocydal agent (EC50 = 7.0 mu M). Formulation of 4c with hydroxypropyl-beta-cyclodextrin yielded good oral bioavailability, encouraging progression to in vivo studies.

Name: Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Linciano, P; Pozzi, C; dello Iacono, L; di Pisa, F; Landi, G; Bonucci, A; Gul, S; Kuzikov, M; Ellinger, B; Witt, G; Santarem, N; Baptista, C; Franco, C; Moraes, CB; Muller, W; Wittig, U; Luciani, R; Sesenna, A; Quotadamo, A; Ferrari, S; Pohner, I; Cordeiro-Da-Silva, A; Mangani, S; Costantino, L; Costi, MP or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

SDS of cas: 91-00-9. In 2019 NATURE published article about DIAZO TRANSFER; IMIDAZOLE-1-SULFONYL AZIDE; DIAZOTRANSFER; CYCLOADDITION; ALKYNES; AMINES; SUFEX; SAFE in [Meng, Genyi; Guo, Taijie; Ma, Tiancheng; Zhang, Jiong; Shen, Yucheng; Sharpless, Karl Barry; Dong, Jiajia] Univ Chinese Acad Sci, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem,Chinese Acad Sci, Shanghai, Peoples R China in 2019, Cited 33. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

Click chemistry is a concept in which modular synthesis is used to rapidly find new molecules with desirable properties(1). Copper(I)-catalysed azide-alkyne cycloaddition (CuAAC) triazole annulation and sulfur(VI) fluoride exchange (SuFEx) catalysis are widely regarded as click reactions(2-4), providing rapid access to their products in yields approaching 100% while being largely orthogonal to other reactions. However, in the case of CuAAC reactions, the availability of azide reagents is limited owing to their potential toxicity and the risk of explosion involved in their preparation. Here we report another reaction to add to the click reaction family: the formation of azides from primary amines, one of the most abundant functional groups(5). The reaction uses just one equivalent of a simple diazotizing species, fluorosulfuryl azide(6-11) (FSO2N3), and enables the preparation of over 1,200 azides on 96-well plates in a safe and practical manner. This reliable transformation is a powerful tool for the CuAAC triazole annulation, the most widely used click reaction at present. This method greatly expands the number of accessible azides and 1,2,3-triazoles and, given the ubiquity of the CuAAC reaction, it should find application in organic synthesis, medicinal chemistry, chemical biology and materials science.

About Diphenylmethanamine, If you have any questions, you can contact Meng, GY; Guo, TJ; Ma, TC; Zhang, J; Shen, YC; Sharpless, KB; Dong, JJ or concate me.. SDS of cas: 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about HETEROCYCLIC CARBENE LIGANDS; H BOND ACTIVATION; ASYMMETRIC HYDROGENATION; B(C6F5)(3)-CATALYZED HYDROSILATION; BORANE; IMINES; ACIDITY; HYDROSILYLATION; POLYMERIZATION; BORYLATION, Saw an article supported by the EPSRCUK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC) [EP/R00188X/1]; AstraZenecaAstraZeneca; Royal SocietyRoyal Society of LondonEuropean Commission [UF/160395]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Mercea, DM; Howlett, MG; Piascik, AD; Scott, DJ; Steven, A; Ashley, AE; Fuchter, MJ. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Recommanded Product: 91-00-9

Enantioselective reduction of ketimines was demonstrated using chiral N-heterocyclic carbene (NHC)-stabilised borenium ions in frustrated Lewis pair catalysis. High levels of enantioselectivity were achieved for substrates featuring secondary N-alkyl substituents. Comparative reactivity and mechanistic studies identify key determinants required to achieve useful enantioselectivity and represent a step forward in the further development of enantioselective FLP methodologies.

About Diphenylmethanamine, If you have any questions, you can contact Mercea, DM; Howlett, MG; Piascik, AD; Scott, DJ; Steven, A; Ashley, AE; Fuchter, MJ or concate me.. Recommanded Product: 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics