Tag: M.W=150-200

Xiong, Hui published the artcileEfficient synthesis of a 7-azabicyclo[2.2.1]heptane based GlyT1 uptake inhibitor, Application In Synthesis of 100377-32-0, the publication is Tetrahedron Letters (2010), 51(51), 6741-6744, database is CAplus.

An efficient synthetic route based on generation and subsequent electrophilic reaction of a Boc-protected azabicyclo[2.2.1]heptane anion to prepare a potent GlyT1 uptake inhibitor I is described.

Tetrahedron Letters published new progress about 100377-32-0. 100377-32-0 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N-Methoxy-N-methylisonicotinamide, and the molecular formula is C12H15ClO3, Application In Synthesis of 100377-32-0.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Ren, Shijin published the artcileAn exploratory study of the use of multivariate techniques to determine mechanisms of toxic action, Related Products of amides-buliding-blocks, the publication is Ecotoxicology and Environmental Safety (2003), 55(1), 86-97, database is CAplus and MEDLINE.

The most successful quant. structure-activity relationships have been developed by separating compounds by their mechanisms of toxic action (MOAs). However, to correctly determine the MOA of a compound is often not easy. The authors investigated the usefulness of discriminant anal. and logistic regression in determining MOAs. The discriminating variables used were the logarithm of octanol-water partition coefficients (log K_ow) and the exptl. toxicity data obtained from Pimephales promelas and Tetrahymena pyriformis assays. Small total error rates were obtained when separating nonpolar narcotic compounds from other compounds, however, relatively high total error rates were obtained when separating less reactive compounds (polar, ester, and amine narcotics) from more reactive compounds (electrophiles, proelectrophiles, and nucleophiles).

Ecotoxicology and Environmental Safety published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Neta, Pedatsur published the artcileUnexpected peaks in tandem mass spectra due to reaction of product ions with residual water in mass spectrometer collision cells, Product Details of C10H14N2O, the publication is Rapid Communications in Mass Spectrometry (2014), 28(23), 2645-2660, database is CAplus and MEDLINE.

Certain product ions in electrospray ionization tandem mass spectrometry react with residual water in the collision cell. This reaction often gives ions that cannot be formed directly from the precursor ions, and this complicates the mass spectra and may distort MRM (multiple reaction monitoring) results. Various drugs, pesticides, metabolites, and other compounds were dissolved in acetonitrile/water/formic acid and studied by electrospray ionization mass spectrometry to record their MS² and MSⁿ spectra in several mass spectrometers (QqQ, QTOF, IT, and Orbitrap HCD). Certain product ions react with residual water in collision cells. The reaction was confirmed by MSⁿ studies and the rate of reaction was determined in the IT instrument using zero collision energy and variable activation times. Examples of product ions reacting with water include Ph and certain substituted Ph cations, benzoyl-type cations formed from protonated folic acid and similar compounds by loss of the glutamate moiety, product ions formed from protonated cyclic siloxanes by loss of methane, product ions formed from organic phosphates, and certain neg. ions. The reactions of product ions with residual water varied greatly in their rate constant and in the extent of reaction (due to isomerization). Thus, various types of product ions react with residual water in mass spectrometer collision cells. As a result, tandem mass spectra may contain unexplained peaks and MRM results may be distorted by the occurrence of such reactions. These often unavoidable reactions must be taken into account when annotating peaks in tandem mass spectra and when interpreting MRM results.

Rapid Communications in Mass Spectrometry published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Product Details of C10H14N2O.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Markovskii, L. N. published the artcileIminothionyl chlorides. X. Synthesis from iminoester. Infrared spectra, Computed Properties of 2447-79-2, the publication is Zhurnal Organicheskoi Khimii (1974), 10(5), 992-7, database is CAplus.

RN:SCl2 [R = Cl3CCO (I), Bz (II), p-ClC6H4CO (III), p-BrC6H4CO (IV), 2,4-Cl2C6H3CO (V), p-O2NC6H4CO (VI), MeSO2 (VII), PhSO2 (VIII)] were prepared by different methods. II, V, VI, VII, and VIII were prepared (60-89%) by reaction of RNH2 with SCl2. I, II, III, IV, V and VI were prepared (57-90%) by reaction of the corresponding alkyl arenecarboximidate with SCl2. II and VI were prepared (59-95%) by reaction of SCl2 with PhC(:NCl)OR (R = alkyl) and p-O2NC6-H4C(:NCl)OR, resp. Reaction of p-O2NC6H4C(OEt):NSN:-C(OEt)C6H4NO2-p with SCl2 gave 62% VI. The ir spectra depended on R.

Zhurnal Organicheskoi Khimii published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, Computed Properties of 2447-79-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sanderson, John M. published the artcilePreparation of novel 3H-trifluoromethyldiazirine-based photoactivatable potassium channel antagonists, Name: N,N-Diethyl-2,2,2-trifluoroacetamide, the publication is Tetrahedron (2005), 61(47), 11244-11252, database is CAplus.

The preparation of a series of photoactivatable precursors for use in photoaffinity labeling of potassium channels is described. 3H-Diazirine functionalities were incorporated into previously described potassium channel antagonists. The ability to perform enantioselective reductions and Wittig reactions in the presence of a diaziridine group was central to this work.

Tetrahedron published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Name: N,N-Diethyl-2,2,2-trifluoroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Ciusa, W. published the artcileThe ultraviolet spectra of the m- and p-substituted N-alkyl derivatives of pyridine, Recommanded Product: N,N-Diethylisonicotinamide, the publication is Bollettino Scientifico della Facolta di Chimica Industriale di Bologna (1959), 12-26, database is CAplus.

cf. CA 53, 5398e; 53, 20059d. Pyridine derivatives, prepared as described in earlier publications, were dissolved in 0.1N NaCl (pH 6-7), 0.1N HCl (pH 1.1), and in 0.1N NaOH (pH 13.0) to give 0.1-0.05M solutions and their ultraviolet spectra obtained for the range 210-460 mμ at 20 ± 2°. These were presented in 37 absorption curves. The λ_maximum and the extinction (ε × 10^-3) at this wave length in HCl, NaCl, and NaOH for these compounds were: pyridine, 256, 5.4, 3.4, 2.5; methylpyridinium (I) iodide, 260, 4.5, 4.4, 4.8; I bromide, 258, 4.5, 4.5 4.5; I chloride, 258, 4.7, 5.0, 4.9; dodecylpyridinium bromide, 260, 4.0, 3.5, 4.1; myristylpyridinium bromide, 260, 4.5, 4.1, 4.6; cetylpyridinium (II) bromide, 260, 3.4, 3.1, 3.5; II chloride, 260, 4.8, 4.6, 4.8; octadecylpyridinium bromide, 260, 4.9, 3.5, 4.0; Et ester of nicotinic acid (III), 260 (265, 262), 5.0, 2.7, 3.0; III MeI salt, 265, 4.5, 3.9, 4.0; III MeBr salt, 265, 4.5, 4.3, 4.0; III MeCl salt, 265, 4.2, 4.3, 3.4; III BuBr salt, 265, 4.2, 4.3, 3.4; III iso-AmBr salt, 265, 4.5, 4.3, 4.3; nicotinic acid (IV), 261 (262, 264), 4.9, 3.6, 2.8; IV MeI salt, 265, 4.3, 4.9, 4.0; trigonelline, 265, 4.0, 3.8, 4.0; IV amide, 260, 4.8, 3.3, 3.0; IV amide-MeI, 265, 4.9, 4.6, 4.8; IV monomethylamide, 262, 5.7, 3.6, 3.5; IV diethylamide (V), 262, 5.2, 3.6, 3.3; V MeCl salt, 268, 4.3, 4.8, 4.6; V EtCl salt, 268, 4.0, 3.8, 3.8; V iso-PrCl salt, 268, 3.5, 3.5, 3.8; V AmCl salt, 265, 4.0, 3.8, 3.0; V AcCl salt, 268, 4.0, 3.8, 3.6; Et ester of isonicotinic acid (VI), 272 (272, 265), 4.5, 2.8, 2.8; VI MeI salt, 275 (278, 268), 4.5, 4.6, 4.4; VI EtBr salt, 275 (268, 265), 4.1, 3.5, 4.1; VI decyl bromide, 275 (278, 265), 4.3, 3.9, 3.5; isonicotinic acid (VII), 270 (263, 265), 4.1, 3.2, 2.1; isotrigonelline, 272 (265, 265), 3.9, 3.9, 4.1; VII amide, 262 (266, 266), 5.0, 2.8, 2.6; VII amide-MeI, 268 (266, 264), 4.7, 4.8, 4.5; VII diethylamide (VIII), 259 (259, 258), 6.3, 3.3, 3.2; VIII MeCl salt, 262, 5.9, 5.9, 5.7; VIII EtCl salt, 262, 5.8, 5.8, 5.5; VIII cetyl chloride, 262, 6.1, 6.3, 5.7. The lack of influence by CO₂H or CO₂R groups was in disagreement with findings by Black (CA 49, 15389h).

Bollettino Scientifico della Facolta di Chimica Industriale di Bologna published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Recommanded Product: N,N-Diethylisonicotinamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Findlay, John B. C. published the artcileA simple and efficient preparation of 3-aryl-3-trifluoromethyl-3H-diazirinyl sulfoxides and sulfones, Computed Properties of 360-92-9, the publication is Synthesis (1995), 553-6, database is CAplus.

All regioisomers of 3-aryl-3-trifluoromethyl-3H-diazirinyl sulfoxides and sulfones I (R = 2-, 3-, and 4-MeSOC₆H₄, -MeSO₂C₆H₄) were prepared in five steps from the corresponding bromothioanisoles in excellent overall yields. The key step involves a simultaneous oxidation of sulfide and diaziridine moieties resp., to yield either the diazirine sulfoxide or sulfone, depending on reaction conditions.

Synthesis published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Computed Properties of 360-92-9.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Saha, Sayantani published the artcileMild catalytic deoxygenation of amides promoted by thorium metallocene, Application of N,N-Diethyl-2,2,2-trifluoroacetamide, the publication is Dalton Transactions (2020), 49(36), 12835-12841, database is CAplus and MEDLINE.

The organoactinide-catalyzed (Cp*₂ThMe₂) hydroborated reduction of a wide range of tertiary, secondary, and primary amides to the corresponding amines/amine-borane adducts via deoxygenation of the amides is reported herein. The catalytic reactions proceed under mild conditions with low catalyst loading and pinacolborane (HBpin) concentration in a selective fashion. Cp*₂ThMe₂ is capable of efficiently catalyzing the gram-scale reaction without a drop in efficiency. The amine-borane adducts are successfully converted into free amine products in high conversions, which increases the usefulness of this catalytic system. A plausible mechanism is proposed based on detailed kinetics, stoichiometric, and deuterium labeling studies.

Dalton Transactions published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Application of N,N-Diethyl-2,2,2-trifluoroacetamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Edward, John T. published the artcileApplicability of the HT acidity function to the protonation of thioamides, thioureas, and thioesters, Quality Control of 64559-06-4, the publication is Canadian Journal of Chemistry (1977), 55(12), 2331-5, database is CAplus.

The protonation of eleven thioamides, five thioureas, and four thionbenzoates in aqueous sulfuric acid follows the HT acidity function. Protonation constants pKTH+ obtained by use of HT agreed fairly well with pKTH+ values obtained by the Bunnett-Olsen method, but less well with those obtained by the Marziano-Cimino-Passerini procedure. Linear free energy relation of pKTH+ values are discussed.

Canadian Journal of Chemistry published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, Quality Control of 64559-06-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Palmisano, Giovanni published the artcileElectrochemical heterocyclization of o-toluenesulfonamides to 3-alkyl-4,5-dihydro-1,2,4-benzothiadiazepine 1,1-dioxides, Application In Synthesis of 489-17-8, the publication is Tetrahedron (1988), 44(5), 1545-52, database is CAplus.

Controlled potential oxidation of a variety of substituted o-toluenesulfonamides at a Pt anode in MeCN using a divided cell forms 3-methyl-4,5-dihydro-1,2,4-benzothiadiazepine-1,1-dioxides selectively and in generally good yields. The scope and limitations of this 1-step heterocyclization sequence are also discussed.

Tetrahedron published new progress about 489-17-8. 489-17-8 belongs to amides-buliding-blocks, auxiliary class Fluoride,Sulfamide,Amine,Benzene, name is 4-Fluoro-2-methylbenzenesulfonamide, and the molecular formula is C7H8FNO2S, Application In Synthesis of 489-17-8.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics