Tag: M.W=150-200

Datta, Bandita published the artcileSilica chloride-catalyzed microwave-assisted efficient and selective one-pot synthesis of amides from aldehydes, Recommanded Product: 2,4-Dichlorobenzamide, the publication is Bulletin of the Korean Chemical Society (2012), 33(7), 2129-2130, database is CAplus.

A one-pot selective conversion of aromatic aldehydes to amides with NH₂OH.HCl by catalytic SiO₂-Cl in a microwave reactor at 100 W was presented. This synthesis is suitable for electron-withdrawing and electron-donating aldehydes. The developed protocol has advantages of short reaction time and high yields, utilizes an efficient and recyclable heterogeneous catalyst, and follows green chem. norms.

Bulletin of the Korean Chemical Society published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Recommanded Product: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Pandey, Lokesh Kumar published the artcileA thiophosphoryl chloride assisted transformation of arylaldoximes to thioamides, COA of Formula: C8H9NOS, the publication is Synthesis (2012), 44(3), 377-379, database is CAplus.

Primary benzothioamides were accessed from benzaldoximes (benzaldehyde oximes) via benzonitriles in a sequential tandem approach utilizing thiophosphoryl chloride as a dehydrating and thionating agent.

Synthesis published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, COA of Formula: C8H9NOS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Lunazzi, L. published the artcileConformational analysis in heteroaromatic carbonyl compounds. I. Radical anions of 2,5-thiophenedicarboxaldehyde and related derivatives, Category: amides-buliding-blocks, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) (1972), 751-4, database is CAplus.

The room temperature ESR spectrum of the photolytically generated radical anion of 2,5-thio-phenedicarboxaldehyde (I) showed the existence of 2 of the 3 possible rotational isomers. The less stable was the O-cis-trans isomer as seen from the nonequivalence of the thiophene proton splittings. Examination of several derivatives of I, e.g. thieno[3,2-b]-thiophene-2,5-dicarboxaldehyde, with different steric requirements allowed the assignment of the O-cis-cis conformation to the other rotamer.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Robins, Morris J. published the artcileImproved Syntheses of 5′-S-(2-Aminoethyl)-6-N-(4-nitrobenzyl)-5′-thioadenosine (SAENTA), Analogues, and Fluorescent Probe Conjugates: Analysis of Cell-Surface Human Equilibrative Nucleoside Transporter 1 (hENT1) Levels for Prediction of the Antitumor Efficacy of Gemcitabine, Quality Control of 1869-45-0, the publication is Journal of Medicinal Chemistry (2010), 53(16), 6040-6053, database is CAplus and MEDLINE.

5′-S-(2-Aminoethyl)-6-N-(4-nitrobenzyl)-5′-thioadenosine (SAENTA), 5′-S-(2-acetamidoethyl)-6-N-[(4-substituted)benzyl]-5′-thioadenosine analogs, 5′-S-[2-(6-aminohexanamido)]ethyl-6-N-(4-nitrobenzyl)-5′-thioadenosine (SAHENTA), and related compounds were synthesized by S_NAr displacement of fluoride from 6-fluoropurine intermediates with 4-(substituted)-benzylamines. Conjugation of the pendant amino groups of SAENTA and SAHENTA with fluorescein-5-yl isothiocyanate (FITC) gave fluorescent probes that bound at nanomolar concentrations specifically to human equilibrative nucleoside transporter 1 (hENT1) produced in recombinant form in model expression systems and in native form in cancer cell lines. Transporter binding effects were studied and the ability of the probes to predict the potential antitumor efficacy of 2′-deoxy-2′,2′-difluorocytidine (gemcitabine) was demonstrated.

Journal of Medicinal Chemistry published new progress about 1869-45-0. 1869-45-0 belongs to amides-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is 2,2,2-Trifluoro-N-(2-mercaptoethyl)acetamide, and the molecular formula is C4H6F3NOS, Quality Control of 1869-45-0.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rihova, Martina published the artcilePhysical and physico-chemical properties of thiobenzamides. Part 11. High-performance liquid chromatography of thiobenzamide derivatives with ultraviolet photometric and electrochemical detection, Product Details of C8H9NOS, the publication is Journal of Chromatography (1986), 347-54, database is CAplus.

Twenty-five thiobenzamide derivatives were separated on a reversed-phase system on various stationary phases, with UV photometric and voltammetric detection. The best results were obtained by using a Partisil ODS column (10 μm, 250 mm × 4.6 mm inner diameter) with a mobile phase consisting of 0.05M NaH₂PO₄ with 30% (volume/volume) MeOH, containing 1.2 × 10^-4M EDTA, at a flow-rate of 1.0 mL/min. Voltammetric detection on a carbon-fiber electrode at +1.4 V (Ag-AgCl) is more sensitive than UV photometric detection at 254 nm, typical detection limits being ∼0.1 and 1.0 ng. Voltammetric calibration curves exhibit good linearity and the measurements are reproducible (relative standard deviation of ca. 2%).

Journal of Chromatography published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, Product Details of C8H9NOS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhang, Juntian published the artcileAtypical Mode of [3 + 2]-Cycloaddition: Pseudo-1,3-dipole Behavior in Reactions of Electron-Deficient Thioamides with Benzynes, Quality Control of 360-92-9, the publication is Organic Letters (2018), 20(18), 5550-5553, database is CAplus and MEDLINE.

Thioamides bearing electron-withdrawing groups on the thiocarbonyl carbon atom react with benzynes [generated by the hexadehydro-Diels-Alder cycloisomerization] in an unprecedented fashion. Namely, the dihydrobenzothiazole products are consistent with a pathway involving initial formation of a stabilized ammonium ylide by a rare type of [3 + 2]-cycloaddition reaction. The fate of this species depends upon the nature of the substituents attached to the ylide nitrogen atom. The demonstration of new modes of reactivity represents the major advance arising from this study.

Organic Letters published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C8H7NO4, Quality Control of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Guo, Chuangxing published the artcileDesign of oxobenzimidazoles and oxindoles as novel androgen receptor antagonists, Formula: C8H9BFNO3, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(7), 2572-2578, database is CAplus and MEDLINE.

Oxobenzimidazoles (e.g., 1), a novel series of androgen receptor (AR) antagonists, were discovered through de novo design guided by structure-based drug design. The compounds in this series were reasonably permeable and metabolically stable, but suffered from poor solubility The incorporation of three dimensional structural features led to improved solubility In addition, the observation of a ‘flipped’ binding mode of an oxobenzimidazole analog in an AR ligand binding domain (LBD) model, led to the design and discovery of the novel oxindole series (e.g., 2, I) that is a potent full antagonist of AR.

Bioorganic & Medicinal Chemistry Letters published new progress about 849833-86-9. 849833-86-9 belongs to amides-buliding-blocks, auxiliary class Fluoride,Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (3-Fluoro-4-(methylcarbamoyl)phenyl)boronic acid, and the molecular formula is C8H9BFNO3, Formula: C8H9BFNO3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rao, Ashwin U. published the artcileSynthesis and structure-activity relationships of 2-(1,4′-bipiperidin-1′-yl)thiazolopyridines as H₃ receptor antagonists, HPLC of Formula: 947533-21-3, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(21), 6176-6180, database is CAplus and MEDLINE.

A series of 2-(1,4′-bipiperidin-1′-yl)thiazolopyridines I (X = N, Y = CH; X = CH, Y = N; R = H, H₂N, CN, Cl, MeCONH, 4-NCC₆H₄, 2-fluoro-3-pyridyl, 5-pyrimidyl, etc.) was synthesized and evaluated as a new lead of non-imidazole histamine H₃ receptor antagonists. Introduction of diversity at the 6-position of the pyridine ring was designed to enhance in vitro potency and decrease hERG activity. The structure-activity relationships for these new thiazolopyridine antagonists are discussed.

Bioorganic & Medicinal Chemistry Letters published new progress about 947533-21-3. 947533-21-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Boronic acid and ester,Amine,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (6-Acetamidopyridin-3-yl)boronic acid, and the molecular formula is C7H9BN2O3, HPLC of Formula: 947533-21-3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zaitseva, N.A. published the artcileSynthesis of fluorinated ketones with organolithium compounds and N,N-dialkylamides of fluorinated acids, Product Details of C6H10F3NO, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1961), 831-5, database is CAplus.

cf. CA 53, 17933g. Adding 17.2 g. CHF₂CONEt₂ (I) in Et₂O to PhLi (0.1 mole PhBr) in Et₂O at -70° and stirring 2 hrs. gave after treatment with dilute HCl 83% CHF₂Bz, b_10-12 63-5°, n²⁰_D 1.4900. Similar reaction with crystalline PhLi in MePh gave a 67% yield, while the use of PhNa in MePh gave but 29% product. 2-Thienyllithium and I gave 75% 2-CHF₂-COC₄H₃S, b₁₁ 77-80°, b₁₃ 80°. Similarly, PhLi and CF₃CONEt₂ (II) gave 74% CF₃Bz, b³⁷ 66-8°, 1.4578, in Et₂O, while the yield was 54.5% in MePh. 2-Thienyllithium and II in Et₂O gave 39% 2-CF₃COC₄H₃S, b_23-4 67°. CF₃COCl and Et₂NH in Et₂O at 0° gave 47.4% II, b₄₃ 74-5°. PhLi in Et₂O and CHFClCONEt₂ gave 53% CHFClBz, b₁₁ 91°. Addition of 40.8 g. I to 0.36 mole BuLi in Et₂O over 2 hrs. at room temperature gave 32.6% CHF₂COBu, b. 111-12°.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C4Br2N2O4S, Product Details of C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Nagl, Michael published the artcileThe BF₃.OEt₂-assisted conversion of nitriles into thioamides with Lawesson’s reagent, SDS of cas: 64559-06-4, the publication is Synthesis (2008), 4012-4018, database is CAplus.

A method for the thiolysis of nitriles by applying Lawesson’s reagent and facilitated by the addition of BF₃.OEt₂ is reported. The method opens an easy access to primary thioamides. Aromatic, benzylic, and aliphatic nitriles were converted into the corresponding thioamides in high to quant. yields (even in unfavorable cases, e.g., ortho-substituted benzonitriles). The reaction was performed in MeO(CH₂)₂OMe/THF or PhMe/OEt₂ solvent mixtures at 20-50°, and exhibited considerable selectivity in the case of multifunctional nitrile substrates, such as cyanomethyl N-acetylphenylalaninate, BzCH₂CN, 4-NCC₆H₄CONH₂, 4-AcC₆H₄CN, or 3-pentenenitrile.

Synthesis published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, SDS of cas: 64559-06-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics