Tag: M.W=150-200

I found the field of Chemistry very interesting. Saw the article Effects of ruthenium hydride species on primary amine synthesis by direct amination of alcohols over a heterogeneous Ru catalyst published in 2020.0. Formula: C13H13N, Reprint Addresses Hara, M (corresponding author), Tokyo Inst Technol, Lab Mat & Struct, Inst Innovat Res, Midori Ku, 4259 Nagatsuta Cho, Yokohama, Kanagawa 2268503, Japan.; Hara, M (corresponding author), Japan Sci & Technol Agcy JST, Adv Low Carbon Technol Res & Dev Program ALCA, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Heterogeneously catalysed synthesis of primary amines by direct amination of alcohols with ammonia has long been an elusive goal. In contrast to reported Ru-based catalytic systems, we report that Ru-MgO/TiO(2)acts as an effective heterogeneous catalyst for the direct amination of a variety of alcohols to primary amines at low temperatures ofca.100 degrees C without the introduction of H(2)gas. The present system could be applied to a variety of alcohols and provides an efficient synthetic route for 2,5-bis(aminomethyl)furan (BAMF), an attention-getting biomonomer. The high catalytic performance can be rationalized by the reactivity tuning of Ru-H species using MgO. Spectroscopic measurements suggest that MgO enhances the reactivity of hydride species by electron donation from MgO to Ru.

Formula: C13H13N. About Diphenylmethanamine, If you have any questions, you can contact Kita, Y; Kuwabara, M; Yamadera, S; Kamata, K; Hara, M or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Metal-Free Transamidation of Primary Amides using Trimethylsilyl Chloride WOS:000487092300006 published article about CATALYZED TRANSAMIDATION; EFFICIENT CATALYST; CARBOXYLIC-ACIDS; SECONDARY AMIDES; CARBOXAMIDES; AMINES; SOLVENT; UREAS; COMPLEX in [Yu, Subeen; Lee, Sunwoo] Chonnam Natl Univ, Dept Chem, Gwangju 61186, South Korea; [Song, Kwang Ho] Korea Univ, Dept Chem & Biol Engn, Seoul 02841, South Korea in 2019.0, Cited 66.0. Quality Control of Diphenylmethanamine. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A metal-free transamidation of primary amides was developed. Trimethylsilyl chloride (TMSCl) acted as the activator in transamidation. In the presence of TMSCl, primary amides reacted with primary amines to yield transamidated secondary amides in NMP solvent. The transamidation of benzamide with secondary amines for the formation of tertiary amides succeeds in an NMP/CHCl3 solvent mixture.

About Diphenylmethanamine, If you have any questions, you can contact Yu, S; Song, KH; Lee, S or concate me.. Quality Control of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Name: Diphenylmethanamine. Authors Sun, WN; Chen, XL; Huang, SZ; Li, WP; Tian, CY; Yang, SY; Li, LL in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Sun, Weining; Tian, Chenyu; Li, Linli] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Minist Educ, Chengdu 610041, Sichuan, Peoples R China; [Chen, Xiuli; Huang, Shenzhen; Li, Wenpei; Yang, Shengyong] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China; [Chen, Xiuli; Huang, Shenzhen; Li, Wenpei; Yang, Shengyong] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Sichuan, Peoples R China in 2020, Cited 14. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

SIRT6 is a deacetylase of histone H3 and inhibitors of SIRT6 have been thought as potential agents for treatment of diabetes. Herein we report the discovery of a series of new SIRT6 inhibitors containing the skeleton 1-phenylpiperazine. Among them, compound 5-(4-methylpiperazin-1-yl)-2-nitroaniline (6d) is the most potent one, which showed an IC50 value of 4.93 mu M against SIRT6 in the Fluor de Lys (FDL) assay. It displayed K-D values of 9.76 mu M and 10 mu M in surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) assays, respectively. In selectivity assay, 6d showed no activity against other members of the HDAC family (SIRT1-3 and HDAC1-11) at concentrations up to 200 mu M. In a mouse model of type 2 diabetes, 6d could significantly increase the level of glucose transporter GLUT-1, thereby reducing blood glucose. Overall, this study provides a promising lead compound for subsequent drug discovery targeting SIRT6.

Name: Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Sun, WN; Chen, XL; Huang, SZ; Li, WP; Tian, CY; Yang, SY; Li, LL or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recently I am researching about DIHYDROFOLATE-REDUCTASE; THYMIDYLATE SYNTHASE; BINDING MODES; LEISHMANIA; IDENTIFICATION; ASSAY; DERIVATIVES; VALIDATION; SOLUBILITY; RESISTANCE, Saw an article supported by the European Union’s Seventh Framework Programme for Research, Technological Development, and Demonstration [603240]; Klaus Tschira Foundation. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Linciano, P; Pozzi, C; dello Iacono, L; di Pisa, F; Landi, G; Bonucci, A; Gul, S; Kuzikov, M; Ellinger, B; Witt, G; Santarem, N; Baptista, C; Franco, C; Moraes, CB; Muller, W; Wittig, U; Luciani, R; Sesenna, A; Quotadamo, A; Ferrari, S; Pohner, I; Cordeiro-Da-Silva, A; Mangani, S; Costantino, L; Costi, MP. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Category: amides-buliding-blocks

2-Amino-benzo[d]thiazole was identified as a new scaffold for the development of improved pteridine reductase-1 (PTR1) inhibitors and anti-trypanosomatidic agents. Molecular docking and crystallography guided the design and synthesis of 42 new benzothiazoles. The compounds were assessed for Trypanosoma brucei and Leishmania major PTR1 inhibition and in vitro activity against T. brucei and amastigote Leishmania infantum. We identified several 2-amino-benzo[d]thiazoles with improved enzymatic activity (TbPTR1 IC50 = 0.35 mu M; LmPTR1 IC50 = 1.9 mu M) and low mu M antiparasitic activity against T. brucei. The ten most active compounds against TbPTR1 were able to potentiate the antiparasitic activity of methotrexate when evaluated in combination against T. brucei, with a potentiating index between 1.2 and 2.7. The compound library was profiled for early ADME toxicity, and 2-amino-N-benzylbenzo[d]thiazole-6-carboxamide (4c) was finally identified as a novel potent, safe, and selective anti-trypanocydal agent (EC50 = 7.0 mu M). Formulation of 4c with hydroxypropyl-beta-cyclodextrin yielded good oral bioavailability, encouraging progression to in vivo studies.

Category: amides-buliding-blocks. About Diphenylmethanamine, If you have any questions, you can contact Linciano, P; Pozzi, C; dello Iacono, L; di Pisa, F; Landi, G; Bonucci, A; Gul, S; Kuzikov, M; Ellinger, B; Witt, G; Santarem, N; Baptista, C; Franco, C; Moraes, CB; Muller, W; Wittig, U; Luciani, R; Sesenna, A; Quotadamo, A; Ferrari, S; Pohner, I; Cordeiro-Da-Silva, A; Mangani, S; Costantino, L; Costi, MP or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Chemistry very interesting. Saw the article Selective Hydrogen Transfer in N-(Diphenylmethyl)-1-phenylethan-1-imine published in 2021.0. Safety of Diphenylmethanamine, Reprint Addresses Xing, JD (corresponding author), Taiyuan Univ Technol, Sch Biomed Engn, Taiyuan 030000, Peoples R China.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Proton transfer processes mediate many organic reactions. How to realize stereochemical control of this process has always been a challenging topic in the field of asymmetric catalysis. In this study, N-(diphenylmethyl)-1-phenylethan-1-imine (Schiff base derived from 2,2-diphenylethan-1-amine and acetophenone) was used as substrate, and different near neutral solvents and various chiral metal complex catalysts were used to carry out photoinduced C=N double bond transfer in the substrate under irradiation with a mercury ultraviolet lamp. The double bond transfer in the substrate molecule was highly selective. Solvents containing strong electronegative atoms like oxygen and chlorine, such as alcohols, aldehydes, and carbon tetrachloride, were more effective than other solvents under high light intensity. The 1,3-proton transfer process involves photoexcitation of the Schiff base and coordination of the latter to the central metal atom of the chiral catalyst, so that the substrate molecule is placed in a stable chiral environment to form a transition state. The strongly electronegative atom of the near-neutral solvent attracts the active a-hydrogen from the excited Schiff base molecule to form a negatively charged delocalized p-bond structure. The subsequent proton addition yields more stable molecular structure to complete the selective proton transfer process. Among the examined chiral catalysts, divalent tin porphyrin was the most effective, and the product yield and enantiomeric excess were 98% and 91.49%, respectively. The described photoinduced C=N double bond transfer in N-(diphenylmethyl)-1-phenylethan-1-imine is characterized by mild conditions (room temperature), high stereoselectivity, and simple operation.

About Diphenylmethanamine, If you have any questions, you can contact Li, J; Xing, JD; Shi, YB or concate me.. Safety of Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

COA of Formula: C13H13N. Recently I am researching about ASYMMETRIC-SYNTHESIS; HYDROPHOSPHONYLATION; AMINALIZATION; IMINES; ACID, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51373067]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Liu, YX; Wang, JD; Wei, ZL; Cao, JG; Liang, DP; Lin, YJ; Duan, HF. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

N,N’-Acetals are sensitive compounds, and the challenging asymmetric synthesis of acyclic N,N’-acetals by the general addition of amines to ketimines has never been reported so far. In this study, highly enantioselective addition of aryl amines to isatin-derived ketimines catalyzed by chiral urea derived from quinine was developed. A series of new acyclic N,N’-acetals were constructed by this protocol in high to excellent yields (78-99%) and high to excellent enantioselectivities (76-96% ee).

About Diphenylmethanamine, If you have any questions, you can contact Liu, YX; Wang, JD; Wei, ZL; Cao, JG; Liang, DP; Lin, YJ; Duan, HF or concate me.. COA of Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Chemical profiling of HIV-1 capsid-targeting antiviral PF74 published in 2020.0. Recommanded Product: 91-00-9, Reprint Addresses Wang, ZQ (corresponding author), Univ Minnesota, Coll Pharm, Ctr Drug Design, Minneapolis, MN 55455 USA.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

The capsid protein (CA) of HIV-1 plays essential roles in multiple steps of the viral replication cycle by assembling into functional capsid core, controlling the kinetics of uncoating and nuclear entry, and interacting with various host factors. Targeting CA represents an attractive yet underexplored antiviral approach. Of all known CA-targeting small molecule chemotypes, the peptidomimetic PF74 is particularly interesting because it binds to the same pocket used by a few important host factors, resulting in highly desirable antiviral phenotypes. However, further development of PF74 entails understanding its pharmacophore and mitigating its poor metabolic stability. We report herein the design, synthesis, and evaluation of a large number of PF74 analogs aiming to provide a comprehensive chemical profiling of PF74 and advance the understanding on its detailed binding mechanism and pharmacophore. The analogs, containing structural variations mainly in the aniline domain and/or the indole domain, were assayed for their effect on stability of CA hexamers, antiviral activity, and cytotoxicity. Selected analogs were also tested for metabolic stability in liver microsomes, alone or in the presence of a CYP3A inhibitor. Collectively, our studies identified important pharmacophore elements and revealed additional binding features of PF74, which could aid in future design of improved ligands to better probe the molecular basis of CA-host factor interactions, design strategies to disrupt them, and ultimately identify viable CA-targeting antiviral leads. (C) 2020 Elsevier Masson SAS. All rights reserved.

Recommanded Product: 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Wang, L; Casey, MC; Vernekar, SKV; Do, HT; Sahani, RL; Kirby, KA; Du, HJ; Hachiya, A; Zhang, HC; Tedbury, PR; Xie, JS; Sarafianos, SG; Wang, ZQ or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Product Details of 91-00-9. In 2020.0 SYNTHETIC COMMUN published article about KABACHNIK-FIELDS REACTION; DOT-H DISTANCES; DERIVATIVES; SOLVENT; BONDS; ACIDS; DFT in [Hudson, Harry R.] London Metropolitan Univ, Fac Life Sci & Comp, London, England; [Tajti, Adam; Balint, Erika; Czugler, Matyas; Keglevich, Gyorgy] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1521 Budapest, Hungary; [Karaghiosoff, Konstantin] Ludwig Maximilians Univ Munchen, Dept Chem, Munich, Germany in 2020.0, Cited 38.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

A series of N-benzhydryl protected alpha-aminophosphonates with alpha-phenyl, alpha-(1-naphtyl), alpha-(9-anthryl) or alpha-(1-pyrenyl) substituents was synthesized by the Kabachnik-Fields condensation of diphenylmethylamine (benzhydrylamine), the corresponding aryl aldehyde and a dialkyl phosphite under MW irradiation. X-ray studies performed at low temperatures for a few of these alpha-aminophosphonates confirmed the presence of unusually short intramolecular C-alpha-H delta+ center dot center dot center dot H delta+-C-peri contacts. [GRAPHICS] .

About Diphenylmethanamine, If you have any questions, you can contact Hudson, HR; Tajti, A; Balint, E; Czugler, M; Karaghiosoff, K; Keglevich, G or concate me.. Product Details of 91-00-9

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocks. Recently I am researching about SOLID-PHASE SYNTHESIS; DDE; STRATEGY; ACIDS; FMOC; BOC, Saw an article supported by the Ministry of Science and Technology of the Republic of China, TaiwanMinistry of Science and Technology, Taiwan [MOST 108-2113-M-029-001]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Chithanna, S; Vyasamudri, S; Yang, DY. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

A simple protocol for the protection of amines was realized through a base-catalyzed one-pot reaction of dimedone, beta-nitroalkene, and amine. Employing this strategy, a variety of amines/amino acids were protected in excellent yields. These acid/base stable protected amines can be deprotected by either ethylene diamine or hydrazine hydrate under mild conditions. The practical application of this orthogonal protecting group was demonstrated by the synthesis of cyclic peptide melanotan II via SPPS.

Category: amides-buliding-blocks. About Diphenylmethanamine, If you have any questions, you can contact Chithanna, S; Vyasamudri, S; Yang, DY or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Quality Control of Diphenylmethanamine. I found the field of Chemistry very interesting. Saw the article Water-mediated C-H activation of arenes with secure carbene precursors: the reaction and its application published in 2019, Reprint Addresses Wang, QT; Wu, Y (corresponding author), Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Sichuan Engn Lab Plant Sourced Drug, Educ Minist,West China Sch Pharm, Chengdu 610041, Sichuan, Peoples R China.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine.

A water-mediated C-H activation using sulfoxonium ylides is reported, providing a general, green and step-economic approach to construct a C-C bond and varieties of useful N-heterocycle scaffolds. Notably, the water-mediated activation, in contrast to that in organic solvents, shows great potential in pharmaceutical, biochemistry and chemical industries.

Quality Control of Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Nie, RF; Lai, RZ; Lv, SY; Xu, YY; Guo, L; Wang, QT; Wu, Y or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics