Tag: M.W=150-200

Rajca, Andrzej published the artcile5-Aryl-2-oxo-1,2,4-oxathiazoles as cyclocarbonylating agents for 2-aminoalcohols and 1,2-diamines, Synthetic Route of 2447-79-2, the publication is Synthesis (1983), 1032-3, database is CAplus.

Cyclocarbonylation of HOCH₂CH₂NHR (R = H, Me) with 2-oxo-5-phenyl- and 5-(2,4-dichlorophenyl)-2-oxo-1,3,4-oxathiazoles gave 68-82% I (X = O; R¹ = H). Similarly, RNHCHR¹CH₂NHR²(R, R¹, R² = H, Me) gave 65-88% I (X = NR²).

Synthesis published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Synthetic Route of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Putta, V. P. Rama Kishore published the artcileThe facile and efficient organocatalytic platform for accessing 1,2,4-selenadiazoles and thiadiazoles under aerobic conditions, SDS of cas: 64559-06-4, the publication is Tetrahedron Letters (2018), 59(10), 904-908, database is CAplus.

The organocatalytic approach towards synthesis of rarely explored 1,2,4-selenadiazole and thiadiazole scaffolds have been devised using corresponding carboxamides as substrates. The transformations were realized using two distinct conditions in the presence of catalytic vitamin B₃ or thiourea under aerobic conditions. Developed methods overcome the associated limitations of previous reported approaches and the desired products were obtained in high yields and selectivity without the formation of toxic side-products.

Tetrahedron Letters published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, SDS of cas: 64559-06-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Bryantsev, Vyacheslav S. published the artcileInvestigation of Fluorinated Amides for Solid-Electrolyte Interphase Stabilization in Li-O₂ Batteries Using Amide-Based Electrolytes, Computed Properties of 360-92-9, the publication is Journal of Physical Chemistry C (2013), 117(23), 11977-11988, database is CAplus.

Solvent and electrode stability is critical for the successful development of the rechargeable, organic electrolyte Li-O₂ (air) battery. Straight-chain alkyl amides, such as N,N-dimethylacetamide (DMA), show superior stability at the O₂ cathode compared to organic carbonates and glymes, but these solvents do not form a stable solid-electrolyte interphase (SEI) to prevent a sustained reaction with Li metal. In this work, we use electrochem. impedance spectroscopy and cycling tests on a sym. Li/electrolyte/Li cell to determine the ability of several fluorinated amide solvents to stabilize the lithium/electrolyte interface. The LiTFSI/N,N-dimethyltrifluoroacetamide (DMTFA) system shows the smallest interfacial impedance and the lowest polarization for Li dissolution and deposition. We present quantum chem. calculations indicating that α-fluorinated alkyl amides are reduced on Li to form insoluble LiF with no or little activation energy. XPS anal. confirms the presence of LiF in the SEI on Li metal exposed to DMTFA, which is likely to play an important role in stabilizing the lithium/electrolyte interface. The improved stability of a metallic Li anode in a rechargeable Li-O₂ battery with LiTFSI/DMA electrolyte is demonstrated using 2% DMTFA as the SEI-stabilizing additive.

Journal of Physical Chemistry C published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Computed Properties of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sleevi, P. published the artcileTrifluoroacetyl chloride for characterization of organic functional groups by fluorine-19 nuclear magnetic resonance spectrometry, Formula: C6H10F3NO, the publication is Analytical Chemistry (1979), 51(12), 1931-4, database is CAplus.

The potential utility of trifluoroacetyl chloride as an anal. ¹⁹F NMR reagent to characterize alcs., phenols, thiols, and primary and secondary amines is discussed. The ¹⁹F chem. shift and yield data for trifluoroacetyl derivatives of approx. 50 model compounds are presented. The importance of an added organic base (2,6-lutidine) in derivative preparation for phenols, and primary and secondary amines is also discussed.

Analytical Chemistry published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C18H34N4O5S, Formula: C6H10F3NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Jagt, Richard B. C. published the artcilePattern-based recognition of heparin contaminants by an array of self-assembling fluorescent receptors, Quality Control of 1869-45-0, the publication is Angewandte Chemie, International Edition (2009), 48(11), 1995-1997, database is CAplus and MEDLINE.

Tracking down potential killers: Strong host-guest interactions enable the facile combination of polycationic cyclodextrin binding motifs (blue) with fluorescent reporters (orange) tethered to a hydrophobic guest mol. (dark green). An array of supramol. fluorescent receptors prepared by this modular approach was used for the pattern-based recognition of neg. charged contaminants in the anticoagulant drug heparin.

Angewandte Chemie, International Edition published new progress about 1869-45-0. 1869-45-0 belongs to amides-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is 2,2,2-Trifluoro-N-(2-mercaptoethyl)acetamide, and the molecular formula is C4H6F3NOS, Quality Control of 1869-45-0.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Song, Guoyong published the artcileSynthesis of Quinolines via Rh(III)-Catalyzed Oxidative Annulation of Pyridines, Formula: C10H14N2O, the publication is Journal of Organic Chemistry (2011), 76(18), 7583-7589, database is CAplus and MEDLINE.

Selective synthesis of quinolines, e.g., I (R¹ = H, Me, MeO, Cl; R² = H, Me, MeO, Cl), has been achieved via oxidative annulation of functionalized pyridines with two alkyne mols. under Rh(III)-catalyzed cascade C-H activation of pyridines using Cu(OAc)₂ as an oxidant. The selectivity of this reaction is oxidant-dependent, particularly on the anion of the oxidant.

Journal of Organic Chemistry published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C8H7NaO4S, Formula: C10H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hernandez-Folgado, Laura published the artcileNovel derivatives of 3-alkyl-1,5-diaryl-1H-1,2,4-triazoles and their pharmacological evaluation as CB₁ cannabinoid ligands, Name: 2,4-Dichlorobenzamide, the publication is Monatshefte fuer Chemie (2008), 139(9), 1073-1082, database is CAplus.

In a previous study, the authors identified 3-alkyl-1,5-diaryl-1H-1,2,4-triazoles, e.g., I, to be a novel class of cannabinoid type-1 (CB₁) receptor antagonists. However, the synthesis yields for the ligands were low. An alternative synthesis pathway with improved yields is presented here. In addition, they have synthesized new structural derivatives and studied their results in competitive radioligand binding assays for cannabinoid receptors.

Monatshefte fuer Chemie published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Name: 2,4-Dichlorobenzamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Waisser, K. published the artcileHydrophobic properties of some thiobenzamides, antimycobacterially active compounds, Category: amides-buliding-blocks, the publication is Folia Pharmaceutica Universitatis Carolinae (1998), 23(Suppl.), 114-115, database is CAplus.

HPLC was used to assess the hydrophobic properties of 11 PhCSNH₂ (R = H, 3- and 4-MeO and -Cl, 4-O₂N, 4-Me₂N, 4-Me, 4-MeS, 3,4-Cl₂, 3-Br). A correlation equation was derived for this series of compounds, based on hydrophobic substituent constants calculated for R.

Folia Pharmaceutica Universitatis Carolinae published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C11H12O4, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Knunyants, I. L. published the artcileNitration of perfluoropropylene by nitrogen dioxide and a study of the nitration products, Recommanded Product: N,N-Diethyl-2,2,2-trifluoroacetamide, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1966), 466-72, database is CAplus.

Perfluoropropylene (I) and N₂O₄ yield O₂NCF₂CF(NO₂)CF₃ (II) along with CF₃CF(ONO)CF₂NO₂ (III). The structure of III was confirmed as shown below. Evidently I and N₂O₄ form intermediate radical [CF₃CFCF₂NO₂] which reacts with the ·NO₂ form of the free radical to yield II; reacting with the ·ONO form of the radical it yields III while reacting with NO it forms CF₃CF(NO)CF₂NO₂ (CA 51, 9472i). CF₃COCF₂NO₂ (IV) treated with absolute EtOH with ice-cooling gave 78% Et hemiacetal, b. 118°, d₂₀ 1.391, n²⁰_D 1.3520. IV treated with CH₂:CO at -30° gave 82% V, b₄₄ 68°, 1.616, 1.3621. IV and dry HCl at -20° gave HOC(CF₃)ClCF₂NO₂, b. 37°, 1.609, 1.3500; HBr similarly gave HOC(CF₃)BrCF₂NO₂, b. 50°, 1.935, 1.3758. IV and HCN mixed at -40° and heated in a sealed tube 2 h. at 100° gave HOC(CN)(CF₃)CF₂NO₂, b₂₀ 64-5°, 1.6282, 1.3495. IV and dry NH₃ in Et₂O at -30° gave CF₃CONH₂, m. 68°. IV. H₂O (b. 119-20°, 1.638, 1.3560)(22.8 g.) added to 50 mL. 10% NaOH at 80° (exothermic reaction) gave a distillate of 62.5% CHF₂NO₂, b. 42°; evaporation of the residual solution gave the Na salt which acidified with H₂SO₄ and heated gave CF₃CO₂H. CHF₂NO₂ (4.1 g.) and 2.4 g. AcH with a trace of K₂CO₃ heated in a sealed tube 4 h. at 100° and 1 h. at 120° gave 64% O₂NCF₂CHMeOH, b₂₅ 64-5°, 1.390, 1.3825; similar reaction with paraformaldehyde gave 88% O₂NCF₂CH₂OH, b₄₀ 65°, 1.4792, 1.3780; similar reaction with Me₂CO gave 44% O₂NCF₂CMe₂OH, b₃₅ 55°, 1.2950, 1.3915. IV treated dropwise with Et₂NH with cooling gave 55% CF₃CONEt₂, b₄ 44°, 1.142, 1.3798. Mixing IV with NOF at -70° and heating in a sealed tube 6 h. at 100° gave 86.5% III, b. 57-8°, 1.637, 1.3276.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Recommanded Product: N,N-Diethyl-2,2,2-trifluoroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Gilligan, Paul J. published the artcilePyrazolo-[1,5-a]-1,3,5-triazine corticotropin-releasing factor (CRF) receptor ligands, Product Details of C7H5Cl2NO, the publication is Bioorganic & Medicinal Chemistry (2003), 11(18), 4093-4102, database is CAplus and MEDLINE.

The syntheses and rat CRF receptor binding affinities of retro-pyrazolotriazine’ corticotropin-releasing factor (CRF) ligands are reported. Some have high affinity for rat CRF receptors (K_i≤10 nM). The data provide addnl. support for the hypothesis that it is possible to interchange isosteric cores with similar electronic properties in the design of high-affinity CRF receptor ligands, provided the peripheral pharmacophore elements are maintained in the same three-dimensional array.

Bioorganic & Medicinal Chemistry published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Product Details of C7H5Cl2NO.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics