Tag: M.W=150-200

Ahmadi, Abbas published the artcileSynthesis and Investigating Hypoglycemic and Hypolipidemic Activities of Some Glibenclamide Analogues in Rats, Recommanded Product: 2,4-Dichlorobenzamide, the publication is Mini-Reviews in Medicinal Chemistry (2014), 14(2), 208-213, database is CAplus and MEDLINE.

Glibenclamide (5-chloro-N-(4-[N-(cyclohexylcarbamoyl) sulfamoyl] phenethyl)-2-methoxybenzamide, Glyburide, E) is a well-known and potent second-generation of sulfonylurea oral hypoglycemic drug which is most widely used in type 2 diabetes recently. It acts upon pancreatic β -cells by stimulating insulin secretion in glucose and lipid-lowering activities. So far, many derivatives of E have been synthesized by adding new structural moieties to its structure while preserving its binding affinity to the receptor before their anti-hyperglycemic and anti hyperlipidemic activities being evaluated. In this study, new analogs of E after changing lipophilic side chain (5-chloro-2-methoxy benzamide) with 4- bromo-3, 5-dimethoxy benzamide and 2, 4-dichloro benzamide were synthesized. Also, their glucose and lipid-lowering activities were evaluated and compared to E and Tolbutamide (a famous first-generation of sulfonylurea oral hypoglycemic drug) by the known procedures. Findings showed that chloride substitution on lipophilic side chain of Glibenclamide could possibly increase the affinity of drug for receptor/or its half life time that resulted in more lasting anti-hyperglycemic and anti lipidemic activities in diabetic rats. However, bromide substitution with addnl. methoxy groups in benzamide ring could slightly improve the anti-hyperglycemic potency of the new drug compared to the root drug (E).

Mini-Reviews in Medicinal Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Recommanded Product: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Noei, Jalil published the artcileTiCl₃OTf-[bmim]Br, a novel and efficient catalyst system for chemoselective one-pot synthesis of thioamides from arylaldoximes, Product Details of C8H9NOS, the publication is Tetrahedron Letters (2008), 49(49), 6969-6971, database is CAplus.

The combination of TiCl₃OTf with 1-butyl-3-methylimidazolium bromide is an efficient and novel catalytic system for chemoselective one-pot transformation of arylaldoximes to their corresponding thioamides in high to excellent yields.

Tetrahedron Letters published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, Product Details of C8H9NOS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Jo, Woohyun published the artcileTransition-Metal-Free Regioselective Alkylation of Pyridine N-Oxides Using 1,1-Diborylalkanes as Alkylating Reagents, Formula: C10H14N2O, the publication is Angewandte Chemie, International Edition (2016), 55(33), 9690-9694, database is CAplus and MEDLINE.

Reported herein is an unprecedented base-promoted deborylative alkylation of pyridine N-oxides using 1,1-diborylalkanes as alkyl sources. The reaction proceeds efficiently for a wide range of pyridine N-oxides and 1,1-diborylalkanes with excellent regioselectivity. The utility of the developed method is demonstrated by the sequential C-H arylation and methylation of pyridine N-oxides. The reaction also can be applied to the direct introduction of a Me group to 9-O-methylquinine N-oxide; thus it can serve as a powerful method for late-stage functionalization.

Angewandte Chemie, International Edition published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Formula: C10H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bruun, L. published the artcileA quantitative enzyme-linked immunoassay for the detection of 2,6-dichlorobenzamide (BAM), a degradation product of the herbicide dichlobenil, Name: 2,4-Dichlorobenzamide, the publication is Journal of Immunological Methods (2000), 240(1-2), 133-142, database is CAplus and MEDLINE.

2,6-Dichlorobenzamide (BAM) is the dominant degradation product in soil of the widely used herbicide dichlobenil. To detect BAM in water, a highly sensitive and specific ELISA was developed. As an alternative to conventional coating of ELISA plates, the assay is based on direct covalent immobilization. A surface was achieved which requires a short time for the immobilization of ligand, is stable under dry storage, and which permits assays with a low CV. The performance of the assay was demonstrated by an inter-well CV that was generally less than 6%, a detection limit (DL₁₅) of 0.02 μg/l and an IC₅₀ of 0.19 μg/l. Cross-reactivity was measured against nine analytes with structural homol. to BAM. The highest degree of cross-reactivity (10.8%) was seen with 2,6-dichlorothiobenzamide (Chlorthiamid). Considering an EU-limit of 0.1 μg/l as the permissible maximum for the presence of pesticides in drinking water, this ELISA-procedure is suitable for large-scale screening of water samples suspected of being contaminated with BAM.

Journal of Immunological Methods published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Name: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rajendar, K. published the artcileMolecular Iodine-Mediated Domino Reaction for the Synthesis of Benzamides, 2,2-Diazidobenzofuran-3(2H)-ones and Benzoxazolones, SDS of cas: 2447-79-2, the publication is Advanced Synthesis & Catalysis (2013), 355(18), 3591-3596, database is CAplus.

A simple and efficient domino protocol has been developed for the preparation of biol. important benzamides, e.g., I, 2,2-diazidobenzofuran-3(2H)-ones, e.g., II, and benzoxazolones, e.g., III, from various structurally and electronically divergent acetophenones and ortho-hydroxyacetophenones in the presence of mol. iodine, sodium azide and sodium bicarbonate at 100 ⁰C in good to excellent yields.

Advanced Synthesis & Catalysis published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, SDS of cas: 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sathe, Pratima A. published the artcileTandem synthesis of aromatic amides from styrenes in water, SDS of cas: 2447-79-2, the publication is Tetrahedron Letters (2018), 59(29), 2820-2823, database is CAplus.

An expedient one-pot synthesis of aromatic amides from styrenes in the presence of N-bromosuccinimide and iodine by using aqueous ammonia in water is reported. The reaction proceeds through the formation of a α-bromoketone as an intermediate in the presence of NBS and water. The α-bromoketone on reaction with iodine forms bromodiiodoketone which on nucleophilic substitution with aqueous ammonia gives aromatic amide. Substituted aromatic amides were obtained in good yields with wide functional group compatibility.

Tetrahedron Letters published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, SDS of cas: 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Piskov, V. B. published the artcileConversion of carboxylic acids to amides, Related Products of amides-buliding-blocks, the publication is Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) (1973), 46(1), 220-1, database is CAplus.

Pelargonic, lauric, and (10) benzoic acid derivatives were converted to the resp. amides (≤99%) by heating with ≥2 equivalent of H2NSO3H in oleum or polyphosphoric acid at 100-20°; 3-02NC6H4CO2H and MeNHSO3H gave 89% 3-O2NC6H4CONHMe under similar conditions.

Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Stockmann, Vegar published the artcileStudies on reactive pyridylketones formed by Weinreb transformations, Application of N-Methoxy-N-methylisonicotinamide, the publication is Journal of Heterocyclic Chemistry (2012), 49(3), 613-620, database is CAplus.

A method was developed to allow the preparation of reactive pure vinyl pyridyl ketones and activated vinyl ketones, in general, to be used in further reactions, such as cycloadditions The process is based on the Weinreb’s amide transformation and includes a quaternary ammonium intermediate and subsequent elimination. Addnl., based on the authors’ previous results on the malonate alkylation of 3-nitropyridines and subsequent synthetic applications, they present studies on the transformation of Me 4-(methoxycarbonyl)-3-pyridineacetate via the corresponding Weinreb amide and reactive methylpyridyl- and allyl pyridyl ketones into isoquinoline derivatives

Journal of Heterocyclic Chemistry published new progress about 100377-32-0. 100377-32-0 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N-Methoxy-N-methylisonicotinamide, and the molecular formula is C6H3ClFNO2, Application of N-Methoxy-N-methylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rudzinski, DiAndra M. published the artcileA Weinreb amide approach to the synthesis of trifluoromethylketones, Quality Control of 100377-32-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2012), 48(77), 9610-9612, database is CAplus and MEDLINE.

A novel route to access trifluoromethylketones (TFMKs) from Weinreb amides is reported. This represents the first documented case of the Ruppert-Prakash reagent (TMS-CF₃) reacting in a constructive manner with an amide and enables synthesis of TFMKs without risk of over-trifluoromethylation.

Chemical Communications (Cambridge, United Kingdom) published new progress about 100377-32-0. 100377-32-0 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N-Methoxy-N-methylisonicotinamide, and the molecular formula is C8H10N2O2, Quality Control of 100377-32-0.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Yagupol’skii, Yu. L. published the artcileN-Substituted perfluoroalkyl thioamides and their derivatives, Quality Control of 360-92-9, the publication is Zhurnal Organicheskoi Khimii (1976), 12(10), 2213-17, database is CAplus.

RCONR1R2 (R = CF3, C3F7, C6F13; R1R2 = Et2, N-methylbenzothiazol-2-ylidene; R1 = H, R2 = Ph, benzothiazol-2-yl) reacted with P2S5 in pyridine to give the corresponding RCSNR1R2 (I) in 45-95% yield. Treating I with Cl gave RCCl2NR1R2 (R1 ≠ H) and RCCl:NR2. Treating I and PhNHCSPh with SF4 yielded RCF2NR1R2 and PhN:CFPh, resp.

Zhurnal Organicheskoi Khimii published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C20H21ClN4O4, Quality Control of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics