Tag: M.W=150-200

Liu, Zhi published the artcileROS-triggered degradable iron-chelating nanogels: Safely improving iron elimination in vivo, Related Products of amides-buliding-blocks, the publication is Journal of Controlled Release (2018), 84-93, database is CAplus and MEDLINE.

Iron-mediated generation of highly toxic Reactive Oxygen Species (ROS) plays a major role in the process leading to iron overload-related diseases. The long-term s.c. administration of Deferoxamine (DFO) is currently clin.-approved to improve patient symptoms and survival. However, non-specific toxicity and short circulation times of the drug in humans often leads to poor patient compliance. Herein, thioketal-based ROS-responsive polymeric nanogels containing DFO moieties (rNG-DFO) were designed to chelate iron and to degrade under oxidative stimuli into fragments <10 nm to enhance excretion of iron-bound chelates. Serum ferritin levels and iron concentrations in major organs of IO mice decreased following treatment with rNG-DFO, and fecal elimination of iron-bound chelates increased compared to free DFO. Furthermore, rNG-DFO decreased iron mediated oxidative stress levels in vitro and reduced iron-mediated inflammation in the liver of IO mice. The study confirms that ROS-responsive nanogels may serve as a promising alternative to DFO for safer and more efficient iron chelation therapy.

Journal of Controlled Release published new progress about 1869-45-0. 1869-45-0 belongs to amides-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is 2,2,2-Trifluoro-N-(2-mercaptoethyl)acetamide, and the molecular formula is C4H6F3NOS, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Queen, Z. Edel published the artcileThe GC MS study of one ayurvedic preparation Amrithamehari churnam, Computed Properties of 2447-79-2, the publication is International Journal of Pharmaceutical Sciences Review and Research (2016), 39(2), 169-172, database is CAplus.

Amrithamehari churnam is an Ayurvedic formulation for the treatment of diabetes, weight loss and bladder disorders. The present study deals with the GC MS anal. of of Amrithamehari churnam. Fifty different peaks were observed indicating various bimols. It was observed that there is an indication of the presence of some compounds such as Pyridinium, 1-(2-hydrazino-2-oxoethyl)-, chloride, Arsonous dichloride, methyl-, 1-Dodecane, 2-Methoxy-4-vinylphenol, 1-Undecanol, 1-hexadecanol, Artumerone, Tumerone, Curlone, 4-Isoquinolinecarboxylic acid, 2, 3, 5, 6, 7, 8-hexahydro-3-oxo-, 1-Docosene, Squalene, á-Sitosterol, Benzenepropanoic acid, 3, 5-bis(1,1-dimethylethyl)-4-hydroxy etc. The medicinal values of each compound have similarity with that of the main drug, Amrithamehari churnam. Further work is in progress to prove the efficacy of this drug by standard methods.

International Journal of Pharmaceutical Sciences Review and Research published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Computed Properties of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Yang, Jianzhong published the artcile3H-1,2,4-Dithiazol-3-one compounds as novel potential affordable antitubercular agents, Product Details of C8H9NOS, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(5), 1424-1427, database is CAplus and MEDLINE.

Small mols. with oxathiazol-2-one moiety were recently reported as potent inhibitors of Mycobacterium bovis var. bacilli Calmette-Guerin (BCG), among which HT1171 (I) was the most potent and selective proteasome inhibitor. Herein we synthesized a series of novel compounds by bioisosteric replacement of the oxathiazol-2-one ring with 3H-1,2,4-dithiazol-3-one, and also fifteen 1,3,4-oxathiazol-2-one mols. in order for potency comparison and structure-activity relationship elucidation since their antibacterial effects on the virulent strains were not evaluated before. All the compounds were assessed for antitubercular activities on the virulent H37Rv strain by a serial dilution method. Among the tested compounds, 3H-1,2,4-dithiazol-3-one derivative II was found to be the most active with a lowest MIC₉₀ value of 1 μg/mL. Furthermore, the cytotoxicities of all the compounds against normal human liver cell line L02 were determined by an MTT method. Compound II displayed a lower inhibitory ratio than HT1171 at the concentration of 100 μM, indicating its better safety profile.

Bioorganic & Medicinal Chemistry Letters published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C27H39ClN2, Product Details of C8H9NOS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bravo-Zhivotovskii, D. A. published the artcileReactions of triethylgermyllithium with N,N-dialkylated carboxamides, Related Products of amides-buliding-blocks, the publication is Journal of Organometallic Chemistry (1983), 248(1), 51-60, database is CAplus.

AcNMe₂, Me₃CCONMe₂, F₃CCONEt₂ and BzNEt₂ reacted with Et₃GeLi, which is made from (Et₃Ge)₂Hg and Li in hexane, to give the corresponding acyltriethylgermanes as the principal product. The regioselectivity depends markedly on the reaction conditions and the nature of the acyl fragment of amides. Thus, Et₃GeLi reacted with AcNMe₂ as metalating agent to give LiCH₂CONMe₂ in THF. Mechanistic interpretations of these results are discussed.

Journal of Organometallic Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bravo-Zhivotovskii, D. A. published the artcileReaction of triethylgermyllithium with N,N-dialkylamides of carboxylic acids, Application In Synthesis of 360-92-9, the publication is Zhurnal Obshchei Khimii (1983), 53(8), 1838-43, database is CAplus.

The title reaction gives the corresponding acylgermanes. The regioselectivity of the reaction depends on the nature of the acyl fragment, the solvent and temperature Thus, reaction of Et₃GeLi with BzNEt₂ in hexane at 20° gave 88% BzGeEt₃.

Zhurnal Obshchei Khimii published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Application In Synthesis of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bravo-Zhivotovskii, D. A. published the artcileReactions of triethylgermyllithium with N,N-dialkylamides of carboxylic acids, Product Details of C6H10F3NO, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1982), 949-51, database is CAplus.

Reaction of Et₃Geli with RCONR¹₂ (R = Ph, R¹ = Et; R = Me, Me₃C, R¹ = Me) gave RCOGeEt₃ (I) and products from the reaction of I with the formed Li derivatives

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Product Details of C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Li, Shasha published the artcileMerging Late-Stage Diversification with Solid-Phase Peptide Synthesis Enabled by High-Throughput On-Resin Reaction Screening, Application of (6-Acetamidopyridin-3-yl)boronic acid, the publication is ACS Catalysis (2022), 12(5), 3201-3210, database is CAplus.

An integrated workflow is described that combines micromole-scale high-throughput experimentation (HTE) reaction screening and solid-phase peptide synthesis (SPPS) to enable rapid synthetic method development for on-resin peptide diversification. Using this new approach, we have identified several sets of robust Suzuki-Miyaura coupling conditions with complementary scope that collectively display broad coverage with respect to both resin-bound peptide substrates containing aryl halide side chains and (hetero)arylboronic acid coupling partners. We have also demonstrated the utility of this integrated SPPS/chem. diversification method by synthesizing a multidimensional library of diverse peptides in high yields.

ACS Catalysis published new progress about 947533-21-3. 947533-21-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Boronic acid and ester,Amine,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (6-Acetamidopyridin-3-yl)boronic acid, and the molecular formula is C7H9BN2O3, Application of (6-Acetamidopyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sud’enkov, Yu. Ya. published the artcileReaction of poly- and perfluoroalkyl perfluoroisopropyl ketones with secondary amines, Quality Control of 360-92-9, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1978), 477-9, database is CAplus.

RCOCF(CF₃)₂ [I; R = CF₃, HCF₂CF₂, H(CF₂)₄] reacted with morpholine at 60° to give 63.3-76.1% RCOX (X = morpholino) and (CF₃)₂CFH. I (R = CF₃, HCF₂) reacted analogously with Et₂NH, I (R = HCF₂CF₂) gave 24.0-47.9% HCF₂CF₂COX (X = NEt₂, NHEt) and 9.4% HCF₂CF₂CH(OH)CF(CF₃)₂ and I [R = H(CF₂)₄] gave 38.1% H(CF₂)₄CONHEt and 35.1% H(CF₂)₄CH(OH)CF(CF₃)₂. HCF₂CF₂COX (X = NEt₂, NHEt) were also prepared from (HCF₂CF₂CO)₂O and the amines.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C20H28BNO5, Quality Control of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Owston, Nathan A. published the artcileIridium-catalyzed conversion of alcohols into amides via oximes, Application In Synthesis of 2447-79-2, the publication is Organic Letters (2007), 9(1), 73-75, database is CAplus and MEDLINE.

The iridium catalyst [Ir(Cp*)Cl₂]₂ is effective for the rearrangement of oximes to furnish amides. The reaction has been combined with catalytic transfer hydrogenation between an alc. and alkene to allow the conversion of alcs. into amides in a one-pot process.

Organic Letters published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Application In Synthesis of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Owston, Nathan A. published the artcileHighly efficient ruthenium-catalyzed oxime to amide rearrangement, Quality Control of 2447-79-2, the publication is Organic Letters (2007), 9(18), 3599-3601, database is CAplus and MEDLINE.

A wide range of aldoximes has been converted into the corresponding amides using the ruthenium-based catalyst Ru(PPh₃)₃(CO)H₂/dppe/TsOH. The amides were generated in high yield and selectivity, with catalyst loading as low as 0.04 mol %.

Organic Letters published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Quality Control of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics